Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

Molecular Cell

Volumn 66, Issue 1, 2017, Pages 154-162.e10

  Xiao, Xu ^a   Tang, Jing Jie ^a   Peng, Chao ^a,d   Wang, Yan ^c   Fu, Lin ^a   Qiu, Zhi Ping ^b   Xiong, Yue ^a   Yang, Lian Fang ^c   Cui, Hai Wei ^c   He, Xiao Long ^c   Yin, Lei ^b   Qi, Wei ^a   Wong, Catherine C L ^a,d   Zhao, Yun ^a   Li, Bo Liang ^a   Qiu, Wen Wei ^c   Song, Bao Liang ^b  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b WUHAN UNIVERSITY   (China)

^c EAST CHINA NORMAL UNIVERSITY   (China)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

cholesterol; cholesterylation; ciliary localization; click chemistry; cysteine rich domain; embryonic lethal; Hedgehog; Patched 1; primary cilia; Smoothened

Indexed keywords

CHOLESTEROL; G PROTEIN COUPLED RECEPTOR; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; PTCH1 PROTEIN, MOUSE; SHH PROTEIN, MOUSE; SMO PROTEIN, HUMAN; SMO PROTEIN, MOUSE;

3T3 CELL LINE; ANIMAL CELL; ARTICLE; CHO CELL LINE; CHOLESTEROL SYNTHESIS; CLICK CHEMISTRY; CONTROLLED STUDY; EMBRYO; GENE OVEREXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; ANIMAL; CILIUM; CONGENITAL HEART MALFORMATION; CRICETULUS; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; METABOLISM; MUTATION; NIH 3T3 CELL LINE; PHENOTYPE; PROTEIN PROCESSING; RNA INTERFERENCE; TRANSGENIC MOUSE;

ANIMALS; CHO CELLS; CHOLESTEROL; CILIA; CRICETULUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC PREDISPOSITION TO DISEASE; HEART DEFECTS, CONGENITAL; HEDGEHOG PROTEINS; HEK293 CELLS; HUMANS; MICE; MICE, TRANSGENIC; MUTATION; NIH 3T3 CELLS; PATCHED-1 RECEPTOR; PHENOTYPE; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOOTHENED RECEPTOR; TRANSFECTION;

EID: 85016062049     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.02.015     Document Type: Article

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