Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 4932-4935

  Zheng, Weihong ^a   Degterev, Alexei ^b,c   Hsu, Emily ^b   Yuan, Junying ^b   Yuan, Chengye ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c TUFTS UNIVERSITY   (United States)

Author keywords

3 Aryl pyrazole; Caspase independent cell death; Inhibitors; Nec 7; Necroptosis; Necrostatin; SAR; Thiazolidin 4 one derivatives

Indexed keywords

NECROSTATIN 7; PYRAZOLE; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; AUTORADIOGRAPHY; DRUG SYNTHESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; JURKAT CELLS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 51349107262     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.058     Document Type: Article

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