Tipping the inflammatory balance: Inflammasome activation distinguishes metabolically unhealthy from healthy obesity

Diabetologia

Volumn 56, Issue 11, 2013, Pages 2343-2346

  Stienstra, Rinke ^a,b   Stefan, Norbert ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

IL 1 ; Inflammasome; Inflammation; Insulin resistance; Metabolically healthy obesity; NOD like receptor family pyrin domain containing 3; Regulatory T cell; Visceral adipose tissue

Indexed keywords

INFLAMMASOME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR LIKE RECEPTOR FAMILY PYRIN DOMAIN CONTAINING 3 INFLAMMASOME; UNCLASSIFIED DRUG;

CELL TYPE; DISEASE PREDISPOSITION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INTRAABDOMINAL FAT; MACROPHAGE; METABOLIC DISORDER; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

CARRIER PROTEINS; HUMANS; INFLAMMASOMES; INSULIN RESISTANCE; INTERLEUKIN-1BETA; INTRA-ABDOMINAL FAT; MODELS, THEORETICAL; OBESITY; T-LYMPHOCYTES, REGULATORY;

EID: 84885849628     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3040-8     Document Type: Review

References (24)

1. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
2. Xu H, Barnes GT, Yang Q et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
3. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
4. Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175-184
5. Osborn O, Olefsky JM (2012) The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 18:363-374
6. Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98-107
7. Cipolletta D, Feuerer M, Li A et al (2012) PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486:549-553
8. DeFuria J, Belkina AC, Jagannathan-Bogdan M et al (2013) B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A 110:5133-5138
9. Mathis D (2013) Immunological goings-on in visceral adipose tissue. Cell Metab 17:851-859
10. Stienstra R, Tack CJ, Kanneganti TD, Joosten LA, Netea MG (2012) The inflammasome puts obesity in the danger zone. Cell Metab 15:10-18
11. Latz E, Xiao TS, Stutz A (2013) Activation and regulation of the inflammasomes. Nat Rev Immunol 13:397-411
12. Seok J, Warren HS, Cuenca AG et al (2013) Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A 110:3507-3512
13. Esser N, L'homme L, De Roover A et al (2013) Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue. Diabetologia doi: 10.1007/s00125-013-3023-9
14. Pal D, Dasgupta S, Kundu R et al (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18:1279-1285
15. Reynolds CM, McGillicuddy FC, Harford KA, Finucane OM, Mills KH, Roche HM (2012) Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. Mol Nutr Food Res 56:1212-1222
16. Stefan N, Häring HU (2013) Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans. Nat Med 19:394-395
17. Klöting N, Fasshauer M, Dietrich A et al (2010) Insulin-sensitive obesity. Am J Physiol Endocrinol Metab 299:E506-E515
18. Stefan N, Häring HU (2013) The role of hepatokines in metabolism. Nat Rev Endocrinol 9:144-152
19. Stefan N, Kantartzis K, Machann J et al (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168:1609-1616
20. Stefan N, Häring HU (2011) The metabolically benign and malignant fatty liver. Diabetes 60:2011-2017
21. Lehmann R, Franken H, Dammeier S et al (2013) Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver. Diabetes Care 36:2331-2338
22. Hasegawa H, Lei J, Matsumoto T, Onishi S, Suemori K, Yasukawa M (2011) Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-β production. Biochem Biophys Res Commun 25:526-531
23. Lamkanfi M, Kanneganti TD, van Damme P et al (2008) Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics 7:2350-2363
24. Chalkiadaki A, Guarente L (2012) High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab 16:180-188