A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 32494-32503

  Chang, Chuang Rung ^a   Manlandro, Cara Marie ^b   Arnoult, Damien ^c   Stadler, Julia ^d   Posey, Ammon E ^b   Hill, R Blake ^b   Blackstone, Craig ^d  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c INSERM   (France)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DEVELOPMENT; CELLULAR DISTRIBUTIONS; DYNAMIN; GTPASE ACTIVITY; HIGHER ORDER; IN-CELL; LETHAL MUTATIONS; MAMMALIAN CELLS; MITOCHONDRIAL FUNCTION; MOLECULAR MECHANISM; OVER-EXPRESSION; TETRAMERIZATION;

CELL CULTURE; MAMMALS;

MITOCHONDRIA;

DYNAMIN I; MUTANT PROTEIN;

ARTICLE; CELL CYCLE ARREST; CELL DIVISION; CELL ELONGATION; CELL FUSION; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC CONSERVATION; LETHAL MUTANT; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL VOLUME; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MULTIMERIZATION; PROTEIN POLYMERIZATION;

AMINO ACID SEQUENCE; ANIMALS; DYNAMINS; GTP PHOSPHOHYDROLASES; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 77957798188     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.142430     Document Type: Article

References (46)

1. Li, Z., Okamoto, K., Hayashi, Y., and Sheng, M. (2004) Cell 119, 873-887
2. Arnoult, D., Rismanchi, N., Grodet, A., Roberts, R. G., Seeburg, D. P., Estaquier, J., Sheng, M., and Blackstone, C. (2005) Curr. Biol. 15, 2112-2118
3. Campello, S., Lacalle, R. A., Bettella, M., Mañes, S., Scorrano, L., and Viola, A. (2006) J. Exp. Med. 203, 2879-2886
4. Chan, D. C. (2006) Cell 125, 1241-1252
5. McBride, H. M., Neuspiel, M., and Wasiak, S. (2006) Curr. Biol. 16, R551-R560
6. Yoon, Y. S., Yoon, D. S., Lim, I. K., Yoon, S. H., Chung, H. Y., Rojo, M., Malka, F., Jou, M. J., Martinou, J. C., and Yoon, G. (2006) J. Cell Physiol. 209, 468-480
7. Lee, S., Jeong, S. Y., Lim, W. C., Kim, S., Park, Y. Y., Sun, X., Youle, R. J., and Cho, H. (2007) J. Biol. Chem. 282, 22977-22983
8. Rismanchi, N., and Blackstone, C. (2007) in Molecular Neurology (Waxman, S. G., ed.) pp. 29-41, Elsevier Science Publishers, San Diego, CA
9. Suen, D. F., Norris, K. L., and Youle, R. J. (2008) Genes Dev. 22, 1577-1590
10. Lee, Y. J., Jeong, S. Y., Karbowski, M., Smith, C. L., and Youle, R. J. (2004) Mol. Biol. Cell 15, 5001-5011
11. Tan, F. J., Husain, M., Manlandro, C. M., Koppenol, M., Fire, A. Z., and Hill, R. B. (2008) J. Cell Sci. 121, 3373-3382
12. Rolland, S. G., Lu, Y., David, C. N., and Conradt, B. (2009) J. Cell Biol. 186, 525-540
13. Okamoto, K., and Shaw, J. M. (2005) Annu. Rev. Genet. 39, 503-536
14. Cerveny, K. L., Tamura, Y., Zhang, Z., Jensen, R. E., and Sesaki, H. (2007) Trends Cell Biol. 17, 563-569
15. Westermann, B. (2008) J. Biol. Chem. 283, 13501-13505
16. Ingerman, E., Perkins, E. M., Marino, M., Mears, J. A., McCaffery, J. M., Hinshaw, J. E., and Nunnari, J. (2005) J. Cell Biol. 170, 1021-1027
17. Hinshaw, J. E. (1999) Curr. Opin. Struct. Biol. 9, 260-267
18. Danino, D., and Hinshaw, J. E. (2001) Curr. Opin. Cell Biol. 13, 454-460
19. Zhang, P., and Hinshaw, J. E. (2001) Nat. Cell Biol. 3, 922-926
20. Schrader, M. (2006) Biochim. Biophys. Acta 1763, 531-541
21. van der Bliek, A. M. (1999) Trends Cell Biol. 9, 96-102
22. Shin, H. W., Takatsu, H., Mukai, H., Munekata, E., Murakami, K., and Nakayama, K. (1999) J. Biol. Chem. 274, 2780-2785
23. Pitts, K. R., McNiven, M. A., and Yoon, Y. (2004) J. Biol. Chem. 279, 50286-50294
24. Zhu, P. P., Patterson, A., Stadler, J., Seeburg, D. P., Sheng, M., and Blackstone, C. (2004) J. Biol. Chem. 279, 35967-35974
25. Chang, C. R., and Blackstone, C. (2007) J. Biol. Chem. 282, 21583-21587
26. Ramachandran, R., Surka, M., Chappie, J. S., Fowler, D. M., Foss, T. R., Song, B. D., and Schmid, S. L. (2007) EMBO J. 26, 559-566
27. Bhar, D., Karren, M. A., Babst, M., and Shaw, J. M. (2006) J. Biol. Chem. 281, 17312-17320
28. Naylor, K., Ingerman, E., Okreglak, V., Marino, M., Hinshaw, J. E., and Nunnari, J. (2006) J. Biol. Chem. 281, 2177-2183
29. Tanaka, A., Kobayashi, S., and Fujiki, Y. (2006) Exp. Cell Res. 312, 1671-1684
30. Waterham, H. R., Koster, J., van Roermund, C. W., Mooyer, P. A., Wanders, R. J., and Leonard, J. V. (2007) N. Engl. J. Med. 356, 1736-1741
31. Pitts, K. R., Yoon, Y., Krueger, E. W., and McNiven, M. A. (1999) Mol. Biol. Cell 10, 4403-4417
32. Smirnova, E., Griparic, L., Shurland, D. L., and van der Bliek, A. M. (2001) Mol. Biol. Cell 12, 2245-2256
33. Yoon, Y., Pitts, K. R., and McNiven, M. A. (2001) Mol. Biol. Cell 12, 2894-2905
34. Rismanchi, N., Soderblom, C., Stadler, J., Zhu, P. P., and Blackstone, C. (2008) Hum. Mol. Genet. 17, 1591-1604
35. Yang, D., Rismanchi, N., Renvoisé, B., Lippincott-Schwartz, J., Blackstone, C., and Hurley, J. H. (2008) Nat. Struct. Mol. Biol. 15, 1278-1286
36. Arnoult, D., Grodet, A., Lee, Y. J., Estaquier, J., and Blackstone, C. (2005) J. Biol. Chem. 280, 35742-35750
37. Muhlberg, A. B., Warnock, D. E., and Schmid, S. L. (1997) EMBO J. 16, 6676-6683
38. Schumacher, B., and Staeheli, P. (1998) J. Biol. Chem. 273, 28365-28370
39. Di Paolo, C., Hefti, H. P., Meli, M., Landis, H., and Pavlovic, J. (1999) J. Biol. Chem. 274, 32071-32078
40. Smirnova, E., Shurland, D. L., Newman-Smith, E. D., Pishvaee, B., and van der Bliek, A. M. (1999) J. Biol. Chem. 274, 14942-14947
41. Prakash, B., Praefcke, G. J., Renault, L., Wittinghofer, A., and Herrmann, C. (2000) Nature 403, 567-571
42. Youle, R. J., and Karbowski, M. (2005) Nat. Rev. Mol. Cell Biol. 6, 657-663
43. Niemann, A., Ruegg, M., La Padula, V., Schenone, A., and Suter, U. (2005) J. Cell Biol. 170, 1067-1078
44. Wen, J., Arakawa, T., and Philo, J. S. (1996) Anal. Biochem. 240, 155-166
45. Andersson, M., Wittgren, B., and Wahlund, K. G. (2003) Anal. Chem. 75, 4279-4291
46. Ye, H. (2006) Anal. Biochem. 356, 76-85