메뉴 건너뛰기




Volumn 33, Issue 10, 2011, Pages 737-741

Exosome nanotechnology: An emerging paradigm shift in drug delivery: Exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers

Author keywords

Blood brain barrier; Dendritic cells; Exosomes; RNAi; Stem cells

Indexed keywords

AMYLOID BETA PROTEIN; CERAMIDE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MESSENGER RNA; MICRORNA; SMALL INTERFERING RNA; SPHINGOMYELIN; VIRUS GLYCOPROTEIN;

EID: 80052831943     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201100076     Document Type: Article
Times cited : (255)

References (27)
  • 1
    • 40049112564 scopus 로고    scopus 로고
    • Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    • Trajkovic K, Hsu C, Chiantia S, Rajendran L, et al. 2008. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319: 1244-7.
    • (2008) Science , vol.319 , pp. 1244-1247
    • Trajkovic, K.1    Hsu, C.2    Chiantia, S.3    Rajendran, L.4
  • 2
    • 4143088359 scopus 로고    scopus 로고
    • PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes
    • Laulagnier K, Grand D, Dujardin A, Hamdi S, et al. 2004. PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes. FEBS Lett 572: 11-4.
    • (2004) FEBS Lett , vol.572 , pp. 11-14
    • Laulagnier, K.1    Grand, D.2    Dujardin, A.3    Hamdi, S.4
  • 3
    • 79958796052 scopus 로고    scopus 로고
    • Diacylglycerol kinase alpha regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes
    • Alonso R, Mazzeo C, Rodriguez MC, Marsh M, et al. 2011. Diacylglycerol kinase alpha regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes. Cell Death Differ 18: 1161-73.
    • (2011) Cell Death Differ , vol.18 , pp. 1161-1173
    • Alonso, R.1    Mazzeo, C.2    Rodriguez, M.C.3    Marsh, M.4
  • 4
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
    • Pan BT, Johnstone RM. 1983. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33: 967-78.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 5
    • 55749112807 scopus 로고    scopus 로고
    • Proteomic profiling of exosomes: current perspectives
    • Simpson RJ, Jensen SS, Lim JW. 2008. Proteomic profiling of exosomes: current perspectives. Proteomics 8: 4083-99.
    • (2008) Proteomics , vol.8 , pp. 4083-4099
    • Simpson, R.J.1    Jensen, S.S.2    Lim, J.W.3
  • 6
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, et al. 2007. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9: 654-9.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4
  • 7
    • 69949117622 scopus 로고    scopus 로고
    • Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity
    • Gibbings DJ, Ciaudo C, Erhardt M, Voinnet O. 2009. Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat Cell Biol 11: 1143-9.
    • (2009) Nat Cell Biol , vol.11 , pp. 1143-1149
    • Gibbings, D.J.1    Ciaudo, C.2    Erhardt, M.3    Voinnet, O.4
  • 9
    • 76749106591 scopus 로고    scopus 로고
    • Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation
    • Nazarenko I, Rana S, Baumann A, Mcalear J, et al. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res 70: 1668-78.
    • Cancer Res , vol.70 , pp. 1668-1678
    • Nazarenko, I.1    Rana, S.2    Baumann, A.3    Mcalear, J.4
  • 10
    • 66549122028 scopus 로고    scopus 로고
    • Cell to cell signalling via exosomes through esRNA
    • Lotvall J, Valadi H. 2007. Cell to cell signalling via exosomes through esRNA. Cell Adh Mig 1: 156-8.
    • (2007) Cell Adh Mig , vol.1 , pp. 156-158
    • Lotvall, J.1    Valadi, H.2
  • 11
    • 3142630225 scopus 로고    scopus 로고
    • Exosomes: endosomal-derived vesicles shipping extracellular messages
    • Fevrier B, Raposo G. 2004. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 16: 415-21.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 415-421
    • Fevrier, B.1    Raposo, G.2
  • 12
    • 43149120419 scopus 로고    scopus 로고
    • Exosome function: from tumor immunology to pathogen biology
    • Schorey JS, Bhatnagar S. 2008. Exosome function: from tumor immunology to pathogen biology. Traffic 9: 871-81.
    • (2008) Traffic , vol.9 , pp. 871-881
    • Schorey, J.S.1    Bhatnagar, S.2
  • 13
    • 79954631518 scopus 로고    scopus 로고
    • Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
    • Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, et al. 2011. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis 42: 360-7.
    • (2011) Neurobiol Dis , vol.42 , pp. 360-367
    • Alvarez-Erviti, L.1    Seow, Y.2    Schapira, A.H.3    Gardiner, C.4
  • 14
    • 77952293014 scopus 로고    scopus 로고
    • Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    • Lai RC, Arslan F, Lee MM, Sze NS, et al. 2010. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res 4: 214-22.
    • (2010) Stem Cell Res , vol.4 , pp. 214-222
    • Lai, R.C.1    Arslan, F.2    Lee, M.M.3    Sze, N.S.4
  • 15
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai S, Wei D, Wu Z, Zhou X, et al. 2008. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther 16: 782-90.
    • (2008) Mol Ther , vol.16 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3    Zhou, X.4
  • 16
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • Alvarez-Erviti L, Seow Y, Yin H, Betts C, et al. 2011. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotech 29: 341-5.
    • (2011) Nat Biotech , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4
  • 17
    • 78649467527 scopus 로고    scopus 로고
    • Pericytes regulate the blood-brain barrier
    • Armulik A, Genove G, Mae M, Nisancioglu MH, et al. 2010. Pericytes regulate the blood-brain barrier. Nature 468: 557-61.
    • (2010) Nature , vol.468 , pp. 557-561
    • Armulik, A.1    Genove, G.2    Mae, M.3    Nisancioglu, M.H.4
  • 18
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: bottleneck in brain drug development
    • Pardridge WM. 2005. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2: 3-14.
    • (2005) NeuroRx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 19
    • 0242330363 scopus 로고    scopus 로고
    • Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway
    • Hook VY, Reisine TD. 2003. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway. J Neurosci Res 74: 393-405.
    • (2003) J Neurosci Res , vol.74 , pp. 393-405
    • Hook, V.Y.1    Reisine, T.D.2
  • 20
    • 79955481749 scopus 로고    scopus 로고
    • Exosomes as intercellular signalosomes and pharmacological effectors
    • Record M, Subra C, Silvente-Poirot S, Poirot M. 2001. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol 81: 1171-82.
    • (2001) Biochem Pharmacol , vol.81 , pp. 1171-1182
    • Record, M.1    Subra, C.2    Silvente-Poirot, S.3    Poirot, M.4
  • 21
    • 36549082845 scopus 로고    scopus 로고
    • Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells
    • Fairchild PJ, Nolan KF, Waldmann H. 2007. Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells. Methods Mol Biol 380: 59-72.
    • (2007) Methods Mol Biol , vol.380 , pp. 59-72
    • Fairchild, P.J.1    Nolan, K.F.2    Waldmann, H.3
  • 22
    • 76549260925 scopus 로고    scopus 로고
    • Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells
    • Aasen T, Belmonte JC. 2010. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nat Prot 5: 371-82.
    • (2010) Nat Prot , vol.5 , pp. 371-382
    • Aasen, T.1    Belmonte, J.C.2
  • 23
    • 65649115029 scopus 로고    scopus 로고
    • Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    • Karumbayaram S, Novitch BG, Patterson M, Umbach JA, et al. 2009. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells 27: 806-11.
    • (2009) Stem Cells , vol.27 , pp. 806-811
    • Karumbayaram, S.1    Novitch, B.G.2    Patterson, M.3    Umbach, J.A.4
  • 24
    • 56449126945 scopus 로고    scopus 로고
    • Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    • Godlewski J, Nowicki MO, Bronisz A, Williams S, et al. 2008. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res 68: 9125-30.
    • (2008) Cancer Res , vol.68 , pp. 9125-9130
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3    Williams, S.4
  • 25
    • 45549089973 scopus 로고    scopus 로고
    • microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma
    • Kefas B, Godlewski J, Comeau L, Li Y, et al. 2008. microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 68: 3566-72.
    • (2008) Cancer Res , vol.68 , pp. 3566-3572
    • Kefas, B.1    Godlewski, J.2    Comeau, L.3    Li, Y.4
  • 26
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, et al. 2008. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27: 2128-36.
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3    Leupold, J.H.4
  • 27
    • 0027535206 scopus 로고
    • Receptor-mediated endocytosis of transferrin at the blood-brain barrier
    • Roberts RL, Fine RE, Sandra A. 1993. Receptor-mediated endocytosis of transferrin at the blood-brain barrier. J Cell Sci 104: 521-32.
    • (1993) J Cell Sci , vol.104 , pp. 521-532
    • Roberts, R.L.1    Fine, R.E.2    Sandra, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.