The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: A study in mice lacking adenosine A1 and/or A2A receptors

Neuropharmacology

Volumn 46, Issue 7, 2004, Pages 1008-1017

  Halldner, Linda ^a   Ådén, Ulrika ^a   Dahlberg, Viktoria ^a   Johansson, Björn ^a   Ledent, Catherine ^b   Fredholm, Bertil B ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

A1R, adenosine A1 receptor; A2AR, adenosine A2A receptor; Adenosine A1 receptors; Adenosine A2A receptors; Caffeine; Knock out; Locomotion; Mice

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; CAFFEINE;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GENOTYPE; HETEROZYGOSITY; KNOCKOUT MOUSE; LOCOMOTION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; STIMULATION; WILD TYPE; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; GENETICS; MOTOR ACTIVITY; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; CAFFEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A;

EID: 1842664298     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2004.01.014     Document Type: Article

References (40)

1. 2A knockout mice. Stroke. 34:2003;739-744. Computer File.
2. Antoniou K., Kafetzopoulos E., Papadopoulou-Daifoti Z., Hyphantis T., Marselos M. D-amphetamine, cocaine and caffeine: a comparative study of acute effects on locomotor activity and behavioural patterns in rats. Neuroscience and Biobehavioral Reviews. 23:1998;189-196.
3. Barraco R.A., Coffin V.L., Altman H.J., Phillis J.W. Central effects of adenosine analogs on locomotor activity in mice and antagonism of caffeine. Brain Research. 272:1983;392-395.
4. 2a double knockout mice. European Journal of Neuroscience. 17:2003;315-324.
5. Chen J.F., Beilstein M., Xu Y.H., Turner T.J., Moratalla R., Standaert D.G., Aloyo V.J., Fink J.S., Schwarzschild M.A. Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors. Neuroscience. 97:2000;195-204.
6. Colmenares C., Heilstedt H.A., Shaffer L.G., Schwartz S., Berk M., Murray J.C., Stavnezer E. Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice. Nature Genetics. 30:2002;106-109.
7. El Yacoubi M., Ledent C., Menard J.F., Parmentier M., Costentin J., Vaugeois J.M. The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors. British Journal of Pharmacology. 129:2000a;1465-1473.
8. El Yacoubi M., Ledent C., Parmentier M., Costentin J., Vaugeois J.M. The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists. Psychopharmacology. 148:2000b;153-163.
9. 2B receptors. Pharmacological Reviews. 49:1997;381-402.
10. 1 receptor-mediated mechanisms. European Journal of Neuroscience. 8:1996;1545-1553.
11. 1 receptors. NeuroReport. 6:1994;73-76.
12. Fredholm B.B. Are methylxanthine effects due to antagonism of endogenous adenosine? Trends in Pharmacological Sciences. 1:1980;129-132.
13. Fredholm B.B., Arslan G., Halldner L., Kull B., Schulte G., Wasserman W. Structure and function of adenosine receptors and their genes. Naunyn Schmiedeberg's Archives of Pharmacology. 362:2000;364-374.
14. Fredholm B.B., Bättig K., Holmén J., Nehlig A., Zvartau E. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews. 51:1999a;83-153.
15. Fredholm B.B., Battig K., Holmen J., Nehlig A., Zvartau E.E. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews. 51:1999b;83-133.
16. 1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate. European Journal of Neuroscience. 16:2002;547-550.
17. 1 receptor knock-out mouse. Abstract Viewer/ Society for Neuroscience Annual meeting No. 783.20.
18. Homanics G.E., Quinlan J.J., Firestone L.L. Pharmacologic and behavioral responses of inbred C57BL/6J and strain 129/SvJ mouse lines. Pharmacology, Biochemistry and Behavior. 63:1999;21-26.
19. Jacobson K.A., Nikodijevic O., Padgett W., Gallo-Rodriguez C., Maillard M., Daly J.W. 8-(3-chlorostyryl)caffeine is a selective A2-adenosine antagonist in vitro and in vivo. FEBS Letters. 323:1993;141-144.
20. 1 receptor. Proceedings of the National Academy of Sciences of the United States of America. 98:2001;9407-9412.
21. Johansson B., Svenningsson P., Ådén U., Lindström K., Fredholm B.B. Evidence that the increase in striatal c-fos following acute high-dose caffeine is not due to direct interaction with striatal adenosine receptors. Acta Physiologica Scandinavica. 146:1992;539-541.
22. Kuzmin A., Johansson B., Fredholm B.B., Ögren S.-O. Caffeine and cocaine stimulate locomotion in mice via different mechanisms-a comparison between 129/OlaHsd and C57 mice. Life Sciences. 66:2000;PL113-PL118.
23. 2A receptor. Nature. 388:1997;674-678.
24. Mahan L.C., McVittie L.D., Smyk-Randall E.M., Nakata H., Monsma F.J. Jr., Gerfen C.R., Sibley D.R. Cloning and expression of an A1 adenosine receptor from rat brain. Molecular Pharmacology. 40:1991;1-7.
25. Marston H.M., Finlayson K., Maemoto T., Olverman H.J., Akahane A., Sharkey J., Butcher S.P. Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques. Journal of Pharmacology and Experimental Therapeutics. 285:1998;1023-1030.
26. McNamara F.N., Clifford J.J., Tighe O., Kinsella A., Drago J., Croke D.T., Waddington J.L. Congenic D(1A) dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype. Neuropsychopharmacology. 28:2003;86-99.
27. Murphy N.P., Lam H.A., Maidment N.T. A comparison of morphine-induced locomotor activity and mesolimbic dopamine release in C57BL6, 129Sv and DBA2 mice. Journal of Neurochemistry. 79:2001;626-635.
28. Nikodijevic O., Daly J.W., Jacobson K.A. Characterization of the locomotor depression produced by an A2-selective adenosine agonist. FEBS Letters. 261:1990;67-70.
29. 2-selective adenosine agonists and antagonists: evidence for synergism and antagonism. Journal of Pharmacology and Experimental Therapeutics. 259:1991;286-294.
30. 1-adenosine receptor that is widely expressed in brain and spinal cord. Molecular Endocrinology. 5:1991;1037-1048.
31. Rodgers R.J., Boullier E., Chatzimichalaki P., Cooper G.D., Shorten A. Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour. Physiology and Behavior. 77:2002;301-310.
32. Silvestre J.S., Fernandez A.G., Palacios J.M. Preliminary evidence for an involvement of the cholinergic system in the sedative effects of rolipram in rats. Pharmacology, Biochemistry and Behavior. 64:1999;1-5.
33. Smith D.F. Effects of lithium and rolipram enantiomers on locomotor activity in inbred mice. Pharmacology and Toxicology. 66:1990;142-145.
34. Strecker R.E., Morairty S., Thakkar M.M., Porkka-Heiskanen T., Basheer R., Dauphin L.J., Rainnie D.G., Portas C.M., Greene R.W., McCarley R.W. Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behavioural Brain Research. 115:2000;183-204.
35. Svenningsson P., Hall H., Sedvall G., Fredholm B.B. Distribution of adenosine receptors in the postmortem human brain: an extended autoradiographic study. Synapse. 27:1997a;322-335.
36. 2A receptors. Progress in Neurobiology. 59:1999a;355-396.
37. Svenningsson P., Nomikos G.G., Fredholm B.B. Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration. The Journal of Neuroscience. 15:1995;7612-7624. Computer File.
38. Svenningsson P., Nomikos G.G., Fredholm B.B. The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions. The Journal of Neuroscience. 19:1999b;4011-4022. Computer File.
39. 2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens. Neuroscience. 79:1997b;753-764.
40. Von Lubitz D.K., Paul I.A., Bartus R.T., Jacobson K.A. Effects of chronic administration of adenosine A1 receptor agonist and antagonist on spatial learning and memory. European Journal of Pharmacology. 249:1993;271-280.