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Volumn 9, Issue 4, 2017, Pages 347-360

Recent progress in GM-CSF-based cancer immunotherapy

Author keywords

Cancer immunotherapy; GM CSF; vaccine

Indexed keywords

CANCER VACCINE; DNA VACCINE; DOCETAXEL; FLUOROURACIL; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; IMATINIB; IPILIMUMAB; MITUMPROTIMUT T; MONTANIDE ISA 51; ONCOLYTIC HERPES VIRUS; OXALIPLATIN; PLACEBO; PREDNISONE; SARGRAMOSTIM; SIPULEUCEL T; TALIMOGENE LAHERPAREPVEC; TUMOR ANTIGEN;

EID: 85015727480     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt-2016-0141     Document Type: Review
Times cited : (161)

References (88)
  • 1
    • 77049151988 scopus 로고
    • A review of the influence of bacterial infection and of bacterial products (Coley's toxins) on malignant tumors in man; A critical analysis of 30 inoperable cases treated by Coley's mixed toxins, in which diagnosis was confirmed by microscopic examination selected for special study
    • Nauts HC, Fowler GA, Bogatko FH. A review of the influence of bacterial infection and of bacterial products (Coley's toxins) on malignant tumors in man; a critical analysis of 30 inoperable cases treated by Coley's mixed toxins, in which diagnosis was confirmed by microscopic examination selected for special study. Acta. Med. Scand. Suppl. 276, 1-103 (1953).
    • (1953) Acta. Med. Scand. Suppl. , vol.276 , pp. 1-103
    • Nauts, H.C.1    Fowler, G.A.2    Bogatko, F.H.3
  • 2
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature 480(7378), 480-489 (2011).
    • (2011) Nature , vol.480 , Issue.7378 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 3
    • 69549103141 scopus 로고    scopus 로고
    • Feedback control of regulatory T cell homeostasis by dendritic cells in vivo
    • Darrasse-Jeze G, Deroubaix S, Mouquet H, et al. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J. Exp. Med. 206(9), 1853-1862 (2009).
    • (2009) J. Exp. Med. , vol.206 , Issue.9 , pp. 1853-1862
    • Darrasse-Jeze, G.1    Deroubaix, S.2    Mouquet, H.3
  • 4
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, long-lasting anti-tumor immunity
    • Dranoff G, Jaffee E, Lazenby A, et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, long-lasting anti-tumor immunity. Proc. Natl Acad. Sci. USA 90(8), 3539-3543 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , Issue.8 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3
  • 5
    • 0034047619 scopus 로고    scopus 로고
    • Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand
    • Mach N, Gillessen S, Wilson SB, Sheehan C, Mihm M, Dranoff G. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. 60(12), 3239-3246 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.12 , pp. 3239-3246
    • MacH, N.1    Gillessen, S.2    Wilson, S.B.3    Sheehan, C.4    Mihm, M.5    Dranoff, G.6
  • 6
    • 70349336496 scopus 로고    scopus 로고
    • The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease
    • Hercus TR, Thomas D, Guthridge MA, et al. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood 114(7), 1289-1298 (2009).
    • (2009) Blood , vol.114 , Issue.7 , pp. 1289-1298
    • Hercus, T.R.1    Thomas, D.2    Guthridge, M.A.3
  • 8
    • 38349157811 scopus 로고    scopus 로고
    • Hematopoietic cytokines
    • Metcalf D. Hematopoietic cytokines. Blood 111(2), 485-491 (2008).
    • (2008) Blood , vol.111 , Issue.2 , pp. 485-491
    • Metcalf, D.1
  • 9
    • 77952921841 scopus 로고    scopus 로고
    • The colony-stimulating factors and cancer
    • Metcalf D. The colony-stimulating factors and cancer. Nat. Rev. Cancer 10(6), 425-434 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.6 , pp. 425-434
    • Metcalf, D.1
  • 10
    • 0034234607 scopus 로고    scopus 로고
    • Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but notCD11b(low)CD11c(high) murine dendritic cells in vivo: A comparative analysis with Flt3 ligand
    • Daro E, Pulendran B, Brasel K, et al. Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but notCD11b(low)CD11c(high) murine dendritic cells in vivo: a comparative analysis with Flt3 ligand. J. Immunol. 165(1), 49-58 (2000).
    • (2000) J. Immunol. , vol.165 , Issue.1 , pp. 49-58
    • Daro, E.1    Pulendran, B.2    Brasel, K.3
  • 11
    • 0031013082 scopus 로고    scopus 로고
    • The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs
    • Vremec D, Lieschke GJ, Dunn AR, Robb L, Metcalf D, Shortman K. The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur. J. Immunol. 27(1), 40-44 (1997).
    • (1997) Eur. J. Immunol. , vol.27 , Issue.1 , pp. 40-44
    • Vremec, D.1    Lieschke, G.J.2    Dunn, A.R.3    Robb, L.4    Metcalf, D.5    Shortman, K.6
  • 12
    • 77952310536 scopus 로고    scopus 로고
    • GM-CSF-dependent CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization
    • King IL, Kroenke MA, Segal BM. GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization. J. Exp. Med. 207(5), 953-961 (2010).
    • (2010) J. Exp. Med. , vol.207 , Issue.5 , pp. 953-961
    • King, I.L.1    Kroenke, M.A.2    Segal, B.M.3
  • 13
    • 84999779395 scopus 로고    scopus 로고
    • GM-CSF: From growth factor to central mediator of tissue inflammation
    • Becher B, Tugues S, Greter M. GM-CSF: from growth factor to central mediator of tissue inflammation. Immunity 45(5), 963-973 (2016).
    • (2016) Immunity , vol.45 , Issue.5 , pp. 963-973
    • Becher, B.1    Tugues, S.2    Greter, M.3
  • 14
    • 84859837162 scopus 로고    scopus 로고
    • Regulation of dendritic cell development by GM-CSF: Molecular control and implications for immune homeostasis and therapy
    • Van De Laar L, Coffer PJ, Woltman AM. Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood 119(15), 3383-3393 (2012).
    • (2012) Blood , vol.119 , Issue.15 , pp. 3383-3393
    • Van De Laar, L.1    Coffer, P.J.2    Woltman, A.M.3
  • 15
    • 84907980704 scopus 로고    scopus 로고
    • In situ modulation of dendritic cells by injectable thermosensitive hydrogels for cancer vaccines in mice
    • Liu Y, Xiao L, Joo KI, Hu B, Fang J, Wang P. In situ modulation of dendritic cells by injectable thermosensitive hydrogels for cancer vaccines in mice. Biomacromolecules 15(10), 3836-3845 (2014).
    • (2014) Biomacromolecules , vol.15 , Issue.10 , pp. 3836-3845
    • Liu, Y.1    Xiao, L.2    Joo, K.I.3    Hu, B.4    Fang, J.5    Wang, P.6
  • 16
    • 84961289256 scopus 로고    scopus 로고
    • Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy
    • Kim J, Li WA, Choi Y, et al. Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy. Nat. Biotechnol. 33(1), 64-72 (2015).
    • (2015) Nat. Biotechnol. , vol.33 , Issue.1 , pp. 64-72
    • Kim, J.1    Li, W.A.2    Choi, Y.3
  • 17
    • 79957879852 scopus 로고    scopus 로고
    • PROVENGE (Sipuleucel-T) in prostate cancer: The first FDA-approved therapeutic cancer vaccine
    • Cheever MA, Higano CS. PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine. Clin. Cancer Res. 17(11), 3520-3526 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.11 , pp. 3520-3526
    • Cheever, M.A.1    Higano, C.S.2
  • 18
    • 84919662329 scopus 로고    scopus 로고
    • Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer
    • Fong L, Carroll P, Weinberg V, et al. Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer. J. Natl Cancer Inst. 106(11), dju268 (2014).
    • (2014) J. Natl Cancer Inst. , vol.106 , Issue.11 , pp. dju268
    • Fong, L.1    Carroll, P.2    Weinberg, V.3
  • 19
    • 0033023432 scopus 로고    scopus 로고
    • Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands
    • Murtaza A, Kuchroo VK, Freeman GJ. Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands. Int. Immunol. 11(3), 407-416 (1999).
    • (1999) Int. Immunol. , vol.11 , Issue.3 , pp. 407-416
    • Murtaza, A.1    Kuchroo, V.K.2    Freeman, G.J.3
  • 20
    • 0035884974 scopus 로고    scopus 로고
    • Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells
    • Metelitsa LS, Naidenko OV, Kant A, et al. Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells. J. Immunol. 167(6), 3114-3122 (2001).
    • (2001) J. Immunol. , vol.167 , Issue.6 , pp. 3114-3122
    • Metelitsa, L.S.1    Naidenko, O.V.2    Kant, A.3
  • 21
    • 0022974714 scopus 로고
    • Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines
    • Ruff MR, Farrar WL, Pert CB. Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines. Proc. Natl Acad. Sci. USA 83(17), 6613-6617 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , Issue.17 , pp. 6613-6617
    • Ruff, M.R.1    Farrar, W.L.2    Pert, C.B.3
  • 22
    • 0024459863 scopus 로고
    • Antiproliferative and differentiative effect of granulocyte-macrophage colony-stimulating factor on a variant human small-cell lung cancer cell line
    • Yamashita Y, Nara N, Aoki N. Antiproliferative and differentiative effect of granulocyte-macrophage colony-stimulating factor on a variant human small-cell lung cancer cell line. Cancer Res. 49(19), 5334-5338 (1989).
    • (1989) Cancer Res. , vol.49 , Issue.19 , pp. 5334-5338
    • Yamashita, Y.1    Nara, N.2    Aoki, N.3
  • 23
    • 84871960166 scopus 로고    scopus 로고
    • Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors
    • Urdinguio RG, Fernandez AF, Moncada-Pazos A, et al. Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res. 73(1), 395-405 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.1 , pp. 395-405
    • Urdinguio, R.G.1    Fernandez, A.F.2    Moncada-Pazos, A.3
  • 24
    • 0033998594 scopus 로고    scopus 로고
    • Adjuvant therapy of stage III and IV malignant melanoma using granulocyte-macrophage colony-stimulating factor
    • Spitler LE, Grossbard ML, Ernstoff MS, et al. Adjuvant therapy of stage III and IV malignant melanoma using granulocyte-macrophage colony-stimulating factor. J. Clin. Oncol. 18(8), 1614-1621 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , Issue.8 , pp. 1614-1621
    • Spitler, L.E.1    Grossbard, M.L.2    Ernstoff, M.S.3
  • 25
    • 67651151520 scopus 로고    scopus 로고
    • Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, sargramostim) administered for 3 years as adjuvant therapy of stages II( T4 III, IV melanoma
    • Spitler LE, Weber RW, Allen RE, et al. Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, sargramostim) administered for 3 years as adjuvant therapy of stages II(T4), III, IV melanoma. J. Immunother. 32(6), 632-637 (2009).
    • (2009) J. Immunother. , vol.32 , Issue.6 , pp. 632-637
    • Spitler, L.E.1    Weber, R.W.2    Allen, R.E.3
  • 26
    • 84951828193 scopus 로고    scopus 로고
    • Randomized, placebo-Controlled, Phase III trial of yeast-Derived granulocyte-macrophage colony-stimulating factor (GM-CSF) versus peptide vaccination versus GM-CSF plus peptide vaccination versus placebo in patients with no evidence of disease after complete surgical resection of locally advanced and/or stage IV melanoma
    • A trial of the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group (E4697)
    • Lawson DH, Lee S, Zhao F, et al. Randomized, placebo-controlled, Phase III trial of yeast-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) versus peptide vaccination versus GM-CSF plus peptide vaccination versus placebo in patients with no evidence of disease after complete surgical resection of locally advanced and/or stage IV melanoma: a trial of the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group (E4697). J. Clin. Oncol. 33(34), 4066-4076 (2015).
    • (2015) J. Clin. Oncol , vol.33 , Issue.34 , pp. 4066-4076
    • Lawson, D.H.1    Lee, S.2    Zhao, F.3
  • 27
    • 0032886907 scopus 로고    scopus 로고
    • Intradermal injection of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with metastatic melanoma recruits dendritic cells
    • Nasi ML, Lieberman P, Busam KJ, et al. Intradermal injection of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with metastatic melanoma recruits dendritic cells. Cytokines Cell. Mol. Ther. 5(3), 139-144 (1999).
    • (1999) Cytokines Cell. Mol. Ther. , vol.5 , Issue.3 , pp. 139-144
    • Nasi, M.L.1    Lieberman, P.2    Busam, K.J.3
  • 28
    • 0034294865 scopus 로고    scopus 로고
    • Tumor growth inhibition by intratumoral inoculation of defective herpes simplex virus vectors expressing granulocyte-macrophage colony-stimulating factor
    • Toda M, Martuza RL, Rabkin SD. Tumor growth inhibition by intratumoral inoculation of defective herpes simplex virus vectors expressing granulocyte-macrophage colony-stimulating factor. Mol. Ther. 2(4), 324-329 (2000).
    • (2000) Mol. Ther. , vol.2 , Issue.4 , pp. 324-329
    • Toda, M.1    Martuza, R.L.2    Rabkin, S.D.3
  • 29
    • 0026539149 scopus 로고
    • The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells
    • Chou J, Roizman B. The gamma 1(34. 5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells. Proc. Natl Acad. Sci. USA 89(8), 3266-3270 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , Issue.8 , pp. 3266-3270
    • Chou, J.1    Roizman, B.2
  • 30
    • 0037295403 scopus 로고    scopus 로고
    • ICP34. 5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, anti-tumour properties
    • Liu BL, Robinson M, Han ZQ, et al. ICP34. 5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, anti-tumour properties. Gene Ther. 10(4), 292-303 (2003).
    • (2003) Gene Ther. , vol.10 , Issue.4 , pp. 292-303
    • Liu, B.L.1    Robinson, M.2    Han, Z.Q.3
  • 31
    • 0029069681 scopus 로고
    • A viral inhibitor of peptide transporters for antigen presentation
    • Fruh K, Ahn K, Djaballah H, et al. A viral inhibitor of peptide transporters for antigen presentation. Nature 375(6530), 415-418 (1995).
    • (1995) Nature , vol.375 , Issue.6530 , pp. 415-418
    • Fruh, K.1    Ahn, K.2    Djaballah, H.3
  • 32
    • 0028283971 scopus 로고
    • A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes
    • York IA, Roop C, Andrews DW, Riddell SR, Graham FL, Johnson DC. A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell 77(4), 525-535 (1994).
    • (1994) Cell , vol.77 , Issue.4 , pp. 525-535
    • York, I.A.1    Roop, C.2    Andrews, D.W.3    Riddell, S.R.4    Graham, F.L.5    Johnson, D.C.6
  • 33
    • 33845336115 scopus 로고    scopus 로고
    • A Phase i study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor
    • Hu JC, Coffin RS, Davis CJ, et al. A Phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor. Clin. Cancer Res. 12(22), 6737-6747 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.22 , pp. 6737-6747
    • Hu, J.C.1    Coffin, R.S.2    Davis, C.J.3
  • 34
    • 84933586864 scopus 로고    scopus 로고
    • Talimogene laherparepvec improves durable response rate in patients with advanced melanoma
    • Andtbacka RH, Kaufman HL, Collichio F, et al. Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J. Clin. Oncol. 33(25), 2780-2788 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , Issue.25 , pp. 2780-2788
    • Andtbacka, R.H.1    Kaufman, H.L.2    Collichio, F.3
  • 35
    • 84977111376 scopus 로고    scopus 로고
    • Current status of granulocyte-macrophage colony-stimulating factor in the immunotherapy of melanoma
    • Kaufman HL, Ruby CE, Hughes T, Slingluff CL Jr. Current status of granulocyte-macrophage colony-stimulating factor in the immunotherapy of melanoma. J. Immunother. Cancer 2, 11 (2014).
    • (2014) J. Immunother. Cancer , vol.2 , pp. 11
    • Kaufman, H.L.1    Ruby, C.E.2    Hughes, T.3    Slingluff, C.L.4
  • 36
    • 84884594361 scopus 로고    scopus 로고
    • OPTiM: A randomized Phase III trial of talimogene laherparepvec (T-VEC) versus subcutaneous (SC) granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanoma
    • SUPPL
    • Collichio FA, Amatruda T, Senzer NN, et al. OPTiM: a randomized Phase III trial of talimogene laherparepvec (T-VEC) versus subcutaneous (SC) granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanoma. J. Clin. Oncol. 31(18 Suppl. ), LBA9008 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.18 , pp. LBA9008
    • Collichio, F.A.1    Amatruda, T.2    Senzer, N.N.3
  • 37
    • 84902173191 scopus 로고    scopus 로고
    • The 'Trojan Horse' approach to tumor immunotherapy: Targeting the tumor microenvironment
    • Nelson D, Fisher S, Robinson B. The 'Trojan Horse' approach to tumor immunotherapy: targeting the tumor microenvironment. J. Immunol. Res. 2014, 789069 (2014).
    • (2014) J. Immunol. Res. , vol.2014 , pp. 789069
    • Nelson, D.1    Fisher, S.2    Robinson, B.3
  • 38
    • 58149230993 scopus 로고    scopus 로고
    • A dose-escalation study of aerosolized sargramostim in the treatment of metastatic melanoma: An NCCTG Study
    • Markovic SN, Suman VJ, Nevala WK, et al. A dose-escalation study of aerosolized sargramostim in the treatment of metastatic melanoma: an NCCTG Study. Am. J. Clin. Oncol. 31(6), 573-579 (2008).
    • (2008) Am. J. Clin. Oncol. , vol.31 , Issue.6 , pp. 573-579
    • Markovic, S.N.1    Suman, V.J.2    Nevala, W.K.3
  • 39
    • 77955122716 scopus 로고    scopus 로고
    • Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: Effects on disease-free survival and immunomodulation
    • A report from the Children's Oncology Group
    • Arndt CA, Koshkina NV, Inwards CY, et al. Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: effects on disease-free survival and immunomodulation. A report from the Children's Oncology Group. Clin. Cancer Res. 16(15), 4024-4030 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.15 , pp. 4024-4030
    • Arndt, C.A.1    Koshkina, N.V.2    Inwards, C.Y.3
  • 40
    • 77953720628 scopus 로고    scopus 로고
    • In situ regulation of DC subsets and T cells mediates tumor regression in mice
    • Ali OA, Emerich D, Dranoff G, Mooney DJ. In situ regulation of DC subsets and T cells mediates tumor regression in mice. Sci. Transl. Med. 1(8), 8ra19 (2009).
    • (2009) Sci. Transl. Med. , vol.1 , Issue.8 , pp. 8ra19
    • Ali, O.A.1    Emerich, D.2    Dranoff, G.3    Mooney, D.J.4
  • 41
    • 69249203628 scopus 로고    scopus 로고
    • Role of GM-CSF signaling in cell-based tumor immunization
    • Zarei S, Schwenter F, Luy P, et al. Role of GM-CSF signaling in cell-based tumor immunization. Blood 113(26), 6658-6668 (2009).
    • (2009) Blood , vol.113 , Issue.26 , pp. 6658-6668
    • Zarei, S.1    Schwenter, F.2    Luy, P.3
  • 42
    • 84879066269 scopus 로고    scopus 로고
    • An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma
    • Reardon DA, Wucherpfennig KW, Freeman G, et al. An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev. Vaccines 12(6), 597-615 (2013).
    • (2013) Expert Rev. Vaccines , vol.12 , Issue.6 , pp. 597-615
    • Reardon, D.A.1    Wucherpfennig, K.W.2    Freeman, G.3
  • 44
    • 84924933672 scopus 로고    scopus 로고
    • Immunology of chronic myeloid leukemia: Current concepts and future goals
    • Vonka V, Petrackova M. Immunology of chronic myeloid leukemia: current concepts and future goals. Expert Rev. Clin. Immunol. 11(4), 511-522 (2015).
    • (2015) Expert Rev. Clin. Immunol. , vol.11 , Issue.4 , pp. 511-522
    • Vonka, V.1    Petrackova, M.2
  • 46
    • 75149121612 scopus 로고    scopus 로고
    • K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate
    • Smith BD, Kasamon YL, Kowalski J, et al. K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate. Clin. Cancer Res. 16(1), 338-347 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.1 , pp. 338-347
    • Smith, B.D.1    Kasamon, Y.L.2    Kowalski, J.3
  • 47
    • 79151486551 scopus 로고    scopus 로고
    • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, immune activation
    • Lutz E, Yeo CJ, Lillemoe KD, et al. A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, immune activation. Ann. Surg. 253(2), 328-335 (2011).
    • (2011) Ann. Surg. , vol.253 , Issue.2 , pp. 328-335
    • Lutz, E.1    Yeo, C.J.2    Lillemoe, K.D.3
  • 48
    • 4644299284 scopus 로고    scopus 로고
    • Phase i study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: Clinical and immunological findings
    • Tani K, Azuma M, Nakazaki Y, et al. Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings. Mol. Ther. 10(4), 799-816 (2004).
    • (2004) Mol. Ther. , vol.10 , Issue.4 , pp. 799-816
    • Tani, K.1    Azuma, M.2    Nakazaki, Y.3
  • 49
    • 33646776056 scopus 로고    scopus 로고
    • Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer
    • Nemunaitis J, Jahan T, Ross H, et al. Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer. Cancer Gene Ther. 13(6), 555-562 (2006).
    • (2006) Cancer Gene Ther. , vol.13 , Issue.6 , pp. 555-562
    • Nemunaitis, J.1    Jahan, T.2    Ross, H.3
  • 50
    • 84936933733 scopus 로고    scopus 로고
    • Safety and immunologic correlates of melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting
    • Lipson EJ, Sharfman WH, Chen S, et al. Safety and immunologic correlates of melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting. J. Transl. Med. 13, 214 (2015).
    • (2015) J. Transl. Med. , vol.13 , pp. 214
    • Lipson, E.J.1    Sharfman, W.H.2    Chen, S.3
  • 51
    • 77958006456 scopus 로고    scopus 로고
    • Cellular vaccine approaches
    • Le DT, Pardoll DM, Jaffee EM. Cellular vaccine approaches. Cancer J. 16(4), 304-310 (2010).
    • (2010) Cancer J. , vol.16 , Issue.4 , pp. 304-310
    • Le Pardoll Dt, D.M.1    Jaffee, E.M.2
  • 52
    • 34447123763 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor-secreting allogeneic cellular immunotherapy for hormone-refractory prostate cancer
    • Small EJ, Sacks N, Nemunaitis J, et al. Granulocyte macrophage colony-stimulating factor-secreting allogeneic cellular immunotherapy for hormone-refractory prostate cancer. Clin. Cancer Res. 13(13), 3883-3891 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.13 , pp. 3883-3891
    • Small, E.J.1    Sacks, N.2    Nemunaitis, J.3
  • 53
    • 52049090425 scopus 로고    scopus 로고
    • Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer
    • Higano CS, Corman JM, Smith DC, et al. Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer. Cancer 113(5), 975-984 (2008).
    • (2008) Cancer , vol.113 , Issue.5 , pp. 975-984
    • Higano, C.S.1    Corman, J.M.2    Smith, D.C.3
  • 54
    • 85047692172 scopus 로고    scopus 로고
    • Therapeutic vaccines for cancer: An overview of clinical trials
    • Melero I, Gaudernack G, Gerritsen W, et al. Therapeutic vaccines for cancer: an overview of clinical trials. Nat. Rev. Clin. Oncol. 11(9), 509-524 (2014).
    • (2014) Nat. Rev. Clin. Oncol. , vol.11 , Issue.9 , pp. 509-524
    • Melero, I.1    Gaudernack, G.2    Gerritsen, W.3
  • 55
    • 84925511280 scopus 로고    scopus 로고
    • A Phase i dose escalation trial of MAGE-A3-and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN)
    • Zandberg DP, Rollins S, Goloubeva O, et al. A Phase I dose escalation trial of MAGE-A3-and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). Cancer Immunol. Immunother. 64(3), 367-379 (2015).
    • (2015) Cancer Immunol. Immunother. , vol.64 , Issue.3 , pp. 367-379
    • Zandberg, D.P.1    Rollins, S.2    Goloubeva, O.3
  • 56
    • 84879066944 scopus 로고    scopus 로고
    • Cancer vaccines targeting carcinoembryonic antigen: State-of-the-art and future promise
    • Gameiro SR, Jammeh ML, Hodge JW. Cancer vaccines targeting carcinoembryonic antigen: state-of-the-art and future promise. Expert Rev. Vaccines 12(6), 617-629 (2013).
    • (2013) Expert Rev. Vaccines , vol.12 , Issue.6 , pp. 617-629
    • Gameiro, S.R.1    Jammeh, M.L.2    Hodge, J.W.3
  • 57
    • 84904621154 scopus 로고    scopus 로고
    • Engineering alpha-fetoprotein-based gene vaccines to prevent and treat hepatocellular carcinoma: Review and future prospects
    • He Y, Hong Y, Mizejewski GJ. Engineering alpha-fetoprotein-based gene vaccines to prevent and treat hepatocellular carcinoma: review and future prospects. Immunotherapy 6(6), 725-736 (2014).
    • (2014) Immunotherapy , vol.6 , Issue.6 , pp. 725-736
    • He, Y.1    Hong, Y.2    Mizejewski, G.J.3
  • 58
    • 84863215164 scopus 로고    scopus 로고
    • Spontaneous antibody CD4 and CD8 T-cell responses against XAGE-1b (GAGED2a) in non-small-cell lung cancer patients
    • Ohue Y, Eikawa S, Okazaki N, et al. Spontaneous antibody, CD4 and CD8 T-cell responses against XAGE-1b (GAGED2a) in non-small-cell lung cancer patients. Int. J. Cancer 131(5), E649-658 (2012).
    • (2012) Int. J. Cancer , vol.131 , Issue.5 , pp. E649-658
    • Ohue, Y.1    Eikawa, S.2    Okazaki, N.3
  • 59
    • 84902124061 scopus 로고    scopus 로고
    • Discovery of mesothelin and exploiting it as a target for immunotherapy
    • Pastan I, Hassan R. Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Res. 74(11), 2907-2912 (2014).
    • (2014) Cancer Res. , vol.74 , Issue.11 , pp. 2907-2912
    • Pastan, I.1    Hassan, R.2
  • 60
    • 0035182192 scopus 로고    scopus 로고
    • Efficient identification of novel HLA-A0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis
    • Kessler JH, Beekman NJ, Bres-Vloemans SA, et al. Efficient identification of novel HLA-A0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis. J. Exp. Med. 193(1), 73-88 (2001).
    • (2001) J. Exp. Med. , vol.193 , Issue.1 , pp. 73-88
    • Kessler, J.H.1    Beekman, N.J.2    Bres-Vloemans, S.A.3
  • 61
    • 84864935156 scopus 로고    scopus 로고
    • Vaccines in non-small-cell lung cancer: Rationale, combination strategies and update on clinical trials
    • De Pas T, Giovannini M, Rescigno M, et al. Vaccines in non-small-cell lung cancer: rationale, combination strategies and update on clinical trials. Crit. Rev. Oncol. Hematol. 83(3), 432-443 (2012).
    • (2012) Crit. Rev. Oncol. Hematol. , vol.83 , Issue.3 , pp. 432-443
    • De Pas, T.1    Giovannini, M.2    Rescigno, M.3
  • 62
    • 84956912951 scopus 로고    scopus 로고
    • Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell-cell interactions
    • Wen Q, Xiong W, He J, et al. Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell-cell interactions. J. Transl. Med. 14, 41 (2016).
    • (2016) J. Transl. Med. , vol.14 , pp. 41
    • Wen, Q.1    Xiong, W.2    He, J.3
  • 63
    • 84938199690 scopus 로고    scopus 로고
    • A novel recombinant protein of ephrinA1-PE38/GM-CSF activate dendritic cells vaccine in rats with glioma
    • Li M, Wang B, Wu Z, et al. A novel recombinant protein of ephrinA1-PE38/GM-CSF activate dendritic cells vaccine in rats with glioma. Tumour Biol. 36(7), 5497-5503 (2015).
    • (2015) Tumour Biol. , vol.36 , Issue.7 , pp. 5497-5503
    • Li, M.1    Wang, B.2    Wu, Z.3
  • 64
    • 0027315755 scopus 로고
    • Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma
    • Tao MH, Levy R. Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Nature 362(6422), 755-758 (1993).
    • (1993) Nature , vol.362 , Issue.6422 , pp. 755-758
    • Tao, M.H.1    Levy, R.2
  • 65
    • 79958264390 scopus 로고    scopus 로고
    • Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma
    • Schuster SJ, Neelapu SS, Gause BL, et al. Vaccination with patient-specific tumor-derived antigen in first remission improves disease-free survival in follicular lymphoma. J. Clin. Oncol. 29(20), 2787-2794 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.20 , pp. 2787-2794
    • Schuster, S.J.1    Neelapu, S.S.2    Gause, B.L.3
  • 66
    • 67649961713 scopus 로고    scopus 로고
    • Placebo-controlled Phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma
    • Freedman A, Neelapu SS, Nichols C, et al. Placebo-controlled Phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma. J. Clin. Oncol. 27(18), 3036-3043 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.18 , pp. 3036-3043
    • Freedman, A.1    Neelapu, S.S.2    Nichols, C.3
  • 67
    • 84878790876 scopus 로고    scopus 로고
    • Successes, failures and new perspectives of idiotypic vaccination for B-cell non-Hodgkin lymphomas
    • Muraro E, Martorelli D, Dolcetti R. Successes, failures and new perspectives of idiotypic vaccination for B-cell non-Hodgkin lymphomas. Hum. Vaccin. Immunother. 9(5), 1078-1083 (2013).
    • (2013) Hum. Vaccin. Immunother. , vol.9 , Issue.5 , pp. 1078-1083
    • Muraro, E.1    Martorelli, D.2    Dolcetti, R.3
  • 68
    • 33846879410 scopus 로고    scopus 로고
    • A Phase i study of immunization using particle-mediated epidermal delivery of genes for gp100 and GM-CSF into uninvolved skin of melanoma patients
    • Cassaday RD, Sondel PM, King DM, et al. A Phase I study of immunization using particle-mediated epidermal delivery of genes for gp100 and GM-CSF into uninvolved skin of melanoma patients. Clin. Cancer Res. 13(2 Pt 1), 540-549 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.2 , pp. 540-549
    • Cassaday, R.D.1    Sondel, P.M.2    King, D.M.3
  • 69
    • 56749170720 scopus 로고    scopus 로고
    • Phase I/II study of GM-CSF DNA as an adjuvant for a multipeptide cancer vaccine in patients with advanced melanoma
    • Perales MA, Yuan J, Powel S, et al. Phase I/II study of GM-CSF DNA as an adjuvant for a multipeptide cancer vaccine in patients with advanced melanoma. Mol. Ther. 16(12), 2022-2029 (2008).
    • (2008) Mol. Ther. , vol.16 , Issue.12 , pp. 2022-2029
    • Perales, M.A.1    Yuan, J.2    Powel, S.3
  • 70
    • 77954951895 scopus 로고    scopus 로고
    • DNA vaccine encoding prostatic acid phosphatase (PAP) elicits long-term T-cell responses in patients with recurrent prostate cancer
    • Becker JT, Olson BM, Johnson LE, Davies JG, Dunphy EJ, Mcneel DG. DNA vaccine encoding prostatic acid phosphatase (PAP) elicits long-term T-cell responses in patients with recurrent prostate cancer. J. Immunother. 33(6), 639-647 (2010).
    • (2010) J. Immunother. , vol.33 , Issue.6 , pp. 639-647
    • Becker, J.T.1    Olson, B.M.2    Johnson, L.E.3    Davies, J.G.4    Dunphy, E.J.5    McNeel, D.G.6
  • 71
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'day SJ, Mcdermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 72
    • 84908664534 scopus 로고    scopus 로고
    • Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: A randomized clinical trial
    • Hodi FS, Lee S, Mcdermott DF, et al. Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial. JAMA 312(17), 1744-1753 (2014).
    • (2014) JAMA , vol.312 , Issue.17 , pp. 1744-1753
    • Hodi, F.S.1    Lee, S.2    McDermott, D.F.3
  • 73
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • Quezada SA, Peggs KS, Curran MA, Allison JP. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J. Clin. Invest. 116(7), 1935-1945 (2006).
    • (2006) J. Clin. Invest. , vol.116 , Issue.7 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4
  • 74
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • Hodi FS, Mihm MC, Soiffer RJ, et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl Acad. Sci. USA 100(8), 4712-4717 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.8 , pp. 4712-4717
    • Hodi, F.S.1    Mihm, M.C.2    Soiffer, R.J.3
  • 75
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: A proof-of-principle trial
    • Golden EB, Chhabra A, Chachoua A, et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol. 16(7), 795-803 (2015).
    • (2015) Lancet Oncol. , vol.16 , Issue.7 , pp. 795-803
    • Golden, E.B.1    Chhabra, A.2    Chachoua, A.3
  • 76
    • 34447121852 scopus 로고    scopus 로고
    • MFG-E8-mediated uptake of apoptotic cells by APCs links the pro-and antiinflammatory activities of GM-CSF
    • Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G. MFG-E8-mediated uptake of apoptotic cells by APCs links the pro-and antiinflammatory activities of GM-CSF. J. Clin. Invest. 117(7), 1902-1913 (2007).
    • (2007) J. Clin. Invest. , vol.117 , Issue.7 , pp. 1902-1913
    • Jinushi, M.1    Nakazaki, Y.2    Dougan, M.3    Carrasco, D.R.4    Mihm, M.5    Dranoff, G.6
  • 77
    • 77955771348 scopus 로고    scopus 로고
    • GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1-bone marrow progenitor cells into myeloid-derived suppressor cells
    • Morales JK, Kmieciak M, Knutson KL, Bear HD, Manjili MH. GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1-bone marrow progenitor cells into myeloid-derived suppressor cells. Breast Cancer Res. Treat. 123(1), 39-49 (2010).
    • (2010) Breast Cancer Res. Treat. , vol.123 , Issue.1 , pp. 39-49
    • Morales, J.K.1    Kmieciak, M.2    Knutson, K.L.3    Bear, H.D.4    Manjili, M.H.5
  • 78
    • 84931351248 scopus 로고    scopus 로고
    • Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer
    • Dufait I, Schwarze JK, Liechtenstein T, et al. Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer. Oncotarget 6(14), 12369-12382 (2015).
    • (2015) Oncotarget , vol.6 , Issue.14 , pp. 12369-12382
    • Dufait, I.1    Schwarze, J.K.2    Liechtenstein, T.3
  • 79
    • 33847258205 scopus 로고    scopus 로고
    • Opposite immune functions of GM-CSF administered as vaccine adjuvant in cancer patients
    • Parmiani G, Castelli C, Pilla L, Santinami M, Colombo MP, Rivoltini L. Opposite immune functions of GM-CSF administered as vaccine adjuvant in cancer patients. Ann. Oncol. 18(2), 226-232 (2007).
    • (2007) Ann. Oncol. , vol.18 , Issue.2 , pp. 226-232
    • Parmiani, G.1    Castelli, C.2    Pilla, L.3    Santinami, M.4    Colombo, M.P.5    Rivoltini, L.6
  • 80
    • 72549116845 scopus 로고    scopus 로고
    • Effect of granulocyte/macrophage colony-stimulating factor on circulating CD8+ and CD4+ T-cell responses to a multipeptide melanoma vaccine: Outcome of a multicenter randomized trial
    • Slingluff CL Jr, Petroni GR, Olson WC, et al. Effect of granulocyte/macrophage colony-stimulating factor on circulating CD8+ and CD4+ T-cell responses to a multipeptide melanoma vaccine: outcome of a multicenter randomized trial. Clin. Cancer Res. 15(22), 7036-7044 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.22 , pp. 7036-7044
    • Slingluff, C.L.1    Petroni, G.R.2    Olson, W.C.3
  • 81
    • 72549086588 scopus 로고    scopus 로고
    • Effect of granulocyte/macrophage colony-stimulating factor on vaccination with an allogeneic whole-cell melanoma vaccine
    • Faries MB, Hsueh EC, Ye X, Hoban M, Morton DL. Effect of granulocyte/macrophage colony-stimulating factor on vaccination with an allogeneic whole-cell melanoma vaccine. Clin. Cancer Res. 15(22), 7029-7035 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.22 , pp. 7029-7035
    • Faries, M.B.1    Hsueh, E.C.2    Ye, X.3    Hoban, M.4    Morton, D.L.5
  • 83
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates splenic Gr-1+/CD11b +myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • Suzuki E, Kapoor V, Jassar AS, Kaiser LR, Albelda SM. Gemcitabine selectively eliminates splenic Gr-1+/CD11b +myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin. Cancer Res. 11(18), 6713-6721 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.18 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5
  • 84
    • 77951086882 scopus 로고    scopus 로고
    • 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity
    • Vincent J, Mignot G, Chalmin F, et al. 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res. 70(8), 3052-3061 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.8 , pp. 3052-3061
    • Vincent, J.1    Mignot, G.2    Chalmin, F.3
  • 85
    • 77956680680 scopus 로고    scopus 로고
    • A novel chemoimmunomodulating property of docetaxel: Suppression of myeloid-derived suppressor cells in tumor bearers
    • Kodumudi KN, Woan K, Gilvary DL, Sahakian E, Wei S, Djeu JY. A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin. Cancer Res. 16(18), 4583-4594 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.18 , pp. 4583-4594
    • Kodumudi, K.N.1    Woan, K.2    Gilvary, D.L.3    Sahakian, E.4    Wei, S.5    Djeu, J.Y.6
  • 86
    • 84894488563 scopus 로고    scopus 로고
    • The effects of gemcitabine and capecitabine combination chemotherapy and of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer
    • Annels NE, Shaw VE, Gabitass RF, et al. The effects of gemcitabine and capecitabine combination chemotherapy and of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer. Cancer Immunol. Immunother. 63(2), 175-183 (2014).
    • (2014) Cancer Immunol. Immunother. , vol.63 , Issue.2 , pp. 175-183
    • Annels, N.E.1    Shaw, V.E.2    Gabitass, R.F.3
  • 87
    • 75549083877 scopus 로고    scopus 로고
    • A Phase II study of oxaliplatin, docetaxel, GM-CSF in patients with previously treated advanced melanoma
    • Locke F, Clark JI, Gajewski TF. A Phase II study of oxaliplatin, docetaxel, GM-CSF in patients with previously treated advanced melanoma. Cancer Chemother. Pharmacol. 65(3), 509-514 (2010).
    • (2010) Cancer Chemother. Pharmacol. , vol.65 , Issue.3 , pp. 509-514
    • Locke, F.1    Clark, J.I.2    Gajewski, T.F.3
  • 88
    • 84959873965 scopus 로고    scopus 로고
    • Beyond antigens and adjuvants: Formulating future vaccines
    • Moyer TJ, Zmolek AC, Irvine DJ. Beyond antigens and adjuvants: formulating future vaccines. J. Clin. Invest. 126(3), 799-808 (2016).
    • (2016) J. Clin. Invest. , vol.126 , Issue.3 , pp. 799-808
    • Moyer, T.J.1    Zmolek, A.C.2    Irvine, D.J.3


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