Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation

Genes and Development

Volumn 30, Issue 16, 2016, Pages 1822-1836

  Zeng, Xing ^a,b   Jedrychowski, Mark P ^b   Chen, Yi ^a,b   Serag, Sara ^a   Lavery, Gareth G ^c   Gygi, Steve P ^b   Spiegelman, Bruce M ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Brown adipose tissue; HSD11B1; LSD1; Mitochondria; PRDM16; Thermogenesis

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; FATTY ACID; GLUCOCORTICOID; HISTONE; HISTONE DEMETHYLASE; HORMONE; LYSINE SPECIFIC DEMETHYLASE 1; NUCLEIC ACID BINDING PROTEIN; PR DOMAIN CONTAINING 16 PROTEIN; UNCLASSIFIED DRUG; AOF2 PROTEIN, MOUSE; DNA BINDING PROTEIN; NORADRENALIN; PRDM16 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; CELL METABOLISM; CONTROLLED STUDY; ENERGY EXPENDITURE; ENHANCER REGION; ENZYME ACTIVITY; FAT MASS; FATTY ACID OXIDATION; GENE EXPRESSION; GENE REPRESSION; HISTONE MODIFICATION; HORMONE SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; THERMOGENESIS; WHITE ADIPOSE TISSUE; ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ENERGY METABOLISM; ENZYME ACTIVATION; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; METHYLATION; MITOCHONDRION; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOCYTES, BROWN; ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; DNA-BINDING PROTEINS; ENERGY METABOLISM; ENZYME ACTIVATION; GENE DELETION; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HISTONE DEMETHYLASES; HISTONES; METHYLATION; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; NOREPINEPHRINE; OXIDATION-REDUCTION; THERMOGENESIS; TRANSCRIPTION FACTORS;

EID: 84986881095     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.285312.116     Document Type: Article

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