A novel necroptosis inhibitor - Necrostatin-21 and its SAR study

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 17, 2013, Pages 4903-4906

  Wu, Zhijie ^a   Li, Ying ^b   Cai, Yu ^a   Yuan, Junying ^a,b   Yuan, Chengye ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Inhibitor; JNK3; Nec 21; Necroptosis; RIP1; SAR study

Indexed keywords

MOLECULAR SCAFFOLD; NECROSTATIN 21; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; CELL DEATH; CYCLIZATION; CYTOTOXICITY; HYDROGEN BOND; METHYLATION; NECROPTOSIS; STRUCTURE ACTIVITY RELATION;

INHIBITOR; JNK3; NEC-21; NECROPTOSIS; RIP1; SAR STUDY;

APOPTOSIS; CARBAZOLES; CELL SURVIVAL; HUMANS; NECROSIS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881373004     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.073     Document Type: Article

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