메뉴 건너뛰기




Volumn 11, Issue 4, 2015, Pages 511-522

Immunology of chronic myeloid leukemia: Current concepts and future goals

Author keywords

bcr abl; cancer vaccines; CML; immunology; immunotherapy; LAAs; tyrosine kinase inhibitors

Indexed keywords

BCR ABL PROTEIN; LEUKEMIA ANTIGEN; TUMOR CELL VACCINE; CANCER VACCINE; PROTEIN KINASE INHIBITOR;

EID: 84924933672     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/1744666X.2015.1019474     Document Type: Review
Times cited : (14)

References (85)
  • 2
    • 84861839077 scopus 로고    scopus 로고
    • Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy
    • Huang X, Cortes J, Kantarjian H. Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy. Cancer 2012;118:3123-7
    • (2012) Cancer , vol.118 , pp. 3123-3127
    • Huang, X.1    Cortes, J.2    Kantarjian, H.3
  • 3
    • 0037295682 scopus 로고    scopus 로고
    • The abl/bcr gene product as a novel leukemia-specific antigen: Peptides spanning the fusion region of abl/bcr can be recognized by both cd4+ and cd8+t lymphocytes
    • Wagner WM, Ouyang Q, Pawelec G. The abl/bcr gene product as a novel leukemia-specific antigen: peptides spanning the fusion region of abl/bcr can be recognized by both CD4+ and CD8+T lymphocytes. Cancer Immunol Immunother 2003;52:89-96
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 89-96
    • Wagner, W.M.1    Ouyang, Q.2    Pawelec, G.3
  • 4
    • 70449382606 scopus 로고    scopus 로고
    • Reciprocal t(9;22) ABL/BCR fusion proteins: Leukemogenic potential and effects on B cell commitment
    • Zheng X, Oancea C, Henschler R, et al. Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment. PLoS One 2009;4: e7661
    • (2009) Plos One , vol.4 , pp. e7661
    • Zheng, X.1    Oancea, C.2    Henschler, R.3
  • 5
    • 19944432748 scopus 로고    scopus 로고
    • Randomized trial of allogeneic related bone marrow transplantation versus peripheral blood stem cell transplantation for chronic myeloid leukemia
    • Oehler VG, Radich JP, Storer B, et al. Randomized trial of allogeneic related bone marrow transplantation versus peripheral blood stem cell transplantation for chronic myeloid leukemia. Biol Blood Marrow Transplant 2005;11:85-92
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 85-92
    • Oehler, V.G.1    Radich, J.P.2    Storer, B.3
  • 6
    • 77957088676 scopus 로고    scopus 로고
    • Stem cell transplant for chronic myeloid leukemia in the imatinib era
    • Radich J. Stem cell transplant for chronic myeloid leukemia in the imatinib era. Semin Hematol 2010;47:354-61
    • (2010) Semin Hematol , vol.47 , pp. 354-361
    • Radich, J.1
  • 7
    • 84892896223 scopus 로고    scopus 로고
    • Determinants of survival in patients with chronic myeloid leukaemia treated in the new era of oral therapy: Findings from a UK population-based patient cohort
    • Smith AG, Painter D, Howell DA, et al. Determinants of survival in patients with chronic myeloid leukaemia treated in the new era of oral therapy: findings from a UK population-based patient cohort. BMJ Open 2014;4:e004266
    • (2014) BMJ Open , vol.4 , pp. e004266
    • Smith, A.G.1    Painter, D.2    Howell, D.A.3
  • 8
    • 0034161460 scopus 로고    scopus 로고
    • Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
    • le Coutre P, Tassi E, Varella-Garcia M, et al. Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood 2000;95: 1758-66
    • (2000) Blood , vol.95 , pp. 1758-1766
    • Le Coutre, P.1    Tassi, E.2    Varella-Garcia, M.3
  • 9
    • 33646259689 scopus 로고    scopus 로고
    • Anticipating clinical resistance to target-directed agents: The BCR-ABL paradigm
    • Azam M, Daley GQ. Anticipating clinical resistance to target-directed agents: the BCR-ABL paradigm. Mol Diagn Ther 2006;10:67-76
    • (2006) Mol Diagn Ther , vol.10 , pp. 67-76
    • Azam, M.1    Daley, G.Q.2
  • 10
    • 84886917643 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib cessation for cml patients with stable undetectable minimal residual disease: Results from the twister study
    • Ross DM, Branford S, Seymour JF, et al. Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study. Blood 2013;122:515-22
    • (2013) Blood , vol.122 , pp. 515-522
    • Ross, D.M.1    Branford, S.2    Seymour, J.F.3
  • 11
    • 77953411111 scopus 로고    scopus 로고
    • Immunotherapy of chronic myeloid leukemia: Present state and future prospects
    • Vonka V. Immunotherapy of chronic myeloid leukemia: present state and future prospects. Immunotherapy 2010;2:227-41
    • (2010) Immunotherapy , vol.2 , pp. 227-241
    • Vonka, V.1
  • 12
    • 65249150201 scopus 로고    scopus 로고
    • The biological basis for immunotherapy in patients with chronic myelogenous leukemia
    • Pinilla-Ibarz J, Shah B, Dubovsky JA. The biological basis for immunotherapy in patients with chronic myelogenous leukemia. Cancer Contr 2009;16:141-52
    • (2009) Cancer Contr , vol.16 , pp. 141-152
    • Pinilla-Ibarz, J.1    Shah, B.2    Dubovsky, J.A.3
  • 13
    • 84896728699 scopus 로고    scopus 로고
    • Immunology and immunotherapy of chronic myeloid leukemia
    • Ilander M, Hekim C, Mustjoki S. Immunology and immunotherapy of chronic myeloid leukemia. Curr Hematol Malig Rep 2014;9:17-23
    • (2014) Curr Hematol Malig Rep , vol.9 , pp. 17-23
    • Ilander, M.1    Hekim, C.2    Mustjoki, S.3
  • 14
    • 63849156664 scopus 로고    scopus 로고
    • Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1-reactive cytotoxic T cells
    • Norde WJ, Overes IM, Maas F, et al. Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1-reactive cytotoxic T cells. Blood 2009;113:2312-23
    • (2009) Blood , vol.113 , pp. 2312-2323
    • Norde, W.J.1    Overes, I.M.2    Maas, F.3
  • 15
    • 0032211172 scopus 로고    scopus 로고
    • The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease
    • Bose S, Deininger M, Gora-Tybor J, et al. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood 1998;92:3362-7
    • (1998) Blood , vol.92 , pp. 3362-3367
    • Bose, S.1    Deininger, M.2    Gora-Tybor, J.3
  • 16
    • 0033152343 scopus 로고    scopus 로고
    • HLA-B8 and HLA-A3 coexpressed with HLA-B8 are associated with a reduced risk of the development of chronic myeloid leukemia the chronic leukemia working party of the ebmt
    • Posthuma EF, Falkenburg JH, Apperley JF, et al. HLA-B8 and HLA-A3 coexpressed with HLA-B8 are associated with a reduced risk of the development of chronic myeloid leukemia. The Chronic Leukemia Working Party of the EBMT. Blood 1999;93:3863-5
    • (1999) Blood , vol.93 , pp. 3863-3865
    • Posthuma, E.F.1    Falkenburg, J.H.2    Apperley, J.F.3
  • 17
    • 35949000567 scopus 로고    scopus 로고
    • HLA class II allele and haplotype frequencies in Iranian patients with leukemia
    • Khosravi F, Amirzargar A, Sarafnejad A, et al. HLA class II allele and haplotype frequencies in Iranian patients with leukemia. Iran J Allergy Asthma Immunol 2007;6:137-42
    • (2007) Iran J Allergy Asthma Immunol , vol.6 , pp. 137-142
    • Khosravi, F.1    Amirzargar, A.2    Sarafnejad, A.3
  • 18
    • 61449252887 scopus 로고    scopus 로고
    • Hla risk markers for chronic myelogenous leukemia in eastern canada
    • Naugler C, Liwski R. HLA risk markers for chronic myelogenous leukemia in Eastern Canada. Leuk Lymphoma 2009;50:254-9
    • (2009) Leuk Lymphoma , vol.50 , pp. 254-259
    • Naugler, C.1    Liwski, R.2
  • 19
    • 33745274757 scopus 로고    scopus 로고
    • BCR-ABL is not an immunodominant antigen in chronic myelogenous leukemia
    • Grunebach F, Mirakaj V, Mirakaj V, et al. BCR-ABL is not an immunodominant antigen in chronic myelogenous leukemia. Cancer Res 2006;66:5892-900
    • (2006) Cancer Res , vol.66 , pp. 5892-5900
    • Grunebach, F.1    Mirakaj, V.2    Mirakaj, V.3
  • 20
    • 34347271941 scopus 로고    scopus 로고
    • BCR-ABL activity is critical for the immunogenicity of chronic myelogenous leukemia cells
    • Brauer KM, Werth D, von SK, et al. BCR-ABL activity is critical for the immunogenicity of chronic myelogenous leukemia cells. Cancer Res 2007;67:5489-97
    • (2007) Cancer Res , vol.67 , pp. 5489-5497
    • Brauer, K.M.1    Werth, D.2    Von, S.K.3
  • 21
    • 43549118425 scopus 로고    scopus 로고
    • Leukemia-associated antigens as target structures for a specific immunotherapy in chronic myeloid leukemia
    • Greiner J, Schmitt M. Leukemia-associated antigens as target structures for a specific immunotherapy in chronic myeloid leukemia. Eur J Haematol 2008;80:461-8
    • (2008) Eur J Haematol , vol.80 , pp. 461-468
    • Greiner, J.1    Schmitt, M.2
  • 22
    • 82355180964 scopus 로고    scopus 로고
    • Antigens in chronic myeloid leukemia: Implications for vaccine development
    • Smahel M. Antigens in chronic myeloid leukemia: implications for vaccine development. Cancer Immunol Immunother 2011;60:1655-68
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1655-1668
    • Smahel, M.1
  • 23
    • 49349108990 scopus 로고    scopus 로고
    • RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of hela cells
    • Wang Q, Li M, Wang Y, et al. RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells. Cancer Lett 2008;269:127-38
    • (2008) Cancer Lett , vol.269 , pp. 127-138
    • Wang, Q.1    Li, M.2    Wang, Y.3
  • 24
    • 84890562713 scopus 로고    scopus 로고
    • Bcr-abl activates aurka and aurkb in chronic myeloid leukemia cells via akt signaling
    • Yang J, Ikezoe T, Nishioka C, et al. Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling. Int J Cancer 2014;134:1183-94
    • (2014) Int J Cancer , vol.134 , pp. 1183-1194
    • Yang, J.1    Ikezoe, T.2    Nishioka, C.3
  • 25
    • 71049153709 scopus 로고    scopus 로고
    • Cancer/testis (CT) antigens: Potential targets for immunotherapy
    • Caballero OL, Chen YT. Cancer/testis (CT) antigens: potential targets for immunotherapy. Cancer Sci 2009;100: 2014-21
    • (2009) Cancer Sci , vol.100 , pp. 2014-2021
    • Caballero, O.L.1    Chen, Y.T.2
  • 26
    • 80054967884 scopus 로고    scopus 로고
    • A majority of the cancer/testis antigens are intrinsically disordered proteins
    • Rajagopalan K, Mooney SM, Parekh N, et al. A majority of the cancer/testis antigens are intrinsically disordered proteins. J Cell Biochem 2011;112:3256-67
    • (2011) J Cell Biochem , vol.112 , pp. 3256-3267
    • Rajagopalan, K.1    Mooney, S.M.2    Parekh, N.3
  • 27
    • 79955610452 scopus 로고    scopus 로고
    • Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome
    • Vavouri T, Lehner B. Chromatin organization in sperm may be the major functional consequence of base composition variation in the human genome. PLoS Genet 2011;7:e1002036
    • (2011) Plos Genet , vol.7 , pp. e1002036
    • Vavouri, T.1    Lehner, B.2
  • 28
    • 36349031851 scopus 로고    scopus 로고
    • Comparative proteome profiling and functional analysis of chronic myelogenous leukemia cell lines
    • Fontana S, Alessandro R, Barranca M, et al. Comparative proteome profiling and functional analysis of chronic myelogenous leukemia cell lines. J Proteome Res 2007;6: 4330-42
    • (2007) J Proteome Res , vol.6 , pp. 4330-4342
    • Fontana, S.1    Alessandro, R.2    Barranca, M.3
  • 29
    • 20444378186 scopus 로고    scopus 로고
    • Ex vivo characterization of multiepitopic tumor-specific CD8 T cells in patients with chronic myeloid leukemia: Implications for vaccine development and adoptive cellular immunotherapy
    • Gannage M, Abel M, Michallet AS, et al. Ex vivo characterization of multiepitopic tumor-specific CD8 T cells in patients with chronic myeloid leukemia: implications for vaccine development and adoptive cellular immunotherapy. J Immunol 2005;174: 8210-18
    • (2005) J Immunol , vol.174 , pp. 8210-8218
    • Gannage, M.1    Abel, M.2    Michallet, A.S.3
  • 30
    • 4344696570 scopus 로고    scopus 로고
    • Expression patterns of WT-1 and Bcr-Abl measured by TaqMan quantitative real-time RT-PCR during follow-up of leukemia patients with the Ph chromosome
    • Chen ZX, Kaeda J, Saunders S, et al. Expression patterns of WT-1 and Bcr-Abl measured by TaqMan quantitative real-time RT-PCR during follow-up of leukemia patients with the Ph chromosome. Chin Med J (Engl) 2004;117:968-71
    • (2004) Chin Med J (Engl , vol.117 , pp. 968-971
    • Chen, Z.X.1    Kaeda, J.2    Saunders, S.3
  • 31
    • 77950636548 scopus 로고    scopus 로고
    • Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia
    • Wang L, Zhu K, Zha X, et al. Evolution of T-cell clonality in a patient with Ph-negative acute lymphocytic leukemia occurring after interferon and imatinib therapy for Ph-positive chronic myeloid leukemia. J Hematol Oncol 2010;3:14
    • (2010) J Hematol Oncol , vol.3 , pp. 14
    • Wang, L.1    Zhu, K.2    Zha, X.3
  • 32
    • 77951257237 scopus 로고    scopus 로고
    • Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens
    • Warren EH, Fujii N, Akatsuka Y, et al. Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. Blood 2010;115:3869-78
    • (2010) Blood , vol.115 , pp. 3869-3878
    • Warren, E.H.1    Fujii, N.2    Akatsuka, Y.3
  • 33
    • 77950858633 scopus 로고    scopus 로고
    • Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy
    • Brown DM. Cytolytic CD4 cells: direct mediators in infectious disease and malignancy. Cell Immunol 2010;262:89-95
    • (2010) Cell Immunol , vol.262 , pp. 89-95
    • Brown, D.M.1
  • 34
    • 0030907467 scopus 로고    scopus 로고
    • A method for the production of CD4+chronic myelogenous leukemia-specific allogeneic T lymphocytes
    • Serody JS, Brecher ME, Dent G, et al. A method for the production of CD4+chronic myelogenous leukemia-specific allogeneic T lymphocytes. Cancer Res 1997;57:1547-53
    • (1997) Cancer Res , vol.57 , pp. 1547-1553
    • Serody, J.S.1    Brecher, M.E.2    Dent, G.3
  • 35
    • 20244374668 scopus 로고    scopus 로고
    • Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant
    • Alyea EP, Soiffer RJ, Canning C, et al. Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant. Blood 1998;91:3671-80
    • (1998) Blood , vol.91 , pp. 3671-3680
    • Alyea, E.P.1    Soiffer, R.J.2    Canning, C.3
  • 36
    • 84890020972 scopus 로고    scopus 로고
    • Tumor protective activity of CD4+ but not of CD8+ T cells in DNA-vaccinated mice challenged with bcr-abl-transformed cells
    • Petrackova M, Lucansky V, Vonka V. Tumor protective activity of CD4+ but not of CD8+ T cells in DNA-vaccinated mice challenged with bcr-abl-transformed cells. Clin Dev Immunol 2013;2013:923107
    • (2013) Clin Dev Immunol , vol.2013 , pp. 923107
    • Petrackova, M.1    Lucansky, V.2    Vonka, V.3
  • 37
    • 0033179344 scopus 로고    scopus 로고
    • A bcr-abl oncoprotein p210b2a2 fusion region sequence is recognized by hla-dr2a restricted cytotoxic t lymphocytes and presented by hla-dr matched cells transfected with an ii(b2a2) construct
    • ten Bosch GJ, Kessler JH, Joosten AM, et al. A BCR-ABL oncoprotein p210b2a2 fusion region sequence is recognized by HLA-DR2a restricted cytotoxic T lymphocytes and presented by HLA-DR matched cells transfected with an Ii(b2a2) construct. Blood 1999;94:1038-45
    • (1999) Blood , vol.94 , pp. 1038-1045
    • Ten Bosch, G.J.1    Kessler, J.H.2    Joosten, A.M.3
  • 38
    • 0032213388 scopus 로고    scopus 로고
    • CD4(+) cytotoxic T-cell clones specific for bcr-abl b3a2 fusion peptide augment colony formation by chronic myelogenous leukemia cells in a b3a2-specific and HLA-DR-restricted manner
    • Yasukawa M, Ohminami H, Kaneko S, et al. CD4(+) cytotoxic T-cell clones specific for bcr-abl b3a2 fusion peptide augment colony formation by chronic myelogenous leukemia cells in a b3a2-specific and HLA-DR-restricted manner. Blood 1998;92: 3355-61
    • (1998) Blood , vol.92 , pp. 3355-3361
    • Yasukawa, M.1    Ohminami, H.2    Kaneko, S.3
  • 39
    • 79957487341 scopus 로고    scopus 로고
    • Stimulating natural killer cells to protect against cancer: Recent developments
    • Gillgrass A, Ashkar A. Stimulating natural killer cells to protect against cancer: recent developments. Expert Rev Clin Immunol 2011;7:367-82
    • (2011) Expert Rev Clin Immunol , vol.7 , pp. 367-382
    • Gillgrass, A.1    Ashkar, A.2
  • 40
    • 1842526926 scopus 로고    scopus 로고
    • Down-regulation of HLA-A and HLA-Bw6 but not HLA-Bw4 allospecificities in leukemic cells: An escape mechanism from CTL and NK attack?
    • Demanet C, Mulder A, Deneys V, et al. Down-regulation of HLA-A and HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: an escape mechanism from CTL and NK attack?. Blood 2004;103: 3122-30
    • (2004) Blood , vol.103 , pp. 3122-3130
    • Demanet, C.1    Mulder, A.2    Deneys, V.3
  • 41
    • 76249127539 scopus 로고    scopus 로고
    • Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells
    • Biernacki MA, Marina O, Zhang W, et al. Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells. Cancer Res 2010;70: 906-15
    • (2010) Cancer Res , vol.70 , pp. 906-915
    • Biernacki, M.A.1    Marina, O.2    Zhang, W.3
  • 42
    • 0035912776 scopus 로고    scopus 로고
    • CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia
    • Yang XF, Wu CJ, McLaughlin S, et al. CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia. Proc Natl Acad Sci USA 2001;98:7492-7
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7492-7497
    • Yang, X.F.1    Wu, C.J.2    McLaughlin, S.3
  • 43
    • 0038493639 scopus 로고    scopus 로고
    • Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia
    • Greiner J, Ringhoffer M, Taniguchi M, et al. Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia. Int J Cancer 2003;106:224-31
    • (2003) Int J Cancer , vol.106 , pp. 224-231
    • Greiner, J.1    Ringhoffer, M.2    Taniguchi, M.3
  • 44
    • 70349562580 scopus 로고    scopus 로고
    • Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression
    • Mumprecht S, Schurch C, Schwaller J, et al. Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression. Blood 2009;114:1528-36
    • (2009) Blood , vol.114 , pp. 1528-1536
    • Mumprecht, S.1    Schurch, C.2    Schwaller, J.3
  • 45
    • 84870918812 scopus 로고    scopus 로고
    • New insights into antigen specific immunotherapy for chronic myeloid leukemia
    • Li Y, Lin C, Schmidt CA. New insights into antigen specific immunotherapy for chronic myeloid leukemia. Cancer Cell Int 2012;12:52-12
    • (2012) Cancer Cell Int , vol.12 , pp. 52-12
    • Li, Y.1    Lin, C.2    Schmidt, C.A.3
  • 47
    • 66549117391 scopus 로고    scopus 로고
    • Defective homing and impaired induction of cytotoxic T cells by BCR/ABL-expressing dendritic cells
    • Mumprecht S, Claus C, Schurch C, et al. Defective homing and impaired induction of cytotoxic T cells by BCR/ABL-expressing dendritic cells. Blood 2009;113:4681-9
    • (2009) Blood , vol.113 , pp. 4681-4689
    • Mumprecht, S.1    Claus, C.2    Schurch, C.3
  • 48
    • 84857996055 scopus 로고    scopus 로고
    • NK cells are dysfunctional in human chronic myelogenous leukemia before and on imatinib treatment and in BCR-ABL-positive mice
    • Chen CI, Koschmieder S, Kerstiens L, et al. NK cells are dysfunctional in human chronic myelogenous leukemia before and on imatinib treatment and in BCR-ABL-positive mice. Leukemia 2012;26:465-74
    • (2012) Leukemia , vol.26 , pp. 465-474
    • Chen, C.I.1    Koschmieder, S.2    Kerstiens, L.3
  • 49
    • 84864001519 scopus 로고    scopus 로고
    • Evidence for BCR-ABL-dependent dysfunctions of iNKT cells from chronic myeloid leukemia patients
    • Rossignol A, Levescot A, Jacomet F, et al. Evidence for BCR-ABL-dependent dysfunctions of iNKT cells from chronic myeloid leukemia patients. Eur J Immunol 2012;42:1870-5
    • (2012) Eur J Immunol , vol.42 , pp. 1870-1875
    • Rossignol, A.1    Levescot, A.2    Jacomet, F.3
  • 50
    • 33747594942 scopus 로고    scopus 로고
    • Immunological profiles of patients with chronic myeloid leukaemia i state before the start of treatment
    • Humlova Z, Klamova H, Janatkova I, et al. Immunological profiles of patients with chronic myeloid leukaemia. I. State before the start of treatment. Folia Biol (Praha) 2006;52:47-58
    • (2006) Folia Biol (Praha , vol.52 , pp. 47-58
    • Humlova, Z.1    Klamova, H.2    Janatkova, I.3
  • 51
    • 84924310773 scopus 로고    scopus 로고
    • Kynurenine and uric acid levels in chronic myeloid leukemia patients
    • In press
    • Vonka V, Humlova Z, Klamova H, et al. Kynurenine and uric acid levels in chronic myeloid leukemia patients. Oncoimmunology 2015; In press
    • (2015) Oncoimmunology
    • Vonka, V.1    Humlova, Z.2    Klamova, H.3
  • 52
    • 79251541730 scopus 로고    scopus 로고
    • Changes of immunological profiles in patients with chronic myeloid leukemia in the course of treatment
    • Humlova Z, Klamova H, Janatkova I, et al. Changes of immunological profiles in patients with chronic myeloid leukemia in the course of treatment. Clin Dev Immunol 2010;2010:137320
    • (2010) Clin Dev Immunol , vol.2010 , pp. 137320
    • Humlova, Z.1    Klamova, H.2    Janatkova, I.3
  • 53
    • 10744226050 scopus 로고    scopus 로고
    • Chronic myeloid leukemia patients resistant to or intolerant of interferon alpha and subsequently treated with imatinib show reduced immunoglobulin levels and hypogammaglobulinemia
    • Steegmann JL, Moreno G, Alaez C, et al. Chronic myeloid leukemia patients resistant to or intolerant of interferon alpha and subsequently treated with imatinib show reduced immunoglobulin levels and hypogammaglobulinemia. Haematologica 2003;88:762-8
    • (2003) Haematologica , vol.88 , pp. 762-768
    • Steegmann, J.L.1    Moreno, G.2    Alaez, C.3
  • 54
    • 9444288216 scopus 로고    scopus 로고
    • Selective effect of imatinib on serum IgM in a patient with CML
    • Nagasawa M, Mizutani S. Selective effect of imatinib on serum IgM in a patient with CML. Int J Hematol 2004;80:381-2
    • (2004) Int J Hematol , vol.80 , pp. 381-382
    • Nagasawa, M.1    Mizutani, S.2
  • 55
    • 84857486102 scopus 로고    scopus 로고
    • Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients
    • Ciarcia R, Vitiello MT, Galdiero M, et al. Imatinib treatment inhibit IL-6, IL-8, NF-KB and AP-1 production and modulate intracellular calcium in CML patients. J Cell Physiol 2012;227:2798-803
    • (2012) J Cell Physiol , vol.227 , pp. 2798-2803
    • Ciarcia, R.1    Vitiello, M.T.2    Galdiero, M.3
  • 56
    • 81255189474 scopus 로고    scopus 로고
    • IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development
    • Reynaud D, Pietras E, Barry-Holson K, et al. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell 2011;20:661-73
    • (2011) Cancer Cell , vol.20 , pp. 661-673
    • Reynaud, D.1    Pietras, E.2    Barry-Holson, K.3
  • 57
    • 0029882074 scopus 로고    scopus 로고
    • Cellular immune responses to autologous chronic myelogenous leukaemia cells in vitro
    • Pawelec G, Rehbein A, Schlotz E, et al. Cellular immune responses to autologous chronic myelogenous leukaemia cells in vitro. Cancer Immunol Immunother 1996;42:193-9
    • (1996) Cancer Immunol Immunother , vol.42 , pp. 193-199
    • Pawelec, G.1    Rehbein, A.2    Schlotz, E.3
  • 58
    • 77958553932 scopus 로고    scopus 로고
    • Immunoprofiling of patients with chronic myeloid leukemia at diagnosis and during tyrosine kinase inhibitor therapy
    • Rohon P, Porkka K, Mustjoki S. Immunoprofiling of patients with chronic myeloid leukemia at diagnosis and during tyrosine kinase inhibitor therapy. Eur J Haematol 2010;85:387-98
    • (2010) Eur J Haematol , vol.85 , pp. 387-398
    • Rohon, P.1    Porkka, K.2    Mustjoki, S.3
  • 59
    • 84873192230 scopus 로고    scopus 로고
    • Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia
    • Christiansson L, Soderlund S, Svensson E, et al. Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia. PLoS One 2013;8: e55818
    • (2013) Plos One , vol.8 , pp. e55818
    • Christiansson, L.1    Soderlund, S.2    Svensson, E.3
  • 60
    • 84904182364 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells (mdscs) are increased and exert immunosuppressive activity together with polymorphonuclear leukocytes (pmns) in chronic myeloid leukemia patients
    • Giallongo C, Parrinello N, Tibullo D, et al. Myeloid derived suppressor cells (MDSCs) are increased and exert immunosuppressive activity together with polymorphonuclear leukocytes (PMNs) in chronic myeloid leukemia patients. PLoS One 2014;9: e101848
    • (2014) Plos One , vol.9 , pp. e101848
    • Giallongo, C.1    Parrinello, N.2    Tibullo, D.3
  • 61
    • 42149183600 scopus 로고    scopus 로고
    • Antibodies against the cancer-testis antigen CTSP-1 are frequently found in prostate cancer patients and are an independent prognostic factor for biochemical-recurrence
    • Parmigiani RB, Bettoni F, Grosso DM, et al. Antibodies against the cancer-testis antigen CTSP-1 are frequently found in prostate cancer patients and are an independent prognostic factor for biochemical-recurrence. Int J Cancer 2008;122:2385-90
    • (2008) Int J Cancer , vol.122 , pp. 2385-2390
    • Parmigiani, R.B.1    Bettoni, F.2    Grosso, D.M.3
  • 62
    • 77956523154 scopus 로고    scopus 로고
    • Expression, epigenetic regulation, and humoral immunogenicity of cancer-testis antigens in chronic myeloid leukemia
    • Luetkens T, Schafhausen P, Uhlich F, et al. Expression, epigenetic regulation, and humoral immunogenicity of cancer-testis antigens in chronic myeloid leukemia. Leuk Res 2010;34:1647-55
    • (2010) Leuk Res , vol.34 , pp. 1647-1655
    • Luetkens, T.1    Schafhausen, P.2    Uhlich, F.3
  • 63
    • 82255169327 scopus 로고    scopus 로고
    • Effects of BCR-ABL inhibitors on anti-tumor immunity
    • Krusch M, Salih HR. Effects of BCR-ABL inhibitors on anti-tumor immunity. Curr Med Chem 2011;18:5174-84
    • (2011) Curr Med Chem , vol.18 , pp. 5174-5184
    • Krusch, M.1    Salih, H.R.2
  • 64
    • 84884291198 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling
    • De Lavallade H, Khoder A, Hart M, et al. Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling. Blood 2013;122:227-38
    • (2013) Blood , vol.122 , pp. 227-238
    • De Lavallade, H.1    Khoder, A.2    Hart, M.3
  • 65
    • 30744462293 scopus 로고    scopus 로고
    • The decreased susceptibility of bcr/abl targets to nk cell-mediated lysis in response to imatinib mesylate involves modulation of nkg2d ligands, gm1 expression, and synapse formation
    • Cebo C, Da RS, Wittnebel S, et al. The decreased susceptibility of Bcr/Abl targets to NK cell-mediated lysis in response to imatinib mesylate involves modulation of NKG2D ligands, GM1 expression, and synapse formation. J Immunol 2006;176: 864-72
    • (2006) J Immunol , vol.176 , pp. 864-872
    • Cebo, C.1    Da, R.S.2    Wittnebel, S.3
  • 66
    • 10744232318 scopus 로고    scopus 로고
    • The effects of STI571 on antigen presentation of dendritic cells generated from patients with chronic myelogenous leukemia
    • Sato N, Narita M, Takahashi M, et al. The effects of STI571 on antigen presentation of dendritic cells generated from patients with chronic myelogenous leukemia. Hematol Oncol 2003;21:67-75
    • (2003) Hematol Oncol , vol.21 , pp. 67-75
    • Sato, N.1    Narita, M.2    Takahashi, M.3
  • 67
    • 2942625414 scopus 로고    scopus 로고
    • Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia
    • Mohty M, Jourdan E, Mami NB, et al. Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia. Blood 2004;103:4666-8
    • (2004) Blood , vol.103 , pp. 4666-4668
    • Mohty, M.1    Jourdan, E.2    Mami, N.B.3
  • 68
    • 52649135956 scopus 로고    scopus 로고
    • Cytotoxic t lymphocytes directed to the preferentially expressed antigen of melanoma (prame) target chronic myeloid leukemia
    • Quintarelli C, Dotti G, De AB, et al. Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia. Blood 2008;112:1876-85
    • (2008) Blood , vol.112 , pp. 1876-1885
    • Quintarelli, C.1    Dotti, G.2    De, A.B.3
  • 69
    • 82155178605 scopus 로고    scopus 로고
    • Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution
    • Li N, Matte-Martone C, Zheng H, et al. Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood 2011;118: 5965-76
    • (2011) Blood , vol.118 , pp. 5965-5976
    • Li, N.1    Matte-Martone, C.2    Zheng, H.3
  • 70
    • 79959826132 scopus 로고    scopus 로고
    • Prophylactic transfer of BCR-ABL- PR1-, and WT1-reactive donor T cells after T cell-depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia
    • Bornhauser M, Thiede C, Platzbecker U, et al. Prophylactic transfer of BCR-ABL-, PR1-, and WT1-reactive donor T cells after T cell-depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia. Blood 2011;117:7174-84
    • (2011) Blood , vol.117 , pp. 7174-7184
    • Bornhauser, M.1    Thiede, C.2    Platzbecker, U.3
  • 71
    • 84908145811 scopus 로고    scopus 로고
    • Chimeric antigen receptor for adoptive immunotherapy of cancer: Latest research and future prospects
    • Shi H, Sun M, Liu L, et al. Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects. Mol Cancer 2014;13:219
    • (2014) Mol Cancer , vol.13 , pp. 219
    • Shi, H.1    Sun, M.2    Liu, L.3
  • 72
    • 84872342603 scopus 로고    scopus 로고
    • The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies
    • Wang D, Li L, Yang H, et al. The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies. Blood 2013;121:329-38
    • (2013) Blood , vol.121 , pp. 329-338
    • Wang, D.1    Li, L.2    Yang, H.3
  • 73
    • 84855350845 scopus 로고    scopus 로고
    • Adoptive T-cell therapy of B-cell malignancies: Conventional and physiological chimeric antigen receptors
    • Liu L, Sun M, Wang Z. Adoptive T-cell therapy of B-cell malignancies: conventional and physiological chimeric antigen receptors. Cancer Lett 2012;316:1-5
    • (2012) Cancer Lett , vol.316 , pp. 1-5
    • Liu, L.1    Sun, M.2    Wang, Z.3
  • 74
    • 84899631361 scopus 로고    scopus 로고
    • Antibody-modified T cells: CARs take the front seat for hematologic malignancies
    • Maus MV, Grupp SA, Porter DL, et al. Antibody-modified T cells: CARs take the front seat for hematologic malignancies. Blood 2014;123:2625-35
    • (2014) Blood , vol.123 , pp. 2625-2635
    • Maus, M.V.1    Grupp, S.A.2    Porter, D.L.3
  • 75
    • 84873495994 scopus 로고    scopus 로고
    • The role of peptide and DNA vaccines in myeloid leukemia immunotherapy
    • Lin C, Li Y. The role of peptide and DNA vaccines in myeloid leukemia immunotherapy. Cancer Cell Int 2013;13:13
    • (2013) Cancer Cell Int , vol.13 , pp. 13
    • Lin, C.1    Li, Y.2
  • 76
    • 70449434669 scopus 로고    scopus 로고
    • DNA vaccination against bcr-abl-positive cells in mice
    • Lucansky V, Sobotkova E, Tachezy R, et al. DNA vaccination against bcr-abl-positive cells in mice. Int J Oncol 2009;35:941-51
    • (2009) Int J Oncol , vol.35 , pp. 941-951
    • Lucansky, V.1    Sobotkova, E.2    Tachezy, R.3
  • 77
    • 73949131500 scopus 로고    scopus 로고
    • Bcr-Abl fusion sequences do not induce immune responses in mice when administered in mouse polyomavirus based virus-like particles
    • Hruskova V, Moravkova A, Babiarova K, et al. Bcr-Abl fusion sequences do not induce immune responses in mice when administered in mouse polyomavirus based virus-like particles. Int J Oncol 2009;35:1247-56
    • (2009) Int J Oncol , vol.35 , pp. 1247-1256
    • Hruskova, V.1    Moravkova, A.2    Babiarova, K.3
  • 78
    • 85047684622 scopus 로고    scopus 로고
    • Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors
    • Petrackova M, Sobotkova E, Duskova M, et al. Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors. Neoplasma 2009;56:194-201
    • (2009) Neoplasma , vol.56 , pp. 194-201
    • Petrackova, M.1    Sobotkova, E.2    Duskova, M.3
  • 79
    • 84860296173 scopus 로고    scopus 로고
    • Properties of bcr-abl-transformed mouse 12B1 cells secreting interleukin-2 and granulocyte-macrophage colony-stimulating factor: I. Derivation, genetic stability, oncogenicity and immunogenicity
    • Petrackova M, Tachezy R, Vonka V. Properties of bcr-abl-transformed mouse 12B1 cells secreting interleukin-2 and granulocyte-macrophage colony-stimulating factor: I. Derivation, genetic stability, oncogenicity and immunogenicity. Int J Oncol 2012;40:1668-76
    • (2012) Int J Oncol , vol.40 , pp. 1668-1676
    • Petrackova, M.1    Tachezy, R.2    Vonka, V.3
  • 80
    • 64849100156 scopus 로고    scopus 로고
    • Combined chemo- and immunotherapy of tumors induced in mice by bcr-abl-transformed cells
    • Sobotkova E, Duskova M, Tachezy R, et al. Combined chemo- and immunotherapy of tumors induced in mice by bcr-abl-transformed cells. Oncol Rep 2009;21:793-9
    • (2009) Oncol Rep , vol.21 , pp. 793-799
    • Sobotkova, E.1    Duskova, M.2    Tachezy, R.3
  • 81
    • 77958570368 scopus 로고    scopus 로고
    • Gene-modified cellular vaccines: Technologic aspects and clinical problems
    • Mackiewicz J, Mackiewicz A. Gene-modified cellular vaccines: technologic aspects and clinical problems. Transplant Proc 2010;42:3287-92
    • (2010) Transplant Proc , vol.42 , pp. 3287-3292
    • MacKiewicz, J.1    MacKiewicz, A.2
  • 82
    • 84861164690 scopus 로고    scopus 로고
    • Whole cell vaccines-past progress and future strategies
    • Keenan BP, Jaffee EM. Whole cell vaccines-past progress and future strategies. Semin Oncol 2012;39:276-86
    • (2012) Semin Oncol , vol.39 , pp. 276-286
    • Keenan, B.P.1    Jaffee, E.M.2
  • 83
    • 75149121612 scopus 로고    scopus 로고
    • K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate
    • Smith BD, Kasamon YL, Kowalski J, et al. K562/GM-CSF immunotherapy reduces tumor burden in chronic myeloid leukemia patients with residual disease on imatinib mesylate. Clin Cancer Res 2010;16:338-47
    • (2010) Clin Cancer Res , vol.16 , pp. 338-347
    • Smith, B.D.1    Kasamon, Y.L.2    Kowalski, J.3
  • 84
    • 84883549115 scopus 로고    scopus 로고
    • Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients
    • Brusic A, Hainz U, Wadleigh M, et al. Detecting T-cell reactivity to whole cell vaccines: proof of concept analysis of T-cell response to K562 cell antigens in CML patients. Oncoimmunology 2012;1: 1095-103
    • (2012) Oncoimmunology , vol.1 , pp. 1095-1103
    • Brusic, A.1    Hainz, U.2    Wadleigh, M.3
  • 85
    • 84891778736 scopus 로고    scopus 로고
    • The impact of the TIM gene family on tumor immunity and immunosuppression
    • Baghdadi M, Jinushi M. The impact of the TIM gene family on tumor immunity and immunosuppression. Cell Mol Immunol 2014;11:41-8
    • (2014) Cell Mol Immunol , vol.11 , pp. 41-48
    • Baghdadi, M.1    Jinushi, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.