-
1
-
-
0023177955
-
Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects
-
Samuelsson B, Dahlen SE, Lindgren JA, et al. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 1987; 237:1171-1176. (Pubitemid 17131222)
-
(1987)
Science
, vol.237
, Issue.4819
, pp. 1171-1176
-
-
Samuelsson, B.1
Dahlen, S.-E.2
Lindgren, J.A.3
-
2
-
-
0035976575
-
Prostaglandins and leukotrienes: Advances in eicosanoid biology
-
DOI 10.1126/science.294.5548.1871
-
Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001; 294:1871-1875. (Pubitemid 33101574)
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1871-1875
-
-
Funk, C.D.1
-
3
-
-
0242611540
-
Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: Implications for cancer therapy
-
DOI 10.1096/fj.03-0053rev
-
Romano M, Clà ria J. Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J 2003; 17:1986-1995. (Pubitemid 37392443)
-
(2003)
FASEB Journal
, vol.17
, Issue.14
, pp. 1986-1995
-
-
Romano, M.1
Claria, J.2
-
4
-
-
42649089790
-
Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators
-
DOI 10.1038/nri2294, PII NRI2294
-
Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual antiinflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008; 8:349-361. (Pubitemid 351595216)
-
(2008)
Nature Reviews Immunology
, vol.8
, Issue.5
, pp. 349-361
-
-
Serhan, C.N.1
Chiang, N.2
Van Dyke, T.E.3
-
5
-
-
77955495763
-
Location, location, location: Compartmentalization of early events in leukotriene biosynthesis
-
Newcomer ME, Gilbert NC. Location, location, location: compartmentalization of early events in leukotriene biosynthesis. J Biol Chem 2010; 285:25109-25114.
-
(2010)
J Biol Chem
, vol.285
, pp. 25109-25114
-
-
Newcomer, M.E.1
Gilbert, N.C.2
-
6
-
-
79954573836
-
Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products
-
Boudreau LH, Bertin J, Robichaud PP, et al. Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products. FASEB J 2011; 25: 1097-1105.
-
(2011)
FASEB J
, vol.25
, pp. 1097-1105
-
-
Boudreau, L.H.1
Bertin, J.2
Robichaud, P.P.3
-
8
-
-
77952308123
-
Advances in eicosanoid research, novel therapeutic implications
-
Haeggström JZ, Rinaldo-Matthis A, Wheelock CE, Wetterholm A. Advances in eicosanoid research, novel therapeutic implications. Biochem Biophys Res Commun 2010; 396:135-139.
-
(2010)
Biochem Biophys Res Commun
, vol.396
, pp. 135-139
-
-
Haeggström, J.Z.1
Rinaldo-Matthis, A.2
Wheelock, C.E.3
Wetterholm, A.4
-
9
-
-
78649726409
-
Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis
-
Iizuka Y, Okuno T, Saeki K, et al. Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis. FASEB J 2010; 24:4678-4690.
-
(2010)
FASEB J
, vol.24
, pp. 4678-4690
-
-
Iizuka, Y.1
Okuno, T.2
Saeki, K.3
-
10
-
-
78650668611
-
BLT2 is upregulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines
-
Cho KJ, Seo JM, Lee MG, Kim JH. BLT2 is upregulated in allergen-stimulated mast cells and mediates the synthesis of Th2 cytokines. J Immunol 2010; 185:6329-6337.
-
(2010)
J Immunol
, vol.185
, pp. 6329-6337
-
-
Cho, K.J.1
Seo, J.M.2
Lee, M.G.3
Kim, J.H.4
-
11
-
-
33847638036
-
New approaches to the modulation of cyclooxygenase-2 and 5-lipoxyenase pathways
-
DOI 10.2174/156802607779941378
-
González-Périz A, Clària J. New approaches to the modulation of the cyclooxygenase-.2. and 5-lipoxygenase pathways. Curr Top Med Chem 2007; 7:297-309. (Pubitemid 46358663)
-
(2007)
Current Topics in Medicinal Chemistry
, vol.7
, Issue.3
, pp. 297-309
-
-
Gonzalez-Periz, A.1
Claria, J.2
-
12
-
-
34547657273
-
Antileukotriene drugs: Clinical application, effectiveness and safety
-
DOI 10.2174/092986707781368522
-
Riccioni G, Bucciarelli T, Mancini B, et al. Antileukotriene drugs: clinical application, effectiveness and safety. Curr Med Chem 2007; 14:1966-1977. (Pubitemid 47209107)
-
(2007)
Current Medicinal Chemistry
, vol.14
, Issue.18
, pp. 1966-1977
-
-
Riccioni, G.1
Bucciarelli, T.2
Mancini, B.3
Di Ilio, C.4
D'Orazio, N.5
-
13
-
-
77949875056
-
Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP)
-
Bain G, King CD, Rewolinski M, et al. Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP). Clin Pharmacol Ther 2010; 87:437-444.
-
(2010)
Clin Pharmacol Ther
, vol.87
, pp. 437-444
-
-
Bain, G.1
King, C.D.2
Rewolinski, M.3
-
14
-
-
77249161707
-
Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1- pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis
-
Sandanayaka V, Mamat B, Mishra RK, et al. Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J Med Chem 2010; 53:573-585.
-
(2010)
J Med Chem
, vol.53
, pp. 573-585
-
-
Sandanayaka, V.1
Mamat, B.2
Mishra, R.K.3
-
15
-
-
67449128722
-
Protective effects of licofelone, a 5-lipoxygenase and cyclooxygenase inhibitor, versus naxopren on cartilage loss in knee osteoarthritis: A first multicentre clinic trial using quantitative MRI
-
Raynauld JP, Martel-Pelletier J, Bias P, et al. Protective effects of licofelone, a 5-lipoxygenase and cyclooxygenase inhibitor, versus naxopren on cartilage loss in knee osteoarthritis: a first multicentre clinic trial using quantitative MRI. Ann Rheum Dis 2009; 68:938-947.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 938-947
-
-
Raynauld, J.P.1
Martel-Pelletier, J.2
Bias, P.3
-
16
-
-
17144453406
-
Lipoxygenase genes and their targeted disruption
-
DOI 10.1016/S0090-6980(02)00036-9, PII S0090698002000369
-
FunkCD, Chen XS, Johnson EN, Zhao L. Lipoxygenase genes and their targeted disruption. Prostaglandins Other Lipid Mediat 2002; 68-69:303-312. (Pubitemid 35247403)
-
(2002)
Prostaglandins and Other Lipid Mediators
, vol.68-69
, pp. 303-312
-
-
Funk, C.D.1
Chen, X.-S.2
Johnson, E.N.3
Zhao, L.4
-
17
-
-
78149489303
-
Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis
-
Chen M, Lam BK, Luster AD, et al. Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis. J Immunol 2010; 185:5503-5511.
-
(2010)
J Immunol
, vol.185
, pp. 5503-5511
-
-
Chen, M.1
Lam, B.K.2
Luster, A.D.3
-
18
-
-
4644301666
-
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia- dependent aortic aneurysm
-
DOI 10.1038/nm1099
-
Zhao L, Moos MP, Grä bner R, et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 2004; 10:966-973. (Pubitemid 39273738)
-
(2004)
Nature Medicine
, vol.10
, Issue.9
, pp. 966-973
-
-
Zhao, L.1
Moos, M.P.W.2
Grabner, R.3
Pedrono, F.4
Fan, J.5
Kaiser, B.6
John, N.7
Schmidt, S.8
Spanbroek, R.9
Lotzer, K.10
Huang, L.11
Cui, J.12
Rader, D.J.13
Evans, J.F.14
Habenicht, A.J.R.15
Funk, C.D.16
-
19
-
-
62649157212
-
Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice
-
Cao RY, St Amand T, Gräbner R, et al. Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice. Atherosclerosis 2009; 203:395-400.
-
(2009)
Atherosclerosis
, vol.203
, pp. 395-400
-
-
Cao, R.Y.1
St Amand, T.2
Gräbner, R.3
-
20
-
-
67649861052
-
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia
-
Chen Y, Hu Y, Zhang H, et al. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nat Genet 2009; 41:783-792.
-
(2009)
Nat Genet
, vol.41
, pp. 783-792
-
-
Chen, Y.1
Hu, Y.2
Zhang, H.3
-
21
-
-
0030898073
-
Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses
-
DOI 10.1084/jem.185.6.1065
-
Byrum RS, Goulet JL, Griffiths RJ, Koller BH. Role of the 5-lipoxygenaseactivating protein (FLAP) in murine acute inflammatory responses. J Exp Med 1997; 185:1065-1075. (Pubitemid 27136799)
-
(1997)
Journal of Experimental Medicine
, vol.185
, Issue.6
, pp. 1065-1075
-
-
Byrum, R.S.1
Goulet, J.L.2
Griffiths, R.J.3
Koller, B.H.4
-
22
-
-
77957344556
-
A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
-
Snelgrove RJ, Jackson PL, Hardison MT, et al. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 2010; 330: 90-94.
-
(2010)
Science
, vol.330
, pp. 90-94
-
-
Snelgrove, R.J.1
Jackson, P.L.2
Hardison, M.T.3
-
23
-
-
78049396132
-
Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis
-
Mathis SP, Jala VR, Lee DM, Haribabu B. Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis. J Immunol 2010; 185:3049-3056.
-
(2010)
J Immunol
, vol.185
, pp. 3049-3056
-
-
Mathis, S.P.1
Jala, V.R.2
Lee, D.M.3
Haribabu, B.4
-
25
-
-
69749102190
-
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes
-
Chakrabarti SK, Cole BK, Wen Y, et al. 12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity 2009; 17:1657-1663.
-
(2009)
Obesity
, vol.17
, pp. 1657-1663
-
-
Chakrabarti, S.K.1
Cole, B.K.2
Wen, Y.3
-
26
-
-
0035910605
-
Overexpression of 12-lipoxygenase causes cardiac fibroblast cell growth
-
Wen Y, Gu J, Liu Y, et al. Overexpression of 12-lipoxygenase causes cardiac fibroblast cell growth. Circ Res 2001; 88:70-76. (Pubitemid 32064085)
-
(2001)
Circulation Research
, vol.88
, Issue.1
, pp. 70-76
-
-
Wen, Y.1
Gu, J.2
Liu, Y.3
Wang, P.H.4
Sun, Y.5
Nadler, J.L.6
-
27
-
-
0030856747
-
Regulation of 12-lipoxygenase by cytokines in vascular smooth muscle cells
-
Natarajan R, Rosdahl J, Gonzales N, Bai W. Regulation of 12-lipoxygenase by cytokines in vascular smooth muscle cells. Hypertension 1997; 30:873-879. (Pubitemid 27441116)
-
(1997)
Hypertension
, vol.30
, Issue.4
, pp. 873-879
-
-
Natarajan, R.1
Rosdahl, J.2
Gonzales, N.3
Bai, W.4
-
28
-
-
67650474213
-
Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure
-
Kayama Y, Minamino T, Toko H, et al. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. J Exp Med 2009; 206:1565-1574.
-
(2009)
J Exp Med
, vol.206
, pp. 1565-1574
-
-
Kayama, Y.1
Minamino, T.2
Toko, H.3
-
29
-
-
0041664876
-
Evidence that increased 12-lipoxygenase expression impairs pancreatic β cell function and viability
-
DOI 10.1016/S0006-291X(03)01418-9
-
Prasad KM, Thimmalapura PR, Woode EA, Nadler JL. Evidence that increased 12-lipoxygenase expression impairs pancreatic beta-cell function and viability. Biochem Biophys Res Commun 2003; 308:427-432. (Pubitemid 36945508)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.308
, Issue.3
, pp. 427-432
-
-
Prasad, K.-M.R.1
Thimmalapura, P.-R.R.2
Woode, E.A.A.3
Nadler, J.L.4
-
30
-
-
0035826892
-
Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice
-
Cyrus T, PraticòD, Zhao L, et al. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice. Circulation 2001; 103:2277-2282. (Pubitemid 32433718)
-
(2001)
Circulation
, vol.103
, Issue.18
, pp. 2277-2282
-
-
Cyrus, T.1
Pratico, D.2
Zhao, L.3
Witztum, J.L.4
Rader, D.J.5
Rokach, J.6
FitzGerald, G.A.7
Funk, C.D.8
-
31
-
-
77953545296
-
Central adiposity, systemic inflammation, and the metabolic syndrome
-
Elks CM, Francis J. Central adiposity, systemic inflammation, and the metabolic syndrome. Curr Hypertens Rep 2010; 12:99-104.
-
(2010)
Curr Hypertens Rep
, vol.12
, pp. 99-104
-
-
Elks, C.M.1
Francis, J.2
-
32
-
-
34548639473
-
Obesity-induced inflammation: A metabolic dialogue in the language of inflammation
-
DOI 10.1111/j.1365-2796.2007.01852.x
-
Ferrante AW Jr. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 2007; 262:408-414. (Pubitemid 47404372)
-
(2007)
Journal of Internal Medicine
, vol.262
, Issue.4
, pp. 408-414
-
-
Ferrante Jr., A.W.1
-
33
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
DOI 10.1172/JCI200523621
-
Donnelly KI, Smith CI, Schwarzenberg SJ, et al. Sources of fatty acids stored in liver and secreted with lipoproteins in patients with nonalcoholic fatty liver diseases. J Clin Invest 2005; 115:1343-1351. (Pubitemid 40629054)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.5
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
34
-
-
78049452485
-
Nonalcoholic fatty liver disease
-
Law K, Brunt EM. Nonalcoholic fatty liver disease. Clin Liver Dis 2010; 14:591-604.
-
(2010)
Clin Liver Dis
, vol.14
, pp. 591-604
-
-
Law, K.1
Brunt, E.M.2
-
35
-
-
33644621593
-
ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance
-
Kaaman M, Rydén M, Axelsson T, et al. ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. Int J Obes 2006; 30:447-452.
-
(2006)
Int J Obes
, vol.30
, pp. 447-452
-
-
Kaaman, M.1
Rydén, M.2
Axelsson, T.3
-
36
-
-
77951630780
-
5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity
-
Horrillo R, González-Périz A, Martínez-Clemente M, et al. 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J Immunol 2010; 184:3978-3987.
-
(2010)
J Immunol
, vol.184
, pp. 3978-3987
-
-
Horrillo, R.1
González-Périz, A.2
Martínez-Clemente, M.3
-
37
-
-
43049088783
-
Identification of ALOX5 as a gene regulating adiposity and pancreatic function
-
Mehrabian M, Schulthess FT, Nebohacova M, et al. Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia 2008; 51:978-988.
-
(2008)
Diabetologia
, vol.51
, pp. 978-988
-
-
Mehrabian, M.1
Schulthess, F.T.2
Nebohacova, M.3
-
38
-
-
78650788269
-
Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats
-
Chakrabarti SK, Wen Y, Dobrian AD, et al. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab 2011; 300:E175-E187.
-
(2011)
Am J Physiol Endocrinol Metab
, vol.300
-
-
Chakrabarti, S.K.1
Wen, Y.2
Dobrian, A.D.3
-
39
-
-
0033826525
-
Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL
-
Gowri MS, Azhar RK, Kraemer FB, et al. Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL. Am J Physiol Endocrinol Metab 2000; 279:E593-E600.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
-
-
Gowri, M.S.1
Azhar, R.K.2
Kraemer, F.B.3
-
40
-
-
57049099790
-
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet
-
Nunemaker CS, Chen M, Pei H, et al. 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Am J Physiol 2008; 295:1065-1075.
-
(2008)
Am J Physiol
, vol.295
, pp. 1065-1075
-
-
Nunemaker, C.S.1
Chen, M.2
Pei, H.3
-
41
-
-
70349639659
-
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice
-
Sears DD, Miles PD, Chapman J, et al. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One 2009; 4:e7250.
-
(2009)
PLoS One
, vol.4
-
-
Sears, D.D.1
Miles, P.D.2
Chapman, J.3
-
42
-
-
78650173914
-
Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects
-
Dobrian AD, Lieb DC, Ma Q, et al. Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects. Biochem Biophys Res Commun 2010; 403:485-490.
-
(2010)
Biochem Biophys Res Commun
, vol.403
, pp. 485-490
-
-
Dobrian, A.D.1
Lieb, D.C.2
Ma, Q.3
-
43
-
-
65349093477
-
Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: Potential involvement of oxysterols
-
FerréN, Martínez-Clemente M, López-Parra M, et al. Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am J Physiol Gastrointest Liver Physiol 2009; 296:G553-G562.
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.296
-
-
Ferré, N.1
Martínez-Clemente, M.2
López-Parra, M.3
-
44
-
-
77950619121
-
5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice
-
Martínez-Clemente M, FerréN, González-Périz A, et al. 5-lipoxygenase deficiency reduces hepatic inflammation and tumor necrosis factor alpha-induced hepatocyte damage in hyperlipidemia-prone ApoE-null mice. Hepatology 2010; 51:817-827.
-
(2010)
Hepatology
, vol.51
, pp. 817-827
-
-
Martínez-Clemente, M.1
Ferrén2
González-Périz, A.3
-
45
-
-
78649573682
-
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease
-
Martínez-Clemente M, FerréN, Titos E, et al. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Hepatology 2010; 52:1980-1991.
-
(2010)
Hepatology
, vol.52
, pp. 1980-1991
-
-
Martínez-Clemente, M.1
Ferré, N.2
Titos, E.3
-
46
-
-
73149094543
-
The plasma lipidomic signature of nonalcoholic steatohepatitis
-
Puri P, Wiest MM, Cheung O, et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology 2009; 50:1827-1838.
-
(2009)
Hepatology
, vol.50
, pp. 1827-1838
-
-
Puri, P.1
Wiest, M.M.2
Cheung, O.3
-
47
-
-
77952322894
-
Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase
-
Titos E, FerréN, Lozano JJ, et al. Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase. Prostaglandins Other Lipid Mediat 2010; 92:54-61.
-
(2010)
Prostaglandins Other Lipid Mediat
, vol.92
, pp. 54-61
-
-
Titos, E.1
Ferrén2
Lozano, J.J.3
|