Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

Cell Metabolism

Volumn 24, Issue 3, 2016, Pages 389-401

  Johnston, Natalie R ^a   Mitchell, Ryan K ^a   Haythorne, Elizabeth ^a   Pessoa, Maria Paiva ^a   Semplici, Francesca ^a   Ferrer, Jorge ^a   Piemonti, Lorenzo ^b   Marchetti, Piero ^c   Bugliani, Marco ^c   Bosco, Domenico ^d   Berishvili, Ekaterine ^d   Duncanson, Philip ^e   Watkinson, Michael ^e   Broichhagen, Johannes ^f   Trauner, Dirk ^f   Rutter, Guy A ^a   Hodson, David J ^a,g,h  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f UNIVERSITY OF MUNICH   (Germany)

^g UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^h Birmingham Women's Hospital NHS Foundation Trust   (United Kingdom)

Author keywords

diabetes; imaging; insulin; islets; optogenetics; cells

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CONNEXIN 36; DIAZOXIDE; GLUCAGON; GLUCAGON RECEPTOR ANTAGONIST; GLUCOKINASE; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NEUROGENIN 3; POTASSIUM CHLORIDE; SHORT HAIRPIN RNA; TETRAMETHYLRHODAMINE ETHYL ESTER; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; TUMOR NECROSIS FACTOR; LIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GAP JUNCTION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; ILLUMINATION; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN SYNTHESIS; IRRADIATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; ANIMAL; CALCIUM SIGNALING; CELL DIFFERENTIATION; COMPUTER SYSTEM; DIABETES MELLITUS; DRUG EFFECTS; HOMEOSTASIS; LIGHT; LIGHT RELATED PHENOMENA; METABOLISM; METABOLOME; METABOLOMICS; PATHOLOGY; PHENOTYPE; RADIATION RESPONSE; SECRETION (PROCESS); SPECIES DIFFERENCE;

ANIMALS; CALCIUM SIGNALING; CELL DIFFERENTIATION; COMPUTER SYSTEMS; DIABETES MELLITUS; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; LIGHT; LIPIDS; METABOLOME; METABOLOMICS; MICE; OPTICAL PHENOMENA; PHENOTYPE; SPECIES SPECIFICITY;

EID: 84990817439     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.06.020     Document Type: Article

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