Hypertonic saline attenuates expression of Notch signaling and proinflammatory mediators in activated microglia in experimentally induced cerebral ischemia and hypoxic BV-2 microglia

BMC Neuroscience

Volumn 18, Issue 1, 2017, Pages

  Zeng, Wen Xin ^a   Han, Yong Li ^a   Zhu, Gao Feng ^a   Huang, Lin Qiang ^a   Deng, Yi Yu ^a   Wang, Qiao Sheng ^a   Jiang, Wen Qiang ^a   Wen, Miao Yun ^a   Han, Qian Peng ^a   Xie, Di ^a   Zeng, Hong Ke ^a  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Cerebral ischemia; Hypertonic saline; Microglia; Neuroinflammation; Notch signaling

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NOTCH RECEPTOR; NOTCH1 RECEPTOR; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; TRANSCRIPTION FACTOR HES 1; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL HYPOXIA; CONTROLLED STUDY; DOWN REGULATION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REPERFUSION INJURY; ANIMAL; CELL LINE; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; RANDOMIZATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN ISCHEMIA; CELL HYPOXIA; CELL LINE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; MALE; MICE; MICROGLIA; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE II; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; RECEPTORS, NOTCH; REPERFUSION INJURY; SALINE SOLUTION, HYPERTONIC; SIGNAL TRANSDUCTION;

EID: 85014905623     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/s12868-017-0351-6     Document Type: Article

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