Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia

Cell Death and Differentiation

Volumn 24, Issue 5, 2017, Pages 917-928

  González Juarbe, Norberto ^a   Bradley, Kelley Margaret ^a   Shenoy, Anukul Taranath ^a   Gilley, Ryan Paul ^b   Reyes, Luis Felipe ^c   Hinojosa, Cecilia Anahí ^c   Restrepo, Marcos Ignacio ^c,d   Dube, Peter Herman ^b   Bergman, Molly Ann ^b,e   Orihuela, Carlos Javier ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c University of Texas Health Science Center   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; DEATH RECEPTOR; PORE FORMING TOXIN; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TOXIN; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG; BACTERIAL TOXIN; CALCIUM; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MLKL PROTEIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN; POTASSIUM; PROTEIN KINASE; RALBP1 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE;

AIRWAY EPITHELIUM CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL PNEUMONIA; CALCIUM TRANSPORT; CELL DAMAGE; CHANNEL GATING; CONTROLLED STUDY; DISEASE EXACERBATION; EPITHELIUM CELL; LUNG EPITHELIUM; MITOCHONDRION; MOUSE; NECROPTOSIS; NONHUMAN; POTASSIUM TRANSPORT; PRIMATE; PRIORITY JOURNAL; SERRATIA MARCESCENS; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIA; A-549 CELL LINE; ANIMAL; APOPTOSIS; BABOON; C57BL MOUSE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ION TRANSPORT; LUNG; METABOLISM; MICROBIOLOGY; MORTALITY; NECROSIS; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; STREPTOCOCCUS PNEUMONIAE; SURVIVAL ANALYSIS;

A549 CELLS; ANIMALS; APOPTOSIS; BACTERIAL TOXINS; CALCIUM; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GTPASE-ACTIVATING PROTEINS; HUMANS; ION TRANSPORT; LUNG; MICE; MICE, INBRED C57BL; NECROSIS; PAPIO; PNEUMONIA, BACTERIAL; PORE FORMING CYTOTOXIC PROTEINS; POTASSIUM; PROTEIN KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECEPTORS, DEATH DOMAIN; SERRATIA MARCESCENS; STREPTOCOCCUS PNEUMONIAE; SURVIVAL ANALYSIS;

EID: 85017131872     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2017.49     Document Type: Article

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