-
1
-
-
0037279517
-
The hypoxic tumour microenvironment and metastatic progression
-
Subarsky P, Hill RP. The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 2003;20: 237-50.
-
(2003)
Clin Exp Metastasis
, vol.20
, pp. 237-250
-
-
Subarsky, P.1
Hill, R.P.2
-
3
-
-
33751280734
-
Lysyl oxidase mediates hypoxic control of metastasis
-
Erler JT, Giaccia AJ. Lysyl oxidase mediates hypoxic control of metastasis. Cancer Res 2006;66: 10238-41.
-
(2006)
Cancer Res
, vol.66
, pp. 10238-10241
-
-
Erler, J.T.1
Giaccia, A.J.2
-
5
-
-
79952340427
-
Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer
-
Cox TR, Erler JT. Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. Dis Model Mech 2011;4: 165-78.
-
(2011)
Dis Model Mech
, vol.4
, pp. 165-178
-
-
Cox, T.R.1
Erler, J.T.2
-
6
-
-
58849126879
-
Three-dimensional context regulation of metastasis
-
Erler JT, Weaver VM. Three-dimensional context regulation of metastasis. Clin Exp Metastasis 2009;26: 35-49.
-
(2009)
Clin Exp Metastasis
, vol.26
, pp. 35-49
-
-
Erler, J.T.1
Weaver, V.M.2
-
7
-
-
70450222098
-
Matrix crosslinking forces tumor progression by enhancing integrin signaling
-
Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 2009;139: 891-906.
-
(2009)
Cell
, vol.139
, pp. 891-906
-
-
Levental, K.R.1
Yu, H.2
Kass, L.3
Lakins, J.N.4
Egeblad, M.5
Erler, J.T.6
-
8
-
-
0036682233
-
A molecular role for lysyl oxidase in breast cancer invasion
-
Kirschmann DA, Seftor EA, Fong SF, Nieva DR, Sullivan CM, Edwards EM, et al. A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res 2002;62: 4478-83.
-
(2002)
Cancer Res
, vol.62
, pp. 4478-4483
-
-
Kirschmann, D.A.1
Seftor, E.A.2
Fong, S.F.3
Nieva, D.R.4
Sullivan, C.M.5
Edwards, E.M.6
-
9
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006;440: 1222-6.
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
Bennewith, K.L.2
Nicolau, M.3
Dornhöfer, N.4
Kong Le C, Q.T.5
-
10
-
-
28644432204
-
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005;438: 820-7.
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
Riba, R.D.2
Zacharoulis, S.3
Bramley, A.H.4
Vincent, L.5
Costa, C.6
-
11
-
-
57849100048
-
Hypoxiainduced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
-
Erler JT,Bennewith KL,CoxTR, Lang G, Bird D,KoongA, et al.Hypoxiainduced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 2009;15: 35-44.
-
(2009)
Cancer Cell
, vol.15
, pp. 35-44
-
-
Erler, J.T.1
Bennewith, K.L.2
Cox, T.R.3
Lang, G.4
Bird, D.5
Koong, A.6
-
12
-
-
43249095919
-
Tumor angiogenesis
-
Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358: 2039-49.
-
(2008)
N Engl J Med
, vol.358
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
13
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438: 967-74.
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
14
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144: 646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
15
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
16
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86: 353-64.
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
17
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23: 1011-27.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
18
-
-
0036780251
-
Clinical translation of angiogenesis inhibitors
-
Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002;2: 727-39.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 727-739
-
-
Kerbel, R.1
Folkman, J.2
-
19
-
-
78649537524
-
Biomarkers to predict the clinical efficacy of bevacizumab in cancer
-
Jubb AM, Harris AL. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. Lancet Oncol 2010;11: 1172-83.
-
(2010)
Lancet Oncol
, vol.11
, pp. 1172-1183
-
-
Jubb, A.M.1
Harris, A.L.2
-
20
-
-
79952327797
-
The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer
-
Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, et al. The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. J Natl Cancer Inst 2011;103: 407-24.
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 407-424
-
-
Baker, A.M.1
Cox, T.R.2
Bird, D.3
Lang, G.4
Murray, G.I.5
Sun, X.F.6
-
21
-
-
33750532981
-
Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer
-
Coghlin C, Carpenter B, Dundas SR, Lawrie LC, Telfer C, Murray GI. Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer. J Pathol 2006;210: 351-7.
-
(2006)
J Pathol
, vol.210
, pp. 351-357
-
-
Coghlin, C.1
Carpenter, B.2
Dundas, S.R.3
Lawrie, L.C.4
Telfer, C.5
Murray, G.I.6
-
22
-
-
33749370720
-
Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer
-
Carpenter B, McKay M, Dundas SR, Lawrie LC, Telfer C, Murray GI. Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. Br J Cancer 2006;95: 921-7.
-
(2006)
Br J Cancer
, vol.95
, pp. 921-927
-
-
Carpenter, B.1
McKay, M.2
Dundas, S.R.3
Lawrie, L.C.4
Telfer, C.5
Murray, G.I.6
-
23
-
-
38549174826
-
Characterisation and protein expression profiling of annexins in colorectal cancer
-
Duncan R, Carpenter B, Main LC, Telfer C, Murray GI. Characterisation and protein expression profiling of annexins in colorectal cancer. Br J Cancer 2008;98: 426-33.
-
(2008)
Br J Cancer
, vol.98
, pp. 426-433
-
-
Duncan, R.1
Carpenter, B.2
Main, L.C.3
Telfer, C.4
Murray, G.I.5
-
24
-
-
38949174649
-
Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation
-
Ma C, Rong Y, Radiloff DR, Datto MB, Centeno B, Bao S, et al. Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev 2008;22: 308-21.
-
(2008)
Genes Dev
, vol.22
, pp. 308-321
-
-
Ma, C.1
Rong, Y.2
Radiloff, D.R.3
Datto, M.B.4
Centeno, B.5
Bao, S.6
-
25
-
-
79952538238
-
Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib
-
Welti JC, Gourlaouen M, Powles T, Kudahetti SC, Wilson P, Berney DM, et al. Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib. Oncogene 2011;30: 1183-93.
-
(2011)
Oncogene
, vol.30
, pp. 1183-1193
-
-
Welti, J.C.1
Gourlaouen, M.2
Powles, T.3
Kudahetti, S.C.4
Wilson, P.5
Berney, D.M.6
-
26
-
-
77956425361
-
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
-
Barry-Hamilton V, Spangler R, Marshall D, McCauley S, RodriguezHM, Oyasu M, et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med 2010;16: 1009-17.
-
(2010)
Nat Med
, vol.16
, pp. 1009-1017
-
-
Barry-Hamilton, V.1
Spangler, R.2
Marshall, D.3
McCauley, S.4
Rodriguez, H.M.5
Oyasu, M.6
-
27
-
-
0024570260
-
Factors influencing blood supply in wound granuloma quantitated by a new in vivo technique
-
Mahadevan V, Hart IR, Lewis GP. Factors influencing blood supply in wound granuloma quantitated by a new in vivo technique. Cancer Res 1989;49: 415-9.
-
(1989)
Cancer Res
, vol.49
, pp. 415-419
-
-
Mahadevan, V.1
Hart, I.R.2
Lewis, G.P.3
-
28
-
-
0017102107
-
Classification of human colorectal adenocarcinoma cell lines
-
Leibovitz A, Stinson JC, McCombs WB III, McCoy CE, Mazur KC, Mabry ND. Classification of human colorectal adenocarcinoma cell lines. Cancer Res 1976;36: 4562-9.
-
(1976)
Cancer Res
, vol.36
, pp. 4562-4569
-
-
Leibovitz, A.1
Stinson, J.C.2
McCombs Iii, W.B.3
McCoy, C.E.4
Mazur, K.C.5
Mabry, N.D.6
-
29
-
-
84876139026
-
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK
-
May 28. [Epub ahead of print]
-
Baker AM, Bird D, Lang G, Cox TR, Erler JT. Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK. Oncogene. 2012 May 28. [Epub ahead of print].
-
(2012)
Oncogene
-
-
Baker, A.M.1
Bird, D.2
Lang, G.3
Cox, T.R.4
Erler, J.T.5
-
30
-
-
79952216170
-
The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth
-
Pez F, Dayan F, Durivault J, Kaniewski B, Aimond G, Le Provost GS, et al. The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. Cancer Res 2011;71: 1647-57.
-
(2011)
Cancer Res
, vol.71
, pp. 1647-1657
-
-
Pez, F.1
Dayan, F.2
Durivault, J.3
Kaniewski, B.4
Aimond, G.5
Le Provost, G.S.6
-
31
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60: 1541-5.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
-
32
-
-
6344275304
-
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism
-
Pore N, Liu S, Shu HK, Li B, Haas-Kogan D, Stokoe D, et al. Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell 2004;15: 4841-53.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 4841-4853
-
-
Pore, N.1
Liu, S.2
Shu, H.K.3
Li, B.4
Haas-Kogan, D.5
Stokoe, D.6
-
33
-
-
77954615408
-
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
-
Hirai H, Sootome H, Nakatsuru Y, Miyama K, Taguchi S, Tsujioka K, et al. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 2010;9: 1956-67.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1956-1967
-
-
Hirai, H.1
Sootome, H.2
Nakatsuru, Y.3
Miyama, K.4
Taguchi, S.5
Tsujioka, K.6
-
34
-
-
53049099771
-
Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells
-
Lucero HA, Ravid K, Grimsby JL, Rich CB, DiCamillo SJ,Mäki JM, et al. Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells. J Biol Chem 2008;283: 24103-17.
-
(2008)
J Biol Chem
, vol.283
, pp. 24103-24117
-
-
Lucero, H.A.1
Ravid, K.2
Grimsby, J.L.3
Rich, C.B.4
Dicamillo, S.J.5
Mäki, J.M.6
-
35
-
-
33847394119
-
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
-
Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, et al. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest 2007;117: 730-8.
-
(2007)
J Clin Invest
, vol.117
, pp. 730-738
-
-
Zhang, H.1
Bajraszewski, N.2
Wu, E.3
Wang, H.4
Moseman, A.P.5
Dabora, S.L.6
-
36
-
-
42549156263
-
PDGF BB induces VEGF secretion in ovarian cancer
-
Matei D, Kelich S, Cao L, Menning N, Emerson RE, Rao J, et al. PDGF BB induces VEGF secretion in ovarian cancer. Cancer Biol Ther 2007;6: 1951-9.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 1951-1959
-
-
Matei, D.1
Kelich, S.2
Cao, L.3
Menning, N.4
Emerson, R.E.5
Rao, J.6
-
37
-
-
29744466285
-
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells
-
Ho CY, Ludovici DW, Maharoof US, Mei J, Sechler JL, Tuman RW, et al. (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J Med Chem 2005;48: 8163-73.
-
(2005)
J Med Chem
, vol.48
, pp. 8163-8173
-
-
Ho, C.Y.1
Ludovici, D.W.2
Maharoof, U.S.3
Mei, J.4
Sechler, J.L.5
Tuman, R.W.6
-
38
-
-
78650874372
-
SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
-
Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2003;2: 471-8.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 471-478
-
-
Abrams, T.J.1
Lee, L.B.2
Murray, L.J.3
Pryer, N.K.4
Cherrington, J.M.5
-
39
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004;3: 391-400.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
40
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349: 427-34.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
Hwu, P.4
Schwartzentruber, D.J.5
Topalian, S.L.6
-
41
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009;27: 3584-90.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Oudard, S.6
-
42
-
-
70349307281
-
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03
-
Le QT, Harris J, Magliocco AM, Kong CS, Diaz R, Shin B, et al. Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03. J Clin Oncol 2009;27: 4281-6.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4281-4286
-
-
Le, Q.T.1
Harris, J.2
Magliocco, A.M.3
Kong, C.S.4
Diaz, R.5
Shin, B.6
-
43
-
-
34547842084
-
Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas
-
Le QT, Kong C, Lavori PW, O'byrne K, Erler JT, Huang X, et al. Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 2007;69: 167-75.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.69
, pp. 167-175
-
-
Le, Q.T.1
Kongt, C.2
Lavori, P.W.3
O'Byrne, K.4
Erler, J.T.5
Huang, X.6
-
44
-
-
72949119124
-
Integrins in cancer: Biological implications and therapeutic opportunities
-
Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010;10: 9-22.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 9-22
-
-
Desgrosellier, J.S.1
Cheresh, D.A.2
-
45
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008;8: 592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
46
-
-
40649128599
-
Interaction between bevacizumab and murine VEGF-A: A reassessment
-
Yu L, Wu X, Cheng Z, Lee CV, LeCouter J, Campa C, et al. Interaction between bevacizumab and murine VEGF-A: a reassessment. Invest Ophthalmol Vis Sci 2008;49: 522-7.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, pp. 522-527
-
-
Yu, L.1
Wu, X.2
Cheng, Z.3
Lee, C.V.4
Lecouter, J.5
Campa, C.6
-
47
-
-
80053648630
-
Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane
-
Bignon M, Pichol-Thievend C, Hardouin J, Malbouyres M, Brechot N, Nasciutti L, et al. Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane. Blood 2011;118: 3979-89.
-
(2011)
Blood
, vol.118
, pp. 3979-3989
-
-
Bignon, M.1
Pichol-Thievend, C.2
Hardouin, J.3
Malbouyres, M.4
Brechot, N.5
Nasciutti, L.6
|