Chronic caffeine treatment reverses memory impairment and the expression of brain BNDF and TrkB in the PS1/APP double transgenic mouse model of Alzheimer's disease

Molecular Medicine Reports

Volumn 8, Issue 3, 2013, Pages 737-740

  Han, Kun ^a   Jia, Ning ^a   Li, Ji ^a   Yang, Li ^a   Min, Lian Qiu ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Brain neurotrophic derived factor; Caffeine; Memory; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CAFFEINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; LONG TERM CARE; MAZE TEST; MEMORY; MEMORY DISORDER; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CAFFEINE; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MEMORY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PRESENILIN-1; RECEPTOR, TRKB;

EID: 84881121689     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1601     Document Type: Article

References (18)

1. Massoud F and Gauthier S: Update on the pharmacological treatment of Alzheimer's disease. Curr Neuropharmacol 1: 69-80, 2010.
2. Ritter JM: Drugs for Alzheimer's disease. Brit J Clin Pharmacol 4: 501-503, 2012.
3. Fisone G, Borgkvist A and Usiello A: Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci 7: 857-872, 2004.
4. Ritchie K, Carrière I, de Mendonca A, et al: The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology 69: 536-545, 2007.
5. Santos C, Lunet N, Azevedo A, et al: Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal. J Alzheimers Dis 20: S175-S185, 2010.
6. Maia L and de Mendonça A: Does caffeine intake protect from Alzheimer's disease? Eur J Neurol 9: 377-382, 2002.
7. Arendash GW, Mori T, Cao C, et al: Caffeine reverses cognitive impairment and decreases brain amyloid-β levels in aged Alzheimer's disease mice. J Alzheimers Dis 17: 661-680, 2009.
8. Arendash G, Schleif W, Rezai-Zadeh K, et al: Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain (beta)-amyloid production. Neuroscience 142: 941-952, 2006.
9. Bekinschtein P, Cammarota M, Igaz LM, et al: Persistence of long-term memory storage requires a late protein synthesis-and BDNF-dependent phase in the hippocampus. Neuron 53: 261-277, 2007.
10. Peng S, Wuu J, Mufson EJ and Fahnestock M: Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem 93: 1412-1421, 2005.
11. Ferrer I, Marín C, Rey MJ, et al: BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J Neuropathol Exp Neurol 58: 729-739, 1999.
12. Kemppainen S, Rantamäki T, Jerónimo-Santos A, et al: Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiol Aging 33: e23-e39, 2011.
13. Lynch G, Kramar EA, Rex CS, et al: Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J Neurosci 27: 4424-4434, 2007.
14. Zeitlin R, Patel S, Burgess S, et al: Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice. Brain Res 1417: 127-136, 2011.
15. Prasanthi JR, Dasari B, Marwarha G, et al: Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med 49: 1212-1220, 2010.
16. Alhaider IA, Aleisa AM, Tran TT, et al: Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity. Sleep 33: 437-444, 2010.
17. Cao C, Wang L, Lin X, et al: Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer's mice. J Alzheimers Dis 25: 323-335, 2011.
18. Nagahara AH, Merrill DA, Coppola G, et al: Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 15: 331-337, 2009.