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Volumn 33, Issue 7, 2014, Pages 842-850

CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma

Author keywords

a SMA; CLIC; microenvironment; p38; PPM1a

Indexed keywords

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; CHLORIDE CHANNELS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MYOFIBROBLASTS; NEOPLASM INVASIVENESS; NEOPLASMS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84894065779     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.18     Document Type: Article
Times cited : (62)

References (54)
  • 1
    • 22944467157 scopus 로고    scopus 로고
    • Intracellular chloride channels: Critical mediators of cell viability and potential targets for cancer therapy
    • Suh KS, Yuspa SH. Intracellular chloride channels: critical mediators of cell viability and potential targets for cancer therapy. Curr Pharm Des 2005; 11: 2753-2764.
    • (2005) Curr Pharm des , vol.11 , pp. 2753-2764
    • Suh, K.S.1    Yuspa, S.H.2
  • 2
    • 77952671282 scopus 로고    scopus 로고
    • The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?
    • Littler DR, Harrop SJ, Goodchild SC, Phang JM, Mynott AV, Jiang L et al. The enigma of the CLIC proteins: ion channels, redox proteins, enzymes, scaffolding proteins? FEBS Lett 2010; 584: 2093-2101.
    • (2010) FEBS Lett , vol.584 , pp. 2093-2101
    • Littler, D.R.1    Harrop, S.J.2    Goodchild, S.C.3    Phang, J.M.4    Mynott, A.V.5
  • 3
    • 10744228816 scopus 로고    scopus 로고
    • The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition
    • Littler DR, Harrop SJ, Fairlie WD, Brown LJ, Pankhurst GJ, Pankhurst S et al. The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. J Biol Chem 2004; 279: 9298-9305.
    • (2004) J Biol Chem , vol.279 , pp. 9298-9305
    • Littler, D.R.1    Harrop, S.J.2    Fairlie, W.D.3    Brown, L.J.4    Pankhurst, G.J.5    Pankhurst, S.6
  • 4
    • 26244442240 scopus 로고    scopus 로고
    • Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4
    • Littler DR, Assaad NN, Harrop SJ, Brown LJ, Pankhurst GJ, Luciani P et al. Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4. FEBS J 2005; 272: 4996-5007.
    • (2005) FEBS J , vol.272 , pp. 4996-5007
    • Littler, D.R.1    Assaad, N.N.2    Harrop, S.J.3    Brown, L.J.4    Pankhurst, G.J.5    Luciani, P.6
  • 5
    • 0242468227 scopus 로고    scopus 로고
    • Molecular cloning and developmental expression of two chloride intracellular channel (CLIC) genes in Xenopus laevis
    • Shorning BY, Wilson DB, Meehan RR, Ashley RH. Molecular cloning and developmental expression of two chloride intracellular channel (CLIC) genes in Xenopus laevis. Dev Genes Evol 2003; 213: 514-518.
    • (2003) Dev Genes Evol , vol.213 , pp. 514-518
    • Shorning, B.Y.1    Wilson, D.B.2    Meehan, R.R.3    Ashley, R.H.4
  • 6
    • 0030747190 scopus 로고    scopus 로고
    • Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum
    • Duncan RR, Westwood PK, Boyd A, Ashley RH. Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum. J Biol Chem 1997; 272: 23880-23886.
    • (1997) J Biol Chem , vol.272 , pp. 23880-23886
    • Duncan, R.R.1    Westwood, P.K.2    Boyd, A.3    Ashley, R.H.4
  • 7
    • 29644445975 scopus 로고    scopus 로고
    • Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis
    • Bohman S, Matsumoto T, Suh K, Dimberg A, Jakobsson L, Yuspa S et al. Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis. J Biol Chem 2005; 280: 42397-42404.
    • (2005) J Biol Chem , vol.280 , pp. 42397-42404
    • Bohman, S.1    Matsumoto, T.2    Suh, K.3    Dimberg, A.4    Jakobsson, L.5    Yuspa, S.6
  • 8
    • 70349500350 scopus 로고    scopus 로고
    • Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro
    • Tung JJ, Hobert O, Berryman M, Kitajewski J. Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro. Angiogenesis 2009; 12: 209-220.
    • (2009) Angiogenesis , vol.12 , pp. 209-220
    • Tung, J.J.1    Hobert, O.2    Berryman, M.3    Kitajewski, J.4
  • 9
    • 62549164694 scopus 로고    scopus 로고
    • Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway
    • Ulmasov B, Bruno J, Gordon N, Hartnett ME, Edwards JC. Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway. Am J Pathol 2009; 174: 1084-1096.
    • (2009) Am J Pathol , vol.174 , pp. 1084-1096
    • Ulmasov, B.1    Bruno, J.2    Gordon, N.3    Hartnett, M.E.4    Edwards, J.C.5
  • 10
    • 84862637276 scopus 로고    scopus 로고
    • Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice
    • Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk KE, Ryscavage A, Dengler SL et al. Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice. Am J Pathol 2012; 181: 74-84.
    • (2012) Am J Pathol , vol.181 , pp. 74-84
    • Padmakumar, V.C.1    Speer, K.2    Pal-Ghosh, S.3    Masiuk, K.E.4    Ryscavage, A.5    Dengler, S.L.6
  • 11
    • 0036971427 scopus 로고    scopus 로고
    • Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts
    • Ronnov-Jessen L, Villadsen R, Edwards JC, Petersen OW. Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. Am J Pathol 2002; 161: 471-480.
    • (2002) Am J Pathol , vol.161 , pp. 471-480
    • Ronnov-Jessen, L.1    Villadsen, R.2    Edwards, J.C.3    Petersen, O.W.4
  • 12
    • 33846275327 scopus 로고    scopus 로고
    • Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers
    • Suh KS, Crutchley JM, Koochek A, Ryscavage A, Bhat K, Tanaka T et al. Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. Clin Cancer Res 2007; 13: 121-131.
    • (2007) Clin Cancer Res , vol.13 , pp. 121-131
    • Suh, K.S.1    Crutchley, J.M.2    Koochek, A.3    Ryscavage, A.4    Bhat, K.5    Tanaka, T.6
  • 13
    • 67349250497 scopus 로고    scopus 로고
    • TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3
    • Shukla A, Malik M, Cataisson C, Ho Y, Friesen T, Suh KS et al. TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3. Nat Cell Biol 2009; 11: 777-784.
    • (2009) Nat Cell Biol , vol.11 , pp. 777-784
    • Shukla, A.1    Malik, M.2    Cataisson, C.3    Ho, Y.4    Friesen, T.5    Suh, K.S.6
  • 14
    • 77957661355 scopus 로고    scopus 로고
    • CLIC4 and Schnurri-2: A dynamic duo in TGF-beta signaling with broader implications in cellular homeostasis and disease
    • Shukla A, Yuspa SH. CLIC4 and Schnurri-2: a dynamic duo in TGF-beta signaling with broader implications in cellular homeostasis and disease. Nucleus 2010; 1: 144-149.
    • (2010) Nucleus , vol.1 , pp. 144-149
    • Shukla, A.1    Yuspa, S.H.2
  • 15
    • 0035019915 scopus 로고    scopus 로고
    • Stromal cells can contribute oncogenic signals
    • Tlsty TD. Stromal cells can contribute oncogenic signals. Semin Cancer Biol 2001; 11: 97-104.
    • (2001) Semin Cancer Biol , vol.11 , pp. 97-104
    • Tlsty, T.D.1
  • 16
    • 53449094862 scopus 로고    scopus 로고
    • Stromal myofibroblasts are drivers of invasive cancer growth
    • De WO, Demetter P, Mareel M, Bracke M. Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer 2008; 123: 2229-2238.
    • (2008) Int J Cancer , vol.123 , pp. 2229-2238
    • De Wo Demetter, P.1    Mareel, M.2    Bracke, M.3
  • 18
    • 0242285692 scopus 로고    scopus 로고
    • TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.1
    • Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR et al. TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.1. J Clin Invest 2003; 112: 1116-1124.
    • (2003) J Clin Invest , vol.112 , pp. 1116-1124
    • Tang, B.1    Vu, M.2    Booker, T.3    Santner, S.J.4    Miller, F.R.5    Anver, M.R.6
  • 19
    • 33847084614 scopus 로고    scopus 로고
    • Formation and function of the myofibroblast during tissue repair.1
    • Hinz B. Formation and function of the myofibroblast during tissue repair.1. J Invest Dermatol 2007; 127: 526-537.
    • (2007) J Invest Dermatol , vol.127 , pp. 526-537
    • Hinz, B.1
  • 20
    • 0030011880 scopus 로고    scopus 로고
    • A function for filamentous alpha-smooth muscle actin: Retardation of motility in fibroblasts.1
    • Ronnov-Jessen L, Petersen OW. A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts.1. J Cell Biol 1996; 134: 67-80.
    • (1996) J Cell Biol , vol.134 , pp. 67-80
    • Ronnov-Jessen, L.1    Petersen, O.W.2
  • 21
    • 65549121606 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration
    • Brenmoehl J, Miller SN, Hofmann C, Vogl D, Falk W, Scholmerich J et al. Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration. World J Gastroenterol 2009; 15: 1431-1442.
    • (2009) World J Gastroenterol , vol.15 , pp. 1431-1442
    • Brenmoehl, J.1    Miller, S.N.2    Hofmann, C.3    Vogl, D.4    Falk, W.5    Scholmerich, J.6
  • 22
    • 33646950265 scopus 로고    scopus 로고
    • PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
    • Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J et al. PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell 2006; 125: 915-928.
    • (2006) Cell , vol.125 , pp. 915-928
    • Lin, X.1    Duan, X.2    Liang, Y.Y.3    Su, Y.4    Wrighton, K.H.5    Long, J.6
  • 23
    • 0032541227 scopus 로고    scopus 로고
    • Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways
    • Takekawa M, Maeda T, Saito H. Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways. EMBO J 1998; 17: 4744-4752.
    • (1998) EMBO J , vol.17 , pp. 4744-4752
    • Takekawa, M.1    Maeda, T.2    Saito, H.3
  • 24
    • 0034602268 scopus 로고    scopus 로고
    • Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms
    • Cheng A, Kaldis P, Solomon MJ. Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms. J Biol Chem 2000; 275: 34744-34749.
    • (2000) J Biol Chem , vol.275 , pp. 34744-34749
    • Cheng, A.1    Kaldis, P.2    Solomon, M.J.3
  • 25
    • 56949087707 scopus 로고    scopus 로고
    • PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation
    • Sun W, Yu Y, Dotti G, Shen T, Tan X, Savoldo B et al. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cell Signal 2009; 21: 95-102.
    • (2009) Cell Signal , vol.21 , pp. 95-102
    • Sun, W.1    Yu, Y.2    Dotti, G.3    Shen, T.4    Tan, X.5    Savoldo, B.6
  • 26
    • 74949093198 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer
    • Miyazono K. Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer. Proc Jpn Acad Ser B Phys Biol Sci 2009; 85: 314-323.
    • (2009) Proc Jpn Acad ser B Phys Biol Sci , vol.85 , pp. 314-323
    • Miyazono, K.1
  • 27
    • 0019471387 scopus 로고
    • Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultures from human squamous cell carcinomas
    • Rheinwald JG, Beckett MA. Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultures from human squamous cell carcinomas. Cancer Res 1981; 41: 1657-1663.
    • (1981) Cancer Res , vol.41 , pp. 1657-1663
    • Rheinwald, J.G.1    Beckett, M.A.2
  • 28
    • 0033215242 scopus 로고    scopus 로고
    • Carcinomaassociated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. Carcinomaassociated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999; 59: 5002-5011.
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 29
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121: 335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6
  • 30
    • 0036605996 scopus 로고    scopus 로고
    • Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model
    • Tuxhorn JA, McAlhany SJ, Dang TD, Ayala GE, Rowley DR. Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model. Cancer Res 2002; 62: 3298-3307.
    • (2002) Cancer Res , vol.62 , pp. 3298-3307
    • Tuxhorn, J.A.1    McAlhany, S.J.2    Dang, T.D.3    Ayala, G.E.4    Rowley, D.R.5
  • 31
    • 0037899253 scopus 로고    scopus 로고
    • Role of tissue stroma in cancer cell invasion
    • De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003; 200: 429-447.
    • (2003) J Pathol , vol.200 , pp. 429-447
    • De Wever, O.1    Mareel, M.2
  • 32
    • 33646537475 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma
    • Lu SL, Herrington H, Reh D, Weber S, Bornstein S, Wang D et al. Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev 2006; 20: 1331-1342.
    • (2006) Genes Dev , vol.20 , pp. 1331-1342
    • Lu, S.L.1    Herrington, H.2    Reh, D.3    Weber, S.4    Bornstein, S.5    Wang, D.6
  • 33
    • 0030051051 scopus 로고    scopus 로고
    • Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction
    • Ronnov-Jessen L, Petersen OW, Bissell MJ. Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 1996; 76: 69-125.
    • (1996) Physiol Rev , vol.76 , pp. 69-125
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Bissell, M.J.3
  • 34
    • 77955064602 scopus 로고    scopus 로고
    • Stromal expression of actin is a marker of aggressiveness in basal cell carcinoma
    • Adegboyega PA, Rodriguez S, McLarty J. Stromal expression of actin is a marker of aggressiveness in basal cell carcinoma. Hum Pathol 2010; 41: 1128-1137.
    • (2010) Hum Pathol , vol.41 , pp. 1128-1137
    • Adegboyega, P.A.1    Rodriguez, S.2    McLarty, J.3
  • 35
    • 0035159094 scopus 로고    scopus 로고
    • Alpha-smooth muscle actin expression upregulates fibroblast contractile activity
    • Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 2001; 12: 2730-2741.
    • (2001) Mol Biol Cell , vol.12 , pp. 2730-2741
    • Hinz, B.1    Celetta, G.2    Tomasek, J.J.3    Gabbiani, G.4    Chaponnier, C.5
  • 36
    • 0034856168 scopus 로고    scopus 로고
    • Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation
    • Hinz B, Mastrangelo D, Iselin CE, Chaponnier C, Gabbiani G. Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am J Pathol 2001; 159: 1009-1020.
    • (2001) Am J Pathol , vol.159 , pp. 1009-1020
    • Hinz, B.1    Mastrangelo, D.2    Iselin, C.E.3    Chaponnier, C.4    Gabbiani, G.5
  • 38
    • 0042831330 scopus 로고    scopus 로고
    • Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression
    • Hu B, Wu Z, Phan SH. Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Am J Respir Cell Mol Biol 2003; 29(3 Pt 1): 397-404.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , Issue.3 PART. 1 , pp. 397-404
    • Hu, B.1    Wu, Z.2    Phan, S.H.3
  • 39
    • 24344500807 scopus 로고    scopus 로고
    • Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization
    • Uemura M, Swenson ES, Gaca MD, Giordano FJ, Reiss M, Wells RG. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell 2005; 16: 4214-4224.
    • (2005) Mol Biol Cell , vol.16 , pp. 4214-4224
    • Uemura, M.1    Swenson, E.S.2    Gaca, M.D.3    Giordano, F.J.4    Reiss, M.5    Wells, R.G.6
  • 40
    • 0037437371 scopus 로고    scopus 로고
    • TGF-beta1-mediated fibroblastmyofibroblast terminal differentiation the role of Smad proteins
    • Evans RA, Tian YC, Steadman R, Phillips AO. TGF-beta1-mediated fibroblastmyofibroblast terminal differentiation-the role of Smad proteins. Exp Cell Res 2003; 282: 90-100.
    • (2003) Exp Cell Res , vol.282 , pp. 90-100
    • Evans, R.A.1    Tian, Y.C.2    Steadman, R.3    Phillips, A.O.4
  • 41
    • 43049175154 scopus 로고    scopus 로고
    • TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts
    • Caraci F, Gili E, Calafiore M, Failla M, La RC, Crimi N et al. TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res 2008; 57: 274-282.
    • (2008) Pharmacol Res , vol.57 , pp. 274-282
    • Caraci, F.1    Gili, E.2    Calafiore, M.3    Failla, M.4    La Crimi, R.C.5
  • 43
    • 70349308726 scopus 로고    scopus 로고
    • CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer
    • Yao Q, Qu X, Yang Q, Wei M, Kong B. CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. Oncol Rep 2009; 22: 541-548.
    • (2009) Oncol Rep , vol.22 , pp. 541-548
    • Yao, Q.1    Qu, X.2    Yang, Q.3    Wei, M.4    Kong, B.5
  • 44
    • 0030465532 scopus 로고    scopus 로고
    • Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution
    • Das AK, Helps NR, Cohen PT, Barford D. Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J 1996; 15: 6798-6809.
    • (1996) EMBO J , vol.15 , pp. 6798-6809
    • Das, A.K.1    Helps, N.R.2    Cohen, P.T.3    Barford, D.4
  • 45
    • 0033555610 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel
    • Qian Z, Okuhara D, Abe MK, Rosner MR. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. J Biol Chem 1999; 274: 1621-1627.
    • (1999) J Biol Chem , vol.274 , pp. 1621-1627
    • Qian, Z.1    Okuhara, D.2    Abe, M.K.3    Rosner, M.R.4
  • 46
    • 8444250723 scopus 로고    scopus 로고
    • Tumour-stroma interaction: Cancer-associated fibroblasts as novel targets in anti-cancer therapy?
    • Micke P, Ostman A. Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy? Lung Cancer 2004; 45(Suppl 2): S163-S175.
    • (2004) Lung Cancer , vol.45 , Issue.SUPPL. 2
    • Micke, P.1    Ostman, A.2
  • 47
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-1428.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 48
    • 80052021537 scopus 로고    scopus 로고
    • Tangled fibroblasts in tumor-stroma interactions
    • Liu M, Xu J, Deng H. Tangled fibroblasts in tumor-stroma interactions. Int J Cancer 2011; 129: 1795-1805.
    • (2011) Int J Cancer , vol.129 , pp. 1795-1805
    • Liu, M.1    Xu, J.2    Deng, H.3
  • 50
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-beta signalling inhibitors for cancer therapy
    • Yingling JM, Blanchard KL, Sawyer JS. Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov 2004; 3: 1011-1022.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 51
    • 79952771133 scopus 로고    scopus 로고
    • Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TbetaRI/II kinase inhibition with LY2109761
    • Connolly EC, Saunier EF, Quigley D, Luu MT, De SA, Hann B et al. Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TbetaRI/II kinase inhibition with LY2109761. Cancer Res 2011; 71: 2339-2349.
    • (2011) Cancer Res , vol.71 , pp. 2339-2349
    • Connolly, E.C.1    Saunier, E.F.2    Quigley, D.3    Luu, M.T.4    De Sa Hann, B.5
  • 52
    • 33745515023 scopus 로고    scopus 로고
    • Tumour microenvironment: TGFbeta: The molecular Jekyll and Hyde of cancer
    • Bierie B, Moses HL. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 2006; 6: 506-520.
    • (2006) Nat Rev Cancer , vol.6 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 53
    • 43149084824 scopus 로고    scopus 로고
    • Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice
    • Lichti U, Anders J, Yuspa SH. Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc 2008; 3: 799-810.
    • (2008) Nat Protoc , vol.3 , pp. 799-810
    • Lichti, U.1    Anders, J.2    Yuspa, S.H.3
  • 54
    • 0040737617 scopus 로고    scopus 로고
    • Weinberg WC. P53 and tumor necrosis factor a regulate the expression of a mitochondrial chloride channel protein
    • Fernandez-Salas E, Sagar M, Cheng C, Yuspa SH, Weinberg WC. p53 and tumor necrosis factor a regulate the expression of a mitochondrial chloride channel protein. J Biol Chem 1999; 274: 36488-36497.
    • (1999) J Biol Chem , vol.274 , pp. 36488-36497
    • Fernandez-Salas, E.1    Sagar, M.2    Cheng, C.3    Yuspa, S.H.4


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