메뉴 건너뛰기




Volumn 92, Issue , 2017, Pages 1135-1137

Is Withaferin A, a magic bullet for metabolic syndrome?

Author keywords

[No Author keywords available]

Indexed keywords

CELASTROL; GLUCOSE; LEPTIN; WITHAFERIN A; PHYTOSTEROL; WITHANOLIDE;

EID: 85017447040     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.04.002     Document Type: Letter
Times cited : (7)

References (48)
  • 1
    • 84980324243 scopus 로고    scopus 로고
    • Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice
    • Lee, J., Liu, J., Feng, X., et al. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice. Nat. Med. 22 (2016), 1023–1032.
    • (2016) Nat. Med. , vol.22 , pp. 1023-1032
    • Lee, J.1    Liu, J.2    Feng, X.3
  • 2
    • 85010223582 scopus 로고    scopus 로고
    • Lipopolysaccharides-stimulated macrophage products enhance Withaferin A-induced apoptosis via activation of caspases and inhibition of NF-κB pathway in human cancer cells
    • Piao, L., Canguo, Z., Wenjie, L., et al. Lipopolysaccharides-stimulated macrophage products enhance Withaferin A-induced apoptosis via activation of caspases and inhibition of NF-κB pathway in human cancer cells. Mol. Immunol. 81 (2017), 92–101.
    • (2017) Mol. Immunol. , vol.81 , pp. 92-101
    • Piao, L.1    Canguo, Z.2    Wenjie, L.3
  • 3
    • 78649272272 scopus 로고    scopus 로고
    • Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: Ashwagandha
    • Ven Murthy, M.R., Ranjekar, P.K., Ramassamy, C., Deshpande, M., Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: Ashwagandha. Cent. Nerv. Syst. Agents Med. Chem. 10 (2010), 238–246.
    • (2010) Cent. Nerv. Syst. Agents Med. Chem. , vol.10 , pp. 238-246
    • Ven Murthy, M.R.1    Ranjekar, P.K.2    Ramassamy, C.3    Deshpande, M.4
  • 5
    • 85020965601 scopus 로고
    • Charak Samhita 6000BC, Translation into English: Translator: Shree Gulabkunverba
    • Ayurvedic Society Jamnagar, India
    • Charaka, Charak Samhita 6000BC, Translation into English: Translator: Shree Gulabkunverba. 1949, Ayurvedic Society, Jamnagar, India.
    • (1949)
    • Charaka1
  • 6
    • 0033845752 scopus 로고    scopus 로고
    • Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review
    • Mishra, L.C., Singh, B.B., Dagenais, S., Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Altern. Med. Rev. 5 (2000), 334–346.
    • (2000) Altern. Med. Rev. , vol.5 , pp. 334-346
    • Mishra, L.C.1    Singh, B.B.2    Dagenais, S.3
  • 7
    • 33845959087 scopus 로고    scopus 로고
    • Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology
    • Winters, M., Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern. Med. Rev. 11 (2006), 269–277.
    • (2006) Altern. Med. Rev. , vol.11 , pp. 269-277
    • Winters, M.1
  • 8
    • 84903887831 scopus 로고
    • Ashwagandharishta – Rastantra Sar Evam Sidhyaprayog Sangrah –Krishna-Gopal Ayurveda Bhawan
    • (Dharmarth Trust), Nagpur
    • G.S. Sharma, Ashwagandharishta – Rastantra Sar Evam Sidhyaprayog Sangrah –Krishna-Gopal Ayurveda Bhawan (Dharmarth Trust), Nagpur, (1938), 743–744.
    • (1938) , pp. 743-744
    • Sharma, G.S.1
  • 9
    • 85021007781 scopus 로고    scopus 로고
    • Ashwagandha, Dravyaguna Vijana, Chaukhambha Viashwabharti Varanasi
    • P.V. Sharma, Ashwagandha, Dravyaguna Vijana, Chaukhambha Viashwabharti Varanasi. (1999) 763–765.
    • (1999) , pp. 763-765
    • Sharma, P.V.1
  • 10
    • 84892426993 scopus 로고    scopus 로고
    • Ashwagandha (Withania somnifera): role in safeguarding health, immunomodulatory effects, combating infections and therapeutic applications: a review
    • Tiwari, R., Chakraborty, S., Saminathan, M., Dhama, K., Singh, S.V., Ashwagandha (Withania somnifera): role in safeguarding health, immunomodulatory effects, combating infections and therapeutic applications: a review. J. Biol. Sci. 14 (2014), 77–94.
    • (2014) J. Biol. Sci. , vol.14 , pp. 77-94
    • Tiwari, R.1    Chakraborty, S.2    Saminathan, M.3    Dhama, K.4    Singh, S.V.5
  • 11
    • 80053203292 scopus 로고    scopus 로고
    • Natural products: an evolving role in future drug discovery
    • Mishra, B.B., Tiwari, V.K., Natural products: an evolving role in future drug discovery. Eur. J. Med. Chem. 46 (2011), 4769–4807.
    • (2011) Eur. J. Med. Chem. , vol.46 , pp. 4769-4807
    • Mishra, B.B.1    Tiwari, V.K.2
  • 12
    • 61849148824 scopus 로고    scopus 로고
    • Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?
    • Ji, H.F., Li, X.J., Zhang, H.Y., Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?. EMBO Rep. 10 (2009), 194–200.
    • (2009) EMBO Rep. , vol.10 , pp. 194-200
    • Ji, H.F.1    Li, X.J.2    Zhang, H.Y.3
  • 13
    • 70149117263 scopus 로고    scopus 로고
    • Natural products as a foundation for drug discovery
    • Beutler, J.A., Natural products as a foundation for drug discovery. Curr. Protoc. Pharmacol. 46 (2009), 1–9.
    • (2009) Curr. Protoc. Pharmacol. , vol.46 , pp. 1-9
    • Beutler, J.A.1
  • 14
    • 84951266237 scopus 로고    scopus 로고
    • Comparative transcriptome analysis of different chemotypes elucidates withanolide biosynthesis pathway from medicinal plant Withania somnifera
    • Gupta, P., Goel, R., Agarwal, A.V., Asif, M.H., Sangwan, N.S., Sangwan, R.S., Kumar Trivedi, P., Comparative transcriptome analysis of different chemotypes elucidates withanolide biosynthesis pathway from medicinal plant Withania somnifera. Sci. Rep. 5 (2015), 18611–18624.
    • (2015) Sci. Rep. , vol.5 , pp. 18611-18624
    • Gupta, P.1    Goel, R.2    Agarwal, A.V.3    Asif, M.H.4    Sangwan, N.S.5    Sangwan, R.S.6    Kumar Trivedi, P.7
  • 15
    • 79953290426 scopus 로고    scopus 로고
    • Water extract of ashwagandha leaves limits proliferation and migration, and induces differentiation in glioma cells
    • Kataria, H., Shah, N., Kaul, S.C., Wadhwa, R., Kaur, G., Water extract of ashwagandha leaves limits proliferation and migration, and induces differentiation in glioma cells. Evid. Based Complement. Altern. Med. 2011 (2011), 1–12.
    • (2011) Evid. Based Complement. Altern. Med. , vol.2011 , pp. 1-12
    • Kataria, H.1    Shah, N.2    Kaul, S.C.3    Wadhwa, R.4    Kaur, G.5
  • 16
    • 79955105327 scopus 로고    scopus 로고
    • In vitro anticancer activity of the root, stem and leaves of Withania somnifera against various human cancer cell lines
    • Yadav, B., Bajaj, A., Saxena, M., Saxena, A.K., In vitro anticancer activity of the root, stem and leaves of Withania somnifera against various human cancer cell lines. Indian J. Pharm. Sci. 72 (2010), 659–663.
    • (2010) Indian J. Pharm. Sci. , vol.72 , pp. 659-663
    • Yadav, B.1    Bajaj, A.2    Saxena, M.3    Saxena, A.K.4
  • 19
    • 80052895887 scopus 로고    scopus 로고
    • Therapeutic uses of Withania Somnifera (Ahwagandha) with a note on Withanalides and its pharmacological actions
    • Sitansu, K.V., Ajay, K., Therapeutic uses of Withania Somnifera (Ahwagandha) with a note on Withanalides and its pharmacological actions. Asian J. Pharm. Clin. Res. 4 (2011), 1–4.
    • (2011) Asian J. Pharm. Clin. Res. , vol.4 , pp. 1-4
    • Sitansu, K.V.1    Ajay, K.2
  • 20
    • 84875888319 scopus 로고    scopus 로고
    • Phytochemical and pharmacological profile of withania somnifera dunal: a review
    • Uddin, Q., Samiulla, L., Singh, V.K., Jamil, S.S., Phytochemical and pharmacological profile of withania somnifera dunal: a review. J. Appl. Pharm. Sci. 2 (2012), 170–175.
    • (2012) J. Appl. Pharm. Sci. , vol.2 , pp. 170-175
    • Uddin, Q.1    Samiulla, L.2    Singh, V.K.3    Jamil, S.S.4
  • 21
    • 84960093514 scopus 로고    scopus 로고
    • Withaferin-A-a natural anticancer agent with pleitropic mechanisms of action
    • Lee, I.C., Choi, B.Y., Withaferin-A-a natural anticancer agent with pleitropic mechanisms of action. Int. J. Mol. Sci. 17 (2016), 1–22.
    • (2016) Int. J. Mol. Sci. , vol.17 , pp. 1-22
    • Lee, I.C.1    Choi, B.Y.2
  • 22
    • 84892648502 scopus 로고    scopus 로고
    • Molecular targets and mechanisms of cancer prevention and treatment by withaferin A, a naturally occurring steroidal lactone
    • Vyas, A.R., Singh, S.V., Molecular targets and mechanisms of cancer prevention and treatment by withaferin A, a naturally occurring steroidal lactone. AAPS J. 16 (2014), 1–10.
    • (2014) AAPS J. , vol.16 , pp. 1-10
    • Vyas, A.R.1    Singh, S.V.2
  • 23
  • 25
    • 78149239365 scopus 로고    scopus 로고
    • Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells
    • Lee, J., Hahm, E.R., Singh, S.V., Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis 31 (2010), 1991–1998.
    • (2010) Carcinogenesis , vol.31 , pp. 1991-1998
    • Lee, J.1    Hahm, E.R.2    Singh, S.V.3
  • 26
    • 66549124710 scopus 로고    scopus 로고
    • Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription factor
    • Prasanna Kumar, S., Shilpa, P., Salimath, B.P., Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription factor. Curr. Trends Biotechnol. Pharm. 3 (2009), 138–148.
    • (2009) Curr. Trends Biotechnol. Pharm. , vol.3 , pp. 138-148
    • Prasanna Kumar, S.1    Shilpa, P.2    Salimath, B.P.3
  • 28
    • 33749157379 scopus 로고    scopus 로고
    • Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization
    • Bargagna, M.P., Ravindranath, P.P., Mohan, R., Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 47 (2006), 4138–4145.
    • (2006) Invest. Ophthalmol. Vis. Sci. , vol.47 , pp. 4138-4145
    • Bargagna, M.P.1    Ravindranath, P.P.2    Mohan, R.3
  • 29
    • 85019234071 scopus 로고    scopus 로고
    • DOXIL when combined with Withaferin A (WFA) targets ALDH1 positive cancer stem cells in ovarian cancer
    • Kakar, S.S., Worth, C.A., Wang, Z., Carter, K., Ratajczak, M., Gunjal, P., DOXIL when combined with Withaferin A (WFA) targets ALDH1 positive cancer stem cells in ovarian cancer. J. Cancer Stem Cell Res., 4, 2016, e1002.
    • (2016) J. Cancer Stem Cell Res. , vol.4 , pp. e1002
    • Kakar, S.S.1    Worth, C.A.2    Wang, Z.3    Carter, K.4    Ratajczak, M.5    Gunjal, P.6
  • 30
    • 84982273207 scopus 로고    scopus 로고
    • Oral administration of withaferin A inhibits carcinogenesis of prostate in TRAMP model
    • Suman, S., Das, T.P., Moselhy, J., et al. Oral administration of withaferin A inhibits carcinogenesis of prostate in TRAMP model. Oncotarget 7 (2016), 53751–53761.
    • (2016) Oncotarget , vol.7 , pp. 53751-53761
    • Suman, S.1    Das, T.P.2    Moselhy, J.3
  • 31
    • 85021014938 scopus 로고    scopus 로고
    • Disease subtype-independent biomarkers of breast cancer chemoprevention by the ayurvedic medicine phytochemical Withaferin A
    • Samanta, S.K., Sehrawat, A., Kim, S.H., et al. Disease subtype-independent biomarkers of breast cancer chemoprevention by the ayurvedic medicine phytochemical Withaferin A. J. Natl. Cancer Inst. 109 (2016), 1–13.
    • (2016) J. Natl. Cancer Inst. , vol.109 , pp. 1-13
    • Samanta, S.K.1    Sehrawat, A.2    Kim, S.H.3
  • 32
    • 81255203811 scopus 로고    scopus 로고
    • An analog of withaferin A activates the MAPK and glutathione stress pathways and inhibits pancreatic cancer cell proliferation
    • Liu, X., Qi, W., Cooke, L.S., et al. An analog of withaferin A activates the MAPK and glutathione stress pathways and inhibits pancreatic cancer cell proliferation. Cancer Invest. 29 (2011), 668–675.
    • (2011) Cancer Invest. , vol.29 , pp. 668-675
    • Liu, X.1    Qi, W.2    Cooke, L.S.3
  • 33
    • 84960081744 scopus 로고    scopus 로고
    • Withaferin-A inhibits colon cancer cell growth by blocking STAT3 transcriptional activity
    • Choi, B.Y., Kim, B.W., Withaferin-A inhibits colon cancer cell growth by blocking STAT3 transcriptional activity. J. Cancer Prev. 20 (2015), 185–192.
    • (2015) J. Cancer Prev. , vol.20 , pp. 185-192
    • Choi, B.Y.1    Kim, B.W.2
  • 34
    • 84989278724 scopus 로고    scopus 로고
    • Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model
    • Li, W., Zhang, C., Du, H., et al. Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model. Mol. Carcinog. 55 (2016), 1739–1746.
    • (2016) Mol. Carcinog. , vol.55 , pp. 1739-1746
    • Li, W.1    Zhang, C.2    Du, H.3
  • 35
    • 84973165876 scopus 로고    scopus 로고
    • Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation
    • Vedi, M., Sabina, E.P., Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation. Cell Biol. Toxicol. 32 (2016), 373–390.
    • (2016) Cell Biol. Toxicol. , vol.32 , pp. 373-390
    • Vedi, M.1    Sabina, E.P.2
  • 36
    • 84939565721 scopus 로고    scopus 로고
    • Withaferin-A reduces acetaminophen-induced liver injury in mice
    • Jadeja, R.N., Urrunaga, N.H., Dash, S., et al. Withaferin-A reduces acetaminophen-induced liver injury in mice. Biochem. Pharmacol. 97 (2015), 122–132.
    • (2015) Biochem. Pharmacol. , vol.97 , pp. 122-132
    • Jadeja, R.N.1    Urrunaga, N.H.2    Dash, S.3
  • 37
    • 61449246353 scopus 로고    scopus 로고
    • Functional genomics of blood cellular LXR-alpha gene in human coronary heart disease
    • Dave, V.P., Kaul, D., Sharma, Y., Bhattacharya, R., Functional genomics of blood cellular LXR-alpha gene in human coronary heart disease. J. Mol. Cell. Cardiol. 46 (2009), 536–544.
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 536-544
    • Dave, V.P.1    Kaul, D.2    Sharma, Y.3    Bhattacharya, R.4
  • 38
    • 79952281538 scopus 로고    scopus 로고
    • LXR-α selectively reprograms cancer cells to enter into apoptosis
    • Mehrotra, A., Kaul, D., Joshi, K., LXR-α selectively reprograms cancer cells to enter into apoptosis. Mol. Cell. Biochem. 349 (2011), 41–55.
    • (2011) Mol. Cell. Biochem. , vol.349 , pp. 41-55
    • Mehrotra, A.1    Kaul, D.2    Joshi, K.3
  • 39
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • Joseph, S.B., Castrillo, A., Laffitte, B.A., Mangelsdorf, D.J., Tontonoz, P., Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9 (2003), 213–219.
    • (2003) Nat. Med. , vol.9 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 40
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element- binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR alpha and LXR beta
    • Repa, J.J., Liang, G., Ou, J., et al. Regulation of mouse sterol regulatory element- binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR alpha and LXR beta. Genes Dev. 14 (2000), 2819–2830.
    • (2000) Genes Dev. , vol.14 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3
  • 41
    • 53349153430 scopus 로고    scopus 로고
    • Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
    • Higuchi, N., Kato, M., Shundo, Y., et al. Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol. Res. 38 (2008), 1122–1129.
    • (2008) Hepatol. Res. , vol.38 , pp. 1122-1129
    • Higuchi, N.1    Kato, M.2    Shundo, Y.3
  • 42
    • 84986247411 scopus 로고    scopus 로고
    • Obesity: will withaferin win the war?
    • Pfluger, P.T., Tschöp, M.H., Obesity: will withaferin win the war?. Nat. Med. 22 (2016), 970–971.
    • (2016) Nat. Med. , vol.22 , pp. 970-971
    • Pfluger, P.T.1    Tschöp, M.H.2
  • 43
    • 84959548594 scopus 로고    scopus 로고
    • Interaction studies of withania somnifera's key metabolite withaferin a with different receptors associated with cardiovascular disease
    • Ravindran, R., Sharma, N., Roy, S., et al. Interaction studies of withania somnifera's key metabolite withaferin a with different receptors associated with cardiovascular disease. Curr. Comput. Aided Drug Des. 11 (2015), 212–221.
    • (2015) Curr. Comput. Aided Drug Des. , vol.11 , pp. 212-221
    • Ravindran, R.1    Sharma, N.2    Roy, S.3
  • 44
    • 84865011936 scopus 로고    scopus 로고
    • Withaferin-A reduces type I collagen expression in vitro and inhibits development of myocardial fibrosis in vivo
    • Challa, A.A., Vukmirovic, M., Blackmon, J., Stefanovic, B., Withaferin-A reduces type I collagen expression in vitro and inhibits development of myocardial fibrosis in vivo. PLoS One, 7, 2012, e42989.
    • (2012) PLoS One , vol.7 , pp. e42989
    • Challa, A.A.1    Vukmirovic, M.2    Blackmon, J.3    Stefanovic, B.4
  • 45
    • 2942716780 scopus 로고    scopus 로고
    • Modern science versus the stigma of obesity
    • Friedman, J.M., Modern science versus the stigma of obesity. Nat. Med. 10 (2004), 563–569.
    • (2004) Nat. Med. , vol.10 , pp. 563-569
    • Friedman, J.M.1
  • 46
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action
    • Frederich, R.C., Hamann, A., Anderson, S., et al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 12 (1995), 1311–1314.
    • (1995) Nat. Med. , vol.12 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3
  • 47
    • 77957768653 scopus 로고    scopus 로고
    • A tale of two hormones
    • Friedman, J.M., A tale of two hormones. Nat. Med. 16 (2010), 1100–1106.
    • (2010) Nat. Med. , vol.16 , pp. 1100-1106
    • Friedman, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.