Notch-1 signaling regulates microglia activation via NF-κB pathway after hypoxic exposure in vivo and in vitro

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Yao, Linli ^a,c   Kan, Enci Mary ^b   Kaur, Charanjit ^c   Dheen, S Thameem ^c   Hao, Aijun ^a   Lu, Jia ^b   Ling, Eng Ang ^c  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b DSO NATIONAL LABORATORIES   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; GAMMA SECRETASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; N [N (3,5 DIFLUOROPHENACETYL) 1 ALANY1]PHENYGLYCINE TERT BUTYL ESTER; NOTCH1 RECEPTOR; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN; BRAIN HYPOXIA; BRAIN INJURY; CELL STRAIN; CELL STRAIN BV 2; CONTROLLED STUDY; DELTA 1 GENE; FEMALE; GENE; GENE EXPRESSION; GENE TARGETING; HES 1 GENE; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; MALE; MICROGLIA; NERVE CELL STIMULATION; NEWBORN; NONHUMAN; PATHOGENESIS; PERINATAL PERIOD; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TRANSCRIPTION REGULATION; UPREGULATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, NEWBORN; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELL LINE, TUMOR; DIPEPTIDES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICROGLIA; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; RATS; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 4;

EID: 84892394146     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078439     Document Type: Article

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