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Volumn 12, Issue 1, 2016, Pages

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

(22)  Wang, Yunpeng a,b,c,d   Thompson, Wesley K e   Schork, Andrew J d   Holland, Dominic d   Chen, Chi Hua d,f   Bettella, Francesco a,b   Desikan, Rahul S d,f   Li, Wen a,b   Witoelar, Aree a,b   Zuber, Verena a,b   Devor, Anna c,d   Nöthen, Markus M g   Rietschel, Marcella h   Chen, Qiang i   Werge, Thomas j   Cichon, Sven k   Weinberger, Daniel R i   Djurovic, Srdjan a,b   O’Donovan, Michael l   Visscher, Peter M m   more..


Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; COVARIATE MODULATED MIXTURE MODELING; EXON; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE REPLICATION; GENE STRUCTURE; GENETIC ALGORITHM; GENETIC ASSOCIATION; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MATHEMATICAL ANALYSIS; MOLECULAR GENETICS; PHENOTYPE; PLEIOTROPY; PROBABILITY; QUANTITATIVE TRAIT LOCUS; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMAN GENOME;

EID: 84958730027     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005803     Document Type: Article
Times cited : (32)

References (34)
  • 1
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies
    • Sullivan PF, Kendler KS, Neale MC, Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Archives of General Psychiatry. 2003;60(12):1187–92. 14662550
    • (2003) Archives of General Psychiatry , vol.60 , Issue.12 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 2
    • 84885020424 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies 13 new risk loci for schizophrenia
    • Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler AK, Akterin S, et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature genetics. 2013;45(10):1150–9. doi: 10.1038/ng.2742 23974872
    • (2013) Nature genetics , vol.45 , Issue.10 , pp. 1150-1159
    • Ripke, S.1    O'Dushlaine, C.2    Chambert, K.3    Moran, J.L.4    Kähler, A.K.5    Akterin, S.6
  • 3
    • 77957914609 scopus 로고    scopus 로고
    • The psychiatric GWAS consortium: big science comes to psychiatry
    • Sullivan PF, The psychiatric GWAS consortium: big science comes to psychiatry. Neuron. 2010;68(2):182–6. doi: 10.1016/j.neuron.2010.10.003 20955924
    • (2010) Neuron , vol.68 , Issue.2 , pp. 182-186
    • Sullivan, P.F.1
  • 4
    • 84862777863 scopus 로고    scopus 로고
    • Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    • Lee SH, DeCandia TR, Ripke S, Yang J, Sullivan PF, Goddard ME, et al. Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nature Genetics. 2012;44(3):247–50. doi: 10.1038/ng.1108 22344220
    • (2012) Nature Genetics , vol.44 , Issue.3 , pp. 247-250
    • Lee, S.H.1    DeCandia, T.R.2    Ripke, S.3    Yang, J.4    Sullivan, P.F.5    Goddard, M.E.6
  • 5
    • 84876847154 scopus 로고    scopus 로고
    • All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs
    • Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, et al. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS genetics. 2013;9(4):e1003449. doi: 10.1371/journal.pgen.1003449 23637621
    • (2013) PLoS genetics , vol.9 , Issue.4 , pp. e1003449
    • Schork, A.J.1    Thompson, W.K.2    Pham, P.3    Torkamani, A.4    Roddey, J.C.5    Sullivan, P.F.6
  • 6
    • 84892659999 scopus 로고    scopus 로고
    • Boosting the power of schizophrenia genetics by leveraging new statistical tools
    • Andreassen OA, Thompson WK, Dale AM, Boosting the power of schizophrenia genetics by leveraging new statistical tools. Schizophrenia bulletin. 2014;40(1):13–7. doi: 10.1093/schbul/sbt168 24319118
    • (2014) Schizophrenia bulletin , vol.40 , Issue.1 , pp. 13-17
    • Andreassen, O.A.1    Thompson, W.K.2    Dale, A.M.3
  • 7
    • 80053385384 scopus 로고    scopus 로고
    • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
    • Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N, et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nature Genetics. 2011;43(10):977. doi: 10.1038/ng.943 21926972
    • (2011) Nature Genetics , vol.43 , Issue.10 , pp. 977
    • Sklar, P.1    Ripke, S.2    Scott, L.J.3    Andreassen, O.A.4    Cichon, S.5    Craddock, N.6
  • 8
    • 84876834541 scopus 로고    scopus 로고
    • Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate
    • Andreassen OA, Thompson WK, Schork AJ, Ripke S, Mattingsdal M, Kelsoe JR, et al. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genetics. 2013;9(4):e1003455. doi: 10.1371/journal.pgen.1003455 23637625
    • (2013) PLoS Genetics , vol.9 , Issue.4 , pp. e1003455
    • Andreassen, O.A.1    Thompson, W.K.2    Schork, A.J.3    Ripke, S.4    Mattingsdal, M.5    Kelsoe, J.R.6
  • 9
    • 84873701087 scopus 로고    scopus 로고
    • Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors
    • Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O’Donovan MC, et al. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. The American Journal of Human Genetics. 2013;92(2):197–209. doi: 10.1016/j.ajhg.2013.01.001 23375658
    • (2013) The American Journal of Human Genetics , vol.92 , Issue.2 , pp. 197-209
    • Andreassen, O.A.1    Djurovic, S.2    Thompson, W.K.3    Schork, A.J.4    Kendler, K.S.5    O’Donovan, M.C.6
  • 10
    • 84876668464 scopus 로고    scopus 로고
    • The ENCODE project: implications for psychiatric genetics
    • Kavanagh D, Dwyer S, O'Donovan M, Owen M, The ENCODE project: implications for psychiatric genetics. Molecular psychiatry. 2013;18(5):540–2. doi: 10.1038/mp.2013.13 23478746
    • (2013) Molecular psychiatry , vol.18 , Issue.5 , pp. 540-542
    • Kavanagh, D.1    Dwyer, S.2    O'Donovan, M.3    Owen, M.4
  • 11
    • 84904804929 scopus 로고    scopus 로고
    • Schizophrenia Working Group of the Psychiatry Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatry Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;(511):421–7.
    • (2014) Nature , Issue.511 , pp. 421-427
  • 12
    • 77955894071 scopus 로고    scopus 로고
    • METAL: fast and efficient meta-analysis of genomewide association scans
    • Willer CJ, Li Y, Abecasis GR, METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26(17):2190–1. doi: 10.1093/bioinformatics/btq340 20616382
    • (2010) Bioinformatics , vol.26 , Issue.17 , pp. 2190-2191
    • Willer, C.J.1    Li, Y.2    Abecasis, G.R.3
  • 15
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nature Genetics. 2010;42(12):1118–25. doi: 10.1038/ng.717 21102463
    • (2010) Nature Genetics , vol.42 , Issue.12 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3    Wang, K.4    Radford-Smith, G.L.5    Ahmad, T.6
  • 16
    • 84904959814 scopus 로고    scopus 로고
    • Covariate-modulated local false discovery rate for genome-wide association studies
    • Zablocki RW, Schork AJ, Levine RA, Andreassen OA, Dale AM, Thompson WK, Covariate-modulated local false discovery rate for genome-wide association studies. Bioinformatics. 2014;30(15):2098–104. doi: 10.1093/bioinformatics/btu145 24711653
    • (2014) Bioinformatics , vol.30 , Issue.15 , pp. 2098-2104
    • Zablocki, R.W.1    Schork, A.J.2    Levine, R.A.3    Andreassen, O.A.4    Dale, A.M.5    Thompson, W.K.6
  • 19
    • 84874783818 scopus 로고    scopus 로고
    • Polygenic modeling with bayesian sparse linear mixed models
    • Zhou X, Carbonetto P, Stephens M, Polygenic modeling with bayesian sparse linear mixed models. PLoS Genetics. 2013;9(2):e1003264. doi: 10.1371/journal.pgen.1003264 23408905
    • (2013) PLoS Genetics , vol.9 , Issue.2 , pp. e1003264
    • Zhou, X.1    Carbonetto, P.2    Stephens, M.3
  • 20
    • 33747595466 scopus 로고    scopus 로고
    • Stratified false discovery control for large‐scale hypothesis testing with application to genome‐wide association studies
    • Sun L, Craiu RV, Paterson AD, Bull SB, Stratified false discovery control for large‐scale hypothesis testing with application to genome‐wide association studies. Genetic epidemiology. 2006;30(6):519–30. 16800000
    • (2006) Genetic epidemiology , vol.30 , Issue.6 , pp. 519-530
    • Sun, L.1    Craiu, R.V.2    Paterson, A.D.3    Bull, S.B.4
  • 21
    • 59249086642 scopus 로고    scopus 로고
    • Learning a prior on regulatory potential from eQTL data
    • Lee S-I, Dudley AM, Drubin D, Silver PA, Krogan NJ, Pe'er D, et al. Learning a prior on regulatory potential from eQTL data. PLoS Genetics. 2009;5(1):e1000358. doi: 10.1371/journal.pgen.1000358 19180192
    • (2009) PLoS Genetics , vol.5 , Issue.1 , pp. e1000358
    • Lee, S.-I.1    Dudley, A.M.2    Drubin, D.3    Silver, P.A.4    Krogan, N.J.5    Pe'er, D.6
  • 22
    • 84898723939 scopus 로고    scopus 로고
    • Joint analysis of functional genomic data and genome-wide association studies of 18 human traits
    • Pickrell JK, Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. The American Journal of Human Genetics. 2014;94(4):559–73. doi: 10.1016/j.ajhg.2014.03.004 24702953
    • (2014) The American Journal of Human Genetics , vol.94 , Issue.4 , pp. 559-573
    • Pickrell, J.K.1
  • 23
    • 84863536292 scopus 로고    scopus 로고
    • Incorporating prior information into association studies
    • Darnell G, Duong D, Han B, Eskin E, Incorporating prior information into association studies. Bioinformatics. 2012;28(12):i147–i53. doi: 10.1093/bioinformatics/bts235 22689754
    • (2012) Bioinformatics , vol.28 , Issue.12 , pp. 147-153
    • Darnell, G.1    Duong, D.2    Han, B.3    Eskin, E.4
  • 24
    • 41649101685 scopus 로고    scopus 로고
    • Increasing power in association studies by using linkage disequilibrium structure and molecular function as prior information
    • Eskin E, Increasing power in association studies by using linkage disequilibrium structure and molecular function as prior information. Genome Research. 2008;18(4):653–60. doi: 10.1101/gr.072785.107 18353808
    • (2008) Genome Research , vol.18 , Issue.4 , pp. 653-660
    • Eskin, E.1
  • 26
    • 80053384370 scopus 로고    scopus 로고
    • Genome-wide association study identifies five new schizophrenia loci
    • Schizophrenia Psychiatry Genome-Wide Association Study (GWAS) ConsortiumGenome-wide association study identifies five new schizophrenia loci. Nature Genetics. 2011;43(10):969–76. doi: 10.1038/ng.940 21926974
    • (2011) Nature Genetics , vol.43 , Issue.10 , pp. 969-976
  • 27
    • 84888317489 scopus 로고    scopus 로고
    • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    • Lambert J-C, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 2013; 45(12):1452–8. doi: 10.1038/ng.2802 24162737
    • (2013) Nature Genetics , vol.45 , Issue.12 , pp. 1452-1458
    • Lambert, J.-C.1    Ibrahim-Verbaas, C.A.2    Harold, D.3    Naj, A.C.4    Sims, R.5    Bellenguez, C.6
  • 28
    • 84873086126 scopus 로고    scopus 로고
    • Chromatin marks identify critical cell types for fine mapping complex trait variants
    • Trynka G, Sandor C, Han B, Xu H, Stranger BE, Liu XS, et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nature genetics. 2013;45(2):124–30. doi: 10.1038/ng.2504 23263488
    • (2013) Nature genetics , vol.45 , Issue.2 , pp. 124-130
    • Trynka, G.1    Sandor, C.2    Han, B.3    Xu, H.4    Stranger, B.E.5    Liu, X.S.6
  • 29
    • 84926348812 scopus 로고    scopus 로고
    • Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci
    • Andreassen O, Harbo H, Wang Y, Thompson W, Schork A, Mattingsdal M, et al. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular psychiatry. 2014:1–8. Epub 28 January 2014. doi: 10.1038/mp.2013.195
    • Molecular psychiatry , vol.2014 , pp. 1-8
    • Andreassen, O.1    Harbo, H.2    Wang, Y.3    Thompson, W.4    Schork, A.5    Mattingsdal, M.6
  • 31
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D, Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics. 2006;38(8):904–9. 16862161
    • (2006) Nature Genetics , vol.38 , Issue.8 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 32
    • 84863845193 scopus 로고    scopus 로고
    • Genotype imputation with thousands of genomes. G3: Genes, Genomes
    • Howie B, Marchini J, Stephens M, Genotype imputation with thousands of genomes. G3: Genes, Genomes, Genetics. 2011;1(6):457–70.
    • (2011) Genetics , vol.1 , Issue.6 , pp. 457-470
    • Howie, B.1    Marchini, J.2    Stephens, M.3
  • 33
    • 84856478855 scopus 로고    scopus 로고
    • A linear complexity phasing method for thousands of genomes
    • Delaneau O, Marchini J, Zagury J-F, A linear complexity phasing method for thousands of genomes. Nature Methods. 2012;9(2):179–81.
    • (2012) Nature Methods , vol.9 , Issue.2 , pp. 179-181
    • Delaneau, O.1    Marchini, J.2    Zagury, J.-F.3


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