Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes

Autophagy

Volumn 13, Issue 4, 2017, Pages 670-685

  Kissing, Sandra ^a   Rudnik, Sönke ^a   Damme, Markus ^a   Lüllmann Rauch, Renate ^a   Ichihara, Atsuhiro ^b   Kornak, Uwe ^c   Eskelinen, Eeva Liisa ^d   Jabs, Sabrina ^e   Heeren, Jörg ^f   De Brabander, Jef K ^g   Haas, Albert ^h   Saftig, Paul ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF HELSINKI   (Finland)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^f UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^h UNIVERSITY OF BONN   (Germany)

Author keywords

ATP6AP2; autophagy; lysosome; MTORC1; ribosomal protein S6 kinase; transcription factor EB; v H+ ATPase complex

Indexed keywords

AMINO ACID; BAFILOMYCIN A1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA N ACETYLHEXOSAMINIDASE; CRE RECOMBINASE; DOUBLE STRANDED RNA; EPOXOMICIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INSULIN RECEPTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITIDE; PROTEIN KINASE B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RHEB PROTEIN; S6 KINASE; SEQUESTOSOME 1; SERINE THREONINE PROTEIN KINASE ULK1; UBIQUITIN; UNCLASSIFIED DRUG; ATP6AP2 PROTEIN, MOUSE; CELL SURFACE RECEPTOR; INSULIN;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BIOACCUMULATION; CELL MATURATION; CELL VACUOLE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVATION; GENE DELETION; LIVER CELL; LYSOSOME; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; FIBROBLAST; KNOCKOUT MOUSE; LIVER; MAMMALIAN EMBRYO; METABOLISM; ULTRASTRUCTURE;

AMINO ACIDS; ANIMALS; AUTOPHAGY; CELLS, CULTURED; EMBRYO, MAMMALIAN; ENDOCYTOSIS; ENDOSOMES; FIBROBLASTS; HEPATOCYTES; INSULIN; LIVER; LYSOSOMES; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICE, KNOCKOUT; PROTON-TRANSLOCATING ATPASES; RECEPTORS, CELL SURFACE; VACUOLES;

EID: 85013498587     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2017.1280216     Document Type: Article

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