Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance

Endocrinology (United States)

Volumn 155, Issue 10, 2014, Pages 3757-3768

  Dadi, Prasanna K ^a   Vierra, Nicholas C ^a   Jacobson, David A ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PORE DOMAIN ACID SENSITIVE POTASSIUM CHANNEL; CALCIUM CHANNEL; CALCIUM ION; GLUCOSE; POTASSIUM CHANNEL; TOLBUTAMIDE; UNCLASSIFIED DRUG; CALCIUM; INSULIN; NERVE PROTEIN; POTASSIUM CHANNEL SUBFAMILY K MEMBER 3; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ABLATION THERAPY; ACTION POTENTIAL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CELL FUNCTION; CELL ISOLATION; CELL MEMBRANE; CELL SPECIFICITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ELECTROPHYSIOLOGICAL PROCEDURES; ELECTROPHYSIOLOGY; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; POPULATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; VOLTAGE CLAMP TECHNIQUE; WESTERN BLOTTING; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CALCIUM SIGNALING; CELL CULTURE; DRUG EFFECTS; GENETICS; GLUCOSE INTOLERANCE; MEMBRANE POTENTIAL; METABOLISM; SECRETION (PROCESS); TRANSGENIC MOUSE;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; FEMALE; GLUCOSE; GLUCOSE INTOLERANCE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; POTASSIUM CHANNELS, TANDEM PORE DOMAIN;

EID: 84907202745     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-2051     Document Type: Article

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