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Volumn 3, Issue 2, 2009, Pages 138-148

Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription factor

Author keywords

Angiogenesis; Ehrlich ascites tumor; Sp1; VEGF; Withaferin A

Indexed keywords

TRANSCRIPTION FACTOR SP1; VASCULOTROPIN; WITHAFERIN A;

EID: 66549124710     PISSN: 09738916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (27)

References (40)
  • 1
    • 33846436451 scopus 로고    scopus 로고
    • Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells
    • Srinivasan, S., Ranga, R.S., Burikihanov, R., Han, S.S. and Chendil, D. (2007). Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells. Cancer Research, 67: 246-53.
    • (2007) Cancer Research , vol.67 , pp. 246-253
    • Srinivasan, S.1    Ranga, R.S.2    Burikihanov, R.3    Han, S.S.4    Chendil, D.5
  • 2
    • 34848858255 scopus 로고    scopus 로고
    • Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine
    • Malik, E, Kumar, A., Bhushan, S., Khan, S., Bhatia, A., Suri, K.A., Qazi, G.N. and Singh, J. (2007). Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine. Apoptosis, 12: 2115-2133.
    • (2007) Apoptosis , vol.12 , pp. 2115-2133
    • Malik, E.1    Kumar, A.2    Bhushan, S.3    Khan, S.4    Bhatia, A.5    Suri, K.A.6    Qazi, G.N.7    Singh, J.8
  • 3
    • 33846186314 scopus 로고    scopus 로고
    • Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex
    • Sen, N., Banerjee, B., Das, B.B., Ganguly, A., Sen, T., Pramanik, S., Mukhopadhyay, S. and Majumder, H.K. (2007). Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex. Cell Death and Differentiation, 14: 358-367.
    • (2007) Cell Death and Differentiation , vol.14 , pp. 358-367
    • Sen, N.1    Banerjee, B.2    Das, B.B.3    Ganguly, A.4    Sen, T.5    Pramanik, S.6    Mukhopadhyay, S.7    Majumder, H.K.8
  • 5
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta, L.A., Steeg, P.S. and Stetler-Stevenson, W.G. (1991). Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell, 64: 327-336.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 6
    • 0031418908 scopus 로고    scopus 로고
    • Antioxidant activity of glycowithanolides from W somnifera in rat brain frontal cortex and striatum
    • Bhattacharya, S.K;, Satyan, K.S. and Ghosal, S. (1997). Antioxidant activity of glycowithanolides from W somnifera in rat brain frontal cortex and striatum. Indian Journal of Experimental Biology, 35: 236-239.
    • (1997) Indian Journal of Experimental Biology , vol.35 , pp. 236-239
    • Bhattacharya, S.K.1    Satyan, K.S.2    Ghosal, S.3
  • 7
    • 0035200453 scopus 로고    scopus 로고
    • Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum
    • Bhattacharya, A., Ghosal, S. and Bhattacharya, S.K. (2001). Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. Journal of Ethnopharmacology, 74: 1-6.
    • (2001) Journal of Ethnopharmacology , vol.74 , pp. 1-6
    • Bhattacharya, A.1    Ghosal, S.2    Bhattacharya, S.K.3
  • 8
    • 0033845752 scopus 로고    scopus 로고
    • Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): A review
    • Mishra, L.C., Singh, B.B. and Dagenais, S. (2000). Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Alternative Medicine Review, 5: 334-346.
    • (2000) Alternative Medicine Review , vol.5 , pp. 334-346
    • Mishra, L.C.1    Singh, B.B.2    Dagenais, S.3
  • 11
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    • Feldser, D., Agani, F., Iyer, N.V., Pak, B., Ferreira, G. and Semenza, G.L. (1999). Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Research, 59: 3915-3918.
    • (1999) Cancer Research , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Ferreira, G.5    Semenza, G.L.6
  • 12
  • 13
    • 0032866999 scopus 로고    scopus 로고
    • The Sp-family of transcription factors
    • Suske, G. (1999). The Sp-family of transcription factors. Gene, 238: 291-300.
    • (1999) Gene , vol.238 , pp. 291-300
    • Suske, G.1
  • 14
    • 46149139074 scopus 로고
    • Promoter-specific activation of RNA polymerase H transcription by Sp1
    • Kadonaga, J.T., Jones, K.A., and Tjian, R. (1986). Promoter-specific activation of RNA polymerase H transcription by Sp1. Trends in Biochemical Sciences, 11: 20-23.
    • (1986) Trends in Biochemical Sciences , vol.11 , pp. 20-23
    • Kadonaga, J.T.1    Jones, K.A.2    Tjian, R.3
  • 15
    • 0003049247 scopus 로고    scopus 로고
    • Biochemical and functional predictions for a growing family of zinc finger transcription factors
    • Cook, T., Gebelein, B. and Urrutia, R. (1999). Biochemical and functional predictions for a growing family of zinc finger transcription factors. Annals of the New York Academy of Sciences, 880: 94-102.
    • (1999) Annals of the New York Academy of Sciences , vol.880 , pp. 94-102
    • Cook, T.1    Gebelein, B.2    Urrutia, R.3
  • 16
    • 0035937586 scopus 로고    scopus 로고
    • Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc
    • Wells, L., Vosseller, K. and Hart, G.W. (2001). Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc. Science, 291: 2376-2823.
    • (2001) Science , vol.291 , pp. 2376-2823
    • Wells, L.1    Vosseller, K.2    Hart, G.W.3
  • 17
    • 0035872399 scopus 로고    scopus 로고
    • Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma
    • Shi, Q., Le, X., Abbruzzese, J.L., Peng, Z., Qian, C.N., Tang, H., Xiong, Q., Wang, B., Li, X.C., Xie, K. (2001). Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Res, 61: 4143-54.
    • (2001) Cancer Res , vol.61 , pp. 4143-4154
    • Shi, Q.1    Le, X.2    Abbruzzese, J.L.3    Peng, Z.4    Qian, C.N.5    Tang, H.6    Xiong, Q.7    Wang, B.8    Li, X.C.9    Xie, K.10
  • 18
    • 3042570272 scopus 로고    scopus 로고
    • Association between Expression of Transcription Factor Sp1 and Increased Vascular Endothelial Growth Factor Expression, Advanced Stage, and Poor Survival in Patients with Resected Gastric Cancer
    • Yao, J.C., Wang, L., Wei, D., Gong, W., Hassan, M., Wu, T. T., Mansfield, P., Ajani, J., Xie, K.(2004) Association between Expression of Transcription Factor Sp1 and Increased Vascular Endothelial Growth Factor Expression, Advanced Stage, and Poor Survival in Patients with Resected Gastric Cancer. Clinical Cancer Research, 10: 4109-4117.
    • (2004) Clinical Cancer Research , vol.10 , pp. 4109-4117
    • Yao, J.C.1    Wang, L.2    Wei, D.3    Gong, W.4    Hassan, M.5    Wu, T.T.6    Mansfield, P.7    Ajani, J.8    Xie, K.9
  • 20
    • 0032440723 scopus 로고    scopus 로고
    • Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis
    • Ilan, N., Mahooti, S. and Madri, J. (1998). Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis. Journal of Cell Science, 111: 3621-3631.
    • (1998) Journal of Cell Science , vol.111 , pp. 3621-3631
    • Ilan, N.1    Mahooti, S.2    Madri, J.3
  • 21
    • 0037283975 scopus 로고    scopus 로고
    • Antiangiogenic effects of butyric acid involve inhibition of VEGF/KDR gene expression and endothelial cell proliferation
    • Gururaj, A.E., Belakavadi, M. and Salimath, B.P. (2003). Antiangiogenic effects of butyric acid involve inhibition of VEGF/KDR gene expression and endothelial cell proliferation. Molecular and Cellular Biochemistry, 243: 107-112.
    • (2003) Molecular and Cellular Biochemistry , vol.243 , pp. 107-112
    • Gururaj, A.E.1    Belakavadi, M.2    Salimath, B.P.3
  • 22
    • 44649153497 scopus 로고    scopus 로고
    • Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-êB and its DNA binding activity
    • Thippeswamy, G., Sheela, M.L. and Salimath. B.P. (2008). Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-êB and its DNA binding activity. European Journal of Pharmacology, 588: 141-50.
    • (2008) European Journal of Pharmacology , vol.588 , pp. 141-150
    • Thippeswamy, G.1    Sheela, M.L.2    Salimath, B.P.3
  • 23
    • 20044386149 scopus 로고    scopus 로고
    • Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-êB and caspase activated DNase
    • Belakavadi, M. and Salimath, B.P. (2005). Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-êB and caspase activated DNase. Molecular and Cellular Biochemistry, 273: 57-67.
    • (2005) Molecular and Cellular Biochemistry , vol.273 , pp. 57-67
    • Belakavadi, M.1    Salimath, B.P.2
  • 24
    • 24044440958 scopus 로고    scopus 로고
    • Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and down regulation of VEGF
    • Belakavadi, M., Prabhakar, B.T. and Salimath, B.P. (2005). Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and down regulation of VEGF, Biochemical and Biophysical Research Communications, 335: 993-1001.
    • (2005) Biochemical and Biophysical Research Communications , vol.335 , pp. 993-1001
    • Belakavadi, M.1    Prabhakar, B.T.2    Salimath, B.P.3
  • 25
    • 0006598811 scopus 로고    scopus 로고
    • Expression of the vascular endothelial growth factor gene is inhibited by p73
    • Salimath, B.P., Marme, D. and Finkenzeller, G. (2000). Expression of the vascular endothelial growth factor gene is inhibited by p73. Oncogene, 19: 3470-3476.
    • (2000) Oncogene , vol.19 , pp. 3470-3476
    • Salimath, B.P.1    Marme, D.2    Finkenzeller, G.3
  • 31
    • 0029087175 scopus 로고
    • In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma
    • Uma Devi, P., Sharada, A.C. and Solomon, F.E. (1995). In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. Cancer Letters, 95: 189-193.
    • (1995) Cancer Letters , vol.95 , pp. 189-193
    • Uma Devi, P.1    Sharada, A.C.2    Solomon, F.E.3
  • 32
    • 21244466505 scopus 로고    scopus 로고
    • Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density
    • Sadick, H., Naim, R., Gossler, U., Hormann, K. and Riedel, F. (2005). Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density. International Journal of Molecular Medicine, 15: 15-19.
    • (2005) International Journal of Molecular Medicine , vol.15 , pp. 15-19
    • Sadick, H.1    Naim, R.2    Gossler, U.3    Hormann, K.4    Riedel, F.5
  • 33
    • 0031719516 scopus 로고    scopus 로고
    • Role of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibition of Ascites Formation by Immunoneutralization
    • Mesiano, S., Ferrara, N. and Jaffe, R.B. (1998). Role of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibition of Ascites Formation by Immunoneutralization. American Journal of Pathology, 153: 1249-1256.
    • (1998) American Journal of Pathology , vol.153 , pp. 1249-1256
    • Mesiano, S.1    Ferrara, N.2    Jaffe, R.B.3
  • 34
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumor growth in-vivo
    • Kim, K.J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H.S. and Ferrara, N. (1993). Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumor growth in-vivo. Nature, 362: 841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 35
    • 33747702255 scopus 로고    scopus 로고
    • Antiangiogenic effect of 2-benzoyl-phenoxy acetamide in EAT cell is mediated by HIF-1 á and down regulation of VEGF in vivo. Investigation of New
    • Prabhakar, B.T., Khanum, S.A., Shashikanth, S. and Salimath, B.P. (2006). Antiangiogenic effect of 2-benzoyl-phenoxy acetamide in EAT cell is mediated by HIF-1 á and down regulation of VEGF in vivo. Investigation of New Drugs, 24: 471-478.
    • (2006) Drugs , vol.24 , pp. 471-478
    • Prabhakar, B.T.1    Khanum, S.A.2    Shashikanth, S.3    Salimath, B.P.4
  • 36
    • 56349123756 scopus 로고    scopus 로고
    • Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation
    • Oh, J.H., Lee, T.J., Kim, S.H., Choi, Y.H., Lee, S.H., Lee, J.M., Kim, Y.H., Park, J.W. and Kwon, T.K. (2008). Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation. Apoptosis, 13: 1494-504.
    • (2008) Apoptosis , vol.13 , pp. 1494-1504
    • Oh, J.H.1    Lee, T.J.2    Kim, S.H.3    Choi, Y.H.4    Lee, S.H.5    Lee, J.M.6    Kim, Y.H.7    Park, J.W.8    Kwon, T.K.9
  • 37
    • 54949113573 scopus 로고    scopus 로고
    • Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-kappaB in RAW 264.7 cells
    • Oh, J.H., Lee, T.J., Park, J.W. and Kwon, T.K. (2008). Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-kappaB in RAW 264.7 cells. European Journal of Pharmacology, 599: 11-7.
    • (2008) European Journal of Pharmacology , vol.599 , pp. 11-17
    • Oh, J.H.1    Lee, T.J.2    Park, J.W.3    Kwon, T.K.4
  • 38
    • 35348907831 scopus 로고    scopus 로고
    • Withania somnifera inhibits NF-êB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells
    • Divya, S., Amita, A., Rakesh, M. and Sita, N. (2007). Withania somnifera inhibits NF-êB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytotherapy Research, 21: 905-913.
    • (2007) Phytotherapy Research , vol.21 , pp. 905-913
    • Divya, S.1    Amita, A.2    Rakesh, M.3    Sita, N.4
  • 40
    • 1542615084 scopus 로고    scopus 로고
    • Celecoxib Inhibits Vascular Endothelial. Growth Factor Expression in and Reduces Angiogenesis and Metastasis of Human Pancreatic Cancer via Suppression of Sp1 Transcription Factor Activity
    • Wei, D., Wang, L., He, Y., Henry James, Q.X., Abbruzzese, L. and Xie, K. (2004). Celecoxib Inhibits Vascular Endothelial. Growth Factor Expression in and Reduces Angiogenesis and Metastasis of Human Pancreatic Cancer via Suppression of Sp1 Transcription Factor Activity. Cancer Research, 64: 2030-2038.
    • (2004) Cancer Research , vol.64 , pp. 2030-2038
    • Wei, D.1    Wang, L.2    He, Y.3    Henry James, Q.X.4    Abbruzzese, L.5    Xie, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.