메뉴 건너뛰기




Volumn 14, Issue 4, 2011, Pages 347-353

The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease

Author keywords

5 lipoxygenase; adipose tissue; inflammation; leukotrienes; metabolic syndrome

Indexed keywords

AM 103; ANTIINFLAMMATORY AGENT; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; BLT1 RECEPTOR; BLT2 RECEPTOR; DG 051; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; LEUKOTRIENE; LEUKOTRIENE B4 RECEPTOR; LICOFELONE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONTELUKAST; OXYGENASE INHIBITOR; PRANLUKAST; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZAFIRLUKAST; ZILEUTON;

EID: 79959227567     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e32834777fa     Document Type: Review
Times cited : (59)

References (47)
  • 1
    • 0023177955 scopus 로고
    • Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects
    • Samuelsson B, Dahlen SE, Lindgren JA, et al. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 1987; 237:1171-1176. (Pubitemid 17131222)
    • (1987) Science , vol.237 , Issue.4819 , pp. 1171-1176
    • Samuelsson, B.1    Dahlen, S.-E.2    Lindgren, J.A.3
  • 2
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: Advances in eicosanoid biology
    • DOI 10.1126/science.294.5548.1871
    • Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001; 294:1871-1875. (Pubitemid 33101574)
    • (2001) Science , vol.294 , Issue.5548 , pp. 1871-1875
    • Funk, C.D.1
  • 3
    • 0242611540 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: Implications for cancer therapy
    • DOI 10.1096/fj.03-0053rev
    • Romano M, Clà ria J. Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J 2003; 17:1986-1995. (Pubitemid 37392443)
    • (2003) FASEB Journal , vol.17 , Issue.14 , pp. 1986-1995
    • Romano, M.1    Claria, J.2
  • 4
    • 42649089790 scopus 로고    scopus 로고
    • Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators
    • DOI 10.1038/nri2294, PII NRI2294
    • Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual antiinflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008; 8:349-361. (Pubitemid 351595216)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.5 , pp. 349-361
    • Serhan, C.N.1    Chiang, N.2    Van Dyke, T.E.3
  • 5
    • 77955495763 scopus 로고    scopus 로고
    • Location, location, location: Compartmentalization of early events in leukotriene biosynthesis
    • Newcomer ME, Gilbert NC. Location, location, location: compartmentalization of early events in leukotriene biosynthesis. J Biol Chem 2010; 285:25109-25114.
    • (2010) J Biol Chem , vol.285 , pp. 25109-25114
    • Newcomer, M.E.1    Gilbert, N.C.2
  • 6
    • 79954573836 scopus 로고    scopus 로고
    • Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products
    • Boudreau LH, Bertin J, Robichaud PP, et al. Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products. FASEB J 2011; 25: 1097-1105.
    • (2011) FASEB J , vol.25 , pp. 1097-1105
    • Boudreau, L.H.1    Bertin, J.2    Robichaud, P.P.3
  • 7
    • 78651453239 scopus 로고    scopus 로고
    • The structure of human 5-lipoxygenase
    • Gilbert NC, Bartlett SG, Waight MT, et al. The structure of human 5-lipoxygenase. Science 2011; 331:217-219.
    • (2011) Science , vol.331 , pp. 217-219
    • Gilbert, N.C.1    Bartlett, S.G.2    Waight, M.T.3
  • 9
    • 78649726409 scopus 로고    scopus 로고
    • Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis
    • Iizuka Y, Okuno T, Saeki K, et al. Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis. FASEB J 2010; 24:4678-4690.
    • (2010) FASEB J , vol.24 , pp. 4678-4690
    • Iizuka, Y.1    Okuno, T.2    Saeki, K.3
  • 10
    • 78650668611 scopus 로고    scopus 로고
    • BLT2 is upregulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines
    • Cho KJ, Seo JM, Lee MG, Kim JH. BLT2 is upregulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines. J Immunol 2010; 185:6329-6337.
    • (2010) J Immunol , vol.185 , pp. 6329-6337
    • Cho, K.J.1    Seo, J.M.2    Lee, M.G.3    Kim, J.H.4
  • 11
    • 33847638036 scopus 로고    scopus 로고
    • New approaches to the modulation of cyclooxygenase-2 and 5-lipoxyenase pathways
    • DOI 10.2174/156802607779941378
    • González-Périz A, Clària J. New approaches to the modulation of the cyclooxygenase-.2. and 5-lipoxygenase pathways. Curr Top Med Chem 2007; 7:297-309. (Pubitemid 46358663)
    • (2007) Current Topics in Medicinal Chemistry , vol.7 , Issue.3 , pp. 297-309
    • Gonzalez-Periz, A.1    Claria, J.2
  • 13
    • 77949875056 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP)
    • Bain G, King CD, Rewolinski M, et al. Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP). Clin Pharmacol Ther 2010; 87:437-444.
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 437-444
    • Bain, G.1    King, C.D.2    Rewolinski, M.3
  • 14
    • 77249161707 scopus 로고    scopus 로고
    • Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1- pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis
    • Sandanayaka V, Mamat B, Mishra RK, et al. Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J Med Chem 2010; 53:573-585.
    • (2010) J Med Chem , vol.53 , pp. 573-585
    • Sandanayaka, V.1    Mamat, B.2    Mishra, R.K.3
  • 15
    • 67449128722 scopus 로고    scopus 로고
    • Protective effects of licofelone, a 5-lipoxygenase and cyclooxygenase inhibitor, versus naxopren on cartilage loss in knee osteoarthritis: A first multicentre clinic trial using quantitative MRI
    • Raynauld JP, Martel-Pelletier J, Bias P, et al. Protective effects of licofelone, a 5-lipoxygenase and cyclooxygenase inhibitor, versus naxopren on cartilage loss in knee osteoarthritis: a first multicentre clinic trial using quantitative MRI. Ann Rheum Dis 2009; 68:938-947.
    • (2009) Ann Rheum Dis , vol.68 , pp. 938-947
    • Raynauld, J.P.1    Martel-Pelletier, J.2    Bias, P.3
  • 17
    • 78149489303 scopus 로고    scopus 로고
    • Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis
    • Chen M, Lam BK, Luster AD, et al. Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis. J Immunol 2010; 185:5503-5511.
    • (2010) J Immunol , vol.185 , pp. 5503-5511
    • Chen, M.1    Lam, B.K.2    Luster, A.D.3
  • 19
    • 62649157212 scopus 로고    scopus 로고
    • Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice
    • Cao RY, St Amand T, Gräbner R, et al. Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice. Atherosclerosis 2009; 203:395-400.
    • (2009) Atherosclerosis , vol.203 , pp. 395-400
    • Cao, R.Y.1    St Amand, T.2    Gräbner, R.3
  • 20
    • 67649861052 scopus 로고    scopus 로고
    • Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
    • Chen Y, Hu Y, Zhang H, et al. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet 2009; 41:783-792.
    • (2009) Nat Genet , vol.41 , pp. 783-792
    • Chen, Y.1    Hu, Y.2    Zhang, H.3
  • 21
    • 0030898073 scopus 로고    scopus 로고
    • Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses
    • DOI 10.1084/jem.185.6.1065
    • Byrum RS, Goulet JL, Griffiths RJ, Koller BH. Role of the 5-lipoxygenaseactivating protein (FLAP) in murine acute inflammatory responses. J Exp Med 1997; 185:1065-1075. (Pubitemid 27136799)
    • (1997) Journal of Experimental Medicine , vol.185 , Issue.6 , pp. 1065-1075
    • Byrum, R.S.1    Goulet, J.L.2    Griffiths, R.J.3    Koller, B.H.4
  • 22
    • 77957344556 scopus 로고    scopus 로고
    • A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    • Snelgrove RJ, Jackson PL, Hardison MT, et al. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 2010; 330: 90-94.
    • (2010) Science , vol.330 , pp. 90-94
    • Snelgrove, R.J.1    Jackson, P.L.2    Hardison, M.T.3
  • 23
    • 78049396132 scopus 로고    scopus 로고
    • Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis
    • Mathis SP, Jala VR, Lee DM, Haribabu B. Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis. J Immunol 2010; 185:3049-3056.
    • (2010) J Immunol , vol.185 , pp. 3049-3056
    • Mathis, S.P.1    Jala, V.R.2    Lee, D.M.3    Haribabu, B.4
  • 25
    • 69749102190 scopus 로고    scopus 로고
    • 12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes
    • Chakrabarti SK, Cole BK, Wen Y, et al. 12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity 2009; 17:1657-1663.
    • (2009) Obesity , vol.17 , pp. 1657-1663
    • Chakrabarti, S.K.1    Cole, B.K.2    Wen, Y.3
  • 27
    • 0030856747 scopus 로고    scopus 로고
    • Regulation of 12-lipoxygenase by cytokines in vascular smooth muscle cells
    • Natarajan R, Rosdahl J, Gonzales N, Bai W. Regulation of 12-lipoxygenase by cytokines in vascular smooth muscle cells. Hypertension 1997; 30:873-879. (Pubitemid 27441116)
    • (1997) Hypertension , vol.30 , Issue.4 , pp. 873-879
    • Natarajan, R.1    Rosdahl, J.2    Gonzales, N.3    Bai, W.4
  • 28
    • 67650474213 scopus 로고    scopus 로고
    • Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure
    • Kayama Y, Minamino T, Toko H, et al. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. J Exp Med 2009; 206:1565-1574.
    • (2009) J Exp Med , vol.206 , pp. 1565-1574
    • Kayama, Y.1    Minamino, T.2    Toko, H.3
  • 30
    • 0035826892 scopus 로고    scopus 로고
    • Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice
    • Cyrus T, PraticòD, Zhao L, et al. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice. Circulation 2001; 103:2277-2282. (Pubitemid 32433718)
    • (2001) Circulation , vol.103 , Issue.18 , pp. 2277-2282
    • Cyrus, T.1    Pratico, D.2    Zhao, L.3    Witztum, J.L.4    Rader, D.J.5    Rokach, J.6    FitzGerald, G.A.7    Funk, C.D.8
  • 31
    • 77953545296 scopus 로고    scopus 로고
    • Central adiposity, systemic inflammation, and the metabolic syndrome
    • Elks CM, Francis J. Central adiposity, systemic inflammation, and the metabolic syndrome. Curr Hypertens Rep 2010; 12:99-104.
    • (2010) Curr Hypertens Rep , vol.12 , pp. 99-104
    • Elks, C.M.1    Francis, J.2
  • 32
    • 34548639473 scopus 로고    scopus 로고
    • Obesity-induced inflammation: A metabolic dialogue in the language of inflammation
    • DOI 10.1111/j.1365-2796.2007.01852.x
    • Ferrante AW Jr. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 2007; 262:408-414. (Pubitemid 47404372)
    • (2007) Journal of Internal Medicine , vol.262 , Issue.4 , pp. 408-414
    • Ferrante Jr., A.W.1
  • 34
    • 78049452485 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Law K, Brunt EM. Nonalcoholic fatty liver disease. Clin Liver Dis 2010; 14:591-604.
    • (2010) Clin Liver Dis , vol.14 , pp. 591-604
    • Law, K.1    Brunt, E.M.2
  • 35
    • 33644621593 scopus 로고    scopus 로고
    • ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance
    • Kaaman M, Rydén M, Axelsson T, et al. ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. Int J Obes 2006; 30:447-452.
    • (2006) Int J Obes , vol.30 , pp. 447-452
    • Kaaman, M.1    Rydén, M.2    Axelsson, T.3
  • 36
    • 77951630780 scopus 로고    scopus 로고
    • 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity
    • Horrillo R, González-Périz A, Martínez-Clemente M, et al. 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J Immunol 2010; 184:3978-3987.
    • (2010) J Immunol , vol.184 , pp. 3978-3987
    • Horrillo, R.1    González-Périz, A.2    Martínez-Clemente, M.3
  • 37
    • 43049088783 scopus 로고    scopus 로고
    • Identification of ALOX5 as a gene regulating adiposity and pancreatic function
    • Mehrabian M, Schulthess FT, Nebohacova M, et al. Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia 2008; 51:978-988.
    • (2008) Diabetologia , vol.51 , pp. 978-988
    • Mehrabian, M.1    Schulthess, F.T.2    Nebohacova, M.3
  • 38
    • 78650788269 scopus 로고    scopus 로고
    • Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats
    • Chakrabarti SK, Wen Y, Dobrian AD, et al. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab 2011; 300:E175-E187.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Chakrabarti, S.K.1    Wen, Y.2    Dobrian, A.D.3
  • 39
    • 0033826525 scopus 로고    scopus 로고
    • Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL
    • Gowri MS, Azhar RK, Kraemer FB, et al. Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL. Am J Physiol Endocrinol Metab 2000; 279:E593-E600.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Gowri, M.S.1    Azhar, R.K.2    Kraemer, F.B.3
  • 40
    • 57049099790 scopus 로고    scopus 로고
    • 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet
    • Nunemaker CS, Chen M, Pei H, et al. 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Am J Physiol 2008; 295:1065-1075.
    • (2008) Am J Physiol , vol.295 , pp. 1065-1075
    • Nunemaker, C.S.1    Chen, M.2    Pei, H.3
  • 41
    • 70349639659 scopus 로고    scopus 로고
    • 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice
    • Sears DD, Miles PD, Chapman J, et al. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One 2009; 4:e7250.
    • (2009) PLoS One , vol.4
    • Sears, D.D.1    Miles, P.D.2    Chapman, J.3
  • 42
    • 78650173914 scopus 로고    scopus 로고
    • Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects
    • Dobrian AD, Lieb DC, Ma Q, et al. Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. Biochem Biophys Res Commun 2010; 403:485-490.
    • (2010) Biochem Biophys Res Commun , vol.403 , pp. 485-490
    • Dobrian, A.D.1    Lieb, D.C.2    Ma, Q.3
  • 43
    • 65349093477 scopus 로고    scopus 로고
    • Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: Potential involvement of oxysterols
    • FerréN, Martínez-Clemente M, López-Parra M, et al. Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am J Physiol Gastrointest Liver Physiol 2009; 296:G553-G562.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Ferré, N.1    Martínez-Clemente, M.2    López-Parra, M.3
  • 44
    • 77950619121 scopus 로고    scopus 로고
    • 5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice
    • Martínez-Clemente M, FerréN, González-Périz A, et al. 5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice. Hepatology 2010; 51:817-827.
    • (2010) Hepatology , vol.51 , pp. 817-827
    • Martínez-Clemente, M.1    Ferrén2    González-Périz, A.3
  • 45
    • 78649573682 scopus 로고    scopus 로고
    • Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease
    • Martínez-Clemente M, FerréN, Titos E, et al. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Hepatology 2010; 52:1980-1991.
    • (2010) Hepatology , vol.52 , pp. 1980-1991
    • Martínez-Clemente, M.1    Ferré, N.2    Titos, E.3
  • 46
    • 73149094543 scopus 로고    scopus 로고
    • The plasma lipidomic signature of nonalcoholic steatohepatitis
    • Puri P, Wiest MM, Cheung O, et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology 2009; 50:1827-1838.
    • (2009) Hepatology , vol.50 , pp. 1827-1838
    • Puri, P.1    Wiest, M.M.2    Cheung, O.3
  • 47
    • 77952322894 scopus 로고    scopus 로고
    • Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase
    • Titos E, FerréN, Lozano JJ, et al. Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase. Prostaglandins Other Lipid Mediat 2010; 92:54-61.
    • (2010) Prostaglandins Other Lipid Mediat , vol.92 , pp. 54-61
    • Titos, E.1    Ferrén2    Lozano, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.