Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

Nature Communications

Volumn 8, Issue , 2017, Pages

  Hernandez Fernaud, Juan R ^a   Ruengeler, Elena ^a   Casazza, Andrea ^b   Neilson, Lisa J ^a   Pulleine, Ellie ^c   Santi, Alice ^a   Ismail, Shehab ^a   Lilla, Sergio ^a   Dhayade, Sandeep ^a   MacPherson, Iain R ^d   McNeish, Iain ^d   Ennis, Darren ^d   Ali, Hala ^e   Kugeratski, Fernanda G ^a   Al Khamici, Heba ^e   Van Den Biggelaar, Maartje ^f   Van Den Berghe, Peter V E ^a   Cloix, Catherine ^a   McDonald, Laura ^a   Millan, David ^g   Hoyle, Aoisha ^g   Kuchnio, Anna ^b   Carmeliet, Peter ^b   Valenzuela, Stella M ^e   Blyth, Karen ^a   Yin, Huabing ^c   Mazzone, Massimiliano ^b   Norman, Jim C ^a   Zanivan, Sara ^a   more..

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^f SANQUIN RESEARCH   (Netherlands)

^g QUEEN ELIZABETH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; CHLORIDE INTRACELLULAR CHANNEL PROTEIN 3; GLUTATHIONE; OXIDOREDUCTASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; UNCLASSIFIED DRUG; CLIC3 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN BINDING; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEOME;

CANCER; CELLS AND CELL COMPONENTS; ENZYME; ENZYME ACTIVITY; INVASIVENESS; PROTEIN; SECRETION; TUMOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CELL; CANCER ASSOCIATED FIBROBLAST; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL INVASION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRADUCTAL CARCINOMA; MOUSE; MOUTH SQUAMOUS CELL CARCINOMA; NONHUMAN; OVARY CANCER; PROTEIN BINDING; PROTEIN SECRETION; PROTEOMICS; STROMA CELL; TUMOR XENOGRAFT; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; DISEASE EXACERBATION; EXTRACELLULAR MATRIX; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PATHOLOGY; SECRETION (PROCESS); SURVIVAL ANALYSIS; TREATMENT OUTCOME; TUMOR CELL LINE; TUMOR INVASION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION;

ANIMALS; CANCER-ASSOCIATED FIBROBLASTS; CELL LINE, TUMOR; CHLORIDE CHANNELS; DISEASE PROGRESSION; EXTRACELLULAR MATRIX; FEMALE; GLUTATHIONE; GTP-BINDING PROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE, INBRED C57BL; MICE, NUDE; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; OXIDOREDUCTASES; PROTEIN BINDING; PROTEOME; PROTEOMICS; SURVIVAL ANALYSIS; TRANSGLUTAMINASES; TREATMENT OUTCOME;

EID: 85012888028     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14206     Document Type: Article

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