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Volumn 7, Issue , 2017, Pages

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; GLUCOSE; INSULIN; MESSENGER RNA; MICRORNA;

EID: 85016157333     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep44986     Document Type: Article
Times cited : (70)

References (53)
  • 1
    • 84858383401 scopus 로고    scopus 로고
    • Diabetes mellitus and the beta cell: The last ten years
    • Ashcroft, F. M. & Rorsman, P. Diabetes mellitus and the beta cell: the last ten years. Cell 148, 1160-1171, doi: 10.1016/j. cell.2012.02.010 (2012).
    • (2012) Cell , vol.148 , pp. 1160-1171
    • Ashcroft, F.M.1    Rorsman, P.2
  • 2
    • 84857785686 scopus 로고    scopus 로고
    • Mitochondrial signals drive insulin secretion in the pancreatic beta-cell
    • Wiederkehr, A. & Wollheim, C. B. Mitochondrial signals drive insulin secretion in the pancreatic beta-cell. Mol Cell Endocrinol 353, 128-137, doi: 10.1016/j.mce.2011.07.016 (2012).
    • (2012) Mol Cell Endocrinol , vol.353 , pp. 128-137
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 3
    • 0036314864 scopus 로고    scopus 로고
    • Is reduced frst-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes 51 Suppl 1
    • Gerich, J. E. Is reduced frst-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes? Diabetes 51 Suppl 1, S117-121 (2002).
    • (2002) S117-121
    • Gerich, J.E.1
  • 4
    • 84925347828 scopus 로고    scopus 로고
    • Genetics of type 2 diabetes-pitfalls and possibilities
    • Prasad, R. B. & Groop, L. Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel) 6, 87-123, doi: 10.3390/genes6010087 (2015).
    • (2015) Genes (Basel) , vol.6 , pp. 87-123
    • Prasad, R.B.1    Groop, L.2
  • 5
    • 84900811419 scopus 로고    scopus 로고
    • Role of non-coding RNAs in pancreatic beta-cell development and physiology
    • Eliasson, L. & Esguerra, J. L. Role of non-coding RNAs in pancreatic beta-cell development and physiology. Acta Physiol (Oxf) 211, 273-284, doi: 10.1111/apha.12285 (2014).
    • (2014) Acta Physiol (Oxf) , vol.211 , pp. 273-284
    • Eliasson, L.1    Esguerra, J.L.2
  • 6
    • 84906226995 scopus 로고    scopus 로고
    • Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans
    • Esguerra, J. L. & Eliasson, L. Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans. Front Genet 5, 209, doi: 10.3389/fgene.2014.00209 (2014).
    • (2014) Front Genet , vol.5 , pp. 209
    • Esguerra, J.L.1    Eliasson, L.2
  • 7
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233, doi: 10.1016/j.cell.2009.01.002 (2009).
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 8
    • 79960322580 scopus 로고    scopus 로고
    • A. MiR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)
    • Pullen, T. J., da Silva Xavier, G., Kelsey, G. & Rutter, G. A. miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1). Mol Cell Biol 31, 3182-3194, doi: 10.1128/MCB.01433-10 (2011).
    • (2011) Mol Cell Biol , vol.31 , pp. 3182-3194
    • Pullen, T.J.1    Da Silva Xavier, G.2    Kelsey, G.3    Rutter, G.4
  • 9
    • 78651472654 scopus 로고    scopus 로고
    • Tissue-specific disallowance of housekeeping genes: The other face of cell diferentiation
    • Torrez, L. et al. Tissue-specific disallowance of housekeeping genes: the other face of cell diferentiation. Genome Res 21, 95-105, doi: 10.1101/gr.109173.110 (2011).
    • (2011) Genome Res , vol.21 , pp. 95-105
    • Torrez, L.1
  • 10
    • 79954555856 scopus 로고    scopus 로고
    • Diferential glucose-regulation of microRNAs in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat
    • Esguerra, J. L., Bolmeson, C., Cilio, C. M. & Eliasson, L. Diferential glucose-regulation of microRNAs in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat. PLoS One 6, e18613, doi: 10.1371/journal.pone.0018613 (2011).
    • (2011) PLoS One , vol.6 , pp. e18613
    • Esguerra, J.L.1    Bolmeson, C.2    Cilio, C.M.3    Eliasson, L.4
  • 11
    • 57649174792 scopus 로고    scopus 로고
    • The GK rat beta-cell: A prototype for the diseased human beta-cell in type 2 diabetes?
    • Portha, B. et al. The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes? Mol Cell Endocrinol 297, 73-85, doi: 10.1016/j.mce.2008.06.013 (2009).
    • (2009) Mol Cell Endocrinol , vol.297 , pp. 73-85
    • Portha, B.1
  • 12
    • 0030058877 scopus 로고    scopus 로고
    • Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
    • Galli, J. et al. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 12, 31-37, doi: 10.1038/ng0196-31 (1996).
    • (1996) Nat Genet , vol.12 , pp. 31-37
    • Galli, J.1
  • 13
    • 0033513495 scopus 로고    scopus 로고
    • Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: Restoration of decreased t-SNARE proteins improves impaired insulin secretion
    • Nagamatsu, S. et al. Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion. Diabetes 48, 2367-2373 (1999).
    • (1999) Diabetes , vol.48 , pp. 2367-2373
    • Nagamatsu, S.1
  • 14
    • 0036827802 scopus 로고    scopus 로고
    • Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment
    • Gaisano, H. Y., Ostenson, C. G., Sheu, L., Wheeler, M. B. & Efendic, S. Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment. Endocrinology 143, 4218-4226, doi: 10.1210/en.2002-220237 (2002).
    • (2002) Endocrinology , vol.143 , pp. 4218-4226
    • Gaisano, H.Y.1    Ostenson, C.G.2    Sheu, L.3    Wheeler, M.B.4    Efendic, S.5
  • 15
    • 74249123937 scopus 로고    scopus 로고
    • Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
    • Rosengren, A. H. et al. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science 327, 217-220, doi: 10.1126/science.1176827 (2010).
    • (2010) Science , vol.327 , pp. 217-220
    • Rosengren, A.H.1
  • 16
    • 33845542356 scopus 로고    scopus 로고
    • Separately inherited deffects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes
    • Granhall, C., Rosengren, A. H., Renstrom, E. & Luthman, H. Separately inherited deffects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes. Diabetes 55, 3494-3500, doi: 10.2337/db06-0796 (2006).
    • (2006) Diabetes , vol.55 , pp. 3494-3500
    • Granhall, C.1    Rosengren, A.H.2    Renstrom, E.3    Luthman, H.4
  • 17
    • 0029122615 scopus 로고
    • Defciency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats
    • Zhou, Y. P., Ostenson, C. G., Ling, Z. C. & Grill, V. Defciency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats. Endocrinology 136, 3546-3551, doi: 10.1210/endo.136.8.7628391 (1995).
    • (1995) Endocrinology , vol.136 , pp. 3546-3551
    • Zhou, Y.P.1    Ostenson, C.G.2    Ling, Z.C.3    Grill, V.4
  • 18
    • 59349118696 scopus 로고    scopus 로고
    • A genetically encoded fuorescent reporter of ATP:ADP ratio
    • Berg, J., Hung, Y. P. & Yellen, G. A genetically encoded fuorescent reporter of ATP:ADP ratio. Nat Methods 6, 161-166, doi: 10.1038/nmeth.1288 (2009).
    • (2009) Nat Methods , vol.6 , pp. 161-166
    • Berg, J.1    Hung, Y.P.2    Yellen, G.3
  • 19
    • 84878854364 scopus 로고    scopus 로고
    • Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca(2+)
    • Li, J., Shuai, H. Y., Gylfe, E. & Tengholm, A. Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca(2+). Diabetologia 56, 1577-1586, doi: 10.1007/s00125-013-2894-0 (2013).
    • (2013) Diabetologia , vol.56 , pp. 1577-1586
    • Li, J.1    Shuai, H.Y.2    Gylfe, E.3    Tengholm, A.4
  • 20
    • 84888873103 scopus 로고    scopus 로고
    • Imaging energy status in live cells with a fuorescent biosensor of the intracellular ATP-to-ADP ratio
    • Tantama, M., Martinez-Francois, J. R., Mongeon, R. & Yellen, G. Imaging energy status in live cells with a fuorescent biosensor of the intracellular ATP-to-ADP ratio. Nat Commun 4, 2550, doi: 10.1038/ncomms3550 (2013).
    • (2013) Nat Commun , vol.4 , pp. 2550
    • Tantama, M.1    Martinez-Francois, J.R.2    Mongeon, R.3    Yellen, G.4
  • 21
    • 0035157768 scopus 로고    scopus 로고
    • Glucose sensing in pancreatic beta-cells: A model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus
    • Schuit, F. C., Huypens, P., Heimberg, H. & Pipeleers, D. G. Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 50, 1-11 (2001).
    • (2001) Diabetes , vol.50 , pp. 1-11
    • Schuit, F.C.1    Huypens, P.2    Heimberg, H.3    Pipeleers, D.G.4
  • 22
    • 0023197704 scopus 로고
    • Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump
    • Rhodes, C. J., Lucas, C. A., Mutkoski, R. L., Orci, L. & Halban, P. A. Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump. J Biol Chem 262, 10712-10717 (1987).
    • (1987) J Biol Chem , vol.262 , pp. 10712-10717
    • Rhodes, C.J.1    Lucas, C.A.2    Mutkoski, R.L.3    Orci, L.4    Halban, P.A.5
  • 23
    • 0023610730 scopus 로고
    • Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles
    • Orci, L. et al. Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell 49, 865-868 (1987).
    • (1987) Cell , vol.49 , pp. 865-868
    • Orci, L.1
  • 24
    • 78649665323 scopus 로고    scopus 로고
    • Beta-Cell-specific pyruvate dehydrogenase defciency impairs glucose-stimulated insulin secretion
    • Srinivasan, M. et al. Beta-Cell-specific pyruvate dehydrogenase defciency impairs glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab 299, E910-917, doi: 10.1152/ajpendo.00339.2010 (2010).
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E910-E917
    • Srinivasan, M.1
  • 25
    • 0026754672 scopus 로고
    • Primary pancreatic beta-cell secretory deffect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young
    • Velho, G. et al. Primary pancreatic beta-cell secretory deffect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 340, 444-448 (1992).
    • (1992) Lancet , vol.340 , pp. 444-448
    • Velho, G.1
  • 26
    • 0342902204 scopus 로고    scopus 로고
    • Neonatal diabetes mellitus due to complete glucokinase defciency
    • Njolstad, P. R. et al. Neonatal diabetes mellitus due to complete glucokinase defciency. N Engl J Med 344, 1588-1592, doi: 10.1056/NEJM200105243442104 (2001).
    • (2001) N Engl J Med , vol.344 , pp. 1588-1592
    • Njolstad, P.R.1
  • 27
    • 48949120517 scopus 로고    scopus 로고
    • Novel aspects of the molecular mechanisms controlling insulin secretion
    • Eliasson, L. et al. Novel aspects of the molecular mechanisms controlling insulin secretion. J Physiol 586, 3313-3324, doi: 10.1113/jphysiol.2008.155317 (2008).
    • (2008) J Physiol , vol.586 , pp. 3313-3324
    • Eliasson, L.1
  • 28
    • 0036261251 scopus 로고    scopus 로고
    • Fast insulin secretion refects exocytosis of docked granules in mouse pancreatic B-cells
    • Olofsson, C. S. et al. Fast insulin secretion refects exocytosis of docked granules in mouse pancreatic B-cells. Pfugers Arch 444, 43-51, doi: 10.1007/s00424-002-0781-5 (2002).
    • (2002) Pfugers Arch , vol.444 , pp. 43-51
    • Olofsson, C.S.1
  • 29
    • 84938384133 scopus 로고    scopus 로고
    • MiRWalk2.0: A comprehensive atlas of microRNA-target interactions
    • Dweep, H. & Gretz, N. miRWalk2.0: a comprehensive atlas of microRNA-target interactions. Nat Methods 12, 697, doi: 10.1038/nmeth.3485 (2015).
    • (2015) Nat Methods , vol.12 , pp. 697
    • Dweep, H.1    Gretz, N.2
  • 30
    • 20044390365 scopus 로고    scopus 로고
    • Functional and molecular deffects of pancreatic islets in human type 2 diabetes
    • Del Guerra, S. et al. Functional and molecular deffects of pancreatic islets in human type 2 diabetes. Diabetes 54, 727-735 (2005).
    • (2005) Diabetes , vol.54 , pp. 727-735
    • Del Guerra, S.1
  • 31
    • 34548366480 scopus 로고    scopus 로고
    • Circadian and age-dependent expression patterns of GLUT2 and glucokinase in the pancreatic beta-cell of diabetic and nondiabetic rats
    • Frese, T., Bazwinsky, I., Muhlbauer, E. & Peschke, E. Circadian and age-dependent expression patterns of GLUT2 and glucokinase in the pancreatic beta-cell of diabetic and nondiabetic rats. Horm Metab Res 39, 567-574, doi: 10.1055/s-2007-984471 (2007).
    • (2007) Horm Metab Res , vol.39 , pp. 567-574
    • Frese, T.1    Bazwinsky, I.2    Muhlbauer, E.3    Peschke, E.4
  • 32
    • 70450285188 scopus 로고    scopus 로고
    • Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion
    • Malmgren, S. et al. Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion. J Biol Chem 284, 32395-32404, doi: 10.1074/jbc.M109.026708 (2009).
    • (2009) J Biol Chem , vol.284 , pp. 32395-32404
    • Malmgren, S.1
  • 33
    • 84868238574 scopus 로고    scopus 로고
    • Cyclic AMP dynamics in the pancreatic beta-cell
    • Tengholm, A. Cyclic AMP dynamics in the pancreatic beta-cell. Ups J Med Sci 117, 355-369, doi: 10.3109/03009734.2012.724732 (2012).
    • (2012) Ups J Med Sci , vol.117 , pp. 355-369
    • Tengholm, A.1
  • 34
    • 84984706989 scopus 로고    scopus 로고
    • Integrator of Stress Responses Calmodulin Binding Transcription Activator 1 (Camta1) Regulates miR-212/miR-132 Expression and Insulin Secretion
    • Mollet, I. G., Malm, H. A., Wendt, A., Orho-Melander, M. & Eliasson, L. Integrator of Stress Responses Calmodulin Binding Transcription Activator 1 (Camta1) Regulates miR-212/miR-132 Expression and Insulin Secretion. J Biol Chem 291, 18440-18452, doi: 10.1074/jbc.M116.716860 (2016).
    • (2016) J Biol Chem , vol.291 , pp. 18440-18452
    • Mollet, I.G.1    Malm, H.A.2    Wendt, A.3    Orho-Melander, M.4    Eliasson, L.5
  • 35
    • 84940727894 scopus 로고    scopus 로고
    • Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic beta-Cells
    • Shang, J. et al. Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic beta-Cells. Mol Endocrinol 29, 1243-1253, doi: 10.1210/me.2014-1335 (2015).
    • (2015) Mol Endocrinol , vol.29 , pp. 1243-1253
    • Shang, J.1
  • 36
    • 84959238487 scopus 로고    scopus 로고
    • Transcriptional regulation of the miR-212/miR-132 cluster in insulin-secreting beta-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases
    • Malm, H. A. et al. Transcriptional regulation of the miR-212/miR-132 cluster in insulin-secreting beta-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases. Mol Cell Endocrinol 424, 23-33, doi: 10.1016/j.mce.2016.01.010 (2016).
    • (2016) Mol Cell Endocrinol , vol.424 , pp. 23-33
    • Malm, H.A.1
  • 37
    • 84890124194 scopus 로고    scopus 로고
    • Identifcation of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes
    • Nesca, V. et al. Identifcation of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes. Diabetologia 56, 2203-2212, doi: 10.1007/s00125-013-2993-y (2013).
    • (2013) Diabetologia , vol.56 , pp. 2203-2212
    • Nesca, V.1
  • 38
    • 84891856209 scopus 로고    scopus 로고
    • Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets
    • Kameswaran, V. et al. Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metab 19, 135-145, doi: 10.1016/j.cmet.2013.11.016 (2014).
    • (2014) Cell Metab , vol.19 , pp. 135-145
    • Kameswaran, V.1
  • 39
    • 84867518459 scopus 로고    scopus 로고
    • Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes
    • Andersson, S. A. et al. Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes. Mol Cell Endocrinol 364, 36-45, doi: 10.1016/j.mce.2012.08.009 (2012).
    • (2012) Mol Cell Endocrinol , vol.364 , pp. 36-45
    • Andersson, S.A.1
  • 40
    • 85011936073 scopus 로고    scopus 로고
    • Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin
    • Burroughs, A. M. et al. Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin. RNA Biol 8, 158-177 (2011).
    • (2011) RNA Biol , vol.8 , pp. 158-177
    • Burroughs, A.M.1
  • 41
    • 84868097965 scopus 로고    scopus 로고
    • MicroRNAs associated with the diferent human Argonaute proteins
    • Dueck, A., Ziegler, C., Eichner, A., Berezikov, E. & Meister, G. microRNAs associated with the diferent human Argonaute proteins. Nucleic Acids Res 40, 9850-9862, doi: 10.1093/nar/gks705 (2012).
    • (2012) Nucleic Acids Res , vol.40 , pp. 9850-9862
    • Dueck, A.1    Ziegler, C.2    Eichner, A.3    Berezikov, E.4    Meister, G.5
  • 42
    • 0028219254 scopus 로고
    • The pyruvate dehydrogenase complex: Cloning of the rat somatic E1 alpha subunit and its coordinate expression with the mRNAs for the E1 beta, E2, and E3 catalytic subunits in developing rat brain
    • Cullingford, T. E., Clark, J. B. & Phillips, I. R. The pyruvate dehydrogenase complex: cloning of the rat somatic E1 alpha subunit and its coordinate expression with the mRNAs for the E1 beta, E2, and E3 catalytic subunits in developing rat brain. J Neurochem 62, 1682-1690 (1994).
    • (1994) J Neurochem , vol.62 , pp. 1682-1690
    • Cullingford, T.E.1    Clark, J.B.2    Phillips, I.R.3
  • 43
    • 84907070978 scopus 로고    scopus 로고
    • Featured Article: Beta cell specific pyruvate dehydrogenase alpha gene deletion results in a reduced islet number and beta-cell mass postnatally
    • Patel, M. S., Srinivasan, M., Strutt, B., Mahmood, S. & Hill, D. J. Featured Article: Beta cell specific pyruvate dehydrogenase alpha gene deletion results in a reduced islet number and beta-cell mass postnatally. Exp Biol Med (Maywood) 239, 975-985, doi: 10.1177/1535370214531895 (2014).
    • (2014) Exp Biol Med (Maywood) , vol.239 , pp. 975-985
    • Patel, M.S.1    Srinivasan, M.2    Strutt, B.3    Mahmood, S.4    Hill, D.J.5
  • 44
    • 84855353341 scopus 로고    scopus 로고
    • The spectrum of pyruvate dehydrogenase complex defciency: Clinical, biochemical and genetic features in 371 patients
    • Patel, K. P., O'Brien, T. W., Subramony, S. H., Shuster, J. & Stacpoole, P. W. The spectrum of pyruvate dehydrogenase complex defciency: clinical, biochemical and genetic features in 371 patients. Mol Genet Metab 105, 34-43, doi: 10.1016/j.ymgme.2011.09.032 (2012).
    • (2012) Mol Genet Metab , vol.105 , pp. 34-43
    • Patel, K.P.1    O'Brien, T.W.2    Subramony, S.H.3    Shuster, J.4    Stacpoole, P.W.5
  • 45
    • 33745937670 scopus 로고    scopus 로고
    • Reconciling diabetes management and the ketogenic diet in a child with pyruvate dehydrogenase defciency
    • Henwood, M. J., Tornton, P. S., Preis, C. M., Chee, C. & Grimberg, A. Reconciling diabetes management and the ketogenic diet in a child with pyruvate dehydrogenase defciency. J Child Neurol 21, 436-439 (2006).
    • (2006) J Child Neurol , vol.21 , pp. 436-439
    • Henwood, M.J.1    Tornton, P.S.2    Preis, C.M.3    Chee, C.4    Grimberg, A.5
  • 46
    • 34147163066 scopus 로고    scopus 로고
    • EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets
    • Konstantinova, I. et al. EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 129, 359-370, doi: 10.1016/j.cell.2007.02.044 (2007).
    • (2007) Cell , vol.129 , pp. 359-370
    • Konstantinova, I.1
  • 47
    • 0031791047 scopus 로고    scopus 로고
    • Disproportionately elevated proinsulin levels refect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
    • Roder, M. E., Porte, D. Jr., Schwartz, R. S. & Kahn, S. E. Disproportionately elevated proinsulin levels refect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 83, 604-608, doi: 10.1210/jcem.83.2.4544 (1998).
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 604-608
    • Roder, M.E.1    Porte, D.2    Schwartz, R.S.3    Kahn, S.E.4
  • 48
    • 0032124812 scopus 로고    scopus 로고
    • C or relating str ucture and function in ATP-sensitive K+ channels
    • Ashcrof, F. M. & Gribble, F. M. C or relating str ucture and function in ATP-sensitive K+ channels. Trends Neurosci 21, 288-294 (1998).
    • (1998) Trends Neurosci , vol.21 , pp. 288-294
    • Ashcrof, F.M.1    Gribble, F.M.2
  • 49
    • 0030874610 scopus 로고    scopus 로고
    • Rapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells
    • Eliasson, L., Renstrom, E., Ding, W. G., Proks, P. & Rorsman, P. Rapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells. J Physiol 503 (Pt 2), 399-412 (1997).
    • (1997) J Physiol , vol.503 , pp. 399-412
    • Eliasson, L.1    Renstrom, E.2    Ding, W.G.3    Proks, P.4    Rorsman, P.5
  • 50
    • 84907222786 scopus 로고    scopus 로고
    • Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes infuencing glucose metabolism
    • Fadista, J. et al. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes infuencing glucose metabolism. P Natl Acad Sci USA 111, 13924-13929 (2014).
    • (2014) P Natl Acad Sci USA , vol.111 , pp. 13924-13929
    • Fadista, J.1
  • 51
    • 0034006587 scopus 로고    scopus 로고
    • Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and-independent glucose-stimulated insulin secretion
    • Hohmeier, H. E. et al. Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and-independent glucose-stimulated insulin secretion. Diabetes 49, 424-430 (2000).
    • (2000) Diabetes , vol.49 , pp. 424-430
    • Hohmeier, H.E.1
  • 52
    • 84940502214 scopus 로고    scopus 로고
    • Predicting efective microRNA target sites in mammalian mRNAs
    • Agarwal, V., Bell, G. W., Nam, J. W. & Bartel, D. P. Predicting efective microRNA target sites in mammalian mRNAs. Elife 4, doi: 10.7554/eLife.05005 (2015).
    • (2015) Elife , vol.4
    • Agarwal, V.1    Bell, G.W.2    Nam, J.W.3    Bartel, D.P.4
  • 53
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, D. W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4, 44-57, doi: 10.1038/nprot.2008.211 (2009).
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.