Sulphonylurea receptor-1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells

Diabetes, Obesity and Metabolism

Volumn 18, Issue 7, 2016, Pages 698-701

  Nenquin, M ^a   Henquin, J C ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

cyclic AMP; Epac; insulin secretion; sulphonylurea receptor 1; sulphonylureas

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BUCLADESINE; CALCIUM CHANNEL; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIAZOXIDE; GLIBENCLAMIDE; GLUCOSE; NIMODIPINE; SULFONYLUREA RECEPTOR 1; TOLBUTAMIDE; ABCC8 PROTEIN, MOUSE; ACETYLCYSTEINE; ANTIDIABETIC AGENT; ERYTHROMYCIN; ERYTHROMYCIN PROPIONATE-N-ACETYLCYSTEINATE; INSULIN; SULFONYLUREA DERIVATIVE; SULFONYLUREA RECEPTOR;

ANIMAL CELL; CHANNEL GATING; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; INSULIN RELEASE; LETTER; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DEFICIENCY; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

ACETYLCYSTEINE; ANIMALS; BUCLADESINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ERYTHROMYCIN; GLYBURIDE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; MICE, INBRED C57BL; SULFONYLUREA COMPOUNDS; SULFONYLUREA RECEPTORS; TOLBUTAMIDE;

EID: 84954139644     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12607     Document Type: Letter

References (17)

1. Henquin JC, Nenquin M, Ravier MA, Szollosi A. Shortcomings of current models of glucose-induced insulin secretion. Diabetes Obes Metab 2009; 11(Suppl 4): 168–179.
2. Amisten S, Salehi A, Rorsman P, Jones PM, Persaud SJ. An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans. Pharmacol Ther 2013; 139: 359–391.
3. Jones PM, Persaud SJ. Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic β-cells. Endocr Rev 1998; 19: 429–461.
4. Shibasaki T, Takahashi T, Takahashi H, Seino S. Cooperation between cAMP signalling and sulfonylurea in insulin secretion. Diabetes Obes Metab 2014; 16(Suppl. 1): 118–125.
5. Chepurny OG, Kelley GG, Dzhura I et al. PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans. Am J Physiol Endocrinol Metab 2010; 298: E622–E633.
6. 2+-mediated activation of Ras in pancreatic β-cells. Sci Signal 2013; 6: ra29.
7. 2+ in female mouse islets stimulated by glucose and tolbutamide. Endocrinology 2014; 155: 3274–3287.
8. Proks P, Reimann F, Green N, Gribble F, Ashcroft FM. Sulfonylurea stimulation of insulin secretion. Diabetes 2002; 51(Suppl. 3): S368–S376.
9. Nakazaki M, Crane A, Hu M et al. cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in Sur1 null islets. Diabetes 2002; 51: 3440–3449.
10. Eliasson L, Ma X, Renstrom M et al. SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol 2003; 121: 181–197.
11. Zhang CL, Katoh M, Shibasaki T et al. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 2009; 325: 607–610.
12. Takahashi T, Shibasaki T, Takahashi H et al. Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A. Sci Signal 2013; 6: ra94.
13. ATP channel-independent regulation of insulin secretion. J Biol Chem 2000; 275: 9270–9277.
14. Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC. Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic β-cells. J Biol Chem 2004; 279: 32316–32324.
15. Rehmann H. Epac2: a sulfonylurea receptor? Biochem Soc Trans 2012; 40: 6–10.
16. + channels owing to a knockout of the pore-forming subunit Kir6.2. Endocrinology 2009; 150: 33–45.
17. Henquin JC, Nenquin M, Sempoux C et al. In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions. J Clin Invest 2011; 121: 3932–3942.