Hyperosmolarity invokes distinct anti-inflammatory mechanisms in pulmonary epithelial cells: Evidence from signaling and transcription layers

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Wright, Franklin L ^a   Gamboni, Fabia ^a   Moore, Ernest E ^b   Nydam, Trevor L ^a   Mitra, Sanchayita ^a   Silliman, Christopher C ^c   Banerjee, Anirban ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b DENVER HEALTH MEDICAL CENTER   (United States)

^c Children's Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; SODIUM CHLORIDE; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; TRANSCRIPTION FACTOR RELA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HYPEROSMOLARITY; LUNG ALVEOLUS EPITHELIUM; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RNA SYNTHESIS; RNA TRANSLATION; SIGNAL TRANSDUCTION; CELL LINE; EPITHELIUM CELL; GENETIC TRANSCRIPTION; GENETICS; INFLAMMATION; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION;

CELL LINE; EPITHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LUNG; NF-KAPPA B; PHOSPHORYLATION; SALINE SOLUTION, HYPERTONIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84915818843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114129     Document Type: Article

References (52)

1. Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV (2002) Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin. J Immunol 168: 1389-1396.
2. Junger WG, Coimbra R, Liu FC, Herdon-Remelius C, Junger W, et al. (1997) Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients? Shock 8: 235-241.
3. Rizoli SB, Rhind SG, Shek PN, Inaba K, Filips D, et al. (2006) The immunomodulatory effects of hypertonic saline resuscitation in patients sustaining traumatic hemorrhagic shock: a randomized, controlled, double-blinded trial. Ann Surg 243: 47-57.
4. Mattox KL, Maningas PA, Moore EE, Mateer JR, Marx JA, et al. (1991) Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. Multicenter Trial. Ann Surg 213: 482-491.
5. Bulger EM, Jurkovich GJ, Nathens AB, Copass MK, Hanson S, et al. (2008) Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg 143: 139-148; discussion 149.
6. Wohlauer M, Moore EE, Silliman CC, Fragoso M, Gamboni F, et al. (2012) Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med 40: 2647-2653.
7. Ciesla DJ, Moore EE, Biffl WL, Gonzalez RJ, Silliman CC (2001) Hypertonic saline attenuation of the neutrophil cytotoxic response is reversed upon restoration of normotonicity and reestablished by repeated hypertonic challenge. Surgery 129: 567-575.
8. Powers KA, Zurawska J, Szaszi K, Khadaroo RG, Kapus A, et al. (2005) Hypertonic resuscitation of hemorrhagic shock prevents alveolar macrophage activation by preventing systemic oxidative stress due to gut ischemia/reperfusion. Surgery 137: 66-74.
9. Magor BG, Magor KE (2001) Evolution of effectors and receptors of innate immunity. Dev Comp Immunol 25: 651-682.
10. Weber A, Wasiliew P, Kracht M (2010) Interleukin-1 (IL-1) pathway. Sci Signal 3: cm1.
11. Bhatia M, Moochhala S (2004) Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. Journal of Pathology 202: 145-156.
12. Goodman RB, Pugin J, Lee JS, Matthay MA (2003) Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev 14: 523-535.
13. Jarrar D, Kuebler JF, Rue LW, 3rd, Matalon S, Wang P, et al. (2002) Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms. Am J Physiol Lung Cell Mol Physiol 283: L799-805.
14. Park WY, Goodman RB, Steinberg KP, Ruzinski JT, Radella F, 2nd, et al. (2001) Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 164: 1896-1903.
15. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, et al. (2008) Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res 102: 804-812.
16. Sato H, Kasai K, Tanaka T, Kita T, Tanaka N (2008) Role of tumor necrosis factor-alpha and interleukin-1beta on lung dysfunction following hemorrhagic shock in rats. Med Sci Monit 14: BR79-87.
17. Nydam TL, Moore EE, McIntyre RC Jr, Wright FL, Gamboni-Robertson F, et al. (2009) Hypertonic saline attenuates TNF-alpha-induced NF-kappaB activation in pulmonary epithelial cells. Shock 31: 466-472.
18. Solt LA, Madge LA, Orange JS, May MJ (2007) Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta. J Biol Chem 282: 8724-8733.
19. Zhao T, Yang L, Sun Q, Arguello M, Ballard DW, et al. (2007) The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Nat Immunol 8: 592-600.
20. Ghosh S, Hayden MS (2008) New regulators of NF-kappaB in inflammation. Nat Rev Immunol 8: 837-848.
21. Shultz DB, Rani MR, Fuller JD, Ransohoff RM, Stark GR (2009) Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma. J Interferon Cytokine Res 29: 817-824.
22. Abraham E (2003) Neutrophils and acute lung injury. Crit Care Med 31: S195-199.
23. Held HD, Boettcher S, Hamann L, Uhlig S (2001) Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kappaB and is blocked by steroids. Am J Respir Crit Care Med 163: 711-716.
24. Solt LA, Madge LA, May MJ (2009) NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation. J Biol Chem 284: 27596-27608.
25. Heinemeyer T, Chen X, Karas H, Kel AE, Kel OV, et al. (1999) Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res 27: 318-322.
26. Werner T, Fessele S, Maier H, Nelson PJ (2003) Computer modeling of promoter organization as a tool to study transcriptional coregulation. FASEB J 17: 1228-1237.
27. Ciesla DJ, Moore EE, Zallen G, Biffl WL, Silliman CC (2000) Hypertonic saline attenuation of polymorphonuclear neutrophil cytotoxicity: timing is everything. J Trauma 48: 388-395.
28. Benjamini Y, Hochberg Y (1995) Controlling the False Discovery Rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society 57 289-300.
29. Belperio JA, Keane MP, Burdick MD, Londhe V, Xue YY, et al. (2002) Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest 110: 1703-1716.
30. Levitt JE, Gould MK, Ware LB, Matthay MA (2009) The Pathogenetic and Prognostic Value of Biologic Markers in Acute Lung Injury. J Intensive Care Med.
31. Matthay MA (2008) Treatment of acute lung injury: clinical and experimental studies. Proc Am Thorac Soc 5: 297-299.
32. Ziegler EC, Ghosh S (2005) Regulating inducible transcription through controlled localization. Sci STKE 2005: re6.
33. Hacker H, Karin M (2006) Regulation and function of IKK and IKK-related kinases. Sci STKE 2006: re13.
34. Ananko EA, Kondrakhin YV, Merkulova TI, Kolchanov NA (2007) Recognition of interferon-inducible sites, promoters, and enhancers. BMC Bioinformatics 8: 56.
35. Banerjee A, Moore EE, McLaughlin NJ, Lee L, Jones WL, et al. (2013) Hyperosmolarity attenuates TNF-alpha-mediated proinflammatory activation of human pulmonary microvascular endothelial cells. Shock 39: 366-372.
36. Eckels PC, Banerjee A, Moore E, McLaughlin NJ, Gries L, et al. (2009) Amantadine Inhibits Platelet-Activating Factor Induced Clathrin-Mediated Endocytosis in Human Neutrophils. Am J Physiol Cell Physiol.
37. Gundersen Y, Ruud TE, Krohn CD, Sveen O, Lyngstadaas SP, et al. (2010) Impact of hypertonic saline on the release of selected cytokines after stimulation with LPS or peptidoglycan in ex vivo whole blood from healthy humans. Shock 34: 450-454.
38. Waskiewicz AJ, Cooper JA (1995) Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol 7: 798-805.
39. Shapiro L, Dinarello CA (1997) Hyperosmotic stress as a stimulant for proinflammatory cytokine production. Exp Cell Res 231: 354-362.
40. Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
41. Chen LF, Greene WC (2004) Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 5: 392-401.
42. Li W, Zheng S, Tang C, Zhu Y, Wang X (2007) JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. Peptides 28: 1252-1259.
43. Shukla A, Hashiguchi N, Chen Y, Coimbra R, Hoyt DB, et al. (2004) Osmotic regulation of cell function and possible clinical applications. Shock 21: 391-400.
44. Buttmann M, Berberich-Siebelt F, Serfling E, Rieckmann P (2007) Interferon-beta is a potent inducer of interferon regulatory factor-1/2-dependent IP-10/CXCL10 expression in primary human endothelial cells. J Vasc Res 44: 51-60.
45. Yarilina A, Park-Min KH, Antoniv T, Hu X, Ivashkiv LB (2008) TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferonresponse genes. Nat Immunol 9: 378-387.
46. dos Santos CC, Han B, Andrade CF, Bai X, Uhlig S, et al. (2004) DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch. Physiol Genomics 19: 331-342.
47. Rose CE Jr, Sung SS, Fu SM (2003) Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung. Microcirculation 10: 273-288.
48. Fehrenbach H (2001) Alveolar epithelial type II cell: defender of the alveolus revisited. Respir Res 2: 33-46.
49. Henriquet C, Gougat C, Combes A, Lazennec G, Mathieu M (2007) Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells. Lung Cancer 56: 167-174.
50. Ochi H, Masuda J, Gimbrone MA (2002) Hyperosmotic stimuli inhibit VCAM-1 expression in cultured endothelial cells via effects on interferon regulatory factor-1 expression and activity. Eur J Immunol 32: 1821-1831.
51. Guggino WB (1999) Cystic fibrosis and the salt controversy. Cell 96: 607-610.
52. Tarran R, Donaldson S, Boucher RC (2007) Rationale for hypertonic saline therapy for cystic fibrosis lung disease. Semin Respir Crit Care Med 28: 295-302.