메뉴 건너뛰기




Volumn 7, Issue 3, 2016, Pages

Necroptosis in niemann–pick disease, type C1: A potential therapeutic target

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 1; RECEPTOR INTERACTING PROTEIN KINASE 3; UNCLASSIFIED DRUG; AGFG1 PROTEIN, HUMAN; CARRIER PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MEMBRANE PROTEIN; NPC1 PROTEIN, HUMAN; NPC1 PROTEIN, MOUSE; NUCLEOPORIN; PROTEIN; RALBP1 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, HUMAN; RIPK3 PROTEIN, MOUSE; RNA BINDING PROTEIN;

EID: 85017320460     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2016.16     Document Type: Article
Times cited : (50)

References (51)
  • 1
    • 77953019480 scopus 로고    scopus 로고
    • Niemann-Pick disease type C
    • Vanier MT. Niemann-Pick disease type C. Orphanet J Rare Dis 2010; 5: 16.
    • (2010) Orphanet J Rare Dis , vol.5 , pp. 16
    • Vanier, M.T.1
  • 2
    • 84954341816 scopus 로고    scopus 로고
    • High incidence of unrecognized visceral/neurological late-onset Niemann-Pick disease, type C1, predicted by analysis of massively parallel sequencing data sets
    • Wassif CA, Cross JL, Iben J, Sanchez-Pulido L, Cougnoux A, Platt FM et al. High incidence of unrecognized visceral/neurological late-onset Niemann-Pick disease, type C1, predicted by analysis of massively parallel sequencing data sets. Genet Med 2015; 18: 41–48.
    • (2015) Genet Med , vol.18 , pp. 41-48
    • Wassif, C.A.1    Cross, J.L.2    Iben, J.3    Sanchez-Pulido, L.4    Cougnoux, A.5    Platt, F.M.6
  • 3
    • 4744365602 scopus 로고    scopus 로고
    • Consequences of NPC1 and NPC2 loss of function in mammalian neurons
    • Walkley SU, Suzuki K. Consequences of NPC1 and NPC2 loss of function in mammalian neurons. Biochim Biophys Acta 2004; 1685: 48–62.
    • (2004) Biochim Biophys Acta , vol.1685 , pp. 48-62
    • Walkley, S.U.1    Suzuki, K.2
  • 4
    • 55549134611 scopus 로고    scopus 로고
    • Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    • Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ et al. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med 2008; 14: 1247–1255.
    • (2008) Nat Med , vol.14 , pp. 1247-1255
    • Lloyd-Evans, E.1    Morgan, A.J.2    He, X.3    Smith, D.A.4    Elliot-Smith, E.5    Sillence, D.J.6
  • 5
    • 34547753513 scopus 로고    scopus 로고
    • Miglustat for treatment of Niemann-Pick C disease: A randomised controlled study
    • Patterson MC, Vecchio D, Prady H, Abel L, Wraith JE. Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study. Lancet Neurol 2007; 6: 765–772.
    • (2007) Lancet Neurol , vol.6 , pp. 765-772
    • Patterson, M.C.1    Vecchio, D.2    Prady, H.3    Abel, L.4    Wraith, J.E.5
  • 6
    • 77649338413 scopus 로고    scopus 로고
    • Miglustat in adult and juvenile patients with Niemann-Pick disease type C: Long-term data from a clinical trial
    • Wraith JE, Vecchio D, Jacklin E, Abel L, Chadha-Boreham H, Luzy C et al. Miglustat in adult and juvenile patients with Niemann-Pick disease type C: long-term data from a clinical trial. Mol Genet Metab 2010; 99: 351–357.
    • (2010) Mol Genet Metab , vol.99 , pp. 351-357
    • Wraith, J.E.1    Vecchio, D.2    Jacklin, E.3    Abel, L.4    Chadha-Boreham, H.5    Luzy, C.6
  • 7
    • 84890144959 scopus 로고    scopus 로고
    • Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease
    • Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP et al. Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease. Cell Rep 2013; 5: 1302–1315.
    • (2013) Cell Rep , vol.5 , pp. 1302-1315
    • Sarkar, S.1    Carroll, B.2    Buganim, Y.3    Maetzel, D.4    Ng, A.H.5    Cassady, J.P.6
  • 8
    • 84902161379 scopus 로고    scopus 로고
    • Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells
    • Maetzel D, Sarkar S, Wang H, Abi-Mosleh L, Xu P, Cheng AW et al. Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells. Stem Cell Rep 2014; 2: 866–880.
    • (2014) Stem Cell Rep , vol.2 , pp. 866-880
    • Maetzel, D.1    Sarkar, S.2    Wang, H.3    Abi-Mosleh, L.4    Xu, P.5    Cheng, A.W.6
  • 9
    • 84868102987 scopus 로고    scopus 로고
    • Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease
    • Elrick MJ, Yu T, Chung C, Lieberman AP. Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease. Hum Mol Genet 2012; 21: 4876–4887.
    • (2012) Hum Mol Genet , vol.21 , pp. 4876-4887
    • Elrick, M.J.1    Yu, T.2    Chung, C.3    Lieberman, A.P.4
  • 10
    • 11444254013 scopus 로고    scopus 로고
    • Apoptosis accompanied by upregulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease
    • Wu YP, Mizukami H, Matsuda J, Saito Y, Proia RL, Suzuki K. Apoptosis accompanied by upregulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease. Mol Genet Metab 2005; 84: 9–17.
    • (2005) Mol Genet Metab , vol.84 , pp. 9-17
    • Wu, Y.P.1    Mizukami, H.2    Matsuda, J.3    Saito, Y.4    Proia, R.L.5    Suzuki, K.6
  • 11
    • 0037097247 scopus 로고    scopus 로고
    • Studies on neuronal death in the mouse model of Niemann-Pick C disease
    • Erickson RP, Bernard O. Studies on neuronal death in the mouse model of Niemann-Pick C disease. J Neurosci Res 2002; 68: 738–744.
    • (2002) J Neurosci Res , vol.68 , pp. 738-744
    • Erickson, R.P.1    Bernard, O.2
  • 12
    • 3042791295 scopus 로고    scopus 로고
    • Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning
    • Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm AC. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. Eur J Neurosci 2004; 19: 3305–3316.
    • (2004) Eur J Neurosci , vol.19 , pp. 3305-3316
    • Hunter, C.L.1    Quintero, E.M.2    Gilstrap, L.3    Bhat, N.R.4    Granholm, A.C.5
  • 13
    • 84255210700 scopus 로고    scopus 로고
    • Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
    • Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012; 19: 107–120.
    • (2012) Cell Death Differ , vol.19 , pp. 107-120
    • Galluzzi, L.1    Vitale, I.2    Abrams, J.M.3    Alnemri, E.S.4    Baehrecke, E.H.5    Blagosklonny, M.V.6
  • 15
    • 41149097657 scopus 로고    scopus 로고
    • Madin-Darby canine kidney II cells: A pharmacologically validated system for NPC1L1-mediated cholesterol uptake
    • Weinglass AB, Kohler MG, Nketiah EO, Liu J, Schmalhofer W, Thomas A et al. Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake. Mol Pharmacol 2008; 73: 1072–1084.
    • (2008) Mol Pharmacol , vol.73 , pp. 1072-1084
    • Weinglass, A.B.1    Kohler, M.G.2    Nketiah, E.O.3    Liu, J.4    Schmalhofer, W.5    Thomas, A.6
  • 16
    • 0442323579 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway
    • Quintero EM, Willis LM, Zaman V, Lee J, Boger HA, Tomac A et al. Glial cell line-derived neurotrophic factor is essential for neuronal survival in the locus coeruleus-hippocampal noradrenergic pathway. Neuroscience 2004; 124: 137–146.
    • (2004) Neuroscience , vol.124 , pp. 137-146
    • Quintero, E.M.1    Willis, L.M.2    Zaman, V.3    Lee, J.4    Boger, H.A.5    Tomac, A.6
  • 17
    • 1642454485 scopus 로고    scopus 로고
    • Localization of Niemann-Pick C1 protein in astrocytes: Implications for neuronal degeneration in Niemann-Pick type C disease
    • Patel SC, Suresh S, Kumar U, Hu CY, Cooney A, Blanchette-Mackie EJ et al. Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann-Pick type C disease. Proc Natl Acad Sci USA 1999; 96: 1657–1662.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1657-1662
    • Patel, S.C.1    Suresh, S.2    Kumar, U.3    Hu, C.Y.4    Cooney, A.5    Blanchette-Mackie, E.J.6
  • 18
    • 0035821438 scopus 로고    scopus 로고
    • Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease
    • German DC, Quintero EM, Liang CL, Ng B, Punia S, Xie C et al. Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease. J Comp Neurol 2001; 433: 415–425.
    • (2001) J Comp Neurol , vol.433 , pp. 415-425
    • German, D.C.1    Quintero, E.M.2    Liang, C.L.3    Ng, B.4    Punia, S.5    Xie, C.6
  • 21
    • 77951251430 scopus 로고    scopus 로고
    • Necroptosis as an alternative form of programmed cell death
    • Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 2010; 22: 263–268.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 263-268
    • Christofferson, D.E.1    Yuan, J.2
  • 23
    • 79954525274 scopus 로고    scopus 로고
    • Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease
    • Zhu S, Zhang Y, Bai G, Li H. Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease. Cell Death Dis 2011; 2: e115.
    • (2011) Cell Death Dis , vol.2 , pp. e115
    • Zhu, S.1    Zhang, Y.2    Bai, G.3    Li, H.4
  • 24
    • 84895508213 scopus 로고    scopus 로고
    • Necroptosis drives motor neuron death in models of both sporadic and familial ALS
    • Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S et al. Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron 2014; 81: 1001–1008.
    • (2014) Neuron , vol.81 , pp. 1001-1008
    • Re, D.B.1    Le Verche, V.2    Yu, C.3    Amoroso, M.W.4    Politi, K.A.5    Phani, S.6
  • 25
    • 84868118468 scopus 로고    scopus 로고
    • Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts
    • Wehrmann ZT, Hulett TW, Huegel KL, Vaughan KT, Wiest O, Helquist P et al. Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts. PLoS One 2012; 7: e48561.
    • (2012) Plos One , vol.7
    • Wehrmann, Z.T.1    Hulett, T.W.2    Huegel, K.L.3    Vaughan, K.T.4    Wiest, O.5    Helquist, P.6
  • 26
    • 33644840693 scopus 로고    scopus 로고
    • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    • Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1: 112–119.
    • (2005) Nat Chem Biol , vol.1 , pp. 112-119
    • Degterev, A.1    Huang, Z.2    Boyce, M.3    Li, Y.4    Jagtap, P.5    Mizushima, N.6
  • 29
    • 2942644795 scopus 로고    scopus 로고
    • Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport
    • te Vruchte D, Lloyd-Evans E, Veldman RJ, Neville DC, Dwek RA, Platt FM et al. Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. J Biol Chem 2004; 279: 26167–26175.
    • (2004) J Biol Chem , vol.279 , pp. 26167-26175
    • Te Vruchte, D.1    Lloyd-Evans, E.2    Veldman, R.J.3    Neville, D.C.4    Dwek, R.A.5    Platt, F.M.6
  • 31
    • 84902186984 scopus 로고    scopus 로고
    • Adaptations of energy metabolism associated with increased levels of mitochondrial cholesterol in Niemann-Pick type C1-deficient cells
    • Kennedy BE, Madreiter CT, Vishnu N, Malli R, Graier WF, Karten B. Adaptations of energy metabolism associated with increased levels of mitochondrial cholesterol in Niemann-Pick type C1-deficient cells. J Biol Chem 2014; 289: 16278–16289.
    • (2014) J Biol Chem , vol.289 , pp. 16278-16289
    • Kennedy, B.E.1    Madreiter, C.T.2    Vishnu, N.3    Malli, R.4    Graier, W.F.5    Karten, B.6
  • 32
    • 2342493785 scopus 로고    scopus 로고
    • Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C
    • Ohara S, Ukita Y, Ninomiya H, Ohno K. Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C. Exp Neurol 2004; 187: 289–298.
    • (2004) Exp Neurol , vol.187 , pp. 289-298
    • Ohara, S.1    Ukita, Y.2    Ninomiya, H.3    Ohno, K.4
  • 33
    • 84881600379 scopus 로고    scopus 로고
    • Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann-Pick disease, type C1
    • Fu R, Wassif CA, Yanjanin NM, Watkins-Chow DE, Baxter LL, Incao A et al. Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann-Pick disease, type C1. Hum Mol Genet 2013; 22: 3508–3523.
    • (2013) Hum Mol Genet , vol.22 , pp. 3508-3523
    • Fu, R.1    Wassif, C.A.2    Yanjanin, N.M.3    Watkins-Chow, D.E.4    Baxter, L.L.5    Incao, A.6
  • 34
    • 84897032167 scopus 로고    scopus 로고
    • Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann-Pick disease type C1 mice
    • Williams IM, Wallom KL, Smith DA, Al Eisa N, Smith C, Platt FM. Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann-Pick disease type C1 mice. Neurobiol Dis 2014; 67: 9–17.
    • (2014) Neurobiol Dis , vol.67 , pp. 9-17
    • Williams, I.M.1    Wallom, K.L.2    Smith, D.A.3    Al Eisa, N.4    Smith, C.5    Platt, F.M.6
  • 36
    • 60549084168 scopus 로고    scopus 로고
    • Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1 − / − mouse
    • Liu B, Turley SD, Burns DK, Miller AM, Repa JJ, Dietschy JM. Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1 − / − mouse. Proc Natl Acad Sci 2009; 106: 2377–2382.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 2377-2382
    • Liu, B.1    Turley, S.D.2    Burns, D.K.3    Miller, A.M.4    Repa, J.J.5    Dietschy, J.M.6
  • 37
    • 0035928841 scopus 로고    scopus 로고
    • Critical role for glycosphingolipids in Niemann-Pick disease type C
    • Zervas M, Somers KL, Thrall MA, Walkley SU. Critical role for glycosphingolipids in Niemann-Pick disease type C. Curr Biol 2001; 11: 1283–1287.
    • (2001) Curr Biol , vol.11 , pp. 1283-1287
    • Zervas, M.1    Somers, K.L.2    Thrall, M.A.3    Walkley, S.U.4
  • 38
    • 60549084168 scopus 로고    scopus 로고
    • Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/-mouse
    • Liu B, Turley SD, Burns DK, Miller AM, Repa JJ, Dietschy JM. Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/-mouse. Proc Natl Acad Sci USA 2009; 106: 2377–2382.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2377-2382
    • Liu, B.1    Turley, S.D.2    Burns, D.K.3    Miller, A.M.4    Repa, J.J.5    Dietschy, J.M.6
  • 39
    • 70349190528 scopus 로고    scopus 로고
    • Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression
    • Davidson CD, Ali NF, Micsenyi MC, Stephney G, Renault S, Dobrenis K et al. Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression. PLoS One 2009; 4: e6951.
    • (2009) Plos One , vol.4
    • Davidson, C.D.1    Ali, N.F.2    Micsenyi, M.C.3    Stephney, G.4    Renault, S.5    Dobrenis, K.6
  • 40
    • 84872310440 scopus 로고    scopus 로고
    • Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase
    • Degterev A, Maki JL, Yuan J. Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death Differ 2013; 20: 366.
    • (2013) Cell Death Differ , vol.20 , pp. 366
    • Degterev, A.1    Maki, J.L.2    Yuan, J.3
  • 41
    • 51349107262 scopus 로고    scopus 로고
    • Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7
    • Zheng W, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett 2008; 18: 4932–4935.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 4932-4935
    • Zheng, W.1    Degterev, A.2    Hsu, E.3    Yuan, J.4    Yuan, C.5
  • 42
    • 84881373004 scopus 로고    scopus 로고
    • A novel necroptosis inhibitor-necrostatin-21 and its SAR study
    • Wu Z, Li Y, Cai Y, Yuan J, Yuan C. A novel necroptosis inhibitor-necrostatin-21 and its SAR study. Bioorg Med Chem Lett 2013; 23: 4903–4906.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 4903-4906
    • Wu, Z.1    Li, Y.2    Cai, Y.3    Yuan, J.4    Yuan, C.5
  • 43
    • 33846913723 scopus 로고    scopus 로고
    • Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5
    • Wang K, Li J, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett 2007; 17: 1455–1465.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 1455-1465
    • Wang, K.1    Li, J.2    Degterev, A.3    Hsu, E.4    Yuan, J.5    Yuan, C.6
  • 44
    • 84870570760 scopus 로고    scopus 로고
    • Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models
    • Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis 2012; 3: e437.
    • (2012) Cell Death Dis , vol.3 , pp. e437
    • Takahashi, N.1    Duprez, L.2    Grootjans, S.3    Cauwels, A.4    Nerinckx, W.5    Duhadaway, J.B.6
  • 46
    • 33847193829 scopus 로고    scopus 로고
    • Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann–Pick disease type C (NPC) fibroblasts: A potential basis for glial cell activation in the NPC brain
    • Suzuki M, Sugimoto Y, Ohsaki Y, Ueno M, Kato S, Kitamura Y et al. Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann–Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain. J Neurosci 2007; 27: 1879–1891.
    • (2007) J Neurosci , vol.27 , pp. 1879-1891
    • Suzuki, M.1    Sugimoto, Y.2    Ohsaki, Y.3    Ueno, M.4    Kato, S.5    Kitamura, Y.6
  • 47
    • 50249132439 scopus 로고    scopus 로고
    • Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice
    • You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD et al. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab 2008; 28: 1564–1573.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1564-1573
    • You, Z.1    Savitz, S.I.2    Yang, J.3    Degterev, A.4    Yuan, J.5    Cuny, G.D.6
  • 48
    • 77956619262 scopus 로고    scopus 로고
    • Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury
    • Xu X, Chua KW, Chua CC, Liu CF, Hamdy RC, Chua BH. Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. Brain Res 2010; 1355: 189–194.
    • (2010) Brain Res , vol.1355 , pp. 189-194
    • Xu, X.1    Chua, K.W.2    Chua, C.C.3    Liu, C.F.4    Hamdy, R.C.5    Chua, B.H.6
  • 49
    • 84905586567 scopus 로고    scopus 로고
    • Niemann-Pick disease type C: Induced pluripotent stem cell-derived neuronal cells for modeling neural disease and evaluating drug efficacy
    • Yu D, Swaroop M, Wang M, Baxa U, Yang R, Yan Y et al. Niemann-Pick disease type C: induced pluripotent stem cell-derived neuronal cells for modeling neural disease and evaluating drug efficacy. J Biomol Screen 2014; 19: 1164–1173.
    • (2014) J Biomol Screen , vol.19 , pp. 1164-1173
    • Yu, D.1    Swaroop, M.2    Wang, M.3    Baxa, U.4    Yang, R.5    Yan, Y.6
  • 50
    • 0030768084 scopus 로고    scopus 로고
    • Murine model of Niemann-Pick C disease: Mutation in a cholesterol homeostasis gene
    • Loftus SK, Morris JA, Carstea ED, Gu JZ, Cummings C, Brown A et al. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science 1997; 277: 232–235.
    • (1997) Science , vol.277 , pp. 232-235
    • Loftus, S.K.1    Morris, J.A.2    Carstea, E.D.3    Gu, J.Z.4    Cummings, C.5    Brown, A.6
  • 51
    • 84865066581 scopus 로고    scopus 로고
    • Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1
    • Cluzeau CV, Watkins-Chow DE, Fu R, Borate B, Yanjanin N, Dail MK et al. Microarray expression analysis and identification of serum biomarkers for Niemann-Pick disease, type C1. Hum Mol Genet 2012; 21: 3632–3646.
    • (2012) Hum Mol Genet , vol.21 , pp. 3632-3646
    • Cluzeau, C.V.1    Watkins-Chow, D.E.2    Fu, R.3    Borate, B.4    Yanjanin, N.5    Dail, M.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.