메뉴 건너뛰기




Volumn 535, Issue 7612, 2016, Pages 430-434

Identification of proliferative and mature β-cells in the islets of langerhans

(26)  Bader, Erik a   Migliorini, Adriana a   Gegg, Moritz a   Moruzzi, Noah a,b   Gerdes, Jantje a   Roscioni, Sara S a   Bakhti, Mostafa a   Brandl, Elisabeth a   Irmler, Martin a,c   Beckers, Johannes a,c,d   Aichler, Michaela a   Feuchtinger, Annette a   Leitzinger, Christin a   Zischka, Hans a   Sattler, Rui Wang a   Jastroch, Martin a,c   Tschöp, Matthias a,c   Machicao, Fausto c,e   Staiger, Harald c,e   Häring, Hans Ulrich c,e   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANATOMY; CELLS AND CELL COMPONENTS; DIABETES; GENE; GENE EXPRESSION; GENETIC MARKER; GLUCOSE; HORMONE; IDENTIFICATION METHOD; LIGAND; MATURATION;

EID: 84978114110     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18624     Document Type: Article
Times cited : (266)

References (45)
  • 1
    • 0022572975 scopus 로고
    • Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells
    • Salomon, D. & Meda, P. Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells. Exp. Cell Res. 162, 507-520 (1986).
    • (1986) Exp. Cell Res , vol.162 , pp. 507-520
    • Salomon, D.1    Meda, P.2
  • 2
    • 0027203345 scopus 로고
    • Heterogeneity in glucose sensitivity among pancreatic β-cells is correlated to differences in glucose phosphorylation rather than glucose transport
    • Heimberg, H. et al. Heterogeneity in glucose sensitivity among pancreatic β-cells is correlated to differences in glucose phosphorylation rather than glucose transport. EMBO J. 12, 2873-2879 (1993).
    • (1993) EMBO J , vol.12 , pp. 2873-2879
    • Heimberg, H.1
  • 3
    • 79952119288 scopus 로고    scopus 로고
    • The adult mouse and human pancreas contain rare multipotent stem cells that express insulin
    • Smukler, S. R. et al. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell 8, 281-293 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 281-293
    • Smukler, S.R.1
  • 4
    • 84929515010 scopus 로고    scopus 로고
    • Diabetes enhances the proliferation of adult pancreatic multipotent progenitor cells and biases their differentiation to more β-cell production
    • Razavi, R. et al. Diabetes enhances the proliferation of adult pancreatic multipotent progenitor cells and biases their differentiation to more β-cell production. Diabetes 64, 1311-1323 (2015).
    • (2015) Diabetes , vol.64 , pp. 1311-1323
    • Razavi, R.1
  • 5
    • 72449156523 scopus 로고    scopus 로고
    • Single pancreatic βcells co-express multiple islet hormone genes in mice
    • Katsuta, H. et al. Single pancreatic β cells co-express multiple islet hormone genes in mice. Diabetologia 53, 128-138 (2010).
    • (2010) Diabetologia , vol.53 , pp. 128-138
    • Katsuta, H.1
  • 6
    • 84980406151 scopus 로고    scopus 로고
    • Flattop regulates basal body docking and positioning in mono-and multiciliated cells
    • Gegg, M. et al. Flattop regulates basal body docking and positioning in mono-and multiciliated cells. eLife 3, e03842 (2014).
    • (2014) Elife , pp. 3
    • Gegg, M.1
  • 7
    • 0023936007 scopus 로고
    • Morphological evidence for pancreatic polarity of β-cells within islets of Langerhans
    • Bonner-Weir, S. Morphological evidence for pancreatic polarity of β-cells within islets of Langerhans. Diabetes 37, 616-621 (1988).
    • (1988) Diabetes , vol.37 , pp. 616-621
    • Bonner-Weir, S.1
  • 8
    • 77950225021 scopus 로고    scopus 로고
    • Pancreatic beta cells require NeuroD to achieve and maintain functional maturity
    • Gu, C. et al. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab. 11, 298-310 (2010).
    • (2010) Cell Metab , vol.11 , pp. 298-310
    • Gu, C.1
  • 9
    • 84857975722 scopus 로고    scopus 로고
    • Functional β-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
    • Blum, B. et al. Functional β-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat. Biotechnol. 30, 261-264 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 261-264
    • Blum, B.1
  • 10
    • 77953920802 scopus 로고    scopus 로고
    • Microscopic anatomy of the human islet of Langerhans
    • In’t Veld, P. & Marichal, M. Microscopic anatomy of the human islet of Langerhans. Adv. Exp. Med. Biol. 654, 1-19 (2010).
    • (2010) Adv. Exp. Med. Biol , vol.654 , pp. 1-19
    • In’t Veld, P.1    Marichal, M.2
  • 11
    • 0018643341 scopus 로고
    • Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion
    • Meda, P., Perrelet, A. & Orci, L. Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion. J. Cell Biol. 82, 441-448 (1979).
    • (1979) J. Cell Biol , vol.82 , pp. 441-448
    • Meda, P.1    Perrelet, A.2    Orci, L.3
  • 12
    • 33947327064 scopus 로고    scopus 로고
    • Tissue/planar cell polarity in vertebrates: New insights and new questions
    • Wang, Y. & Nathans, J. Tissue/planar cell polarity in vertebrates: new insights and new questions. Development 134, 647-658 (2007).
    • (2007) Development , vol.134 , pp. 647-658
    • Wang, Y.1    Nathans, J.2
  • 13
    • 84870182902 scopus 로고    scopus 로고
    • Planar cell polarity and the developmental control of cell behavior in vertebrate embryos
    • Wallingford, J. B. Planar cell polarity and the developmental control of cell behavior in vertebrate embryos. Annu. Rev. Cell Dev. Biol. 28, 627-653 (2012).
    • (2012) Annu. Rev. Cell Dev. Biol , vol.28 , pp. 627-653
    • Wallingford, J.B.1
  • 14
    • 79953749322 scopus 로고    scopus 로고
    • Self-organizing optic-cup morphogenesis in three-dimensional culture
    • Eiraku, M. et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472, 51-56 (2011).
    • (2011) Nature , vol.472 , pp. 51-56
    • Eiraku, M.1
  • 15
    • 84918561297 scopus 로고    scopus 로고
    • Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
    • McCracken, K. W. et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516, 400-404 (2014).
    • (2014) Nature , vol.516 , pp. 400-404
    • McCracken, K.W.1
  • 16
    • 0016746044 scopus 로고
    • A morphological basis for intercellular communication between α-and β-cells in the endocrine pancreas
    • Orci, L. et al. A morphological basis for intercellular communication between α-and β-cells in the endocrine pancreas. J. Clin. Invest. 56, 1066-1070 (1975).
    • (1975) J. Clin. Invest , vol.56 , pp. 1066-1070
    • Orci, L.1
  • 17
    • 84856329578 scopus 로고    scopus 로고
    • Fltp(T2AiCre): A new knock-in mouse line for conditional gene targeting in distinct mono-and multiciliated tissues
    • Lange, A. et al. Fltp(T2AiCre): a new knock-in mouse line for conditional gene targeting in distinct mono-and multiciliated tissues. Differentiation 83, S105-S113 (2012).
    • (2012) Differentiation , vol.83 , pp. S105-S113
    • Lange, A.1
  • 18
    • 35548932872 scopus 로고    scopus 로고
    • A global doublefluorescent Cre reporter mouse
    • Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global doublefluorescent Cre reporter mouse. Genesis 45, 593-605 (2007).
    • (2007) Genesis , vol.45 , pp. 593-605
    • Muzumdar, M.D.1    Tasic, B.2    Miyamichi, K.3    Li, L.4    Luo, L.5
  • 19
    • 77949324263 scopus 로고    scopus 로고
    • Expansion of β-cell mass in response to pregnancy. Trends Endocrinol
    • Rieck, S. & Kaestner, K. H. Expansion of β-cell mass in response to pregnancy. Trends Endocrinol. Metab. 21, 151-158 (2010).
    • (2010) Metab , vol.21 , pp. 151-158
    • Rieck, S.1    Kaestner, K.H.2
  • 20
    • 43249084544 scopus 로고    scopus 로고
    • Noninvasive in vivo imaging of pancreatic islet cell biology. Nat
    • Speier, S. et al. Noninvasive in vivo imaging of pancreatic islet cell biology. Nat. Med. 14, 574-578 (2008).
    • (2008) Med , vol.14 , pp. 574-578
    • Speier, S.1
  • 22
    • 57649200109 scopus 로고    scopus 로고
    • Role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans.
    • Kitsou-Mylona, I., Burns, C. J., Squires, P. E., Persaud, S. J. & Jones, P. M. A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans. Cell. Physiol. Biochem. 22, 557-566 (2008)
    • (2008) Cell. Physiol. Biochem , vol.22 , pp. 557-566
    • Kitsou-Mylona, I.1    Burns, C.J.2    Squires, P.E.3    Persaud, S.J.4    Jones, P.5
  • 23
    • 84959479728 scopus 로고    scopus 로고
    • Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: A note of caution
    • Schulze, T., Morsi, M., Bruning, D., Schumacher, K. & Rustenbeck, I. Different responses of mouse islets and MIN6 pseudo-islets to metabolic stimulation: a note of caution. Endocrine 51, 440-447 (2016).
    • (2016) Endocrine , vol.51 , pp. 440-447
    • Schulze, T.1    Morsi, M.2    Bruning, D.3    Schumacher, K.4    Rustenbeck, I.5
  • 24
    • 70349503932 scopus 로고    scopus 로고
    • LKB1 regulates pancreatic βcell size, polarity, and function
    • Granot, Z. et al. LKB1 regulates pancreatic β cell size, polarity, and function. Cell Metab. 10, 296-308 (2009).
    • (2009) Cell Metab , vol.10 , pp. 296-308
    • Granot, Z.1
  • 25
    • 84882958111 scopus 로고    scopus 로고
    • Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet βcells.
    • Kalwat, M. A. & Thurmond, D. C. Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells. Exp. Mol. Med. 45, e37 (2013).
    • (2013) Exp. Mol. Med , pp. 45
    • Kalwat, M.A.1    Thurmond, D.C.2
  • 26
    • 84876744461 scopus 로고    scopus 로고
    • Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived ‘browning’ factor irisin, determines insulin sensitivity
    • Staiger, H. et al. Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived ‘browning’ factor irisin, determines insulin sensitivity. PLoS One 8, e61903 (2013).
    • (2013) Plos One , pp. 8
    • Staiger, H.1
  • 27
    • 84893510559 scopus 로고    scopus 로고
    • Pdx1 maintains βcell identity and function by repressing an αcell program
    • Gao, T. et al. Pdx1 maintains β cell identity and function by repressing an α cell program. Cell Metab. 19, 259-271 (2014).
    • (2014) Cell Metab , vol.19 , pp. 259-271
    • Gao, T.1
  • 28
    • 84900330718 scopus 로고    scopus 로고
    • Pancreatic βcell dedifferentiation in diabetes and redifferentiation following insulin therapy
    • Wang, Z., York, N. W., Nichols, C. G. & Remedi, M. S. Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metab. 19, 872-882 (2014).
    • (2014) Cell Metab , vol.19 , pp. 872-882
    • Wang, Z.1    York, N.W.2    Nichols, C.G.3    Remedi, M.S.4
  • 29
    • 84866389264 scopus 로고    scopus 로고
    • Pancreatic βcell dedifferentiation as a mechanism of diabetic βcell failure
    • Talchai, C., Xuan, S., Lin, H. V., Sussel, L. & Accili, D. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell 150, 1223-1234 (2012).
    • (2012) Cell , vol.150 , pp. 1223-1234
    • Talchai, C.1    Xuan, S.2    Lin, H.V.3    Sussel, L.4    Accili, D.5
  • 30
    • 0033553462 scopus 로고    scopus 로고
    • Chronic hyperglycemia triggers loss of pancreatic βcell differentiation in an animal model of diabetes
    • Jonas, J. C. et al. Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes. J. Biol. Chem. 274, 14112-14121 (1999)
    • (1999) J. Biol. Chem , vol.274 , pp. 14112-14121
    • Jonas, J.C.1
  • 32
    • 80052343967 scopus 로고    scopus 로고
    • A genetically engineered human pancreatic βcell line exhibiting glucose-inducible insulin secretion
    • Ravassard, P. et al. A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion. J. Clin. Invest. 121, 3589-3597 (2011).
    • (2011) J. Clin. Invest , vol.121 , pp. 3589-3597
    • Ravassard, P.1
  • 33
    • 0025281303 scopus 로고
    • Establishment of a pancreatic βcell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
    • Miyazaki, J. et al. Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127, 126-132 (1990).
    • (1990) Endocrinology , vol.127 , pp. 126-132
    • Miyazaki, J.1
  • 34
    • 84940105815 scopus 로고    scopus 로고
    • Distinct roles of β-cell mass and function during type 1 diabetes onset and remission
    • Chmelova, H. et al. Distinct roles of β-cell mass and function during type 1 diabetes onset and remission. Diabetes 64, 2148-2160 (2015).
    • (2015) Diabetes , vol.64 , pp. 2148-2160
    • Chmelova, H.1
  • 35
    • 84862520770 scopus 로고    scopus 로고
    • Fiji: An open-source platform for biological-image analysis. Nat
    • Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676-682 (2012).
    • (2012) Methods , vol.9 , pp. 676-682
    • Schindelin, J.1
  • 36
    • 0001066006 scopus 로고
    • A chrome-osmium fixative for electron microscopy.
    • Dalton, A. J. A chrome-osmium fixative for electron microscopy. Anat. Rec. 121, 281 (1955).
    • (1955) Anat. Rec , vol.121 , pp. 281
    • Dalton, A.J.1
  • 37
    • 84920551161 scopus 로고    scopus 로고
    • Image analysis of immunohistochemistry is superior to visual scoring as shown for patient outcome of esophageal adenocarcinoma. Histochem
    • Feuchtinger, A. et al. Image analysis of immunohistochemistry is superior to visual scoring as shown for patient outcome of esophageal adenocarcinoma. Histochem. Cell Biol. 143, 1-9 (2015).
    • (2015) Cell Biol , vol.143 , pp. 1-9
    • Feuchtinger, A.1
  • 38
    • 84980406151 scopus 로고    scopus 로고
    • Flattop regulates basal body docking and positioning in mono-and multiciliated cells
    • Gegg, M. et al. Flattop regulates basal body docking and positioning in mono-and multiciliated cells. Elife 3, e03842 (2014).
    • (2014) Elife , pp. 3
    • Gegg, M.1
  • 39
    • 79957887666 scopus 로고    scopus 로고
    • Growth hormone receptor regulates βcell hyperplasia and glucose-stimulated insulin secretion in obese mice
    • Wu, Y. et al. Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. J. Clin. Invest. 121, 2422-2426 (2011).
    • (2011) J. Clin. Invest , vol.121 , pp. 2422-2426
    • Wu, Y.1
  • 40
    • 27744492082 scopus 로고    scopus 로고
    • Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
    • Stefan, N. et al. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia 48, 2282-2291 (2005).
    • (2005) Diabetologia , vol.48 , pp. 2282-2291
    • Stefan, N.1
  • 41
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • Matsuda, M. & DeFronzo, R. A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22, 1462-1470 (1999).
    • (1999) Diabetes Care , vol.22 , pp. 1462-1470
    • Matsuda, M.1    Defronzo, R.A.2
  • 42
    • 84907222786 scopus 로고    scopus 로고
    • Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
    • Fadista, J. et al. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc. Natl Acad. Sci. USA 111, 13924-13929 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 13924-13929
    • Fadista, J.1
  • 43
    • 77953176036 scopus 로고    scopus 로고
    • A scaling normalization method for differential expression analysis of RNA-seq data.
    • Robinson, M. D. & Oshlack, A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 11, R25 (2010).
    • (2010) Genome Biol , vol.11
    • Robinson, M.D.1    Oshlack, A.2
  • 45
    • 33747839466 scopus 로고    scopus 로고
    • CARMAweb: Comprehensive R-and bioconductor-based web service for microarray data analysis
    • Rainer, J., Sanchez-Cabo, F., Stocker, G., Sturn, A. & Trajanoski, Z. CARMAweb: comprehensive R-and bioconductor-based web service for microarray data analysis. Nucleic Acids Res. 34, W498-W503 (2006).
    • (2006) Nucleic Acids Res , vol.34 , pp. W498-W503
    • Rainer, J.1    Sanchez-Cabo, F.2    Stocker, G.3    Sturn, A.4    Trajanoski, Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.