Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

Molecular Psychiatry

Volumn 20, Issue 5, 2015, Pages 647-656

  Cornelis, M C ^a,b   Byrne, E M ^c   Esko, T ^d,e,f,g   Nalls, M A ^h   Ganna, A ⁱ   Paynter, N ^f   Monda, K L ^j   Amin, N ^k   Fischer, K ^d   Renstrom, F ^l   Ngwa, J S ^m   Huikari, V ⁿ   Cavadino, A ^o   Nolte, I M ^p   Teumer, A ^q   Yu, K ^r   Marques Vidal, P ^s   Rawal, R ^t   Manichaikul, A ^u   Wojczynski, M K ^v   Vink, J M ^w   Zhao, J H ^x   Burlutsky, G ^y   Lahti, J ^z,aa   Mikkila V ^z,ab   Lemaitre, R N ^ac   Eriksson, J ^ad   Musani, S K ^ae   Tanaka, T ^h   Geller, F ^af   Luan, J ^x   Hui, J ^ag,ah,ai   Magi R ^d   Dimitriou, M ^aj   Garcia, M E ^h   Ho, W K ^ak   Wright, M J ^al   Rose, L M ^f   Magnusson, P K E ⁱ   Pedersen, N L ⁱ   Couper, D ^j   Oostra, B A ^k   Hofman, A ^k   Ikram, M A ^k   Tiemeier, H W ^k   Uitterlinden, A G ^k   van Rooij, F J A ^k   Barroso, I ^am,an   Johansson, I ^ao   Xue, L ^m   Kaakinen, M ^n,ap   Milani, L ^d   Power, C ^o   Snieder, H ^p   Stolk, R P ^p   Baumeister, S E ^q   Biffar, R ^q   Gu, F ^r   Bastardot, F ^aq   Kutalik, Z ^s,ar,as   Jacobs, D R ^at   Forouhi, N G ^x   Mihailov, E ^d   Lind, L ^au   Lindgren, C ^av   Michaelsson K ^au   Morris, A ^av   Jensen, M ^b   Khaw, K T ^ak   Luben, R N ^ak   Wang, J J ^y   Mannisto S ^aw   Perala M M ^aw   Kahonen M ^ax   Lehtimaki T ^ay   Viikari, J ^az   Mozaffarian, D ^a,b,ba   Mukamal, K ^bb   Psaty, B M ^ac,bc,bd   Doring A ^t   Heath, A C ^v   Montgomery, G W ^al   Dahmen, N ^be   Carithers, T ^bf   Tucker, K L ^bg   Ferrucci, Luigi ^h   Boyd, H A ^af   Melbye, M ^af   Treur, J L ^w   Mellstrom D ^ad   Hottenga, J J ^w   Prokopenko, I ^av,bh   Tonjes A ^bi,bj   Deloukas, P ^am,bk,bl   Kanoni, S ^bk   Lorentzon, M ^ad   Houston, D K ^bm   Liu, Y ^bn   Danesh, J ^ak   Rasheed, A ^bo   Mason, M A ^h   Zonderman, A B ^h   Franke, L ^p   Kristal, B S ^f,bp   Karjalainen, J ^p   Reed, D R ^bq   Westra, H J ^p   Evans, M K ^h   Saleheen, D ^ak,bo   Harris, T B ^h   Dedoussis, G ^aj   Curhan, G ^a   Stumvoll, M ^bi,bj   Beilby, J ^ag,ah,ai   Pasquale, L R ^a,br   Feenstra, B ^af   Bandinelli, S ^bs   Ordovas, J M ^bt   Chan, A T ^a,bu   Peters, U ^bv   Ohlsson, C ^ad   Gieger, C ^t   Martin, N G ^al   Waldenberger, M ^t   Siscovick, D S ^ac   Raitakari, O ^ab,bw   Eriksson, J G ^z,aa,bx   Mitchell, P ^y   Hunter, D J ^a,b   Kraft, P ^b   Rimm, E B ^a,b   Boomsma, D I ^w   Borecki, I B ^v   Loos, R J F ^x,by   Wareham, N J ^x   Vollenweider, P ^aq   Caporaso, N ^r   Grabe, H J ^q   Neuhouser, M L ^bv   Wolffenbuttel, B H R ^p   Hu, F B ^a,b   Hypponen E ^o,bz,ca   Jarvelin M R ^n,ap,aw,cb   Cupples, L A ^m,cc   Franks, P W ^b,l,ao   Ridker, P M ^f   van Duijn, C M ^k,cd   Heiss, G ^j   Metspalu, A ^d   North, K E ^j   Ingelsson, E ^au,av   Nettleton, J A ^ce   van Dam, R M ^cf   Chasman, D I ^f   Nalls, Michael A ^h   Plagnol, Vincent ^cg   Hernandez, Dena G ^ch   Sharma, Manu ^ci   Sheerin, Una Marie ^ch   Saad, Mohamad ^cj   Simón Sánchez, Javier ^ck   Schulte, Claudia ^ci   Lesage, Suzanne ^cl   Sveinbjörnsdóttir, Sigurlaug ^cm,cn,co   Arepalli, Sampath ^h,cp   Barker, Roger ^an   Ben Shlomo, Yoav ^cq   Berendse, Henk W ^ck   Berg, Daniela ^cr   Bhatia, Kailash ^ch   de Bie, Rob M A ^cs   Biffi, Alessandro ^g,bu   Bloem, Bas ^ct   Bochdanovits, Zoltan ^ct   Bonin, Michael ^cu   Bras, Jose M ^ch   Brockmann, Kathrin ^cr   Brooks, Janet ^cv   Burn, David J ^cw   Charlesworth, Gavin ^ch   Chen, Honglei ^cx   Chinnery, Patrick F ^cy   Chong, Sean ^cp   Clarke, Carl E ^cz,da   Cookson, Mark R ^cp   Cooper, J Mark ^ch   Corvol, Jean Christophe ^db   Counsell, Carl ^dc   Damier, Philippe ^dd   Dartigues, Jean François ^db   Deloukas, Panos ^am   Deuschl, Günther ^de   Dexter, David T ^df   Dijk, Karin D van ^ck   Dillman, Allissa ^h,i,cp   Durif, Frank ^dg   Dürr, Alexandra ^db   Edkins, Sarah ^am   Evans, Jonathan R ^dh   Foltynie, Thomas ^ch   Dong, Jing ^di   Gardner, Michelle ^ch   Gibbs, J Raphael ^h,ch   Goate, Alison ^v   Gray, Emma ^am   Guerreiro, Rita ^ch   Harris, Clare ^dj   Hilten, Jacobus J van ^dk   Hollenbeck, Albert ^dl   Holton, Janice ^ch   Hu, Michele ^dm   Huang, Xuemei ^dn   Wurster, Isabel ^cr   Mätzler, Walter ^cr   Hudson, Gavin ^cy   Hunt, Sarah E ^am   Huttenlocher, Johanna ^do   Illig, Thomas ^t   Jónsson, Pálmi V ^cm   Lambert, Jean Charles ^db,dp   Langford, Cordelia ^dh   Lees, Andrew ^dq   Lichtner, Peter ^t   Limousin, Patricia ^ch   Lopez, Grisel ^dr   Lorenz, Delia ^ds   McNeill, Alisdair ^ch   Moorby, Catriona ^cz   Moore, Matthew ^cp   Morris, Huw R ^dt   Morrison, Karen E ^cz   Mudanohwo, Ese ^ch   O’sullivan, Sean S ^du   Pearson, Justin ^dv   Perlmutter, Joel S ^dw   Pétursson, Hjörvar ^cu   Pollak, Pierre ^dx   Post, Bart ^ct   Potter, Simon ^am   Ravina, Bernard ^dy   Revesz, Tamas ^dz   Riess, Olaf ^cu   Rivadeneira, Fernando ^k   Rizzu, Patrizia ^ck   Ryten, Mina ^ch,er   Sawcer, Stephen ^ea   Schapira, Anthony ^ch   Scheffer, Hans ^ct   Shaw, Karen ^eb   Shoulson, Ira ^ec   Sidransky, Ellen ^ed   Smith, Colin ^ee,el   Spencer, Chris CA ^av   Stefánsson, Hreinn ^do   Bettella, Francesco ^do   Stockton, Joanna D ^ef   Strange, Amy ^av   Talbot, Kevin ^eg   Tanner, Carlie M ^eh   Tashakkori Ghanbaria, Avazeh ^am   Tison, François ^ei   Trabzuni, Daniah ^ch,er,et   Traynor, Bryan J ^ej   Velseboer, Daan ^ek   Vidailhet, Marie ^db   Walker, Robert ^el,el   Warrenburg, Bart van de ^ct   Wickremaratchi, Mirdhu ^em   Williams, Nigel ^dv   Williams Gray, Caroline H ^en   Winder Rhodes, Sophie ^an   Stefánsson, Kári ^do   Martinez, Maria ^eo   Wood, Nicholas W ^ch   Hardy, John ^ch,er   Heutink, Peter ^ck   Brice, Alexis ^db   Gasser, Thomas ^cr   Singleton, Andrew B ^cp   Singleton, Andrew ^h   Cookson, Mark ^h   Lila, Reta ^ch   Hernandez, Dena ^h   Nalls, Michael ^h   Zonderman, Alan ^h   Johnson, Robert ^ep   Longo, Dan ^h   O'brien, Richard ^eq   Traynor, Bryan ^h   Troncoso, Juan ^eq   Brug, Marcel van der ^h   Zielke, Ronald ^ep   Weale, Michael ^es   Ramasamy, Adaikalavan ^es   more..

^a CHANNING LABORATORY   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF TARTU   (Estonia)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^h NATIONAL INSTITUTE ON AGING   (United States)

ⁱ KAROLINSKA INSTITUTE   (Sweden)

^j UNIVERSITY OF NORTH CAROLINA   (United States)

^k ERASMUS MEDICAL CENTER   (Netherlands)

^l LUND UNIVERSITY   (Sweden)

^m BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

ⁿ UNIVERSITY OF OULU   (Finland)

^o UNIVERSITY COLLEGE LONDON   (United Kingdom)

^p UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^q UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^r NATIONAL CANCER INSTITUTE   (United States)

^s UNIVERSITY OF LAUSANNE   (Switzerland)

^t INSTITUTE OF EPIDEMIOLOGY   (Germany)

^u UNIVERSITY OF VIRGINIA   (United States)

^v WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^w VU UNIVERSITY AMSTERDAM   (Netherlands)

^x MRC EPIDEMIOLOGY UNIT   (United Kingdom)

^y UNIVERSITY OF SYDNEY   (Australia)

^z UNIVERSITY OF HELSINKI   (Finland)

^aa FOLKHÄLSAN RESEARCH CENTER   (Finland)

^ab UNIVERSITY OF TURKU   (Finland)

^ac UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^ad UNIVERSITY OF GOTHENBURG   (Sweden)

^ae UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^af STATENS SERUM INSTITUT   (Denmark)

^ag Busselton Population Medical Research Foundation Inc   (Australia)

^ah PATHWEST LABORATORY MEDICINE   (Australia)

^ai UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^aj HAROKOPIO UNIVERSITY   (Greece)

^ak UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^al QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^am WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^an UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^ao UMEÅ UNIVERSITY   (Sweden)

^ap UK   (United Kingdom)

^aq LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^ar UNIVERSITY OF LAUSANNE   (Switzerland)

^as SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^at UNIVERSITY OF MINNESOTA   (United States)

^au UPPSALA UNIVERSITY   (Sweden)

^av UNIVERSITY OF OXFORD   (United Kingdom)

^aw NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^ax TAMPERE UNIVERSITY HOSPITAL   (Finland)

^ay FIMLAB LABORATORIES   (Finland)

^az UNIVERSITY OF TURKU   (Finland)

^ba TUFTS UNIVERSITY   (United States)

^bb BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^bc UNIVERSITY OF WASHINGTON   (United States)

^bd CENTER FOR HEALTH STUDIES   (United States)

^be JOHANNES GUTENBERG UNIVERSITY   (Germany)

^bf UNIVERSITY OF MISSISSIPPI   (United States)

^bg M/A COM in Lowell   (United States)

^bh IMPERIAL COLLEGE LONDON   (United Kingdom)

^bi UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^bj UNIVERSITY OF LEIPZIG   (Germany)

^bk QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^bl KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^bm WAKE FOREST SCHOOL OF MEDICINE   (United States)

^bn WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^bo Center for Non Communicable Diseases   (Pakistan)

^bp BRIGHAM AND WOMEN S HOSPITAL   (United States)

^bq MONELL CHEMICAL SENSES CENTER   (United States)

^br MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^bs SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^bt TUFTS UNIVERSITY   (United States)

^bu MASSACHUSETTS GENERAL HOSPITAL   (United States)

^bv Fred Hutchinson Cancer Research Center   (United States)

^bw TURKU UNIVERSITY HOSPITAL   (Finland)

^bx HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^by MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^bz UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^ca SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^cb OULU UNIVERSITY HOSPITAL   (Finland)

^cc FRAMINGHAM HEART STUDY   (United States)

^cd Netherlands Consortium for Health Ageing   (Netherlands)

^ce UNIVERSITY OF TEXAS   (United States)

^cf Dept Medicine Endocrinol Diabet   (Singapore)

^cg UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ch UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ci UNIVERSITY OF TÜBINGEN   (Germany)

^cj Université Paul Sabatier   (France)

^ck VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^cl SORBONNE UNIVERSITÉ   (France)

^cm LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^cn BROOMFIELD HOSPITAL   (United Kingdom)

^co QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^cp National Institute on Aging   (United Kingdom)

^cq UNIVERSITY OF BRISTOL   (United Kingdom)

^cr GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^cs UNIVERSITY OF AMSTERDAM   (Netherlands)

^ct RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^cu UNIVERSITY OF TÜBINGEN   (Germany)

^cv UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^cw NEWCASTLE UNIVERSITY   (United Kingdom)

^cx NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^cy NEWCASTLE UNIVERSITY   (United Kingdom)

^cz UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^da CITY HOSPITAL   (United Kingdom)

^db INSERM   (France)

^dc UNIVERSITY OF ABERDEEN   (United Kingdom)

^dd NANTES UNIVERSITY HOSPITAL   (France)

^de UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^df IMPERIAL COLLEGE LONDON   (United Kingdom)

^dg SERVICE DE RHUMATOLOGIE   (France)

^dh UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^di National Institute of Environmental Health Sciences   (United Kingdom)

^dj UNIVERSITY OF ABERDEEN   (United Kingdom)

^dk LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^dl AARP   (United States)

^dm JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^dn PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^do DECODE GENETICS   (Iceland)

^dp UNIV LILLE   (France)

^dq Queen Square Brain Bank for Neurological Disorders   (France)

^dr National Institutes of Health   (United Kingdom)

^ds UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^dt CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^du The Queen Square Brain Bank for Neurological Disorders   (United Kingdom)

^dv Cardiff University   (United Kingdom)

^dw WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^dx GRENOBLE UNIVERSITY HOSPITAL   (France)

^dy BIOGEN   (United States)

^dz Queen Square Brain Bank for Neurological Disorders   (United States)

^ea UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^eb Queen Square Brain Bank for Neurological Disorders   (Netherlands)

^ec UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^ed Section on Molecular Neurogenetics   (United Kingdom)

^ee UNIVERSITY OF EDINBURGH   (United Kingdom)

^ef School of Clinical Experimental Medicine   (United Kingdom)

^eg UNIVERSITY OF OXFORD   (United Kingdom)

^eh PARKINSON S INSTITUTE   (United States)

^ei HAUT LÉVÊQUE HOSPITAL   (France)

^ej National Institute on Aging   (France)

^ek Academic Medical Center   (France)

^el UNIVERSITY OF EDINBURGH   (United Kingdom)

^em CARDIFF UNIVERSITY   (United Kingdom)

^en ADDENBROOKE S HOSPITAL   (United Kingdom)

^eo UNIVERSITÉ PAUL SABATIER   (France)

^ep UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^eq JOHNS HOPKINS UNIVERSITY   (United States)

^er UNIVERSITY COLLEGE LONDON   (United Kingdom)

^es GUY S HOSPITAL   (United Kingdom)

^et KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 REDUCTASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; SEROTONIN TRANSPORTER; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; GCKR PROTEIN, HUMAN; MLXIPL PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

3' UNTRANSLATED REGION; AFRICAN AMERICAN; ALLELE; BIPOLAR DISORDER; BIRTH WEIGHT; BLOOD PRESSURE; CHROMOSOME 7; COFFEE; CORRELATION ANALYSIS; DNA RESPONSIVE ELEMENT; EFFECT SIZE; ENHANCER REGION; EUROPEAN; FOLLOW UP; FOOD INTAKE; FRONTAL CORTEX; GENE LOCUS; GENETIC ASSOCIATION; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MAJOR DEPRESSION; MISSENSE MUTATION; NOTE; OBESITY; PARKINSON DISEASE; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TASTE PREFERENCE; TRANSCRIPTION INITIATION; XENOBIOTIC METABOLISM; COFFEA; FEEDING BEHAVIOR; GENETICS; GENOME-WIDE ASSOCIATION STUDY; META ANALYSIS; METABOLISM; PHENOTYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COFFEA; CYTOCHROME P-450 CYP1A2; FEEDING BEHAVIOR; GENOME-WIDE ASSOCIATION STUDY; HUMANS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84929128366     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2014.107     Document Type: Note

References (42)

1. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 1999; 51: 83-133
2. Cornelis MC. Gene-coffee interactions and health. Curr Nutr Rep 2014; 3: 178-195
3. Spiller MA. The chemical components of coffee. In: Spiller GA (eds) Caffeine. CRC: Boca Raton, 1998, pp 97-161
4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th edn. American Psychiatric Publishing: Arlington, VA, 2013
5. Cornelis MC. Coffee intake. Prog Mol Biol Transl Sci 2012; 108: 293-322
6. Yang A, Palmer AA, de Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology 2010; 211: 245-257
7. Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, et al. Genomewide meta-Analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet 2011; 7: e1002033
8. Sulem P, Gudbjartsson DF, Geller F, Prokopenko I, Feenstra B, Aben KK, et al. Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption. Hum Mol Genet 2011; 20: 2071-2077
9. Amin N, Byrne E, Johnson J, Chenevix-Trench G, Walter S, Nolte IM, et al. Genomewide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry 2011; 17: 1116-1129
10. Kot M, Daniel WA. The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms. Biochem Pharmacol 2008; 76: 543-551
11. Le Vee M, Jouan E, Fardel O. Involvement of aryl hydrocarbon receptor in basal and 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes. Toxicol In Vitro 2010; 24: 1775-1781
12. Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-Analysis of genomewide association scans. Bioinformatics 2010; 26: 2190-2191
13. Mägi R, Morris AP. GWAMA: software for genome-wide association meta-Analysis. BMC Bioinformatics 2010; 11: 288
14. Yang J, Lee SH, Goddard ME, Visscher PM. GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 2011; 88: 76-82
15. Segre AV, Groop L, Mootha VK, Daly MJ, Altshuler D. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet 2010; 6: e1001058
16. Yang J, Ferreira T, Morris AP, Medland SE, Madden PA, Heath AC, et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet 2012; 44: 369-375, S361-S363
17. Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, et al. Discovery and fine mapping of serum protein loci through transethnic meta-Analysis. Am J Hum Genet 2012; 91: 744-753
18. Stephens M, Balding DJ. Bayesian statistical methods for genetic association studies. Nat Rev Genet 2009; 10: 681-690
19. Sellke T, Bayarri M, Berger J. Calibration of P values for testing precise null hypotheses. Am Stat 2001; 55: 62-71
20. Hindorff LA, MacArthur J, Morales J, Junkins HA, Hall PN, Klemm AK, et al. A catalog of published genome-wide association studies. Available at: www.genome.gov/gwastudies; accessed 1 January 2013
21. Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, et al. An atlas of genetic influences on human blood metabolites. Nat Genet 2014; 46: 543-550
22. Soderberg MM, Haslemo T, Molden E, Dahl ML. Influence of CYP1A1/CYP1A2 and AHR polymorphisms on systemic olanzapine exposure. Pharmacogenet Genomics 2013; 23: 279-285
23. Jorge-Nebert LF, Jiang Z, Chakraborty R, Watson J, Jin L, McGarvey ST, et al. Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations. Hum Mutat 2010; 31: 27-40
24. Swanson HI. DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation. Chem Biol Interact 2002; 141: 63-76
25. Hu L, Zhuo W, He YJ, Zhou HH, Fan L. Pharmacogenetics of P450 oxidoreductase: implications in drug metabolism and therapy. Pharmacogenet Genomics 2012; 22: 812-819
26. Rome S, Meugnier E, Lecomte V, Berbe V, Besson J, Cerutti C, et al. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domaincontaining, class B, 2 protein (BHLHB2). Diabetologia 2009; 52: 1899-1912
27. Pandey AV, Fluck CE. NADPH P450 oxidoreductase: structure, function, and pathology of diseases. Pharmacol Ther 2013; 138: 229-254
28. Woodward OM, Tukaye DN, Cui J, Greenwell P, Constantoulakis LM, Parker BS, et al. Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules. Proc Natl Acad Sci USA 2013; 110: 5223-5228
29. Numakawa T, Suzuki S, Kumamaru E, Adachi N, Richards M, Kunugi H. BDNF function and intracellular signaling in neurons. Histol Histopathol 2010; 25: 237-258
30. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112: 257-269
31. Nosrat IV, Margolskee RF, Nosrat CA. Targeted taste cell-specific overexpression of brain-derived neurotrophic factor in adult taste buds elevates phosphorylated TrkB protein levels in taste cells, increases taste bud size, and promotes gustatory innervation. J Biol Chem 2012; 287: 16791-16800
32. Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 2011; 473: 43-49
33. Canli T, Lesch KP. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 2007; 10: 1103-1109
34. Beer NL, Tribble ND, McCulloch LJ, Roos C, Johnson PR, Orho-Melander M, et al. The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet 2009; 18: 4081-4088
35. Alvarez E, Roncero I, Chowen JA, Vazquez P, Blazquez E. Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain. J Neurochem 2002; 80: 45-53
36. Lindskog M, Svenningsson P, Pozzi L, Kim Y, Fienberg AA, Bibb JA, et al. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature 2002; 418: 774-778
37. Reed DR, Zhu G, Breslin PA, Duke FF, Henders AK, Campbell MJ, et al. The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Hum Mol Genet 2010; 19: 4278-4285
38. Ledda M, Kutalik Z, Souza Destito MC, Souza MM, Cirillo CA, Zamboni A, et al. GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics. Hum Mol Genet 2013; 23: 259-267
39. Byrne EM, Johnson J, McRae AF, Nyholt DR, Medland SE, Gehrman PR, et al. A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. Sleep 2012; 35: 967-975
40. Tobacco and Genetics Consortium. Genome-wide meta-Analyses identify multiple loci associated with smoking behavior. Nat Genet 2010; 42: 441-447
41. Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D, et al. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci USA 2011; 108: 7119-7124
42. Vinkhuyzen AA, Wray NR, Yang J, Goddard ME, Visscher PM. Estimation and partition of heritability in human populations using whole-genome analysis methods. Annu Rev Genet 2013; 47: 75-95