β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance

Cell Metabolism

Volumn 25, Issue 4, 2017, Pages 898-910.e5

  Aguayo Mazzucato, Cristina ^a   van Haaren, Mark ^a   Mruk, Magdalena ^a   Lee, Terence B ^a   Crawford, Caitlin ^a   Hollister Lock, Jennifer ^a   Sullivan, Brooke A ^a   Johnson, James W ^a   Ebrahimi, Aref ^a   Dreyfuss, Jonathan M ^a,b   Van Deursen, Jan ^c   Weir, Gordon C ^a   Bonner Weir, Susan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Boston University   (United States)

^c MAYO CLINIC   (United States)

Author keywords

aging markers; beta cell heterogeneity; islets

Indexed keywords

BETA GALACTOSIDASE; CD99 ANTIGEN; CELL SURFACE MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GLUCOSE; INSULIN; MESSENGER RNA; SOMATOMEDIN C RECEPTOR; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1; UVOMORULIN; BIOLOGICAL MARKER; GREEN FLUORESCENT PROTEIN; TP53BP1 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL HETEROGENEITY; CELL STRESS; CELL SUBPOPULATION; CHRONIC STRESS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GROUPS BY AGE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INSULIN RELEASE; INSULIN RESISTANCE; MALE; METABOLIC STRESS; MIDDLE AGED; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; YOUNG ADULT; AGED; AGING; ANIMAL; C57BL MOUSE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; HEMOLYTIC PLAQUE ASSAY; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS;

ADOLESCENT; ADULT; AGED; AGING; ANIMALS; BIOMARKERS; CELL AGING; DIABETES MELLITUS, TYPE 2; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE; GREEN FLUORESCENT PROTEINS; HEMOLYTIC PLAQUE TECHNIQUE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MICE, INBRED C57BL; MIDDLE AGED; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; YOUNG ADULT;

EID: 85017021803     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.03.015     Document Type: Article

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