Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: A potential basis for glial cell activation in the NPC brain

Journal of Neuroscience

Volumn 27, Issue 8, 2007, Pages 1879-1891

  Suzuki, Michitaka ^a   Sugimoto, Yuko ^a   Ohsaki, Yuki ^a   Ueno, Makoto ^a   Kato, Shinsuke ^a   Kitamura, Yukisato ^a   Hosokawa, Hiroshi ^b   Davies, Joanna P ^c   Ioannou, Yiannis A ^c   Vanier, Marie T ^d   Ohno, Kousaku ^a   Ninomiya, Haruaki ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

Cholesterol; Glia; IL 6; Niemann Pick; STAT; Toll like receptor

Indexed keywords

BETA INTERFERON; CHOLESTEROL; INTERLEUKIN 6; INTERLEUKIN 8; SMALL INTERFERING RNA; STAT PROTEIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL CULTURE; ARTICLE; BRAIN LEVEL; BRAIN NERVE CELL; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; ENDOSOME; FIBROBLAST; GENE DELETION; GLIA CELL; HUMAN; HUMAN CELL; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CELLS, CULTURED; CULTURE MEDIA; CYTOKINES; ENDOSOMES; FIBROBLASTS; HUMANS; INTERFERON-BETA; INTERLEUKIN-6; INTERLEUKIN-8; LONGEVITY; MICE; MICE, KNOCKOUT; NEUROGLIA; NIEMANN-PICK DISEASE, TYPE C; STAT TRANSCRIPTION FACTORS; TOLL-LIKE RECEPTOR 4;

EID: 33847193829     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5282-06.2007     Document Type: Article

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