메뉴 건너뛰기




Volumn 32, Issue 5, 2016, Pages 373-390

Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation

Author keywords

Anti oxidant; Glutathione; Liver; Mitochondria

Indexed keywords

ACETYLGLUCOSAMINIDASE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BETA GALACTOSIDASE; BILIRUBIN; BROMOBENZENE; CATALASE; CATHEPSIN D; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOCHONDRIAL ENZYME; PROTEIN BAX; PROTEIN BCL 2; SILYMARIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; UREA; URIC ACID; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; WITHAFERIN A; ANTIOXIDANT; IL1B PROTEIN, MOUSE; OXIDIZING AGENT; WITHANOLIDE;

EID: 84973165876     PISSN: 07422091     EISSN: 15736822     Source Type: Journal    
DOI: 10.1007/s10565-016-9340-2     Document Type: Article
Times cited : (38)

References (47)
  • 1
    • 0035990394 scopus 로고    scopus 로고
    • A toxicologist’s guide to biomarkers of hepatic response
    • COI: 1:CAS:528:DC%2BD38Xmt1Gksb4%3D, PID: 12141396
    • Amacher DE. A toxicologist’s guide to biomarkers of hepatic response. Hum Exp Toxicol. 2002;21:253–62.
    • (2002) Hum Exp Toxicol , vol.21 , pp. 253-262
    • Amacher, D.E.1
  • 2
    • 77951234639 scopus 로고    scopus 로고
    • Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis
    • COI: 1:CAS:528:DC%2BC3cXisFaktrc%3D, PID: 20048155
    • Bargagna-Mohan P, Paranthan RR, Hamza A, Dimova N, Trucchi B, Srinivasan C, et al. Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis. J Biol Chem. 2010;285:7657–69.
    • (2010) J Biol Chem , vol.285 , pp. 7657-7669
    • Bargagna-Mohan, P.1    Paranthan, R.R.2    Hamza, A.3    Dimova, N.4    Trucchi, B.5    Srinivasan, C.6
  • 3
    • 49749224003 scopus 로고    scopus 로고
    • A colorimetric method for determination of isocitrate dehydrogenase
    • Bell JL, Baron DN. A colorimetric method for determination of isocitrate dehydrogenase. Clin Chem Acta. 2001;5:740–7.
    • (2001) Clin Chem Acta , vol.5 , pp. 740-747
    • Bell, J.L.1    Baron, D.N.2
  • 4
    • 84867851794 scopus 로고    scopus 로고
    • Molecular insight in the multifunctional activities of withaferin A
    • Berghe WV, Sabbe L, Kaileh M, Haegeman G, Heyninck K. Molecular insight in the multifunctional activities of withaferin A. Biochem Pharmacol. 2012;84(10):1282–91.
    • (2012) Biochem Pharmacol , vol.84 , Issue.10 , pp. 1282-1291
    • Berghe, W.V.1    Sabbe, L.2    Kaileh, M.3    Haegeman, G.4    Heyninck, K.5
  • 5
    • 0001473390 scopus 로고
    • Presence of enzyme system in mammalian tissues
    • Bilter EE, (ed), Wiley Inter Science, London
    • Bonting SL. Presence of enzyme system in mammalian tissues. In: Bilter EE, editor. Membrane and ion transport. London: Wiley Inter Science; 1970. p. 257–63.
    • (1970) Membrane and ion transport , pp. 257-263
    • Bonting, S.L.1
  • 6
    • 0037025531 scopus 로고    scopus 로고
    • Acute and subacute nephrotoxicity of 2-bromophenol in rats
    • COI: 1:CAS:528:DC%2BD38XmtlCmtLo%3D, PID: 12191884
    • Bruchajzer E, Szymanska J, Piotrowski JK. Acute and subacute nephrotoxicity of 2-bromophenol in rats. Toxicol Lett. 2002;134:245–52.
    • (2002) Toxicol Lett , vol.134 , pp. 245-252
    • Bruchajzer, E.1    Szymanska, J.2    Piotrowski, J.K.3
  • 7
    • 0037204948 scopus 로고    scopus 로고
    • Goeddel DV.TNF-R1 signaling: a beautiful pathway
    • COI: 1:CAS:528:DC%2BD38XktlChtrg%3D, PID: 12040173
    • Chen G. Goeddel DV.TNF-R1 signaling: a beautiful pathway. Science. 2002;296:1634–5.
    • (2002) Science , vol.296 , pp. 1634-1635
    • Chen, G.1
  • 8
    • 84985871590 scopus 로고    scopus 로고
    • Acute and chronic toxicity, cytochrome P450 enzyme inhibition, and hERG channel blockade studies with a polyherbal, ayurvedic formulation for inflammation
    • Dey D, Sunetra C, Nitin A, Deepa C. Acute and chronic toxicity, cytochrome P450 enzyme inhibition, and hERG channel blockade studies with a polyherbal, ayurvedic formulation for inflammation. Biomed Res Int. 2015; 1–9.
    • (2015) Biomed Res Int , pp. 1-9
    • Dey, D.1    Sunetra, C.2    Nitin, A.3    Deepa, C.4
  • 9
    • 34548379435 scopus 로고    scopus 로고
    • The significance of mitochondrial toxicity testing in drug development
    • Dykens JA, Will Y. The significance of mitochondrial toxicity testing in drug development. Drug Discov Today. 2008;12:777–85.
    • (2008) Drug Discov Today , vol.12 , pp. 777-785
    • Dykens, J.A.1    Will, Y.2
  • 10
    • 0014599008 scopus 로고
    • Membrane adenosine triphosphatase of E. coli activation by calcium ions and inhibition by monovalent cations
    • COI: 1:CAS:528:DyaE3cXpsVKn, PID: 4242923
    • Evans DJ. Membrane adenosine triphosphatase of E. coli activation by calcium ions and inhibition by monovalent cations. J Bacteriol. 1969;100(2):914–22.
    • (1969) J Bacteriol , vol.100 , Issue.2 , pp. 914-922
    • Evans, D.J.1
  • 11
    • 0000154206 scopus 로고
    • The colorimetric determination of phosphorus
    • COI: 1:CAS:528:DyaB28XoslGn
    • Fiske CH, Subbarow Y. The colorimetric determination of phosphorus. J Biol Chem. 1925;66:375–400.
    • (1925) J Biol Chem , vol.66 , pp. 375-400
    • Fiske, C.H.1    Subbarow, Y.2
  • 12
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • COI: 1:CAS:528:DyaE38Xkslagsbw%3D, PID: 4337382
    • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 13
    • 0642283970 scopus 로고    scopus 로고
    • Regulation of proliferation, survival and apoptosis by members of the TNF superfamily
    • COI: 1:CAS:528:DC%2BD3sXnvVeru7k%3D, PID: 14555214
    • Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem Pharmacol. 2003;66:1403–8.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1403-1408
    • Gaur, U.1    Aggarwal, B.B.2
  • 14
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-jB: players, pathways, perspectives
    • COI: 1:CAS:528:DC%2BD28XhtFektL7E, PID: 17072321
    • Gilmore TD. Introduction to NF-jB: players, pathways, perspectives. Oncogene. 2006;25:6680–4.
    • (2006) Oncogene , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 15
    • 72149113021 scopus 로고    scopus 로고
    • Beneficial effect of the administration of Hemidesmus indicus against bromobenzene induced oxidative stress in rat liver mitochondria
    • COI: 1:STN:280:DC%2BC3c%2FotFKmsw%3D%3D, PID: 19799985
    • Gopi S, Setty OH. Beneficial effect of the administration of Hemidesmus indicus against bromobenzene induced oxidative stress in rat liver mitochondria. J Ethnopharmacol. 2010;127:200–20.
    • (2010) J Ethnopharmacol , vol.127 , pp. 200-220
    • Gopi, S.1    Setty, O.H.2
  • 16
    • 0016275313 scopus 로고
    • Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation
    • COI: 1:CAS:528:DyaE2MXltlahtg%3D%3D, PID: 4436300
    • Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249:7130–9.
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 17
    • 84878617527 scopus 로고    scopus 로고
    • Effects of black seed oil on resolution of hepato-renal toxicity induced by bromobenzene in rats
    • COI: 1:STN:280:DC%2BC3srhtVyhsg%3D%3D, PID: 23543440
    • Hamed MA, El-Rigal NS, Ali SA. Effects of black seed oil on resolution of hepato-renal toxicity induced by bromobenzene in rats. Eur Rev Med Pharmacol Sci. 2013;17:569–81.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 569-581
    • Hamed, M.A.1    El-Rigal, N.S.2    Ali, S.A.3
  • 18
    • 0037333902 scopus 로고    scopus 로고
    • Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach
    • COI: 1:CAS:528:DC%2BD3sXhs1Clsbw%3D, PID: 12628495
    • Heijne WHM, Stierum RH, Slijper M, Bladeren PJ, Ommen B. Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach. Biochem Pharmacol. 2003;65:857–75.
    • (2003) Biochem Pharmacol , vol.65 , pp. 857-875
    • Heijne, W.H.M.1    Stierum, R.H.2    Slijper, M.3    Bladeren, P.J.4    Ommen, B.5
  • 20
    • 0020623732 scopus 로고
    • Purification and characterization of two forms of a low affinity Ca2+-ATPase from erythrocyte membranes
    • Hjertan S, Pan H. Purification and characterization of two forms of a low affinity Ca2+-ATPase from erythrocyte membranes. Biochem Biophys Acta. 1983;728(2):281–8.
    • (1983) Biochem Biophys Acta , vol.728 , Issue.2 , pp. 281-288
    • Hjertan, S.1    Pan, H.2
  • 21
    • 77957010110 scopus 로고
    • Isolation of liver or kidney mitochondria
    • London: Academic
    • Johnson D, Lardy H. Isolation of liver or kidney mitochondria. In: Methods in enzymology. London: Academic; 1981. p. 94–96.
    • (1981) Methods in enzymology , pp. 94-96
    • Johnson, D.1    Lardy, H.2
  • 22
    • 0033013143 scopus 로고    scopus 로고
    • Paracetamol hepatotoxicity and microsomal function
    • COI: 1:CAS:528:DyaK1MXitl2ntL4%3D, PID: 21781911
    • Kaushal R, Dave KR, Katyare SS. Paracetamol hepatotoxicity and microsomal function. Environ Toxicol Pharmacol. 1999;7:67–74.
    • (1999) Environ Toxicol Pharmacol , vol.7 , pp. 67-74
    • Kaushal, R.1    Dave, K.R.2    Katyare, S.S.3
  • 23
    • 0034486022 scopus 로고    scopus 로고
    • Identification of three protein targets for reactive metabolites of bromobenzene in rat liver cytosol
    • COI: 1:CAS:528:DC%2BD3cXnvVKnur8%3D, PID: 11123975
    • Koen YM, Williams TD, Hanzlik RP. Identification of three protein targets for reactive metabolites of bromobenzene in rat liver cytosol. Chem Res Toxicol. 2000;13(12):1326–35.
    • (2000) Chem Res Toxicol , vol.13 , Issue.12 , pp. 1326-1335
    • Koen, Y.M.1    Williams, T.D.2    Hanzlik, R.P.3
  • 24
    • 0033375267 scopus 로고    scopus 로고
    • Hepatoprotection by dimethyl sulfoxide. II. Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury
    • COI: 1:CAS:528:DC%2BD3cXitVCrtw%3D%3D
    • Lind CL, Gandolfi AJ. Hepatoprotection by dimethyl sulfoxide. II. Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury. Exp Toxic Pathol. 1999;51:537–43.
    • (1999) Exp Toxic Pathol , vol.51 , pp. 537-543
    • Lind, C.L.1    Gandolfi, A.J.2
  • 25
    • 81255203811 scopus 로고    scopus 로고
    • An analog of withaferin A activates the MAPK and glutathione “stress” pathways and inhibits pancreatic cancer cell proliferation
    • COI: 1:CAS:528:DC%2BC3MXhsVymur%2FP, PID: 22085270
    • Liu X, Qi W, Cooke LS, Kithsiri Wijeratne EM, Xu YM, Marron MT, et al. An analog of withaferin A activates the MAPK and glutathione “stress” pathways and inhibits pancreatic cancer cell proliferation. Cancer Invest. 2011;29(10):668–75. doi:10.3109/07357907.2011.626478.
    • (2011) Cancer Invest , vol.29 , Issue.10 , pp. 668-675
    • Liu, X.1    Qi, W.2    Cooke, L.S.3    Kithsiri Wijeratne, E.M.4    Xu, Y.M.5    Marron, M.T.6
  • 26
    • 84922931416 scopus 로고    scopus 로고
    • Amelioration of bromobenzene hepatotoxicity by Withania somnifera pretreatment: role of mitochondrial oxidative stress
    • Mahima V, Rasool M, Sabina EP. Amelioration of bromobenzene hepatotoxicity by Withania somnifera pretreatment: role of mitochondrial oxidative stress. Toxicol Rep. 2014a;1:629–38.
    • (2014) Toxicol Rep , vol.1 , pp. 629-638
    • Mahima, V.1    Rasool, M.2    Sabina, E.P.3
  • 27
    • 84904641129 scopus 로고    scopus 로고
    • Protective effect of Withania somnifera against bromobenzene-induced nephrotoxicity and mitochondrial oxidative stress in rats
    • Mahima V, Rasool MK, Sabina EP. Protective effect of Withania somnifera against bromobenzene-induced nephrotoxicity and mitochondrial oxidative stress in rats. Ren Fail. 2014b;36(7):1095–103.
    • (2014) Ren Fail , vol.36 , Issue.7 , pp. 1095-1103
    • Mahima, V.1    Rasool, M.K.2    Sabina, E.P.3
  • 28
    • 0016272750 scopus 로고
    • Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase
    • COI: 1:CAS:528:DyaE2MXhtlGm, PID: 4215654
    • Marklund SL, Marklund G. Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47:469–74.
    • (1974) Eur J Biochem , vol.47 , pp. 469-474
    • Marklund, S.L.1    Marklund, G.2
  • 29
    • 84957841390 scopus 로고
    • The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate
    • COI: 1:CAS:528:DyaH1cXjvVOgsA%3D%3D, PID: 18871256
    • Mehler AH, Kornberg A, Grisolia S, Ochoa S. The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate. J Biol Chem. 1948;174:961–77.
    • (1948) J Biol Chem , vol.174 , pp. 961-977
    • Mehler, A.H.1    Kornberg, A.2    Grisolia, S.3    Ochoa, S.4
  • 30
    • 73649196367 scopus 로고
    • Studies on the respiratory chain-linked dihydrodiphosphopyridine nucleotide dehydrogenase. I. Assay of the enzyme in particulate and in soluble preparation
    • COI: 1:CAS:528:DyaF38XmvVelsg%3D%3D, PID: 14474263
    • Minakami S, Ringler RL, Singer TP. Studies on the respiratory chain-linked dihydrodiphosphopyridine nucleotide dehydrogenase. I. Assay of the enzyme in particulate and in soluble preparation. J Biol Chem. 1962;237:569–76.
    • (1962) J Biol Chem , vol.237 , pp. 569-576
    • Minakami, S.1    Ringler, R.L.2    Singer, T.P.3
  • 31
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver
    • COI: 1:CAS:528:DyaE1MXhtVSkurw%3D, PID: 760819
    • Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochem Biophys Acta. 1979;582:67–78.
    • (1979) Biochem Biophys Acta , vol.582 , pp. 67-78
    • Moron, M.S.1    Depierre, J.W.2    Mannervik, B.3
  • 32
    • 0020060819 scopus 로고
    • A comparative study of plasma membrane Mg2+-ATPase activities in normal, regenerating and malignant cells
    • Ohinishi T, Suzuki T, Suzuki Y, Ozawa K. A comparative study of plasma membrane Mg2+-ATPase activities in normal, regenerating and malignant cells. Biochem Biophys Acta. 1982;684(1):67–74.
    • (1982) Biochem Biophys Acta , vol.684 , Issue.1 , pp. 67-74
    • Ohinishi, T.1    Suzuki, T.2    Suzuki, Y.3    Ozawa, K.4
  • 33
    • 0018384650 scopus 로고    scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid
    • Ohkawa H, Ohish N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid. Anal Biochem. 1997;95:351–8.
    • (1997) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohish, N.2    Yagi, K.3
  • 34
    • 0001732361 scopus 로고
    • Microdetermination of cytochrome oxidase in rat tissues by the oxidation of N-phenyl-p-phenylenediamine or ascorbic acid
    • Pearl W, Cascarano J, Zweifach BW. Microdetermination of cytochrome oxidase in rat tissues by the oxidation of N-phenyl-p-phenylenediamine or ascorbic acid. J Histochem Cytochem. 1963;2:102–4.
    • (1963) J Histochem Cytochem , vol.2 , pp. 102-104
    • Pearl, W.1    Cascarano, J.2    Zweifach, B.W.3
  • 36
    • 77956995420 scopus 로고
    • α-Ketoglutarate dehydrogenase complex from Escherichia coli
    • Colowick SP, Kaplon NO, (eds), 13, Academic, New York
    • Reed LJ, Mukherjee RB. α-Ketoglutarate dehydrogenase complex from Escherichia coli. In: Colowick SP, Kaplon NO, editors. Methods in enzymology, vol. 13. New York: Academic; 1969. p. 53–61.
    • (1969) Methods in enzymology , pp. 53-61
    • Reed, L.J.1    Mukherjee, R.B.2
  • 37
  • 38
    • 65249139441 scopus 로고    scopus 로고
    • Inhibition of monosodium urate crystal-induced inflammation by withaferin A
    • COI: 1:CAS:528:DC%2BD1MXht1ClsbrL, PID: 19183513
    • Sabina EP, Chandal S, Rasool MK. Inhibition of monosodium urate crystal-induced inflammation by withaferin A. J Pharm Pharm Sci. 2008;11:46–55.
    • (2008) J Pharm Pharm Sci , vol.11 , pp. 46-55
    • Sabina, E.P.1    Chandal, S.2    Rasool, M.K.3
  • 39
    • 0015353270 scopus 로고
    • Colorimetric assay of catalase
    • Sinha AK. Colorimetric assay of catalase. Anal Biochem. 1974;147:389–94.
    • (1974) Anal Biochem , vol.147 , pp. 389-394
    • Sinha, A.K.1
  • 40
    • 84958688743 scopus 로고
    • The effect of fluoride on succinic oxidase system
    • COI: 1:CAS:528:DyaG3sXjsFyr
    • Slater EC, Bonner WDJ. The effect of fluoride on succinic oxidase system. Biochemistry. 1952;52:185–95.
    • (1952) Biochemistry , vol.52 , pp. 185-195
    • Slater, E.C.1    Bonner, W.D.J.2
  • 41
    • 77953325281 scopus 로고    scopus 로고
    • Improved docking, screening and selectivity prediction for small molecule nuclear receptor modulators using conformational ensembles
    • So-Jung P, Kufareva I, Abagyan R. Improved docking, screening and selectivity prediction for small molecule nuclear receptor modulators using conformational ensembles. J Comput Aided Mol Des. 2010;24:459–71.
    • (2010) J Comput Aided Mol Des , vol.24 , pp. 459-471
    • So-Jung, P.1    Kufareva, I.2    Abagyan, R.3
  • 42
    • 0014883924 scopus 로고
    • Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity
    • COI: 1:CAS:528:DyaE3MXjvFShtg%3D%3D, PID: 5473551
    • Sunderman WF, Nomoto S. Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity. Clin Chem. 1970;16(11):903–10.
    • (1970) Clin Chem , vol.16 , Issue.11 , pp. 903-910
    • Sunderman, W.F.1    Nomoto, S.2
  • 43
    • 0031950744 scopus 로고    scopus 로고
    • Hepatotoxicity of brominated benzenes: relationship between chemical structure and hepatotoxic effects in acute intoxication of mice
    • Szymanaska JA. Hepatotoxicity of brominated benzenes: relationship between chemical structure and hepatotoxic effects in acute intoxication of mice. Arch Toxicol. 1998;72:97–103.
    • (1998) Arch Toxicol , vol.72 , pp. 97-103
    • Szymanaska, J.A.1
  • 44
    • 68949149772 scopus 로고    scopus 로고
    • Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice
    • Tsai CF, Hsu YW, Chen WK, Chang WH, Yen CC, Ho YH, et al. Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2009;27:2031–6.
    • (2009) Food Chem Toxicol , vol.27 , pp. 2031-2036
    • Tsai, C.F.1    Hsu, Y.W.2    Chen, W.K.3    Chang, W.H.4    Yen, C.C.5    Ho, Y.H.6
  • 45
    • 23344450788 scopus 로고    scopus 로고
    • Induction of phase I, II and III drug metabolism/transport by xenobiotics
    • COI: 1:CAS:528:DC%2BD2MXjt1Krtb0%3D, PID: 15832810
    • Xu C, Li CYT, Kong ANT. Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res. 2005;28(3):249–68.
    • (2005) Arch Pharm Res , vol.28 , Issue.3 , pp. 249-268
    • Xu, C.1    Li, C.Y.T.2    Kong, A.N.T.3
  • 46
    • 84885394819 scopus 로고    scopus 로고
    • Yang J, Dongmei L, Weixin J, Hans-Uwe D, Lan WB. Effects of cadmium on lipid storage and metabolism in the freshwater crab Sinopotamon henanense. Plos One. 2013;8(10)
    • Yang J, Dongmei L, Weixin J, Hans-Uwe D, Lan WB. Effects of cadmium on lipid storage and metabolism in the freshwater crab Sinopotamon henanense. Plos One. 2013;8(10).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.