메뉴 건너뛰기




Volumn 22, Issue 6, 2017, Pages 792-801

Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia

(18)  Devor, A a,b,c,d   Andreassen, O A d,e   Wang, Y a,d,e   Maki Marttunen T d,e   Smeland, O B d,e   Fan, C C a,b   Schork, A J f,g   Holland, D a   Thompson, W K g,h   Witoelar, A d,e   Chen, C H h   Desikan, R S b,i   McEvoy, L K b   Djurovic, S e,j   Greengard, P k   Svenningsson, P l   Einevoll, G T d,m   Dale, A M a,b,f  


Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; IONOTROPIC RECEPTOR; PHOSPHOPROTEIN DARPP 32; 4 AMINOBUTYRIC ACID; DOPAMINE; METABOTROPIC RECEPTOR;

EID: 85016106888     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2017.33     Document Type: Review
Times cited : (63)

References (84)
  • 3
    • 77957914609 scopus 로고    scopus 로고
    • The psychiatric GWAS consortium: Big science comes to psychiatry
    • Sullivan PF. The psychiatric GWAS consortium: big science comes to psychiatry. Neuron 2010; 68: 182-186.
    • (2010) Neuron , vol.68 , pp. 182-186
    • Sullivan, P.F.1
  • 4
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Cross-Disorder Group of the Psychiatric Genomics C.
    • Cross-Disorder Group of the Psychiatric Genomics C. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013; 381: 1371-1379.
    • (2013) Lancet , vol.381 , pp. 1371-1379
  • 5
    • 80053384370 scopus 로고    scopus 로고
    • Genome-wide association study identifies five new schizophrenia loci
    • Schizophrenia Psychiatric Genome-Wide Association Study C.
    • Schizophrenia Psychiatric Genome-Wide Association Study C. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011; 43: 969-976.
    • (2011) Nat Genet , vol.43 , pp. 969-976
  • 6
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-Associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics C
    • Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-Associated genetic loci. Nature 2014; 511: 421-427.
    • (2014) Nature , vol.511 , pp. 421-427
  • 7
    • 84876847154 scopus 로고    scopus 로고
    • All SNPs are not created equal: Genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs
    • Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, et al. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet 2013; 9: e1003449.
    • (2013) PLoS Genet , vol.9 , pp. e1003449
    • Schork, A.J.1    Thompson, W.K.2    Pham, P.3    Torkamani, A.4    Roddey, J.C.5    Sullivan, P.F.6
  • 8
    • 84958730027 scopus 로고    scopus 로고
    • Leveraging genomic annotations and pleiotropic enrichment for improved replication rates in schizophrenia GWAS
    • Wang Y, Thompson WK, Schork AJ, Holland D, Chen CH, Bettella F, et al. Leveraging genomic annotations and pleiotropic enrichment for improved replication rates in schizophrenia GWAS. PLoS Genet 2016; 12: e1005803.
    • (2016) PLoS Genet , vol.12 , pp. e1005803
    • Wang, Y.1    Thompson, W.K.2    Schork, A.J.3    Holland, D.4    Chen, C.H.5    Bettella, F.6
  • 9
    • 68949180394 scopus 로고    scopus 로고
    • Schizophrenia
    • van Os J, Kapur S. Schizophrenia. Lancet 2009; 374: 635-645.
    • (2009) Lancet , vol.374 , pp. 635-645
    • Van Os, J.1    Kapur, S.2
  • 10
    • 84856120944 scopus 로고    scopus 로고
    • From revolution to evolution: The glutamate hypothesis of schizophrenia and its implication for treatment
    • Moghaddam B, Javitt D. From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacology 2012; 37: 4-15.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 4-15
    • Moghaddam, B.1    Javitt, D.2
  • 12
    • 84905899513 scopus 로고    scopus 로고
    • Calcium signalling and psychiatric disease: Bipolar disorder and schizophrenia
    • Berridge MJ. Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia. Cell Tissue Res 2014; 357: 477-492.
    • (2014) Cell Tissue Res , vol.357 , pp. 477-492
    • Berridge, M.J.1
  • 13
    • 0141853757 scopus 로고    scopus 로고
    • Calcium signaling dysfunction in schizophrenia: A unifying approach
    • Lidow MS. Calcium signaling dysfunction in schizophrenia: a unifying approach. Brain Res Brain Res Rev 2003; 43: 70-84.
    • (2003) Brain Res Brain Res Rev , vol.43 , pp. 70-84
    • Lidow, M.S.1
  • 14
    • 0002820468 scopus 로고    scopus 로고
    • The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia
    • Moises HW, Zoega T, Gottesman II. The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia. BMC Psychiatry 2002; 2: 8.
    • (2002) BMC Psychiatry , vol.2 , pp. 8
    • Moises, H.W.1    Zoega, T.2    Gottesman, I.I.3
  • 15
    • 84859313330 scopus 로고    scopus 로고
    • Calcium signalling remodelling and disease
    • Berridge MJ. Calcium signalling remodelling and disease. Biochem Soc Trans 2012; 40: 297-309.
    • (2012) Biochem Soc Trans , vol.40 , pp. 297-309
    • Berridge, M.J.1
  • 17
    • 79952032110 scopus 로고    scopus 로고
    • The physiology, signaling, and pharmacology of dopamine receptors
    • Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 2011; 63: 182-217.
    • (2011) Pharmacol Rev , vol.63 , pp. 182-217
    • Beaulieu, J.M.1    Gainetdinov, R.R.2
  • 18
  • 19
    • 84923077204 scopus 로고    scopus 로고
    • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
    • Network, Pathway Analysis Subgroup of Psychiatric Genomics C.
    • Network, Pathway Analysis Subgroup of Psychiatric Genomics C. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 2015; 18: 199-209.
    • (2015) Nat Neurosci , vol.18 , pp. 199-209
  • 20
    • 84930520305 scopus 로고    scopus 로고
    • Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia
    • Pocklington AJ, Rees E, Walters JT, Han J, Kavanagh DH, Chambert KD, et al. Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia. Neuron 2015; 86: 1203-1214.
    • (2015) Neuron , vol.86 , pp. 1203-1214
    • Pocklington, A.J.1    Rees, E.2    Walters, J.T.3    Han, J.4    Kavanagh, D.H.5    Chambert, K.D.6
  • 23
    • 78149428430 scopus 로고    scopus 로고
    • Rethinking schizophrenia
    • Insel TR. Rethinking schizophrenia. Nature 2010; 468: 187-193.
    • (2010) Nature , vol.468 , pp. 187-193
    • Insel, T.R.1
  • 24
    • 84886999278 scopus 로고    scopus 로고
    • Progress in the genetics of polygenic brain disorders: Significant new challenges for neurobiology
    • McCarroll SA, Hyman SE. Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. Neuron 2013; 80: 578-587.
    • (2013) Neuron , vol.80 , pp. 578-587
    • McCarroll, S.A.1    Hyman, S.E.2
  • 25
    • 0020696442 scopus 로고
    • A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions
    • Walaas SI, Aswad DW, Greengard P. A dopamine- And cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Nature 1983; 301: 69-71.
    • (1983) Nature , vol.301 , pp. 69-71
    • Walaas, S.I.1    Aswad, D.W.2    Greengard, P.3
  • 26
    • 0035798093 scopus 로고    scopus 로고
    • The neurobiology of slow synaptic transmission
    • Greengard P. The neurobiology of slow synaptic transmission. Science 2001; 294: 1024-1030.
    • (2001) Science , vol.294 , pp. 1024-1030
    • Greengard, P.1
  • 28
    • 84876919334 scopus 로고    scopus 로고
    • Regulation of Ca( V)2 calcium channels by G protein coupled receptors
    • Zamponi GW, Currie KP. Regulation of Ca(V)2 calcium channels by G protein coupled receptors. Biochim Biophys Acta 2013; 1828: 1629-1643.
    • (2013) Biochim Biophys Acta , vol.1828 , pp. 1629-1643
    • Zamponi, G.W.1    Currie, K.P.2
  • 30
    • 84876896913 scopus 로고    scopus 로고
    • Structure and function of the beta subunit of voltage-gated Ca( 2) (+) channels
    • Buraei Z, Yang J. Structure and function of the beta subunit of voltage-gated Ca(2) (+) channels. Biochim Biophys Acta 2013; 1828: 1530-1540.
    • (2013) Biochim Biophys Acta , vol.1828 , pp. 1530-1540
    • Buraei, Z.1    Yang, J.2
  • 31
    • 84901313139 scopus 로고    scopus 로고
    • Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells
    • Brennand KJ, Landek-Salgado MA, Sawa A. Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells. Biol Psychiatry 2014; 75: 936-944.
    • (2014) Biol Psychiatry , vol.75 , pp. 936-944
    • Brennand, K.J.1    Landek-Salgado, M.A.2    Sawa, A.3
  • 32
    • 77956648156 scopus 로고    scopus 로고
    • N-methyl-D-Aspartate (NMDA receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?
    • Kantrowitz JT, Javitt DC. N-methyl-D-Aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?. Brain Res Bull 2010; 83: 108-121.
    • (2010) Brain Res Bull , vol.83 , pp. 108-121
    • Kantrowitz, J.T.1    Javitt, D.C.2
  • 33
    • 84866736529 scopus 로고    scopus 로고
    • Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia
    • International Schizophrenia C.et al
    • Lips ES, Cornelisse LN, Toonen RF, Min JL, Hultman CM, International Schizophrenia C, et al. Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Mol Psychiatry 2012; 17: 996-1006.
    • (2012) Mol Psychiatry , vol.17 , pp. 996-1006
    • Lips, E.S.1    Cornelisse, L.N.2    Toonen, R.F.3    Min, J.L.4    Hultman, C.M.5
  • 34
    • 53649098737 scopus 로고    scopus 로고
    • Pathway analysis of seven common diseases assessed by genome-wide association
    • Torkamani A, Topol EJ, Schork NJ. Pathway analysis of seven common diseases assessed by genome-wide association. Genomics 2008; 92: 265-272.
    • (2008) Genomics , vol.92 , pp. 265-272
    • Torkamani, A.1    Topol, E.J.2    Schork, N.J.3
  • 35
    • 67649584052 scopus 로고    scopus 로고
    • Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder
    • Holmans P, Green EK, Pahwa JS, Ferreira MA, Purcell SM, Sklar P, et al. Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am J Hum Genet 2009; 85: 13-24.
    • (2009) Am J Hum Genet , vol.85 , pp. 13-24
    • Holmans, P.1    Green, E.K.2    Pahwa, J.S.3    Ferreira, M.A.4    Purcell, S.M.5    Sklar, P.6
  • 38
    • 79951799418 scopus 로고    scopus 로고
    • The pleiotropic structure of the genotype-phenotype map: The evolvability of complex organisms
    • Wagner GP, Zhang J. The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. Nat Rev Genet 2011; 12: 204-213.
    • (2011) Nat Rev Genet , vol.12 , pp. 204-213
    • Wagner, G.P.1    Zhang, J.2
  • 40
    • 3142642672 scopus 로고    scopus 로고
    • Delineating novel signature patterns of altered gene expression in schizophrenia using gene microarrays
    • Mirnics K, Middleton FA, Lewis DA, Levitt P. Delineating novel signature patterns of altered gene expression in schizophrenia using gene microarrays. Scientific World J 2001; 1: 114-116.
    • (2001) Scientific World J , vol.1 , pp. 114-116
    • Mirnics, K.1    Middleton, F.A.2    Lewis, D.A.3    Levitt, P.4
  • 42
    • 0035426751 scopus 로고    scopus 로고
    • Analysis of complex brain disorders with gene expression microarrays: Schizophrenia as a disease of the synapse
    • Mirnics K, Middleton FA, Lewis DA, Levitt P. Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci 2001; 24: 479-486.
    • (2001) Trends Neurosci , vol.24 , pp. 479-486
    • Mirnics, K.1    Middleton, F.A.2    Lewis, D.A.3    Levitt, P.4
  • 43
    • 0033637841 scopus 로고    scopus 로고
    • Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
    • Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 2000; 28: 53-67.
    • (2000) Neuron , vol.28 , pp. 53-67
    • Mirnics, K.1    Middleton, F.A.2    Marquez, A.3    Lewis, D.A.4    Levitt, P.5
  • 44
  • 45
    • 33947519123 scopus 로고    scopus 로고
    • Molecular profiling of antipsychotic drug function: Convergent mechanisms in the pathology and treatment of psychiatric disorders
    • Thomas EA. Molecular profiling of antipsychotic drug function: convergent mechanisms in the pathology and treatment of psychiatric disorders. Mol Neurobiol 2006; 34: 109-128.
    • (2006) Mol Neurobiol , vol.34 , pp. 109-128
    • Thomas, E.A.1
  • 46
    • 80054738623 scopus 로고    scopus 로고
    • Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32
    • Valjent E, Bertran-Gonzalez J, Bowling H, Lopez S, Santini E, Matamales M, et al. Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32. Neuropsychopharmacology 2011; 36: 2561-2570.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2561-2570
    • Valjent, E.1    Bertran-Gonzalez, J.2    Bowling, H.3    Lopez, S.4    Santini, E.5    Matamales, M.6
  • 47
    • 84875252689 scopus 로고    scopus 로고
    • A cellular mechanism for cortical associations: An organizing principle for the cerebral cortex
    • Larkum M. A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex. Trends Neurosci 2013; 36: 141-151.
    • (2013) Trends Neurosci , vol.36 , pp. 141-151
    • Larkum, M.1
  • 48
    • 0034207818 scopus 로고    scopus 로고
    • The neurodevelopmental hypothesis of schizophrenia: Following a trail of evidence from cradle to grave
    • Marenco S, Weinberger DR. The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave. Dev Psychopathol 2000; 12: 501-527.
    • (2000) Dev Psychopathol , vol.12 , pp. 501-527
    • Marenco, S.1    Weinberger, D.R.2
  • 49
    • 33845680588 scopus 로고    scopus 로고
    • Electrical activity in early neuronal development
    • Spitzer NC. Electrical activity in early neuronal development. Nature 2006; 444: 707-712.
    • (2006) Nature , vol.444 , pp. 707-712
    • Spitzer, N.C.1
  • 50
    • 34548085412 scopus 로고    scopus 로고
    • Elevated NMDA receptor levels and enhanced postsynaptic long-Term potentiation induced by prenatal exposure to valproic acid
    • Rinaldi T, Kulangara K, Antoniello K, Markram H. Elevated NMDA receptor levels and enhanced postsynaptic long-Term potentiation induced by prenatal exposure to valproic acid. Proc Natl Acad Sci USA 2007; 104: 13501-13506.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13501-13506
    • Rinaldi, T.1    Kulangara, K.2    Antoniello, K.3    Markram, H.4
  • 51
    • 40849139253 scopus 로고    scopus 로고
    • Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid
    • Rinaldi T, Silberberg G, Markram H. Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid. Cereb Cortex 2008; 18: 763-770.
    • (2008) Cereb Cortex , vol.18 , pp. 763-770
    • Rinaldi, T.1    Silberberg, G.2    Markram, H.3
  • 52
    • 67149107463 scopus 로고    scopus 로고
    • The intense world syndrome-An alternative hypothesis for autism
    • Markram H, Rinaldi T, Markram K. The intense world syndrome-An alternative hypothesis for autism. Front Neurosci 2007; 1: 77-96.
    • (2007) Front Neurosci , vol.1 , pp. 77-96
    • Markram, H.1    Rinaldi, T.2    Markram, K.3
  • 54
    • 81555203199 scopus 로고    scopus 로고
    • Linking neurodevelopmental and synaptic theories of mental illness through DISC1
    • Brandon NJ, Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci 2011; 12: 707-722.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 707-722
    • Brandon, N.J.1    Sawa, A.2
  • 57
    • 84880688248 scopus 로고    scopus 로고
    • Optogenetic pharmacology for control of native neuronal signaling proteins
    • Kramer RH, Mourot A, Adesnik H. Optogenetic pharmacology for control of native neuronal signaling proteins. Nat Neurosci 2013; 16: 816-823.
    • (2013) Nat Neurosci , vol.16 , pp. 816-823
    • Kramer, R.H.1    Mourot, A.2    Adesnik, H.3
  • 58
    • 84995595297 scopus 로고    scopus 로고
    • Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits
    • Spangler SM, Bruchas MR. Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits. Curr Opin Pharmacol 2016; 32: 56-70.
    • (2016) Curr Opin Pharmacol , vol.32 , pp. 56-70
    • Spangler, S.M.1    Bruchas, M.R.2
  • 59
    • 84958212495 scopus 로고    scopus 로고
    • Dreadds for neuroscientists
    • Roth BL. DREADDs for neuroscientists. Neuron 2016; 89: 683-694.
    • (2016) Neuron , vol.89 , pp. 683-694
    • Roth, B.L.1
  • 60
    • 84985011825 scopus 로고    scopus 로고
    • Optical sensors to gain mechanistic insights into signaling assemblies
    • Tenner B, Mehta S, Zhang J. Optical sensors to gain mechanistic insights into signaling assemblies. Curr Opin Struct Biol 2016; 41: 203-210.
    • (2016) Curr Opin Struct Biol , vol.41 , pp. 203-210
    • Tenner, B.1    Mehta, S.2    Zhang, J.3
  • 62
    • 84975296951 scopus 로고    scopus 로고
    • Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels
    • Zhang H, Reichert E, Cohen AE. Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels. Elife 2016; 5: e15202.
    • (2016) Elife , vol.5 , pp. e15202
    • Zhang, H.1    Reichert, E.2    Cohen, A.E.3
  • 64
    • 84934442315 scopus 로고    scopus 로고
    • Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
    • Pasca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, et al. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods 2015; 12: 671-678.
    • (2015) Nat Methods , vol.12 , pp. 671-678
    • Pasca, A.M.1    Sloan, S.A.2    Clarke, L.E.3    Tian, Y.4    Makinson, C.D.5    Huber, N.6
  • 65
    • 84873282055 scopus 로고    scopus 로고
    • Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo
    • Espuny-Camacho I, Michelsen KA, Gall D, Linaro D, Hasche A, Bonnefont J, et al. Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron 2013; 77: 440-456.
    • (2013) Neuron , vol.77 , pp. 440-456
    • Espuny-Camacho, I.1    Michelsen, K.A.2    Gall, D.3    Linaro, D.4    Hasche, A.5    Bonnefont, J.6
  • 66
    • 79952690820 scopus 로고    scopus 로고
    • Annual Research Review transgenic mouse models of childhood-onset psychiatric disorders
    • Robertson HR, Feng G. Annual Research Review: transgenic mouse models of childhood-onset psychiatric disorders. J Child Psychol Psychiatry 2011; 52: 442-475.
    • (2011) J Child Psychol Psychiatry , vol.52 , pp. 442-475
    • Robertson, H.R.1    Feng, G.2
  • 67
    • 84866739960 scopus 로고    scopus 로고
    • From antipsychotic to anti-schizophrenia drugs: Role of animal models
    • Geyer MA, Olivier B, Joels M, Kahn RS. From antipsychotic to anti-schizophrenia drugs: role of animal models. Trends Pharmacol Sci 2012; 33: 515-521.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 515-521
    • Geyer, M.A.1    Olivier, B.2    Joels, M.3    Kahn, R.S.4
  • 68
    • 84855954394 scopus 로고    scopus 로고
    • DISC1 at 10: Connecting psychiatric genetics and neuroscience
    • Porteous DJ, Millar JK, Brandon NJ, Sawa A. DISC1 at 10: connecting psychiatric genetics and neuroscience. Trends Mol Med 2011; 17: 699-706.
    • (2011) Trends Mol Med , vol.17 , pp. 699-706
    • Porteous, D.J.1    Millar, J.K.2    Brandon, N.J.3    Sawa, A.4
  • 70
    • 84912059989 scopus 로고    scopus 로고
    • Computational psychiatry
    • Wang XJ, Krystal JH. Computational psychiatry. Neuron 2014; 84: 638-654.
    • (2014) Neuron , vol.84 , pp. 638-654
    • Wang, X.J.1    Krystal, J.H.2
  • 72
    • 84867634970 scopus 로고    scopus 로고
    • Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits
    • Hill SL, Wang Y, Riachi I, Schurmann F, Markram H. Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits. Proc Natl Acad Sci USA 2012; 109: E2885-E2894.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. E2885-E2894
    • Hill, S.L.1    Wang, Y.2    Riachi, I.3    Schurmann, F.4    Markram, H.5
  • 74
    • 84880654087 scopus 로고    scopus 로고
    • A biophysically detailed model of neocortical local field potentials predicts the critical role of active membrane currents
    • Reimann MW, Anastassiou CA, Perin R, Hill SL, Markram H, Koch C. A biophysically detailed model of neocortical local field potentials predicts the critical role of active membrane currents. Neuron 2013; 79: 375-390.
    • (2013) Neuron , vol.79 , pp. 375-390
    • Reimann, M.W.1    Anastassiou, C.A.2    Perin, R.3    Hill, S.L.4    Markram, H.5    Koch, C.6
  • 76
    • 84994896186 scopus 로고    scopus 로고
    • Sensorimotor gating of the startle reflex: What we said 25 years ago, what has happened since then, and what comes next
    • Swerdlow NR, Braff DL, Geyer MA. Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next. J Psychopharmacol 2016; 30: 1072-1081.
    • (2016) J Psychopharmacol , vol.30 , pp. 1072-1081
    • Swerdlow, N.R.1    Braff, D.L.2    Geyer, M.A.3
  • 77
    • 84946593489 scopus 로고    scopus 로고
    • New statistical approaches exploit the polygenic architecture of schizophrenia-implications for the underlying neurobiology
    • Schork AJ, Wang Y, Thompson WK, Dale AM, Andreassen OA. New statistical approaches exploit the polygenic architecture of schizophrenia-implications for the underlying neurobiology. Curr Opin Neurobiol 2016; 36: 89-98.
    • (2016) Curr Opin Neurobiol , vol.36 , pp. 89-98
    • Schork, A.J.1    Wang, Y.2    Thompson, W.K.3    Dale, A.M.4    Andreassen, O.A.5
  • 78
    • 84876834541 scopus 로고    scopus 로고
    • Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate
    • Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, et al. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet 2013; 9: e1003455.
    • (2013) PLoS Genet , vol.9 , pp. e1003455
    • Andreassen, O.A.1    Thompson, W.K.2    Schork, A.J.3    Ripke, S.4    Mattingsdal, M.5    Kelsoe, J.R.6
  • 79
    • 85020070074 scopus 로고    scopus 로고
    • Identification of gene loci that overlap between schizophrenia and educational attainment
    • pii: sbw085 (e-pub ahead of print
    • Le Hellard S, Wang Y, Witoelar A, Zuber V, Bettella F, Hugdahl K, et al. Identification of gene loci that overlap between schizophrenia and educational attainment. Schizophr Bull 2016: pii: sbw085 (e-pub ahead of print
    • (2016) Schizophr Bull
    • Le Hellard, S.1    Wang, Y.2    Witoelar, A.3    Zuber, V.4    Bettella, F.5    Hugdahl, K.6
  • 80
    • 84947616699 scopus 로고    scopus 로고
    • Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus
    • Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, et al. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Mol Psychiatry 2015; 20: 1588-1595.
    • (2015) Mol Psychiatry , vol.20 , pp. 1588-1595
    • Desikan, R.S.1    Schork, A.J.2    Wang, Y.3    Witoelar, A.4    Sharma, M.5    McEvoy, L.K.6
  • 81
    • 84926348812 scopus 로고    scopus 로고
    • Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: Differential involvement of immune-related gene loci
    • Andreassen OA, Harbo HF, Wang Y, Thompson WK, Schork AJ, Mattingsdal M, et al. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Mol Psychiatry 2015; 20: 207-214.
    • (2015) Mol Psychiatry , vol.20 , pp. 207-214
    • Andreassen, O.A.1    Harbo, H.F.2    Wang, Y.3    Thompson, W.K.4    Schork, A.J.5    Mattingsdal, M.6
  • 82
    • 84954561386 scopus 로고    scopus 로고
    • Identifying novel gene variants in coronary artery disease and shared genes with several cardiovascular risk factors
    • LeBlanc M, Zuber V, Andreassen BK, Witoelar A, Zeng L, Bettella F, et al. Identifying novel gene variants in coronary artery disease and shared genes with several cardiovascular risk factors. Circulation research 2016; 118: 83-94.
    • (2016) Circulation Research , vol.118 , pp. 83-94
    • LeBlanc, M.1    Zuber, V.2    Andreassen, B.K.3    Witoelar, A.4    Zeng, L.5    Bettella, F.6
  • 84
    • 84873701087 scopus 로고    scopus 로고
    • Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors
    • Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O'Donovan MC, et al. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet 2013; 92: 197-209.
    • (2013) Am J Hum Genet , vol.92 , pp. 197-209
    • Andreassen, O.A.1    Djurovic, S.2    Thompson, W.K.3    Schork, A.J.4    Kendler, K.S.5    O'Donovan, M.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.