메뉴 건너뛰기




Volumn 23, Issue 4, 2017, Pages 272-290

The neuroprotective effects of caffeine in neurodegenerative diseases

Author keywords

adenosine receptor; Alzheimer disease; amyotrophic lateral sclerosis; caffeine; dosage; Huntington disease; neurodegenerative disease; neuroprotection; Parkinson disease

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4; CAFFEINE; CALCIUM; CYTOCHROME P450 1A2; ESTROGEN; PHOSPHODIESTERASE; RILUZOLE; NEUROPROTECTIVE AGENT;

EID: 85015722418     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12684     Document Type: Review
Times cited : (203)

References (107)
  • 1
    • 84922374057 scopus 로고    scopus 로고
    • Does acute caffeine ingestion alter brain metabolism in young adults?
    • Xu F, Liu P, Pekar JJ, Lu H. Does acute caffeine ingestion alter brain metabolism in young adults? NeuroImage. 2015;110C:39-47.
    • (2015) NeuroImage , vol.110C , pp. 39-47
    • Xu, F.1    Liu, P.2    Pekar, J.J.3    Lu, H.4
  • 2
    • 84941655060 scopus 로고    scopus 로고
    • Feeling smart: effects of caffeine and glucose on cognition, mood and self-judgment
    • Ullrich S, de Vries Y, Kühn S, Repantis D, Dresler M, Ohla K. Feeling smart: effects of caffeine and glucose on cognition, mood and self-judgment. Physiol Behav. 2015;151:629-637.
    • (2015) Physiol Behav , vol.151 , pp. 629-637
    • Ullrich, S.1    de Vries, Y.2    Kühn, S.3    Repantis, D.4    Dresler, M.5    Ohla, K.6
  • 3
    • 84942297421 scopus 로고    scopus 로고
    • Plant alkaloids as drug leads for Alzheimer's disease
    • Pong NY, Or TCT, Ip NY. Plant alkaloids as drug leads for Alzheimer's disease. Neurochem Int. 2015;89:260-270.
    • (2015) Neurochem Int , vol.89 , pp. 260-270
    • Pong, N.Y.1    Or, T.C.T.2    Ip, N.Y.3
  • 5
    • 84887783158 scopus 로고    scopus 로고
    • Variation in caffeine concentration in single coffee beans
    • Fox GP, Wu A, Yiran L, Force L. Variation in caffeine concentration in single coffee beans. J Agric Food Chem. 2013;61:10772-10778.
    • (2013) J Agric Food Chem , vol.61 , pp. 10772-10778
    • Fox, G.P.1    Wu, A.2    Yiran, L.3    Force, L.4
  • 7
    • 33750984544 scopus 로고    scopus 로고
    • Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain Beta-amyloid production
    • Arendash GW, Schleif W, Rezai-Zadeh K, et al. Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain Beta-amyloid production. Neuroscience. 2006;142:941-952.
    • (2006) Neuroscience , vol.142 , pp. 941-952
    • Arendash, G.W.1    Schleif, W.2    Rezai-Zadeh, K.3
  • 8
    • 0036710108 scopus 로고    scopus 로고
    • Effects of caffeine on human behavior
    • Smith A. Effects of caffeine on human behavior. Food Chem Toxicol. 2002;40:1243-1255.
    • (2002) Food Chem Toxicol , vol.40 , pp. 1243-1255
    • Smith, A.1
  • 9
    • 34548433951 scopus 로고    scopus 로고
    • The neuroprotective effects of caffeine: a prospective population study (the Three City Study)
    • Ritchie K, Carriere I, de Mendonca A, et al. The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology. 2007;69:536-545.
    • (2007) Neurology , vol.69 , pp. 536-545
    • Ritchie, K.1    Carriere, I.2    de Mendonca, A.3
  • 10
    • 33846983228 scopus 로고    scopus 로고
    • Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study
    • van Gelder BM, Buijsse B, Tijhuis M, et al. Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study. Eur J Clin Nutr. 2007;61:226-232.
    • (2007) Eur J Clin Nutr , vol.61 , pp. 226-232
    • van Gelder, B.M.1    Buijsse, B.2    Tijhuis, M.3
  • 11
    • 58849083195 scopus 로고    scopus 로고
    • Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study
    • Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis. 2009;16:85-91.
    • (2009) J Alzheimers Dis , vol.16 , pp. 85-91
    • Eskelinen, M.H.1    Ngandu, T.2    Tuomilehto, J.3    Soininen, H.4    Kivipelto, M.5
  • 12
    • 0029904160 scopus 로고    scopus 로고
    • Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species
    • Devasagayam TP, Kamat JP, Mohan H, Kesavan PC. Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species. Biochim Biophys Acta. 1996;1282:63-70.
    • (1996) Biochim Biophys Acta , vol.1282 , pp. 63-70
    • Devasagayam, T.P.1    Kamat, J.P.2    Mohan, H.3    Kesavan, P.C.4
  • 13
    • 84908681056 scopus 로고    scopus 로고
    • Improvement of mitochondrial NAD(+)/FAD(+)-linked state-3 respiration by caffeine attenuates quinolinic acid induced motor impairment in rats: implications in Huntington's disease
    • Mishra J, Kumar A. Improvement of mitochondrial NAD(+)/FAD(+)-linked state-3 respiration by caffeine attenuates quinolinic acid induced motor impairment in rats: implications in Huntington's disease. Pharmacol Rep. 2014;66:1148-1155.
    • (2014) Pharmacol Rep , vol.66 , pp. 1148-1155
    • Mishra, J.1    Kumar, A.2
  • 14
    • 84947024027 scopus 로고    scopus 로고
    • Caffeine prevents D-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain
    • Ullah F, Ali T, Kim MO. Caffeine prevents D-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. Neurochem Int. 2015;90:114-124.
    • (2015) Neurochem Int , vol.90 , pp. 114-124
    • Ullah, F.1    Ali, T.2    Kim, M.O.3
  • 15
    • 84948457825 scopus 로고    scopus 로고
    • Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against β-amyloid-induced alterations in red blood cells
    • Carelli-Alinovi C, Ficarra S, Russo AM, et al. Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against β-amyloid-induced alterations in red blood cells. Biochimie. 2016;121:52-59.
    • (2016) Biochimie , vol.121 , pp. 52-59
    • Carelli-Alinovi, C.1    Ficarra, S.2    Russo, A.M.3
  • 16
    • 34248641060 scopus 로고    scopus 로고
    • Activation of human erythrocyte glutathione-s- transferase (EC. 2.5.1.18) by caffeine (1,3,7- trimethylxanthine)
    • Spiff AI, Uwakwe AA. Activation of human erythrocyte glutathione-s- transferase (EC. 2.5.1.18) by caffeine (1,3,7- trimethylxanthine). J Appl Sci Environ Manag. 2003;7:45-48.
    • (2003) J Appl Sci Environ Manag , vol.7 , pp. 45-48
    • Spiff, A.I.1    Uwakwe, A.A.2
  • 17
    • 84964215755 scopus 로고    scopus 로고
    • Molecular vibration-activity relationship in the agonism of adenosine receptors
    • Chee HK, Oh SJ. Molecular vibration-activity relationship in the agonism of adenosine receptors. Genomics Inform. 2013;11:282-288.
    • (2013) Genomics Inform , vol.11 , pp. 282-288
    • Chee, H.K.1    Oh, S.J.2
  • 18
    • 0347510989 scopus 로고    scopus 로고
    • Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling
    • Moro S, Deflorian F, Spalluto G, et al. Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling. Chem Commun (Camb). 2003;24:2949-2956.
    • (2003) Chem Commun (Camb) , vol.24 , pp. 2949-2956
    • Moro, S.1    Deflorian, F.2    Spalluto, G.3
  • 19
    • 84948809161 scopus 로고    scopus 로고
    • Purinergic signalling in brain ischemia
    • Pedata F, Dettori I, Coppi E, et al. Purinergic signalling in brain ischemia. Neuropharmacology. 2016;104:105-130.
    • (2016) Neuropharmacology , vol.104 , pp. 105-130
    • Pedata, F.1    Dettori, I.2    Coppi, E.3
  • 21
    • 0034623827 scopus 로고    scopus 로고
    • Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C
    • Kamp TJ, Hell JW. Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ Res. 2000;87:1095-1102.
    • (2000) Circ Res , vol.87 , pp. 1095-1102
    • Kamp, T.J.1    Hell, J.W.2
  • 22
  • 23
    • 1842664298 scopus 로고    scopus 로고
    • The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors
    • Halldner L, Adén U, Dahlberg V, Johansson B, Ledent C, Fredholm BB. The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors. Neuropharmacology. 2004;46:1008-1017.
    • (2004) Neuropharmacology , vol.46 , pp. 1008-1017
    • Halldner, L.1    Adén, U.2    Dahlberg, V.3    Johansson, B.4    Ledent, C.5    Fredholm, B.B.6
  • 24
    • 0038415954 scopus 로고    scopus 로고
    • Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity
    • DallIgna OP, Porciúncula LO, Souza DO, Cunha RA, Lara DR. Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity. Br J Pharmacol. 2003;138:1207-1209.
    • (2003) Br J Pharmacol , vol.138 , pp. 1207-1209
    • DallIgna, O.P.1    Porciúncula, L.O.2    Souza, D.O.3    Cunha, R.A.4    Lara, D.R.5
  • 25
    • 0027524469 scopus 로고
    • Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain
    • Shi D, Nikodijevic O, Jacobson KA, Daly JW. Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain. Cell Mol Neurobiol. 1993;13:247-261.
    • (1993) Cell Mol Neurobiol , vol.13 , pp. 247-261
    • Shi, D.1    Nikodijevic, O.2    Jacobson, K.A.3    Daly, J.W.4
  • 26
    • 1242336753 scopus 로고    scopus 로고
    • A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis
    • Tsutsui S, Schnermann J, Noorbakhsh F, et al. A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. Neurobiol Dis. 2004;24:1521-1529.
    • (2004) Neurobiol Dis , vol.24 , pp. 1521-1529
    • Tsutsui, S.1    Schnermann, J.2    Noorbakhsh, F.3
  • 27
    • 84905161640 scopus 로고    scopus 로고
    • Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride
    • Giunta S, Andriolo V, Castorina A. Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride. Int J Biochem Cell Biol. 2014;54C:122-136.
    • (2014) Int J Biochem Cell Biol , vol.54C , pp. 122-136
    • Giunta, S.1    Andriolo, V.2    Castorina, A.3
  • 28
    • 84862899861 scopus 로고    scopus 로고
    • SCH58261 the selective adenosine A2A receptor blocker modulates ischemia reperfusion injury following bilateral carotid occlusion: role of inflammatory mediators
    • Mohamed RA, Agha AM, Nassar NN. SCH58261 the selective adenosine A2A receptor blocker modulates ischemia reperfusion injury following bilateral carotid occlusion: role of inflammatory mediators. Neurochem Res. 2012;37:538-547.
    • (2012) Neurochem Res , vol.37 , pp. 538-547
    • Mohamed, R.A.1    Agha, A.M.2    Nassar, N.N.3
  • 29
    • 84953238526 scopus 로고    scopus 로고
    • Adenosine receptor targets for pain
    • Sawynok J. Adenosine receptor targets for pain. Neuroscience. 2016;338:1-18.
    • (2016) Neuroscience , vol.338 , pp. 1-18
    • Sawynok, J.1
  • 30
    • 84954090494 scopus 로고    scopus 로고
    • Role of adenosine A2A receptor in ischemia reperfusion injury: signaling to extracellular signal-regulated protein kinase
    • Mohamed R, Agha A, Abdel-Rahman A, Nassar N. Role of adenosine A2A receptor in ischemia reperfusion injury: signaling to extracellular signal-regulated protein kinase. Neuroscience. 2016;314:145-159.
    • (2016) Neuroscience , vol.314 , pp. 145-159
    • Mohamed, R.1    Agha, A.2    Abdel-Rahman, A.3    Nassar, N.4
  • 31
    • 84934894606 scopus 로고    scopus 로고
    • Caffeine acts through neuronal adenosine A 2A receptors to prevent mood and memory dysfunction triggered by chronic stress
    • Kaster MP, Machado NJ, Silva HB, et al. Caffeine acts through neuronal adenosine A 2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Proc Natl Acad Sci. 2015;112:201423088.
    • (2015) Proc Natl Acad Sci , vol.112 , pp. 201423088
    • Kaster, M.P.1    Machado, N.J.2    Silva, H.B.3
  • 32
    • 84929940043 scopus 로고    scopus 로고
    • Adenosine A2A receptors modulate acute injury and neuroinflammation in brain ischemia
    • Pedata F, Pugliese AM, Coppi E, et al. Adenosine A2A receptors modulate acute injury and neuroinflammation in brain ischemia. Mediators Inflamm. 2014;2014:805198.
    • (2014) Mediators Inflamm , vol.2014 , pp. 805198
    • Pedata, F.1    Pugliese, A.M.2    Coppi, E.3
  • 33
    • 84928780805 scopus 로고    scopus 로고
    • Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling
    • Dobson KL, Jackson C, Balakrishnan S, Bellamy TC. Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling. PLoS One. 2015;10:1-23.
    • (2015) PLoS One , vol.10 , pp. 1-23
    • Dobson, K.L.1    Jackson, C.2    Balakrishnan, S.3    Bellamy, T.C.4
  • 34
    • 84901341037 scopus 로고    scopus 로고
    • The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease
    • Liu J, Supnet C, Sun S, et al. The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease. Channels. 2014;8:230-242.
    • (2014) Channels , vol.8 , pp. 230-242
    • Liu, J.1    Supnet, C.2    Sun, S.3
  • 35
    • 0036788917 scopus 로고    scopus 로고
    • Ryanodine receptor calcium release channels
    • Fill M, Copell JA. Ryanodine receptor calcium release channels. Physiol Rev. 2002;82:893-922.
    • (2002) Physiol Rev , vol.82 , pp. 893-922
    • Fill, M.1    Copell, J.A.2
  • 36
    • 26844513636 scopus 로고    scopus 로고
    • The potential of caffeine for functional modification from cortical synapses to neuron networks in the brain
    • Yoshimura H. The potential of caffeine for functional modification from cortical synapses to neuron networks in the brain. Curr Neuropharmacol. 2005;3:309-316.
    • (2005) Curr Neuropharmacol , vol.3 , pp. 309-316
    • Yoshimura, H.1
  • 37
    • 52449085476 scopus 로고    scopus 로고
    • Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor
    • Kong H, Jones PP, Koop A, et al. Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. Biochem J. 2009;414:441-452.
    • (2009) Biochem J , vol.414 , pp. 441-452
    • Kong, H.1    Jones, P.P.2    Koop, A.3
  • 38
    • 0345561561 scopus 로고    scopus 로고
    • Actions of caffeine in the brain with special reference to factors that contribute to its widespread use
    • Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51:83-133.
    • (1999) Pharmacol Rev , vol.51 , pp. 83-133
    • Fredholm, B.B.1    Bättig, K.2    Holmén, J.3    Nehlig, A.4    Zvartau, E.E.5
  • 39
    • 0030754563 scopus 로고    scopus 로고
    • The role of dopamine in the behavioral effects of caffeine in animals and humans
    • Garrett BE, Griffiths RR. The role of dopamine in the behavioral effects of caffeine in animals and humans. Pharmacol Biochem Behav. 1997;57:533-541.
    • (1997) Pharmacol Biochem Behav , vol.57 , pp. 533-541
    • Garrett, B.E.1    Griffiths, R.R.2
  • 41
    • 84879480610 scopus 로고    scopus 로고
    • Association between caffeine intake and age at onset in Huntington's disease
    • Simonin C, Duru C, Salleron J, et al. Association between caffeine intake and age at onset in Huntington's disease. Neurobiol Dis. 2013;58:179-182.
    • (2013) Neurobiol Dis , vol.58 , pp. 179-182
    • Simonin, C.1    Duru, C.2    Salleron, J.3
  • 42
    • 0036830947 scopus 로고    scopus 로고
    • Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
    • LaFerla FM. Calcium dyshomeostasis and intracellular signalling in alzheimer's disease. Nat Rev. 2002;3:862-872.
    • (2002) Nat Rev , vol.3 , pp. 862-872
    • LaFerla, F.M.1
  • 43
    • 84911446629 scopus 로고    scopus 로고
    • Therapeutic benefits of a component of coffee in a rat model of Alzheimer disease
    • Basurto-Islas G, Blanchard J, Tung YC, et al. Therapeutic benefits of a component of coffee in a rat model of Alzheimer disease. Neurobiol Aging. 2014;35:2701-2712.
    • (2014) Neurobiol Aging , vol.35 , pp. 2701-2712
    • Basurto-Islas, G.1    Blanchard, J.2    Tung, Y.C.3
  • 44
    • 0036725818 scopus 로고    scopus 로고
    • Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging
    • Lindsay J, Laurin D, Verreault R, et al. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol. 2002;156:445-453.
    • (2002) Am J Epidemiol , vol.156 , pp. 445-453
    • Lindsay, J.1    Laurin, D.2    Verreault, R.3
  • 45
    • 0036046427 scopus 로고    scopus 로고
    • Does caffeine intake protect from Alzheimer ‘s disease ?
    • Maia L, de Mendonca A. Does caffeine intake protect from Alzheimer ‘s disease ? Eur J Neurol. 2002;9:377-382.
    • (2002) Eur J Neurol , vol.9 , pp. 377-382
    • Maia, L.1    de Mendonca, A.2
  • 46
    • 84924170711 scopus 로고    scopus 로고
    • Caffeine intake from coffee or tea and cognitive disorders : a meta-analysis of observational studies
    • Kim Y, Mi S, Myung S. Caffeine intake from coffee or tea and cognitive disorders : a meta-analysis of observational studies. Neuroepidemiology. 2015;769:51-63.
    • (2015) Neuroepidemiology , vol.769 , pp. 51-63
    • Kim, Y.1    Mi, S.2    Myung, S.3
  • 47
    • 0036522987 scopus 로고    scopus 로고
    • Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum
    • Popoli P, Pintor A, Domenici MR, et al. Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum. J Neurosci. 2002;22:1967-1975.
    • (2002) J Neurosci , vol.22 , pp. 1967-1975
    • Popoli, P.1    Pintor, A.2    Domenici, M.R.3
  • 48
    • 84951905228 scopus 로고    scopus 로고
    • A2A adenosine receptor deletion is protective in a mouse model of Tauopathy
    • Laurent C, Burnouf S, Ferry B, et al. A2A adenosine receptor deletion is protective in a mouse model of Tauopathy. Mol Psychiatry. 2014;2016:97-107.
    • (2014) Mol Psychiatry , vol.2016 , pp. 97-107
    • Laurent, C.1    Burnouf, S.2    Ferry, B.3
  • 49
    • 84865781758 scopus 로고    scopus 로고
    • Crude caffeine reduces memory impairment and amyloid β1-42 levels in an Alzheimer's mouse model
    • Chu YF, Chang WH, Black RM, et al. Crude caffeine reduces memory impairment and amyloid β1-42 levels in an Alzheimer's mouse model. Food Chem. 2012;135:2095-2102.
    • (2012) Food Chem , vol.135 , pp. 2095-2102
    • Chu, Y.F.1    Chang, W.H.2    Black, R.M.3
  • 50
    • 67849083449 scopus 로고    scopus 로고
    • Caffeine reverses cognitive impairment and decreases brain amyloid levels in aged alzheimer's disease mice
    • Arendash GW, Mori T, Cao C, et al. Caffeine reverses cognitive impairment and decreases brain amyloid levels in aged alzheimer's disease mice. J Alzheimers Dis. 2009;17:661-680.
    • (2009) J Alzheimers Dis , vol.17 , pp. 661-680
    • Arendash, G.W.1    Mori, T.2    Cao, C.3
  • 52
    • 84863895905 scopus 로고    scopus 로고
    • Enhanced brain amyloid-β clearance by Rifampicin and caffeine as a possible protection mechanism against Alzheimer's disease
    • Qosa H, Abuznait AH, Hill RA, Kaddoumi A. Enhanced brain amyloid-β clearance by Rifampicin and caffeine as a possible protection mechanism against Alzheimer's disease. J Alzheimers Dis. 2012;31:151-165.
    • (2012) J Alzheimers Dis , vol.31 , pp. 151-165
    • Qosa, H.1    Abuznait, A.H.2    Hill, R.A.3    Kaddoumi, A.4
  • 53
    • 84881121689 scopus 로고    scopus 로고
    • Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease
    • Han K, Jia N, Li J, Yang L, Min LQ. Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease. Mol Med Rep. 2013;8:737-740.
    • (2013) Mol Med Rep , vol.8 , pp. 737-740
    • Han, K.1    Jia, N.2    Li, J.3    Yang, L.4    Min, L.Q.5
  • 54
    • 85012960803 scopus 로고    scopus 로고
    • Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer's disease
    • Ghoneim FM, Khalaf HA, Elsamanoudy AZ, El-khair SMA, Helaly AMN. Protective effect of chronic caffeine intake on gene expression of brain derived neurotrophic factor signaling and the immunoreactivity of glial fibrillary acidic protein and Ki-67 in Alzheimer's disease. Int J Clin Exp Pathol. 2015;8:7710-7728.
    • (2015) Int J Clin Exp Pathol , vol.8 , pp. 7710-7728
    • Ghoneim, F.M.1    Khalaf, H.A.2    Elsamanoudy, A.Z.3    El-khair, S.M.A.4    Helaly, A.M.N.5
  • 55
    • 80053221873 scopus 로고    scopus 로고
    • Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice
    • Zeitlin R, Patel S, Burgess S, Arendash GW, Echeverria V. Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice. Brain Res. 2011;1417:127-136.
    • (2011) Brain Res , vol.1417 , pp. 127-136
    • Zeitlin, R.1    Patel, S.2    Burgess, S.3    Arendash, G.W.4    Echeverria, V.5
  • 56
    • 84867526964 scopus 로고    scopus 로고
    • Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells
    • Dragicevic N, Delic V, Cao C, et al. Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer's mice and cells. Neuropharmacology. 2012;63:1368-1379.
    • (2012) Neuropharmacology , vol.63 , pp. 1368-1379
    • Dragicevic, N.1    Delic, V.2    Cao, C.3
  • 57
    • 15744389445 scopus 로고    scopus 로고
    • Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease
    • Sato A, Terata K, Miura H, et al. Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol. 2005;288:H1633-H1640.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288 , pp. H1633-H1640
    • Sato, A.1    Terata, K.2    Miura, H.3
  • 58
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 59
    • 77956180469 scopus 로고    scopus 로고
    • Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet
    • Prasanthi JRP, Bhanu D, Marwarha G, et al. Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med. 2010;49:1212-1220.
    • (2010) Free Radic Biol Med , vol.49 , pp. 1212-1220
    • Prasanthi, J.R.P.1    Bhanu, D.2    Marwarha, G.3
  • 60
    • 0023878396 scopus 로고
    • Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apoprotein E and cholesterol metabolism
    • Boerwinkle E, Utermannt G. Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apoprotein E and cholesterol metabolism. Am J Hum Genet. 1988;42:104-112.
    • (1988) Am J Hum Genet , vol.42 , pp. 104-112
    • Boerwinkle, E.1    Utermannt, G.2
  • 61
    • 33644911218 scopus 로고    scopus 로고
    • Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba
    • Hall K, Murrell J, Ogunniyi A, et al. Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba. Neurology. 2006;66:223-227.
    • (2006) Neurology , vol.66 , pp. 223-227
    • Hall, K.1    Murrell, J.2    Ogunniyi, A.3
  • 62
    • 84946057538 scopus 로고    scopus 로고
    • Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson's Disease
    • Kumar PM, Paing SST, Li H, et al. Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson's Disease. Sci Rep. 2015;5:15492.
    • (2015) Sci Rep , vol.5 , pp. 15492
    • Kumar, P.M.1    Paing, S.S.T.2    Li, H.3
  • 63
    • 84954074747 scopus 로고    scopus 로고
    • Neuroprotective effects of caffeine in MPTP model of Parkinson's disease: a 13C NMR study
    • Bagga P, Chugani AN, Patel AB. Neuroprotective effects of caffeine in MPTP model of Parkinson's disease: a 13C NMR study. Neurochem Int. 2016;92:24-35.
    • (2016) Neurochem Int , vol.92 , pp. 24-35
    • Bagga, P.1    Chugani, A.N.2    Patel, A.B.3
  • 64
    • 77956209909 scopus 로고    scopus 로고
    • Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms
    • Prediger RDS. Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms. J Alzheimers Dis. 2010;20:s205-s220.
    • (2010) J Alzheimers Dis , vol.20 , pp. s205-s220
    • Prediger, R.D.S.1
  • 65
    • 84877743637 scopus 로고    scopus 로고
    • A disruption mechanism of the molecular clock in a MPTP mouse model of parkinson's disease
    • Hayashi A, Matsunaga N, Okazaki H, et al. A disruption mechanism of the molecular clock in a MPTP mouse model of parkinson's disease. Neuromolecular Med. 2013;15:238-251.
    • (2013) Neuromolecular Med , vol.15 , pp. 238-251
    • Hayashi, A.1    Matsunaga, N.2    Okazaki, H.3
  • 66
    • 84866103728 scopus 로고    scopus 로고
    • Caffeine for treatment of Parkinson disease: a randomized controlled trial
    • Postuma RB, Lang AE, Munhoz RP, et al. Caffeine for treatment of Parkinson disease: a randomized controlled trial. Neurology. 2012;79:651-658.
    • (2012) Neurology , vol.79 , pp. 651-658
    • Postuma, R.B.1    Lang, A.E.2    Munhoz, R.P.3
  • 67
    • 0034738134 scopus 로고    scopus 로고
    • Association of coffee and caffeine intake with the risk of Parkinson disease
    • Ross GW, Abbott RD, Petrovitch H, et al. Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA. 2000;283:2674-2679.
    • (2000) JAMA , vol.283 , pp. 2674-2679
    • Ross, G.W.1    Abbott, R.D.2    Petrovitch, H.3
  • 68
    • 84862202565 scopus 로고    scopus 로고
    • Caffeine intake, smoking, and risk of Parkinson disease in men and women
    • Liu R, Guo X, Park Y, et al. Caffeine intake, smoking, and risk of Parkinson disease in men and women. Am J Epidemiol. 2012;175:1200-1207.
    • (2012) Am J Epidemiol , vol.175 , pp. 1200-1207
    • Liu, R.1    Guo, X.2    Park, Y.3
  • 69
    • 84897489405 scopus 로고    scopus 로고
    • Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease
    • Qi H, Li S. Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Geriatr Gerontol Int. 2014;14:430-439.
    • (2014) Geriatr Gerontol Int , vol.14 , pp. 430-439
    • Qi, H.1    Li, S.2
  • 70
    • 84866293285 scopus 로고    scopus 로고
    • Caffeine and risk of Parkinson's disease in a large cohort of men and women
    • Palacios N, Gao X, McCullough ML, et al. Caffeine and risk of Parkinson's disease in a large cohort of men and women. Mov Disord. 2012;27:1276-1282.
    • (2012) Mov Disord , vol.27 , pp. 1276-1282
    • Palacios, N.1    Gao, X.2    McCullough, M.L.3
  • 73
    • 84904977412 scopus 로고    scopus 로고
    • Reproductive factors and Parkinson's disease risk in Danish women
    • Greene N, Lassen CF, Rugbjerg K, Ritz B. Reproductive factors and Parkinson's disease risk in Danish women. Eur J Neurol. 2014;21:1168, e68.
    • (2014) Eur J Neurol , vol.21
    • Greene, N.1    Lassen, C.F.2    Rugbjerg, K.3    Ritz, B.4
  • 75
    • 32544436383 scopus 로고    scopus 로고
    • Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • Xu K, Xu Y, Brown-Jermyn D, et al. Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Neurosci. 2006;26:535-541.
    • (2006) J Neurosci , vol.26 , pp. 535-541
    • Xu, K.1    Xu, Y.2    Brown-Jermyn, D.3
  • 76
    • 84862821537 scopus 로고    scopus 로고
    • Delayed caffeine treatment nigral dopamine neuron loss in a progressive rat model of Parkinson's disease
    • Sonsalla PK, Wong L-Y, Harris SL, et al. Delayed caffeine treatment nigral dopamine neuron loss in a progressive rat model of Parkinson's disease. Exp Neurol. 2012;234:482-487.
    • (2012) Exp Neurol , vol.234 , pp. 482-487
    • Sonsalla, P.K.1    Wong, L.-Y.2    Harris, S.L.3
  • 77
    • 0035874345 scopus 로고    scopus 로고
    • Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease
    • Chen JF, Xu K, Petzer JP, et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci. 2001;21:1-6.
    • (2001) J Neurosci , vol.21 , pp. 1-6
    • Chen, J.F.1    Xu, K.2    Petzer, J.P.3
  • 78
    • 39149085654 scopus 로고    scopus 로고
    • Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells
    • Nakaso K, Ito S, Nakashima K. Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells. Neurosci Lett. 2008;432:146-150.
    • (2008) Neurosci Lett , vol.432 , pp. 146-150
    • Nakaso, K.1    Ito, S.2    Nakashima, K.3
  • 79
    • 84863398762 scopus 로고    scopus 로고
    • Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2
    • Arita R, Yanagi Y, Honda N, et al. Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2. Ophthalmology. 2012;119:972-978.
    • (2012) Ophthalmology , vol.119 , pp. 972-978
    • Arita, R.1    Yanagi, Y.2    Honda, N.3
  • 81
    • 0028241592 scopus 로고
    • Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms
    • Tassaneeyakul W, Birkett DJ, McManus ME, et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem Pharmacol. 1994;47:1767-1776.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1767-1776
    • Tassaneeyakul, W.1    Birkett, D.J.2    McManus, M.E.3
  • 82
    • 0033341632 scopus 로고    scopus 로고
    • Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women
    • Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol. 1999;39:936-940.
    • (1999) J Clin Pharmacol , vol.39 , pp. 936-940
    • Pollock, B.G.1    Wylie, M.2    Stack, J.A.3
  • 83
    • 34247609838 scopus 로고    scopus 로고
    • Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans
    • Ghotbi R, Christensen M, Roh HK, Ingelman-Sundberg M, Aklillu E, Bertilsson L. Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur J Clin Pharmacol. 2007;63:537-546.
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 537-546
    • Ghotbi, R.1    Christensen, M.2    Roh, H.K.3    Ingelman-Sundberg, M.4    Aklillu, E.5    Bertilsson, L.6
  • 84
    • 84865334258 scopus 로고    scopus 로고
    • Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption
    • Josse AR, Da Costa LA, Campos H, El-Sohemy A. Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption. Am J Clin Nutr. 2012;96:665-671.
    • (2012) Am J Clin Nutr , vol.96 , pp. 665-671
    • Josse, A.R.1    Da Costa, L.A.2    Campos, H.3    El-Sohemy, A.4
  • 85
    • 33847079175 scopus 로고    scopus 로고
    • In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios
    • Begas E, Kouvaras E, Tsakalof A, Papakosta S, Asprodini E. In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomed Chromatogr. 2007;21:190-200.
    • (2007) Biomed Chromatogr , vol.21 , pp. 190-200
    • Begas, E.1    Kouvaras, E.2    Tsakalof, A.3    Papakosta, S.4    Asprodini, E.5
  • 86
    • 84929128366 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
    • Cornelis MC, Byrne EM, Esko T, et al. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry. 2015;20:647-656.
    • (2015) Mol Psychiatry , vol.20 , pp. 647-656
    • Cornelis, M.C.1    Byrne, E.M.2    Esko, T.3
  • 87
    • 77950867025 scopus 로고    scopus 로고
    • Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease
    • Xu K, Xu YH, Chen JF, Schwarzschild MA. Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease. Neuroscience. 2010;167:475-481.
    • (2010) Neuroscience , vol.167 , pp. 475-481
    • Xu, K.1    Xu, Y.H.2    Chen, J.F.3    Schwarzschild, M.A.4
  • 88
    • 84924956494 scopus 로고    scopus 로고
    • Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis
    • Ng SK, Higashimori H, Tolman M, Yang Y. Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis. Exp Neurol. 2015;267:115-122.
    • (2015) Exp Neurol , vol.267 , pp. 115-122
    • Ng, S.K.1    Higashimori, H.2    Tolman, M.3    Yang, Y.4
  • 89
    • 84905497633 scopus 로고    scopus 로고
    • Adenosine A2A receptors activation facilitates neuromuscular transmission in the pre-symptomatic phase of the SOD1(G93A) ALS mice, but not in the symptomatic phase
    • Nascimento F, Pousinha PA, Correia AM, Gomes R, Sebastião AM, Ribeiro JA. Adenosine A2A receptors activation facilitates neuromuscular transmission in the pre-symptomatic phase of the SOD1(G93A) ALS mice, but not in the symptomatic phase. PLoS One. 2014;9:e104081.
    • (2014) PLoS One , vol.9
    • Nascimento, F.1    Pousinha, P.A.2    Correia, A.M.3    Gomes, R.4    Sebastião, A.M.5    Ribeiro, J.A.6
  • 90
    • 84934967279 scopus 로고    scopus 로고
    • Dietary vitamin D3 restriction exacerbates disease pathophysiology in the spinal cord of the G93A mouse model of amyotrophic lateral sclerosis
    • Moghimi E, Solomon JA, Gianforcaro A, Hamadeh MJ. Dietary vitamin D3 restriction exacerbates disease pathophysiology in the spinal cord of the G93A mouse model of amyotrophic lateral sclerosis. PLoS One. 2015;10:e0126355.
    • (2015) PLoS One , vol.10
    • Moghimi, E.1    Solomon, J.A.2    Gianforcaro, A.3    Hamadeh, M.J.4
  • 91
    • 33749056809 scopus 로고    scopus 로고
    • ALS: a disease of motor neurons and their nonneuronal neighbors
    • Boillée S, Vande Velde C, Cleveland DW. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron. 2006;52:39-59.
    • (2006) Neuron , vol.52 , pp. 39-59
    • Boillée, S.1    Vande Velde, C.2    Cleveland, D.W.3
  • 92
    • 85015754365 scopus 로고    scopus 로고
    • Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: results from five cohort studies
    • Fondell E, ÉiJ O, Fitzgerald KC, et al. Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: results from five cohort studies. Amyotroph Lateral Scler Frontemporal Degener. 2014;2015:1-6.
    • (2014) Amyotroph Lateral Scler Frontemporal Degener , vol.2015 , pp. 1-6
    • Fondell, E.1    Éij, O.2    Fitzgerald, K.C.3
  • 93
    • 84947612410 scopus 로고    scopus 로고
    • Presymptomatic and symptomatic ALS SOD1 (G93A) mice differ in adenosine A1 and A2A receptor-mediated tonic modulation of neuromuscular transmission
    • Nascimento F, Sebastião AM, Ribeiro JA. Presymptomatic and symptomatic ALS SOD1 (G93A) mice differ in adenosine A1 and A2A receptor-mediated tonic modulation of neuromuscular transmission. Purinergic Signal. 2015;11:471-480.
    • (2015) Purinergic Signal , vol.11 , pp. 471-480
    • Nascimento, F.1    Sebastião, A.M.2    Ribeiro, J.A.3
  • 95
    • 0030924553 scopus 로고    scopus 로고
    • Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro
    • Sanderink G-J, Bournique B, Stevens J, Petry M, Martinet M. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. J Pharmacol Exp Ther. 1997;282:1465-1472.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 1465-1472
    • Sanderink, G.-J.1    Bournique, B.2    Stevens, J.3    Petry, M.4    Martinet, M.5
  • 96
    • 78650609433 scopus 로고    scopus 로고
    • A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease
    • Mievis S, Blum D, Ledent C. A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease. Neurobiol Dis. 2011;41:570-576.
    • (2011) Neurobiol Dis , vol.41 , pp. 570-576
    • Mievis, S.1    Blum, D.2    Ledent, C.3
  • 97
    • 0038231381 scopus 로고    scopus 로고
    • Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics
    • Blum D, Hourez R, Galas M, Popoli P, Schiffmann SN. Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics. Lancet Neurol. 2003;2:366-374.
    • (2003) Lancet Neurol , vol.2 , pp. 366-374
    • Blum, D.1    Hourez, R.2    Galas, M.3    Popoli, P.4    Schiffmann, S.N.5
  • 98
    • 0345060347 scopus 로고    scopus 로고
    • Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively
    • Alfinito PD, Wang S-P, Manzino L, Rijhsinghani S, Zeevalk GD, Sonsalla PK. Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. J Neurosci. 2003;23:10982-10987.
    • (2003) J Neurosci , vol.23 , pp. 10982-10987
    • Alfinito, P.D.1    Wang, S.-P.2    Manzino, L.3    Rijhsinghani, S.4    Zeevalk, G.D.5    Sonsalla, P.K.6
  • 100
    • 84940439979 scopus 로고    scopus 로고
    • Toward therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance
    • Li X, Liu H, Fischhaber PL, Tang T-S. Toward therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance. Prog Neurobiol. 2015;132:34-58.
    • (2015) Prog Neurobiol , vol.132 , pp. 34-58
    • Li, X.1    Liu, H.2    Fischhaber, P.L.3    Tang, T.-S.4
  • 101
    • 84355161952 scopus 로고    scopus 로고
    • Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease
    • Koch P, Breuer P, Peitz M, et al. Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature. 2011;480:543-548.
    • (2011) Nature , vol.480 , pp. 543-548
    • Koch, P.1    Breuer, P.2    Peitz, M.3
  • 102
    • 84878306815 scopus 로고    scopus 로고
    • Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease
    • Gonçalves N, Simões AT, Cunha RA, De Almeida LP. Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease. Ann Neurol. 2013;73:655-666.
    • (2013) Ann Neurol , vol.73 , pp. 655-666
    • Gonçalves, N.1    Simões, A.T.2    Cunha, R.A.3    De Almeida, L.P.4
  • 103
    • 77956195944 scopus 로고    scopus 로고
    • Caffeine and coffee as therapeutics against Alzheimer's disease
    • Arendash GW, Cao C. Caffeine and coffee as therapeutics against Alzheimer's disease. J Alzheimers Dis. 2010;20(Suppl. 1):117-126.
    • (2010) J Alzheimers Dis , vol.20 , pp. 117-126
    • Arendash, G.W.1    Cao, C.2
  • 104
  • 105
    • 84859435773 scopus 로고    scopus 로고
    • Pain in Parkinson's disease
    • Ford B. Pain in Parkinson's disease. Mov Disord. 2012;27:485-491.
    • (2012) Mov Disord , vol.27 , pp. 485-491
    • Ford, B.1
  • 106
    • 84858337675 scopus 로고    scopus 로고
    • Pain in amyotrophic lateral sclerosis: a Neglected aspect of disease
    • Handy CR, Krudy C, Boulis N, Federici T. Pain in amyotrophic lateral sclerosis: a Neglected aspect of disease. Neurol Res Int. 2011;2011:1-8.
    • (2011) Neurol Res Int , vol.2011 , pp. 1-8
    • Handy, C.R.1    Krudy, C.2    Boulis, N.3    Federici, T.4
  • 107
    • 0036786720 scopus 로고    scopus 로고
    • Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers
    • Bell DG, McLellan TM. Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers. J Appl Physiol. 2002;93:1227-1234.
    • (2002) J Appl Physiol , vol.93 , pp. 1227-1234
    • Bell, D.G.1    McLellan, T.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.