Evidence that γ-secretase-mediated notch signaling induces neuronal cell death via the nuclear factor-κB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke

Molecular Pharmacology

Volumn 80, Issue 1, 2011, Pages 23-31

  Arumugam, Thiruma V ^a   Cheng, Yi Lin ^a   Choi, Yuri ^b   Choi, Yun Hyung ⁱ   Yang, Sunghee ^b   Yun, Young Kwang ^b   Park, Jong Sung ^b   Yang, Dong Kwon ^c   Thundyil, John ^a   Gelderblom, Mathias ^d   Karamyan, Vardan T ^e   Tang, Sung Chun ^f   Chan, Sic L ^g   Magnus, Tim ^d   Sobey, Christopher G ^h   Jo, Dong Gyu ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Sungkyunkwan University   (South Korea)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^f NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^g UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^h MONASH UNIVERSITY   (Australia)

ⁱ NONE

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; NOTCH1 RECEPTOR; PROTEIN BCL 2; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CALCIUM SIGNALING; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; MALE; MICE; MICE, INBRED C57BL; NEURONS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STROKE;

EID: 79959320245     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.071076     Document Type: Article

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