Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders

Journal of Biological Chemistry

Volumn 291, Issue 10, 2016, Pages 5185-5198

  Kang, Soojeong ^a   Dahl, Russell ^b   Hsieh, Wilson ^a   Shin, Andrew ^a   Zsebo, Krisztina M ^c   Buettner, Christoph ^a   Hajjar, Roger J ^a   Lebeche, Djamel ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^c Celladon Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CALORIMETRY; CELL DEATH; CELL MEMBRANES; CHEMICAL ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE; INSULIN; MAGNETIC RESONANCE IMAGING; MAMMALS; MEDICAL PROBLEMS; METABOLISM; PROTEINS; TISSUE;

ALLOSTERIC ACTIVATOR; AMP-ACTIVATED PROTEIN KINASE; ENDOPLASMIC RETICULUM; ENERGY EXPENDITURE; INSULIN RESISTANCE; METABOLIC DISORDERS; MITOCHONDRIAL BIOGENESIS; UNCOUPLING PROTEIN-1;

ELECTRIC RESISTANCE;

ADENOSINE TRIPHOSPHATASE (CALCIUM); CDN 1163; ENZYME ACTIVATOR; GLUCOSE; GLUCOSE 6 PHOSPHATASE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 3; AMINOQUINOLINE DERIVATIVE; ANTIDIABETIC AGENT; BENZAMIDE DERIVATIVE; CDN1163; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CALCIUM TRANSPORT; CALORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; ENERGY EXPENDITURE; ENZYME ACTIVATION; FATTY LIVER; GENE EXPRESSION REGULATION; GENE FUNCTION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; LIPID METABOLISM; MALE; METABOLIC DISORDER; MITOCHONDRIAL BIOGENESIS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; THERMOGENESIS; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ADIPOSE TISSUE; ANIMAL; APOPTOSIS; CELL LINE; DIABETES MELLITUS; DRUG EFFECTS; ENERGY METABOLISM; INSULIN RESISTANCE; LIPOGENESIS; LIVER; METABOLISM; MOUSE MUTANT; ORGANELLE BIOGENESIS;

ADIPOSE TISSUE; AMINOQUINOLINES; ANIMALS; APOPTOSIS; BENZAMIDES; BLOOD GLUCOSE; CELL LINE; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; ENERGY METABOLISM; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIPOGENESIS; LIVER; MALE; MICE; MICE, OBESE; OBESITY; ORGANELLE BIOGENESIS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 84964599823     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.705012     Document Type: Article

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