Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model

Molecular Carcinogenesis

Volumn 55, Issue 11, 2016, Pages 1739-1746

  Li, Wenjuan ^a,b   Zhang, Chunjing ^a,c   Du, Hongyan ^a,d   Huang, Vincent ^a   Sun, Brandi ^a   Harris, John P ^a   Richardson, Quitin ^a   Shen, Xinggui ^a   Jin, Rong ^a   Li, Guohong ^a   Kevil, Christopher G ^a   Gu, Xin ^a   Shi, Runhua ^e   Zhao, Yunfeng ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b HEBEI UNIVERSITY   (China)

^c QIQIHAR MEDICAL UNIVERSITY   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

^e LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

ACC1; apoptosis; cell proliferation; skin carcinogenesis; withaferin A

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ANTIBODY; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; WITHAFERIN A; ACC1 PROTEIN, MOUSE; WITHANOLIDE;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BASAL CELL CARCINOMA; CANCER INHIBITION; CANCER TISSUE; CELL COUNT; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG MECHANISM; FIBROXANTHOMA; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MELANOMA; MELANOMA CELL; MICROARRAY ANALYSIS; MITOSIS; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKIN CANCER; SKIN CARCINOGENESIS; SKIN PAPILLOMA; UPREGULATION; ANIMAL; CELL PROLIFERATION; CHEMICALLY INDUCED; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SKIN NEOPLASMS; TUMOR CELL LINE;

ACETYL-COA CARBOXYLASE; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; SKIN NEOPLASMS; TRANSCRIPTION FACTOR AP-1; UP-REGULATION; WITHANOLIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84989278724     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22423     Document Type: Article

References (31)

1. Chowdhury K, Neogy RK. Mode of action of Withaferin A and Withanolide D. Biochem Pharmacol 1975; 24:919–920.
2. Stan SD, Hahm ER, Warin R, Singh SV. Withaferin A causes FOXO3a-and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Res 2008; 68:7661–7669.
3. Ndlovu N, Van Lint C, Van Wesemael K, et al. Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells. Mol Cell Biol 2009; 29:5488–5504.
4. Hahm ER, Lee J, Kim SH, et al. Metabolic alterations in mammary cancer prevention by Withaferin A in a clinically relevant mouse model. J Natl Cancer Inst 2013; 105:1111–1122.
5. Srinivasan S, Ranga RS, Burikhanov R, Han SS, Chendil D. Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells. Cancer Res 2007; 67:246–253.
6. Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C. Notch-1 inhibition by Withaferin-A: A therapeutic target against colon carcinogenesis. Mol Cancer Ther 2010; 9:202–210.
7. Yu Y, Hamza A, Zhang T, et al. Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochem Pharmacol 2010; 79:542–551.
8. Shah N, Kataria H, Kaul SC, Ishii T, Kaur G, Wadhwa R. Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: Combinational approach for enhanced differentiation. Cancer Sci 2009; 100:1740–1747.
9. Lee TJ, Um HJ, Min dS, et al. Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med 2009; 46:1639–1649.
10. Mandal C, Dutta A, Mallick A, et al. Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade. Apoptosis 2008; 13:1450–1464.
11. Walker K, Padhiar M. AACR-NCI-EORTC--21st International Symposium. Molecular targets and cancer therapeutics—Part 1. IDrugs 2010; 13:7–9.
12. Li W, Zhao Y. Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells. Cancer Sci 2013; 104:143–148.
13. Milgraum LZ, Witters LA, Pasternack GR, Kuhajda FP. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 1997; 3:2115–2120.
14. Swinnen JV, Vanderhoydonc F, Elgamal AA, et al. Selective activation of the fatty acid synthesis pathway in human prostate cancer. Int J Cancer 2000; 88:176–179.
15. Yahagi N, Shimano H, Hasegawa K, et al. Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma. Eur J Cancer 2005; 41:1316–1322.
16. Beckers A, Organe S, Timmermans L, et al. Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res 2007; 67:8180–8187.
17. Wang C, Rajput S, Watabe K, Liao DF, Cao D. Acetyl-CoA carboxylase-a as a novel target for cancer therapy. Front Biosci (Schol Ed) 2010; 2:515–526.
18. Zhao Y, St Clair DK. Detection of the content and activity of the transcription factor AP-1 in a multistage skin carcinogenesis model. Methods Mol Biol 2003; 218:177–184.
19. Liu J, Gu X, Li G, Shi R, McCord JM, Zhao Y. Suppression of skin carcinogenesis by a potent antioxidant dietary approach. PLoS ONE 2009; 4:e5284.
20. Jin R, Yu S, Song Z, et al. Soluble CD40 ligand stimulates CD40-dependent activation of the β2 integrin Mac-1 and protein kinase C zeda (PKCζ) in neutrophils: Implications for neutrophil-platelet interactions and neutrophil oxidative burst. PLoS ONE 2013; 8:e64631.
21. Zhao Y, Oberley TD, Chaiswing L, et al. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene 2002; 21:3836–3846.
22. Robbins D, Gu X, Liu J, et al. The Chemopreventive effects of Protandim: Modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis. PLoS ONE 2010; 5:e11902.
23. Colburn NH, Former BF, Nelson KA, Yuspa SH. Tumour promoter induces anchorage independence irreversibly. Nature 1979; 281:589–591.
24. Zhao Y, Xue Y, Oberley TD, et al. Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. Cancer Res 2001; 61:6082–6088.
25. Mao J, Chirala SS, Wakil SJ. Human acetyl-CoA carboxylase 1 gene: Presence of three promoters and heterogeneity at the 5'-untranslated mRNA region. Proc Natl Acad Sci USA 2003; 100:7515–7520.
26. Stan SD, Zeng Y, Singh SV. Ayurvedic medicine constituent withaferin a causes G2 and M phase cell cycle arrest in human breast cancer cells. Nutr Cancer 2008; 60:51–60.
27. Oh JH, Lee TJ, Kim SH, et al. Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation. Apoptosis 2008; 13:1494–1504.
28. Bargagna-Mohan P, Hamza A, Kim YE, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol 2007; 14:623–634.
29. Uma Devi P, Kamath R. Radiosensitizing effect of withaferin A combined with hyperthermia on mouse fibrosarcoma and melanoma. J Radiat Res 2003; 44:1–6.
30. Wakil SJ, Abu-Elheiga LA. Fatty acid metabolism: Target for metabolic syndrome. J Lipid Res 2009; 50:S138–S143.
31. Li W, Liu J, Zhao Y. PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells. Mol Carcinog 2014; 53:403–412.