An overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 8, Issue 5 SUPPL., 2011, Pages 208-213

  Singh, Narendra ^a   Bhalla, Mohit ^a   de Jager, Prashanti ^a   Gilca, Marilena ^a,b  

^a International Institute of Herbal Medicine (IIHM)   (India)

^b CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Adaptogen anti stress; Anti arthritic; Anti tumor; Neuroregenerative; Rejuvenator; Withania somnifera

Indexed keywords

PLANT EXTRACT;

ANIMAL; AYURVEDA; CHEMISTRY; MOUSE; PHYTOTHERAPY; RAT; REJUVENATION; REVIEW; WITHANIA; WITHANIA SOMNIFERA;

ANIMALS; MEDICINE, AYURVEDIC; MICE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; REJUVENATION; WITHANIA;

EID: 84872035165     PISSN: None     EISSN: 01896016     Source Type: Journal    
DOI: 10.4314/ajtcam.v8i5S.9     Document Type: Article

References (53)

1. Abbas, S.S. and Singh, N. (2006). Anti-stress Agents (Herbs) of Indian Origin-Herbal Drugs, A twenty first century perspective. Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization (DRDO), Govt. of India, Delhi, 578-591.
2. Abbas, S. S, Singh, V., Bhalla, M., and Singh, N. (2004). Clinical Study of Organic Ashwagandha in cases of Parkinsonism, Neuropathy, Paralysis and Uterine Tumours (Fibroids and other tumours) including Cutaneous Endodermal Carcinoma. Proc., National Seminar on "Eco-friendly Herbs of Ayurveda in Healthcare of Mankind: A Strategy for Scientific Evaluation an Uniform Standardization"-Lucknow, 81.
3. Abbas, S.S., Bhalla, M. and Singh, N. (2005). A clinical study of Organic Ashwagandha in some cases of uterine tumors (fibroids) and dermatofibrosarcoma. Proc. workshop on essential medicines, adverse drug reactions and therapeutic drug monitoring. Scientific Convention Centre, Lucknow, 143-144.
4. Abdel-Magied, E.M., Abdel-Rahman, H.A. and Harraz, F.M. (2001). The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. J. Ethnopharmacol., 75: 1-4.
5. Archana, R., Namasivayam, A (1999). Antistressor effect of Withania somnifera. J. Ethnopharmacol., 64: 91-93.
6. Atta-ur-Rahman, Samina-Abbas, Dur-e-Shahwar, Jamal, S.A., Choudhary, M.I. and Abbas. S. (1991). New withanolides from Withania spp. Journal of Natural Products 56: 1000-1006.
7. Begum, V.H., Sadique, J. (1987). Effect Of Withania-Somnifera On Glycosaminoglycan Synthesis in Carrageenin-Induced Air Pouch Granuloma. Biochemical Medicine and Metabolic Biology, 38(3): 272-277.
8. Bhandari, C.R. (1970). Ashwagandha (Withania somnifera) "Vanaushadhi Chandroday" (An Encyclopedia of Indian Herbs). Publisher: CS Series of Varanasi Vidyavilas Press, Varanasi, India, 1: 96-97.
9. Bhattacharya, S.K., Goel, R.K., Kaur, R., Ghosal, S. (1987). Anti-stress activity of Sitoindosides VII and VIII. New Acylsterylglucosides from Withania somnifera. Phytother. Res., 1: 32-37.
10. Bhattacharya, S. K, Kumar, A., and Ghosal, S. (1995). Effects of glycowithanolides from Withania somnifera on animal model of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats. Phytother. Res., 9: 110-113.
11. Budhiraja, R.D. and Sudhir, S. (1987). Review of biological activity of withanolides. JSIR, 46: 488-491.
12. Changhadi Govardhan Sharma (1938)-Ashwagandharishta-Rastantra Sar Evam Sidhyaprayog Sangrah-Krishna-Gopal Ayurveda Bhawan (Dharmarth Trust), Nagpur 743-744.
13. Charak Samhita 6000BC (1949). Charaka translation into English: Translator: Shree Gulabkunverba Ayurvedic Society, Jamnagar, India.
14. Dekosky, S. and Scheff, S.W. (1990). Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann. Neurol., 27: 457-464.
15. Dickon T.C. and Vickers J.C. (2001). The morphological phenotype of b-amyloid plaques and associated neuritic changes in Alzheimer's disease. Neuroscience, 105: 99-107.
16. Dixit, K.S., Agarwal, A.K., Seth, P.K. and Singh, N. (1995). Effect of Withania somnifera, Panex ginseng and Cannabis indica and radio ligand binding with neurohumoral in the CNS, World Congress on Biotech. Dev. Med. Subs. Plants & Marine Origin, King George Medical College, Lucknow (India), 141.
17. Ghosal S., Srivastava R.S., Bhattacharya S.K., Upadhyay S.N., Jaiswal A.K., Chattopadhyay U. (1989). Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycowithanolides form Withania somnifera. Phytother. Res., 2: 201-206.
18. Gunne L.M. and Andren P.E. (1993). An animal model for coexisting tardive dyskinesia and tardive parkinsonism: A glutamate hypothesis for tardive dyskinesia. Clin. Neuropharmacol., 16: 90-95.
19. Kalsi, R., Singh, N. and Gupta, G.P. (1987). Effects of stress and anti-stress drugs on succinate dehydrogenase enzyme (SDH) in rat brain (A possible role of SDH in stress adaptation phenomenon) Physiology of Human Performance, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization (DRDO), Govt. of India, Delhi, 114-117.
20. nd Edition, IIIrd Vol., Lalit Mohan Basu, Allahabad, 1774-1776.
21. Kuboyam, A. T., Tohda, C., Komatsu, K. (2006). Withanoside IV and its active metabolite, sominone, attenuate A beta(25-35)-induced neurodegeneration. Eur J Neurosci., 23(6): 1417-1426.
22. Kulkarni, S.K., Sharma, A, Verma, A. and Ticku, M.K. (1993). GABA receptor mediated anticonvulsant action of Withania somnifera root extract. Indian Drugs, 30: 305-312.
23. Mazen, E.S., Pavelescu, M., Grigorescu, E. (1990). Contributions to the Pharmacodynamic Study of roots of Withania somnifera Dun Species Of Pakistani origin. Testing of Analgesic Activity of Dichloromethanic and Methanolic Extract from Withania-Somnifera Roots; Revista Medico-Chirurgicala Societatii de Medici si Naturalisti din Iasi 94 (3-4): 603-605.
24. Misra B. (2004). Ashwagandha-Bhavprakash Nigantu (Indian Materia Medica)-Chaukhambha Bharti Academy, Varanasi, 393-394.
25. Mishra, L.C., Singh, B.B., Dagenais, S. (2000). Scientific basis for the therapeutic use of Withania somnifera. (Ashwagandha): A review. Alternative Medicine Reviews 5: 334-46.
26. Nagashyana N, Sankarankutty P, Nampoothiri MRV, Moahan P, Mohan Kumar P. (2000). Association of L-dopa with recovery following Ayurvedic medication in Parkinson's disease. J. Neurol. Sci., 176: 1121-1127.
27. Sharma G.S. (1938). Ashwagandharishta-Rastantra Sar Evam Sidhyaprayog Sangrah-Krishna-Gopal Ayurveda Bhawan (Dharmarth Trust), Nagpur 743-744.
28. Sharma, P.V. (1999). Ashwagandha, Dravyaguna Vijana, Chaukhambha Viashwabharti, Varanasi, 763-765.
29. Singh, N., Agarwal, A.K., Lata, A. and Kohli, R.P. (1976). Evaluation of 'adaptogenic' properties of Withania somnifera. Proc. Indian Pharmacological Society, 17.
30. Singh, N., Agarwal, A.K., Lata, A. and Kohli, R.P. (1977). Experimental evaluation of 'adaptogenic' properties of Withania somnifera. XIIth Scientific Seminar on Indian Medicine, Institute of Medical Sciences. Varanasi. 4.
31. Singh, N. (1981). A new concept on the possible therapy of stress disease with 'Adaptogens' (Anti-stress drugs) of indigenous plant origin. Curr. Med. Prac., 25: 50-55.
32. Singh, N., Singh, S.P., Sinha, J.N., Shanker, K., and Kohli, R.P. (1982). Withania somnifera (Ashwagandha) A rejuvenator herbal drug which enhances survival during stress (An adaptogen). Int. J. Crude Drug Res., 3: 29-35.
33. th Sepal Congress of Rheumatology, Bangkok, 37.
34. Singh, N. (1986). A pharmaco-clinical evaluation of some Ayurvedic crude plant drugs as anti-stress agents and their usefulness in some stress diseases of man. Ann. Nat. Acad. Ind. Med., 2(1):14-26.
35. Singh, N., Singh, S.P., Dixit, K.S., Saxena, R.C. and Kohli, R.P. (1986a). A Placebo Controlled Clinical Trial of Cyprus rotundus, Withania somnifera and their Combination in cases of Rheumatoid Arthritis. Proc. International Seminar., 2: 18-21.
36. Singh, N., Singh, S.P., Nath, R., Singh, D.R., Gupta, M.L., Kohli, R.P. and Bhargava, K.P. (1986b). Prevention or Urethane-induced lung adenomas by Withania somnifera (L.) Dunal in albino mice. Int. J. Crude Drug Res. 24(2): 99-100.
37. Singh, N. (1988). Effect of Withania somnifera and Panax ginseng on dopaminergic receptors in rat brain during stress. XXXVIth Annual Congress on Medicinal Plant Research (Freiburg), 28.
38. Singh, N. (1993a). Stress disease and herbal medicine, Inaugural issue of J. Biotech. Med. Plant Res., Lucknow, 2-4.
39. Singh, N. (1993b). Effect of Anti-stress agents on receptor population in rat brain, Inaugural issue of J. Biotech. Med. Plant Res., Lucknow, 14.
40. Singh, N. and Misra, N. (1993). Experimental methods tools for assessment of anti-stress activity in medicinal plants. Journal of Biomedical Research., 12(182): 124-127.
41. Singh, N. (1995a). Stress disease and herbal medicine. World Congress on Biotech. Dev. Med. Subs. Plants & Marine Origin, King George Medical College, Lucknow (India), 48.
42. Singh, N. (1995b). Anti-stress (Ayurvedic Plants) Ocimum sanctum (Tulsi) and Withania somnifera (Ashwagandha) in prevention and treatment of cardiovascular disorders. Proc. Vth W.C.C.N., China, 10.
43. nd World Cong. Biotech. Dev. Herbal Med., Lucknow (India), 33.
44. Singh, N. (2005). Dilemma of Ayurvedic Herbal Medicines / Food Supplements Proc. workshop on Essential Medicines, Adverse Drug Reactions and Therapeutic Drug Monitoring, Dept. of Pharmacology & Therapeutics, KGMU, Scientific Convention Centre, Lucknow, 35-41.
45. Singh, N. (2006). Ayurvedo-Herbal Medicines-The Need of the Time-Herbal Drugs, A twenty first century perspective. Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization (DRDO), Govt. of India, Delhi, 535-547.
46. Singh, N. (2008). Herbs-The Life of Man, Need Pharmaco-clinical Studies for their Scientific Validation-Relevance of Modern Methods of Pharmacological Studies to Traditional Medicine, Department of Pharmacology & Therapeutics, C.S.M. Medical University, Scientific Convention Centre, Lucknow, 37-43.
47. Singh, N. and Gilca, M. (2010). Herbal Medicine-Science embraces tradition-a new insight into the ancient Ayurveda, Lambert Academic Publishing (Germany), 51-67.
48. nd Edition, International Institute of Herbal Medicine, Lucknow, 28-32.
49. Singh R.H., Udupa K.N. (1993) Clinical and experimental studies on rasayana drugs and rasayana therapy. Special Research Monograph, Central Council for Research in Ayurveda and Siddha (CCRAS), Ministry of Health and Family Welfare, New Delhi.
50. Singh, R.S. (1983). Ashwagandha, Vanaushadhi Nidharsika (Ayurvedic Pharmacopia), UP Sansthan, 30-31.
51. Singh, S.P., Singh, D.R., Gupta, M.L., Singh, N. and Kohli, R.P. (1979). An experimental evaluation of anti-tumor activity of Withania somnifera (Ashwagandha) and "Geriforte. " XI Annual Conf. IPS. Ind. Jour. Pharmacol 11(1): 65.
52. Sumanran, V.N., Boddul, S. and Madhuri, D. (2007). Differential growth inhibitory effects of Withania somnifera root on CHO cells. Phytother. Res., 21: 1-4.
53. Twaij, H.A.A., Elisha, E.E. and Khalid, R.M., (1989). Analgesic studies on some Iraqi medicinal plants; International Journal of Crude Research 27: 109-112.