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Volumn 61, Issue 5, 2016, Pages 1398-1405

Novel Pharmacotherapy Options for NASH

Author keywords

Aramchol; Cenicriviroc; Elafibranor; Liraglutide; Nonalcoholic steatohepatitis; Obeticholic acid

Indexed keywords

ABC TRANSPORTER A1; ACYL COENZYME A DESATURASE 1; ALANINE AMINOTRANSFERASE; ANTIFIBROTIC AGENT; ARAMCHOL; BILE ACID CONJUGATE; CENICRIVIROC; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; ELAFIBRANOR; FARNESOID X RECEPTOR; GALECTIN 3; GR MD 02; INCRETIN; INSULIN; LIRAGLUTIDE; LIVER PROTECTIVE AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOUNSATURATED FATTY ACID; NEW DRUG; OBETICHOLIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; RANTES; SIMTUZUMAB; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84961848398     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-016-4128-z     Document Type: Review
Times cited : (34)

References (79)
  • 1
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American association for the study of liver diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • PID: 22488764
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American association for the study of liver diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55:2005–2023.
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 2
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • COI: 1:STN:280:DC%2BC3MnlsVamsg%3D%3D, PID: 21623852
    • Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther. 2011;34:274–285.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 3
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • COI: 1:CAS:528:DC%2BD28XhtFyqsrzN, PID: 17006923
    • Ekstedt M, Franzen LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology. 2006;44:865–873.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 4
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • PID: 20014114
    • Soderberg C, Stal P, Askling J, et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology. 2010;51:595–602.
    • (2010) Hepatology , vol.51 , pp. 595-602
    • Soderberg, C.1    Stal, P.2    Askling, J.3
  • 5
    • 77952529040 scopus 로고    scopus 로고
    • A position statement on NAFLD/NASH based on the EASL 2009 special conference
    • PID: 20494470
    • Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010;53:372–384.
    • (2010) J Hepatol , vol.53 , pp. 372-384
    • Ratziu, V.1    Bellentani, S.2    Cortez-Pinto, H.3    Day, C.4    Marchesini, G.5
  • 6
    • 67649306197 scopus 로고    scopus 로고
    • Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BD1MXnvVams7g%3D, PID: 19501928
    • Argo CK, Northup PG, Al-Osaimi AM, Caldwell SH. Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J Hepatol. 2009;51:371–379.
    • (2009) J Hepatol , vol.51 , pp. 371-379
    • Argo, C.K.1    Northup, P.G.2    Al-Osaimi, A.M.3    Caldwell, S.H.4
  • 7
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC3cXhsVCqtbg%3D, PID: 19827166
    • Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51:121–129.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 8
    • 84929354082 scopus 로고    scopus 로고
    • Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology
    • Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015;149:367–378 e365; quiz e314–365.
  • 9
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss
    • PID: 15185306
    • Dixon JB, Bhathal PS, Hughes NR, O’Brien PE. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology. 2004;39:1647–1654.
    • (2004) Hepatology , vol.39 , pp. 1647-1654
    • Dixon, J.B.1    Bhathal, P.S.2    Hughes, N.R.3    O’Brien, P.E.4
  • 10
    • 0348047323 scopus 로고    scopus 로고
    • Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis
    • PID: 14694300
    • Kral JG, Thung SN, Biron S, et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery. 2004;135:48–58.
    • (2004) Surgery , vol.135 , pp. 48-58
    • Kral, J.G.1    Thung, S.N.2    Biron, S.3
  • 11
    • 84925374835 scopus 로고    scopus 로고
    • Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop
    • PID: 25557690
    • Sanyal AJ, Friedman SL, McCullough AJ, Dimick-Santos L. Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop. Hepatology. 2015;61:1392–1405.
    • (2015) Hepatology , vol.61 , pp. 1392-1405
    • Sanyal, A.J.1    Friedman, S.L.2    McCullough, A.J.3    Dimick-Santos, L.4
  • 12
    • 84930654328 scopus 로고    scopus 로고
    • Current efforts and trends in the treatment of NASH
    • COI: 1:CAS:528:DC%2BC2MXnvFChtbk%3D, PID: 25920092
    • Ratziu V, Goodman Z, Sanyal A. Current efforts and trends in the treatment of NASH. J Hepatol. 2015;62:S65–S75.
    • (2015) J Hepatol , vol.62 , pp. S65-S75
    • Ratziu, V.1    Goodman, Z.2    Sanyal, A.3
  • 13
    • 77952529040 scopus 로고    scopus 로고
    • A position paper on NAFLD/NASH based on the EASL 2009 special conference
    • PID: 20494470
    • Ratziu V, Bellentani S, Cortez-Pinto H, Day CP, Marchesini G. A position paper on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010;53:372–384.
    • (2010) J Hepatol , vol.53 , pp. 372-384
    • Ratziu, V.1    Bellentani, S.2    Cortez-Pinto, H.3    Day, C.P.4    Marchesini, G.5
  • 14
    • 84859404868 scopus 로고    scopus 로고
    • Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications Gastroenterology
    • Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications Gastroenterology. 2012;142:711–725 e716.
  • 15
    • 77955690182 scopus 로고    scopus 로고
    • Hepatic lipotoxicity and the pathogenesis of NASH: the central role of nontriglyceride fatty acid metabolites
    • PID: 20683968
    • Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of NASH: the central role of nontriglyceride fatty acid metabolites. Hepatology. 2010;52:774–788.
    • (2010) Hepatology , vol.52 , pp. 774-788
    • Neuschwander-Tetri, B.A.1
  • 16
    • 84900793058 scopus 로고    scopus 로고
    • Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation
    • COI: 1:CAS:528:DC%2BC2MXjtFyntLc%3D, PID: 24830559
    • Peverill W, Powell LW, Skoien R. Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation. Int J Mol Sci. 2014;15:8591–8638.
    • (2014) Int J Mol Sci , vol.15 , pp. 8591-8638
    • Peverill, W.1    Powell, L.W.2    Skoien, R.3
  • 17
    • 84891735940 scopus 로고    scopus 로고
    • Bile acid receptors as targets for drug development
    • COI: 1:CAS:528:DC%2BC3sXhsVWqsLbP, PID: 23982684
    • Schaap FG, Trauner M, Jansen PL. Bile acid receptors as targets for drug development. Nat Rev Gastroenterol Hepatol. 2014;11:55–67.
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , pp. 55-67
    • Schaap, F.G.1    Trauner, M.2    Jansen, P.L.3
  • 18
    • 84865499656 scopus 로고    scopus 로고
    • Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC38XosFWgtLc%3D, PID: 22652341
    • Adorini L, Pruzanski M, Shapiro D. Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today. 2012;17:988–997.
    • (2012) Drug Discov Today , vol.17 , pp. 988-997
    • Adorini, L.1    Pruzanski, M.2    Shapiro, D.3
  • 19
    • 84925362562 scopus 로고    scopus 로고
    • Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid
    • Hirschfield GM, Mason A, Luketic V, et al. Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology. 2015;148:e758.
    • (2015) Gastroenterology , vol.148 , pp. e758
    • Hirschfield, G.M.1    Mason, A.2    Luketic, V.3
  • 20
    • 84911199789 scopus 로고    scopus 로고
    • Lammers WJ, van Buuren HR, Hirschfield GM et al. Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study Gastroenterology
    • Lammers WJ, van Buuren HR, Hirschfield GM et al. Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study Gastroenterology. 2014;147:1338–1349 e1335; quiz e1315.
  • 21
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • COI: 1:CAS:528:DC%2BD28XjsVWnurk%3D, PID: 16557297
    • Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006;116:1102–1109.
    • (2006) J Clin Invest , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 22
    • 56149085041 scopus 로고    scopus 로고
    • Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
    • COI: 1:CAS:528:DC%2BD1cXhsVKmt77J, PID: 18972444
    • Wang YD, Chen WD, Wang M, Yu D, Forman BM, Huang W. Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology. 2008;48:1632–1643.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 23
    • 67649210759 scopus 로고    scopus 로고
    • Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BD1MXnvVams7k%3D, PID: 19501927
    • Zhang S, Wang J, Liu Q, Harnish DC. Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J Hepatol. 2009;51:380–388.
    • (2009) J Hepatol , vol.51 , pp. 380-388
    • Zhang, S.1    Wang, J.2    Liu, Q.3    Harnish, D.C.4
  • 24
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3sXhtlyrsr3O, PID: 23727264
    • Mudaliar S, Henry RR, Sanyal AJ, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology. 2013;145:574–582.
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3
  • 25
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri BA, Loomba R, Sanyal AJ, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 2015;85:956–965.
    • (2015) Lancet , vol.85 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3
  • 26
    • 84963647487 scopus 로고    scopus 로고
    • Ubeda M, Lario M, Munoz L et al. Obeticholic acid reduces bacterial translocation, restores intestinal barrier and inhibits inflammation in cirrhotic rats J Hepatol. 2016
    • Ubeda M, Lario M, Munoz L et al. Obeticholic acid reduces bacterial translocation, restores intestinal barrier and inhibits inflammation in cirrhotic rats J Hepatol. 2016;in press.
  • 27
    • 84901605121 scopus 로고    scopus 로고
    • Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats
    • COI: 1:CAS:528:DC%2BC2cXovFahurc%3D, PID: 24259407
    • Verbeke L, Farre R, Trebicka J, et al. Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats. Hepatology. 2014;59:2286–2298.
    • (2014) Hepatology , vol.59 , pp. 2286-2298
    • Verbeke, L.1    Farre, R.2    Trebicka, J.3
  • 28
    • 49649129066 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
    • COI: 1:CAS:528:DC%2BD1cXhtVCqt73E, PID: 18627005
    • Qin X, Xie X, Fan Y, et al. Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology. 2008;48:432–441.
    • (2008) Hepatology , vol.48 , pp. 432-441
    • Qin, X.1    Xie, X.2    Fan, Y.3
  • 29
    • 33644645013 scopus 로고    scopus 로고
    • PPAR delta: a dagger in the heart of the metabolic syndrome
    • COI: 1:CAS:528:DC%2BD28XitlGkt7w%3D, PID: 16511591
    • Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006;116:590–597.
    • (2006) J Clin Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 30
    • 84875190733 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta: a multifaceted metabolic player
    • COI: 1:CAS:528:DC%2BC3sXjvVeju70%3D, PID: 23481229
    • Bojic LA, Huff MW. Peroxisome proliferator-activated receptor delta: a multifaceted metabolic player. Curr Opin Lipidol. 2013;24:171–177.
    • (2013) Curr Opin Lipidol , vol.24 , pp. 171-177
    • Bojic, L.A.1    Huff, M.W.2
  • 31
    • 84923067081 scopus 로고    scopus 로고
    • Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC2MXivFequ7g%3D, PID: 25450203
    • Pawlak M, Lefebvre P, Staels B. Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J Hepatol. 2015;62:720–733.
    • (2015) J Hepatol , vol.62 , pp. 720-733
    • Pawlak, M.1    Lefebvre, P.2    Staels, B.3
  • 32
    • 84888285959 scopus 로고    scopus 로고
    • Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC3sXhvVGku7vJ, PID: 23703580
    • Staels B, Rubenstrunk A, Noel B, et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology. 2013;58:1941–1952.
    • (2013) Hepatology , vol.58 , pp. 1941-1952
    • Staels, B.1    Rubenstrunk, A.2    Noel, B.3
  • 33
    • 79960988152 scopus 로고    scopus 로고
    • Effects of the new dual PPAR alpha/delta agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism
    • COI: 1:CAS:528:DC%2BC3MXht1OgsLfO, PID: 21816979
    • Cariou B, Zair Y, Staels B, Bruckert E. Effects of the new dual PPAR alpha/delta agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes Care. 2011;34:2008–2014.
    • (2011) Diabetes Care , vol.34 , pp. 2008-2014
    • Cariou, B.1    Zair, Y.2    Staels, B.3    Bruckert, E.4
  • 34
    • 84888285959 scopus 로고    scopus 로고
    • Hepato-protective effects of the dual PPARalpha/delta agonist GFT505 in rodent models of NAFLD/NASH
    • COI: 1:CAS:528:DC%2BC3sXhvVGku7vJ, PID: 23703580
    • Staels B, Rubenstrunk A, Noel B, et al. Hepato-protective effects of the dual PPARalpha/delta agonist GFT505 in rodent models of NAFLD/NASH. Hepatology. 2013;58:1941–1952.
    • (2013) Hepatology , vol.58 , pp. 1941-1952
    • Staels, B.1    Rubenstrunk, A.2    Noel, B.3
  • 35
    • 84885405205 scopus 로고    scopus 로고
    • Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects
    • COI: 1:CAS:528:DC%2BC3sXhs1ylt7vI, PID: 23715754
    • Cariou B, Hanf R, Lambert-Porcheron S, et al. Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. Diabetes Care. 2013;36:2923–2930.
    • (2013) Diabetes Care , vol.36 , pp. 2923-2930
    • Cariou, B.1    Hanf, R.2    Lambert-Porcheron, S.3
  • 36
    • 84960140218 scopus 로고    scopus 로고
    • Ratziu V, Harrison S, Franque S et al. Elafibranor, an agonist of the peroxisome proliferator-activated receptor alpha and delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Gastroenterology. 2016
    • Ratziu V, Harrison S, Franque S et al. Elafibranor, an agonist of the peroxisome proliferator-activated receptor alpha and delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Gastroenterology. 2016;in press.
  • 37
    • 78049415469 scopus 로고    scopus 로고
    • Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
    • COI: 1:CAS:528:DC%2BC3cXhsVWgtbnO, PID: 20978355
    • Berres ML, Koenen RR, Rueland A, et al. Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest. 2010;120:4129–4140.
    • (2010) J Clin Invest , vol.120 , pp. 4129-4140
    • Berres, M.L.1    Koenen, R.R.2    Rueland, A.3
  • 38
    • 81155123815 scopus 로고    scopus 로고
    • Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis
    • COI: 1:CAS:528:DC%2BC3MXhs1ansLvK, PID: 22150762
    • Zimmermann HW, Tacke F. Modification of chemokine pathways and immune cell infiltration as a novel therapeutic approach in liver inflammation and fibrosis. Inflamm Allergy Drug Targets. 2011;10:509–536.
    • (2011) Inflamm Allergy Drug Targets , vol.10 , pp. 509-536
    • Zimmermann, H.W.1    Tacke, F.2
  • 39
    • 84861872575 scopus 로고    scopus 로고
    • Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
    • COI: 1:CAS:528:DC%2BC38XhtVGlsrrI, PID: 22442158
    • Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012;302:G1310–G1321.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G1310-G1321
    • Miura, K.1    Yang, L.2    van Rooijen, N.3    Ohnishi, H.4    Seki, E.5
  • 40
    • 84857055199 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • COI: 1:CAS:528:DC%2BC38Xlt1Srsrc%3D, PID: 21813474
    • Baeck C, Wehr A, Karlmark KR, et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut. 2012;61:416–426.
    • (2012) Gut , vol.61 , pp. 416-426
    • Baeck, C.1    Wehr, A.2    Karlmark, K.R.3
  • 41
    • 84928184342 scopus 로고    scopus 로고
    • Anti-fibrotic and anti-inflammatory activity of the dual CCR2 and CCR5 antagonist cenicriviroc in a mouse model of NASH
    • Lefebvre E, Hashiguchi T, Jenkins H, et al. Anti-fibrotic and anti-inflammatory activity of the dual CCR2 and CCR5 antagonist cenicriviroc in a mouse model of NASH. Hepatology. 2013;58:221A–222A.
    • (2013) Hepatology , vol.58 , pp. 221A-222A
    • Lefebvre, E.1    Hashiguchi, T.2    Jenkins, H.3
  • 42
    • 84906558405 scopus 로고    scopus 로고
    • Significant anti-fibrotic activity of cenicriviroc, a dual CCR2/CCR5 antagonist, in a rat model of thioacetamide-induced liver fibrosis and cirrhosis
    • Hong F, Chou H, Friedman SL. Significant anti-fibrotic activity of cenicriviroc, a dual CCR2/CCR5 antagonist, in a rat model of thioacetamide-induced liver fibrosis and cirrhosis. Hepatology. 2013;58:S1.
    • (2013) Hepatology , vol.58 , pp. S1
    • Hong, F.1    Chou, H.2    Friedman, S.L.3
  • 43
    • 84960110717 scopus 로고    scopus 로고
    • Friedman SL, Sanyal A, Goodman Z et al. Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design. Contemp Clin Trials. 2016
    • Friedman SL, Sanyal A, Goodman Z et al. Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design. Contemp Clin Trials. 2016;in press.
  • 44
    • 77958028757 scopus 로고    scopus 로고
    • Fatty acid bile acid conjugates (FABACs)—new molecules for the prevention of cholesterol crystallisation in bile
    • COI: 1:CAS:528:DC%2BD3MXntFKmsw%3D%3D, PID: 11115826
    • Gilat T, Somjen GJ, Mazur Y, et al. Fatty acid bile acid conjugates (FABACs)—new molecules for the prevention of cholesterol crystallisation in bile. Gut. 2001;48:75–79.
    • (2001) Gut , vol.48 , pp. 75-79
    • Gilat, T.1    Somjen, G.J.2    Mazur, Y.3
  • 45
    • 0041764976 scopus 로고    scopus 로고
    • Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC)
    • COI: 1:CAS:528:DC%2BD3sXmvFSmur0%3D, PID: 12883488
    • Gilat T, Leikin-Frenkel A, Goldiner I, et al. Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC). Hepatology. 2003;38:436–442.
    • (2003) Hepatology , vol.38 , pp. 436-442
    • Gilat, T.1    Leikin-Frenkel, A.2    Goldiner, I.3
  • 46
    • 78049421656 scopus 로고    scopus 로고
    • Fatty acid bile acid conjugate inhibits hepatic stearoyl coenzyme A desaturase and is non-atherogenic
    • COI: 1:CAS:528:DC%2BC3cXhtlOhsbbE, PID: 21044742
    • Leikin-Frenkel A, Gonen A, Shaish A, et al. Fatty acid bile acid conjugate inhibits hepatic stearoyl coenzyme A desaturase and is non-atherogenic. Arch Med Res. 2010;41:397–404.
    • (2010) Arch Med Res , vol.41 , pp. 397-404
    • Leikin-Frenkel, A.1    Gonen, A.2    Shaish, A.3
  • 47
    • 33744974101 scopus 로고    scopus 로고
    • ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid–bile acid conjugates (FABACs)
    • COI: 1:CAS:528:DC%2BD28XltVWlsLo%3D, PID: 16522192
    • Goldiner I, van der Velde AE, Vandenberghe KE, et al. ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid–bile acid conjugates (FABACs). Biochem J. 2006;396:529–536.
    • (2006) Biochem J , vol.396 , pp. 529-536
    • Goldiner, I.1    van der Velde, A.E.2    Vandenberghe, K.E.3
  • 48
    • 33745212925 scopus 로고    scopus 로고
    • Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
    • COI: 1:CAS:528:DC%2BD28XlsFWqsrc%3D, PID: 16741579
    • Gutierrez-Juarez R, Pocai A, Mulas C, et al. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest. 2006;116:1686–1695.
    • (2006) J Clin Invest , vol.116 , pp. 1686-1695
    • Gutierrez-Juarez, R.1    Pocai, A.2    Mulas, C.3
  • 49
    • 84892755312 scopus 로고    scopus 로고
    • An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009–2013)
    • COI: 1:CAS:528:DC%2BC2cXptlWgsQ%3D%3D, PID: 24251719
    • Powell DA. An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009–2013). Expert Opin Ther Pat. 2014;24:155–175.
    • (2014) Expert Opin Ther Pat , vol.24 , pp. 155-175
    • Powell, D.A.1
  • 50
    • 84918843434 scopus 로고    scopus 로고
    • The fatty acid–bile acid conjugate aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
    • Safadi R, Konikoff FM, Mahamid M, et al. The fatty acid–bile acid conjugate aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014;12:e2081.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. e2081
    • Safadi, R.1    Konikoff, F.M.2    Mahamid, M.3
  • 51
    • 23044512117 scopus 로고    scopus 로고
    • Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease
    • PID: 15981216
    • Villanova N, Moscatiello S, Ramilli S, et al. Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease. Hepatology. 2005;42:473–480.
    • (2005) Hepatology , vol.42 , pp. 473-480
    • Villanova, N.1    Moscatiello, S.2    Ramilli, S.3
  • 52
    • 84887579055 scopus 로고    scopus 로고
    • The role of gastrointestinal hormones in hepatic lipid metabolism
    • COI: 1:CAS:528:DC%2BC3sXhvVGrt77P, PID: 24222092
    • Mells JE, Anania FA. The role of gastrointestinal hormones in hepatic lipid metabolism. Semin Liver Dis. 2013;33:343–357.
    • (2013) Semin Liver Dis , vol.33 , pp. 343-357
    • Mells, J.E.1    Anania, F.A.2
  • 53
    • 79959778328 scopus 로고    scopus 로고
    • Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability
    • COI: 1:CAS:528:DC%2BC3MXntlKksLY%3D, PID: 21525469
    • Garber AJ. Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability. Diabetes Care. 2011;34:S279–S284.
    • (2011) Diabetes Care , vol.34 , pp. S279-S284
    • Garber, A.J.1
  • 54
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • COI: 1:CAS:528:DC%2BC3cXntFCqtb0%3D, PID: 20225248
    • Gupta NA, Mells J, Dunham RM, et al. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology. 2010;51:1584–1592.
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3
  • 55
    • 84855317103 scopus 로고    scopus 로고
    • Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6 J mice fed a Western diet
    • COI: 1:CAS:528:DC%2BC38XhvVKqu70%3D, PID: 22038829
    • Mells JE, Fu PP, Sharma S, et al. Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6 J mice fed a Western diet. Am J Physiol Gastrointest Liver Physiol. 2012;302:G225–G235.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G225-G235
    • Mells, J.E.1    Fu, P.P.2    Sharma, S.3
  • 56
    • 80052517174 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC3MXhtlans77E, PID: 21745271
    • Svegliati-Baroni G, Saccomanno S, Rychlicki C, et al. Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver Int. 2011;31:1285–1297.
    • (2011) Liver Int , vol.31 , pp. 1285-1297
    • Svegliati-Baroni, G.1    Saccomanno, S.2    Rychlicki, C.3
  • 57
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • COI: 1:CAS:528:DC%2BD28Xpt1Snsw%3D%3D, PID: 16374859
    • Ding X, Saxena NK, Lin S, Gupta NA, Anania FA. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology. 2006;43:173–181.
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 58
    • 84954384684 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC2MXhvVGnurzO, PID: 26394161
    • Armstrong MJ, Hull D, Guo K, et al. Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis. J Hepatol. 2016;64:399–408.
    • (2016) J Hepatol , vol.64 , pp. 399-408
    • Armstrong, M.J.1    Hull, D.2    Guo, K.3
  • 59
    • 84936166069 scopus 로고    scopus 로고
    • A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
    • PID: 26132939
    • Pi-Sunyer X, Astrup A, Fujioka K, et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373:11–22.
    • (2015) N Engl J Med , vol.373 , pp. 11-22
    • Pi-Sunyer, X.1    Astrup, A.2    Fujioka, K.3
  • 60
    • 84872864369 scopus 로고    scopus 로고
    • Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program
    • COI: 1:CAS:528:DC%2BC3sXjvVaku74%3D, PID: 23163663
    • Armstrong MJ, Houlihan DD, Rowe IA, et al. Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program. Aliment Pharmacol Ther. 2013;37:234–242.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 234-242
    • Armstrong, M.J.1    Houlihan, D.D.2    Rowe, I.A.3
  • 61
    • 84957840942 scopus 로고    scopus 로고
    • Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
    • COI: 1:CAS:528:DC%2BC2MXhvVygsbzK, PID: 26608256
    • Armstrong MJ, Gaunt P, Aithal GP, et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet. 2016;387:679–690.
    • (2016) Lancet , vol.387 , pp. 679-690
    • Armstrong, M.J.1    Gaunt, P.2    Aithal, G.P.3
  • 62
    • 57349116772 scopus 로고    scopus 로고
    • Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon
    • PID: 19052125
    • Di Bisceglie AM, Shiffman ML, Everson GT, et al. Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon. N Engl J Med. 2008;359:2429–2441.
    • (2008) N Engl J Med , vol.359 , pp. 2429-2441
    • Di Bisceglie, A.M.1    Shiffman, M.L.2    Everson, G.T.3
  • 64
    • 33947362952 scopus 로고    scopus 로고
    • Final results of a double-blind, placebo-controlled trial of the antifibrotic efficacy of interferon-gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosis
    • COI: 1:CAS:528:DC%2BD2sXjs1GktbY%3D, PID: 17326152
    • Pockros PJ, Jeffers L, Afdhal N, et al. Final results of a double-blind, placebo-controlled trial of the antifibrotic efficacy of interferon-gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosis. Hepatology. 2007;45:569–578.
    • (2007) Hepatology , vol.45 , pp. 569-578
    • Pockros, P.J.1    Jeffers, L.2    Afdhal, N.3
  • 65
    • 84874118665 scopus 로고    scopus 로고
    • Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study
    • COI: 1:CAS:528:DC%2BC3sXnvVyrsw%3D%3D, PID: 23159770
    • Poynard T, Bruix J, Schiff ER, et al. Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: a randomized study. J Hepatol. 2013;58:452–459.
    • (2013) J Hepatol , vol.58 , pp. 452-459
    • Poynard, T.1    Bruix, J.2    Schiff, E.R.3
  • 66
    • 0037371153 scopus 로고    scopus 로고
    • Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
    • COI: 1:CAS:528:DC%2BD3sXhslWis7s%3D, PID: 12577300
    • Kagan HM, Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem. 2003;88:660–672.
    • (2003) J Cell Biochem , vol.88 , pp. 660-672
    • Kagan, H.M.1    Li, W.2
  • 67
    • 0027973699 scopus 로고
    • Lysyl oxidase: mechanism, regulation and relationship to liver fibrosis
    • COI: 1:CAS:528:DyaK2MXivFWisrc%3D, PID: 7899140
    • Kagan HM. Lysyl oxidase: mechanism, regulation and relationship to liver fibrosis. Pathol Res Pract. 1994;190:910–919.
    • (1994) Pathol Res Pract , vol.190 , pp. 910-919
    • Kagan, H.M.1
  • 68
    • 23444453195 scopus 로고    scopus 로고
    • Abnormal deposition of collagen around hepatocytes in Wilson’s disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2
    • COI: 1:CAS:528:DC%2BD2MXntVCku7Y%3D, PID: 16023247
    • Vadasz Z, Kessler O, Akiri G, et al. Abnormal deposition of collagen around hepatocytes in Wilson’s disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2. J Hepatol. 2005;43:499–507.
    • (2005) J Hepatol , vol.43 , pp. 499-507
    • Vadasz, Z.1    Kessler, O.2    Akiri, G.3
  • 69
    • 77956425361 scopus 로고    scopus 로고
    • Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
    • COI: 1:CAS:528:DC%2BC3cXhtFWksrvF, PID: 20818376
    • Barry-Hamilton V, Spangler R, Marshall D, et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med. 2010;16:1009–1017.
    • (2010) Nat Med , vol.16 , pp. 1009-1017
    • Barry-Hamilton, V.1    Spangler, R.2    Marshall, D.3
  • 70
    • 45449112374 scopus 로고    scopus 로고
    • Galectins: structure, function and therapeutic potential
    • PID: 18549522
    • Yang RY, Rabinovich GA, Liu FT. Galectins: structure, function and therapeutic potential. Expert Rev Mol Med. 2008;10:e17.
    • (2008) Expert Rev Mol Med , vol.10 , pp. e17
    • Yang, R.Y.1    Rabinovich, G.A.2    Liu, F.T.3
  • 71
    • 67649831425 scopus 로고    scopus 로고
    • The regulation of inflammation by galectin-3
    • COI: 1:CAS:528:DC%2BD1MXhsFGls7fP, PID: 19594635
    • Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev. 2009;230:160–171.
    • (2009) Immunol Rev , vol.230 , pp. 160-171
    • Henderson, N.C.1    Sethi, T.2
  • 72
    • 33645533798 scopus 로고    scopus 로고
    • Galectin-3 regulates myofibroblast activation and hepatic fibrosis
    • COI: 1:CAS:528:DC%2BD28XjsVGlsbs%3D, PID: 16549783
    • Henderson NC, Mackinnon AC, Farnworth SL, et al. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc Natl Acad Sci USA. 2006;103:5060–5065.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5060-5065
    • Henderson, N.C.1    Mackinnon, A.C.2    Farnworth, S.L.3
  • 73
    • 84885155926 scopus 로고    scopus 로고
    • Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease
    • COI: 1:CAS:528:DC%2BC3sXhs1aksLjO, PID: 24130706
    • Traber PG, Chou H, Zomer E, et al. Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS One. 2013;8:e75361.
    • (2013) PLoS One , vol.8 , pp. e75361
    • Traber, P.G.1    Chou, H.2    Zomer, E.3
  • 74
    • 84893191346 scopus 로고    scopus 로고
    • Therapy of experimental NASH and fibrosis with galectin inhibitors
    • PID: 24367597
    • Traber PG, Zomer E. Therapy of experimental NASH and fibrosis with galectin inhibitors. PLoS One. 2013;8:e83481.
    • (2013) PLoS One , vol.8 , pp. e83481
    • Traber, P.G.1    Zomer, E.2
  • 75
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC3cXls1Oltr4%3D, PID: 20427778
    • Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362:1675–1685.
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 76
    • 84938057875 scopus 로고    scopus 로고
    • Liver fibrosis, but no other histologic features, associates with long-term outcomes of patients with nonalcoholic fatty liver disease
    • PID: 25935633
    • Angulo P, Kleiner DE, Dam-Larsen S, et al. Liver fibrosis, but no other histologic features, associates with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology. 2015;149:389–397.
    • (2015) Gastroenterology , vol.149 , pp. 389-397
    • Angulo, P.1    Kleiner, D.E.2    Dam-Larsen, S.3
  • 77
    • 79957521377 scopus 로고    scopus 로고
    • Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality
    • PID: 21360720
    • Younossi ZM, Stepanova M, Rafiq N, et al. Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality. Hepatology. 2011;53:1874–1882.
    • (2011) Hepatology , vol.53 , pp. 1874-1882
    • Younossi, Z.M.1    Stepanova, M.2    Rafiq, N.3
  • 78
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • PID: 15915461
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 79
    • 84904747070 scopus 로고    scopus 로고
    • Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC2cXht1WmsL7J, PID: 24753132
    • Bedossa P. Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease. Hepatology. 2014;60:565–575.
    • (2014) Hepatology , vol.60 , pp. 565-575
    • Bedossa, P.1


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