Pharmacological approach to understanding the control of insulin secretion in human islets

Diabetes, Obesity and Metabolism

Volumn 19, Issue 8, 2017, Pages 1061-1070

  Henquin, Jean Claude ^a   Dufrane, Denis ^b   Gmyr, Valery ^c   Kerr Conte, Julie ^c   Nenquin, Myriam ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^c UNIV LILLE   (France)

Author keywords

diazoxide; glucokinase; human islets; insulin secretion; ionic channels; microfilaments; sulphonylureas

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; DIAZOXIDE; ENZYME ACTIVATOR; GLUCOKINASE; GLUCOSE; INSULIN; JASPAMIDE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LATRUNCULIN B; MEMBRANE PROTEIN; NIMODIPINE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; RO 28 1675; SK4 CHANNEL; SODIUM CHANNEL; SULFONYLUREA; TASK 1 CHANNEL; TETRODOTOXIN; TETRYLAMMONIUM; TOLBUTAMIDE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; ANTIDIABETIC AGENT; SULFONYLUREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INSULIN RELEASE; METABOLISM; MICROFILAMENT; NONHUMAN; PANCREAS ISLET BETA CELL; REGULATORY MECHANISM; RODENT MODEL; ACTIN FILAMENT; ADULT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CALCIUM SIGNALING; DONOR; EXOCYTOSIS; FEMALE; MALE; MOUSE; PANCREAS ISLET; RAT; SECRETION (PROCESS); SPECIES DIFFERENCE; TISSUE CULTURE TECHNIQUE;

ACTIN CYTOSKELETON; ADULT; ANIMALS; CALCIUM SIGNALING; EXOCYTOSIS; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; KATP CHANNELS; MALE; MEMBRANE TRANSPORT MODULATORS; MICE; MODELS, BIOLOGICAL; RATS; SPECIES SPECIFICITY; SULFONYLUREA COMPOUNDS; TISSUE CULTURE TECHNIQUES; TISSUE DONORS;

EID: 85017393067     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12887     Document Type: Article

References (44)

1. Henquin JC, Nenquin M, Ravier MA, Szollosi A. Shortcomings of current models of glucose-induced insulin secretion. Diabetes Obes Metab. 2009;11(suppl 4):168-179.
2. ATP channel-independent signaling pathways in human islets. Diabetes. 1998;47:758-763.
3. Henquin JC, Dufrane D, Nenquin M. Nutrient control of insulin secretion in isolated normal human islets. Diabetes. 2006;55:3470-3477.
4. Ferdaoussi M, Dai X, Jensen MV, et al. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β-cells. J Clin Invest. 2015;125:3847-3860.
5. Amisten S, Salehi A, Rorsman P, Jones PM, Persaud SJ. An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans. Pharmacol Ther. 2013;139:359-391.
6. Fridlyand LE, Jacobson DA, Philipson LH. Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis. Islets. 2013;5:1-15.
7. Rorsman P, Braun M. Regulation of insulin secretion in human pancreatic islets. Annu Rev Physiol. 2013;75:155-179.
8. Henquin JC, Dufrane D, Kerr-Conte J, Nenquin M. Dynamics of glucose-induced insulin secretion in normal human islets. Am J Physiol Endocrinol Metab. 2015;309:E640-E650.
9. Dufrane D, Goebbels RM, Guiot Y, Squifflet JP, Henquin JC, Gianello P. A simple method using a polymethylpenten chamber for isolation of human pancreatic islets. Pancreas. 2005;30:e51-e59.
10. Kerr-Conte J, Vandewalle B, Moerman E, et al. Upgrading pretransplant human islet culture technology requires human serum combined with media renewal. Transplantation. 2010;89:1154-1160.
11. Bedoya FJ, Wilson JM, Ghosh AK, Finegold D, Matschinsky FM. The glucokinase glucose sensor in human pancreatic islet tissue. Diabetes. 1986;35:61-67.
12. De Vos A, Heimberg H, Quartier E, et al. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest. 1995;96:2489-2495.
13. Grimsby J, Sarabu R, Corbett WL, et al. Allosteric activators of glucokinase: potential role in diabetes therapy. Science. 2003;301:370-373.
14. Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ. Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator. Diabetes. 2007;56:1694-1702.
15. Doliba NM, Qin W, Najafi H, et al. Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics. Am J Physiol Endocrinol Metab. 2012;302:E87-E102.
16. Henquin JC, Sempoux C, Marchandise J, et al. Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells. Diabetes. 2013;62:1689-1696.
17. i oscillations in single human pancreatic islets. Cell Calcium. 1996;20:409-414.
18. Shibasaki T, Takahashi T, Takahashi H, Seino S. Cooperation between cAMP signalling and sulfonylurea in insulin secretion. Diabetes Obes Metab. 2014;16(Suppl 1):118-125.
19. Nenquin M, Henquin JC. Sulfonylurea receptor-1, sulfonylureas, and amplification of insulin secretion by Epac activation in β-cells. Diabetes Obes Metab. 2016;18:698-701.
20. Li C, Buettger C, Kwagh J, et al. A signaling role of glutamine in insulin secretion. J Biol Chem. 2004;279:13393-13401.
21. ATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH. Am J Physiol Endocrinol Metab. 2003;285:E380-E389.
22. 2+ entry. Diabetes. 1992;41:662-670.
23. Rojas E, Carroll PB, Ricordi C, Boschero AC, Stojilkovic SS, Atwater I. Control of cytosolic free calcium in cultured human pancreatic beta-cells occurs by external calcium-dependent and independent mechanisms. Endocrinology. 1994;134:1771-1781.
24. Mourad NI, Nenquin M, Henquin JC. Metabolic amplifying pathway increases both phases of insulin secretion independently of beta-cell actin microfilaments. Am J Physiol Cell Physiol. 2010;299:C389-C398.
25. + channel in human pancreatic islet cells. Diabetes. 1989;38:422-427.
26. Herrington J, Sanchez M, Wunderler D, et al. Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells. J Physiol. 2005;567:159-175.
27. Braun M, Ramracheya R, Bengtsson M, et al. Voltage-gated ion channels in human pancreatic β-cells: electrophysiological characterization and role in insulin secretion. Diabetes. 2008;57:1618-1628.
28. + channels in the control of glucose-induced electrical activity in pancreatic B-cells. Pflugers Arch. 1990;416:568-572.
29. Li XN, Herrington J, Petrov A, et al. The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. J Pharmacol Exp Ther. 2013;344:407-416.
30. Dadi PK, Vierra NC, Jacobson DA. Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance. Endocrinology. 2014;155:3757-3768.
31. + channels are expressed in pancreatic islets and regulate glucose responses. Diabetes. 2003;52:2000-2006.
32. slow tail current and modulate insulin secretion. J Gen Physiol. 2005;126:353-363.
33. Düfer M, Gier B, Wolpers D, Krippeit-Drews P, Ruth P, Drews G. Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells. Diabetes. 2009;58:1835-1843.
34. Jacobson DA, Mendez F, Thompson M, et al. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010;588:3525-3537.
35. Riz M, Braun M, Pedersen MG. Mathematical modeling of heterogeneous electrophysiological responses in human β-cells. PLoS Comput Biol. 2014;10:e1003389.
36. Henquin JC, Charles S, Nenquin M, Mathot F, Tamagawa T. Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli. Diabetes. 1982;31:776-783.
37. Davalli AM, Biancardi E, Pollo A, et al. Dihydropyridine-sensitive and -insensitive voltage-operated calcium channels participate in the control of glucose-induced insulin release from human pancreatic β-cells. J Endocrinol. 1996;150:195-203.
38. Donatsch P, Lowe DA, Richardson BP, Taylor P. The functional significance of sodium channels in pancreatic beta-cell membranes. J Physiol. 1977;267:357-376.
39. Pace CS. Activation of Na channels in islet cells: metabolic and secretory effects. Am J Physiol. 1979;237:E130-E135.
40. ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol. 2007;5:e143.
41. + currents in cultured mouse pancreatic B-cells. Pfluegers Arch. 1988;411:429-435.
42. 2+ currents in human pancreatic islet β-cells: evidence for roles in the generation of action potentials and insulin secretion. Pfluegers Arch. 1995;431:272-282.
43. Grespan E, Giorgino T, Natali A, Ferrannini E, Mari A. A mathematical modelling of the beta-cell explaining in vitro and in vivo findings with consistent mechanisms. Diabetologia. 2016;59(suppl.1):S261-S262, abstract 547.
44. MacDonald MJ, Longacre MJ, Stoker SW, et al. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, ATP citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. J Biol Chem. 2011;286:18383-18396.