Demethylase Kdm6a epigenetically promotes IL-6 and IFN-β production in macrophages

Journal of Autoimmunity

Volumn 80, Issue , 2017, Pages 85-94

  Li, Xia ^a,b   Zhang, Qian ^c   Shi, Qingzhu ^d   Liu, Yin ^a   Zhao, Kai ^a   Shen, Qicong ^c   Shi, Yang ^d   Liu, Xingguang ^c   Wang, Chunmei ^a   Li, Nan ^c   Ma, Yuanfang ^b   Cao, Xuetao ^a,c,d  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b HENAN UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

H3K27me3; IFN ; IL 6; Inflammation; Kdm6a; Macrophages

Indexed keywords

BETA INTERFERON; COMPLEMENTARY DNA; DEMETHYLASE KDM6A; ENHANCER DERIVED RNA S IRE1; INTERLEUKIN 6; METHYLTRANSFERASE; RNA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; HISTONE; HISTONE DEMETHYLASE; HISTONE LYSINE METHYLTRANSFERASE; MLL4 PROTEIN, MOUSE; UTX PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENHANCER REGION; ENZYME ACTIVITY; EPIGENETICS; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETIC VARIATION; HUMAN; HUMAN CELL; IFNB1 GENE; INNATE IMMUNITY; LIMIT OF QUANTITATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; ANIMAL; C57BL MOUSE; CELL CULTURE; DNA METHYLATION; GENETIC EPIGENESIS; GENETICS; MAPK SIGNALING; METABOLISM; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; DNA METHYLATION; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; HISTONE DEMETHYLASES; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; IMMUNITY, INNATE; INTERFERON-BETA; INTERLEUKIN-6; MACROPHAGES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC;

EID: 85015796997     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2017.02.007     Document Type: Article

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