메뉴 건너뛰기




Volumn 5, Issue 4, 2016, Pages 395-402

Emerging role of microRNA-21 in cancer (Review)

Author keywords

Carcinogenesis; Hematological malignancy; MicroRNA 21

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MEMBRANE RECEPTOR; MICRORNA 155; MICRORNA 21; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGRAMMED DEATH 4 RECEPTOR; PROTEIN P53; STAT3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG;

EID: 85012871287     PISSN: 20499434     EISSN: 20499442     Source Type: Journal    
DOI: 10.3892/br.2016.747     Document Type: Review
Times cited : (364)

References (97)
  • 2
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: Coordinated cropping and dicing
    • Kim VN: MicroRNA biogenesis: Coordinated cropping and dicing. Nat Rev Mol Cell Biol 6: 376-385, 2005.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 376-385
    • Kim, V.N.1
  • 3
    • 78751498848 scopus 로고    scopus 로고
    • Deregulated expression of sprouty2 and microRNA-21 in human colon cancer: Correlation with the clinical stage of the disease
    • Feng YH, Wu CL, Tsao CJ, Chang JG, Lu PJ, Yeh KT, Uen YH, Lee JC and Shiau AL: Deregulated expression of sprouty2 and microRNA-21 in human colon cancer: Correlation with the clinical stage of the disease. Cancer Biol Ther 11: 111-121, 2011.
    • (2011) Cancer Biol Ther , vol.11 , pp. 111-121
    • Feng, Y.H.1    Wu, C.L.2    Tsao, C.J.3    Chang, J.G.4    Lu, P.J.5    Yeh, K.T.6    Uen, Y.H.7    Lee, J.C.8    Shiau, A.L.9
  • 5
    • 77956339881 scopus 로고    scopus 로고
    • OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
    • Medina PP, Nolde M and Slack FJ: OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467: 86-90, 2010.
    • (2010) Nature , vol.467 , pp. 86-90
    • Medina, P.P.1    Nolde, M.2    Slack, F.J.3
  • 7
    • 84926657876 scopus 로고    scopus 로고
    • Turning 21: Induction of miR-21 as a key switch in the inflammatory response
    • Sheedy FJ: Turning 21: Induction of miR-21 as a key switch in the inflammatory response. Front Immunol 6: 19, 2015.
    • (2015) Front Immunol , vol.6 , pp. 19
    • Sheedy, F.J.1
  • 9
    • 58649087374 scopus 로고    scopus 로고
    • MiR-21: A small multi-faceted RNA
    • Krichevsky AM and Gabriely G: miR-21: A small multi-faceted RNA. J Cell Mol Med 13: 39-53, 2009.
    • (2009) J Cell Mol Med , vol.13 , pp. 39-53
    • Krichevsky, A.M.1    Gabriely, G.2
  • 11
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan JA, Krichevsky AM and Kosik KS: MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65: 6029-6033, 2005.
    • (2005) Cancer Res , vol.65 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 12
    • 33750600178 scopus 로고    scopus 로고
    • MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior
    • Roldo C, Missiaglia E, Hagan JP, Falconi M, Capelli P, Bersani S, Calin GA, Volinia S, Liu CG, Scarpa A, et al: MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol 24: 4677-4684, 2006.
    • (2006) J Clin Oncol , vol.24 , pp. 4677-4684
    • Roldo, C.1    Missiaglia, E.2    Hagan, J.P.3    Falconi, M.4    Capelli, P.5    Bersani, S.6    Calin, G.A.7    Volinia, S.8    Liu, C.G.9    Scarpa, A.10
  • 14
    • 34250172419 scopus 로고    scopus 로고
    • MicroRNA expression signature and antisense‑mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation
    • Ji R, Cheng Y, Yue J, Yang J, Liu X, Chen H, Dean DB and Zhang C: MicroRNA expression signature and antisense‑mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ Res 100: 1579-1588, 2007.
    • (2007) Circ Res , vol.100 , pp. 1579-1588
    • Ji, R.1    Cheng, Y.2    Yue, J.3    Yang, J.4    Liu, X.5    Chen, H.6    Dean, D.B.7    Zhang, C.8
  • 16
    • 65249106172 scopus 로고    scopus 로고
    • MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression
    • Lu TX, Munitz A and Rothenberg ME: MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol 182: 4994-5002, 2009.
    • (2009) J Immunol , vol.182 , pp. 4994-5002
    • Lu, T.X.1    Munitz, A.2    Rothenberg, M.E.3
  • 17
    • 80053074068 scopus 로고    scopus 로고
    • MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity
    • Lu TX, Hartner J, Lim EJ, Fabry V, Mingler MK, Cole ET, Orkin SH, Aronow BJ and Rothenberg ME: MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol 187: 3362-3373, 2011.
    • (2011) J Immunol , vol.187 , pp. 3362-3373
    • Lu, T.X.1    Hartner, J.2    Lim, E.J.3    Fabry, V.4    Mingler, M.K.5    Cole, E.T.6    Orkin, S.H.7    Aronow, B.J.8    Rothenberg, M.E.9
  • 18
    • 84929600786 scopus 로고    scopus 로고
    • MicroRNA-21, T helper lineage and autoimmunity
    • Murugaiyan G, Garo LP and Weiner HL: MicroRNA-21, T helper lineage and autoimmunity. Oncotarget 6: 9644-9645, 2015.
    • (2015) Oncotarget , vol.6 , pp. 9644-9645
    • Murugaiyan, G.1    Garo, L.P.2    Weiner, H.L.3
  • 19
    • 42249090353 scopus 로고    scopus 로고
    • Sakurai K and Iba H: MiR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism
    • Fujita S, Ito T, Mizutani T, Minoguchi S, Yamamichi N, Sakurai K and Iba H: miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol 378: 492-504, 2008.
    • (2008) J Mol Biol , vol.378 , pp. 492-504
    • Fujita, S.1    Ito, T.2    Mizutani, T.3    Minoguchi, S.4    Yamamichi, N.5
  • 20
    • 78650385772 scopus 로고    scopus 로고
    • MicroRNA-21: A novel therapeutic target in human cancer
    • Pan X, Wang ZX and Wang R: MicroRNA-21: A novel therapeutic target in human cancer. Cancer Biol Ther 10: 1224-1232, 2010.
    • (2010) Cancer Biol Ther , vol.10 , pp. 1224-1232
    • Pan, X.1    Wang, Z.X.2    Wang, R.3
  • 23
    • 0038209450 scopus 로고    scopus 로고
    • Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation
    • Yang HS, Knies JL, Stark C and Colburn NH: Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation. Oncogene 22: 3712-3720, 2003.
    • (2003) Oncogene , vol.22 , pp. 3712-3720
    • Yang, H.S.1    Knies, J.L.2    Stark, C.3    Colburn, N.H.4
  • 25
    • 34347266556 scopus 로고    scopus 로고
    • MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
    • Zhu S, Si ML, Wu H and Mo YY: MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282: 14328-14336, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 14328-14336
    • Zhu, S.1    Si, M.L.2    Wu, H.3    Mo, Y.Y.4
  • 27
    • 40249092910 scopus 로고    scopus 로고
    • MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
    • Zhu S, Wu H, Wu F, Nie D, Sheng S and Mo YY: MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 18: 350-359, 2008.
    • (2008) Cell Res , vol.18 , pp. 350-359
    • Zhu, S.1    Wu, H.2    Wu, F.3    Nie, D.4    Sheng, S.5    Mo, Y.Y.6
  • 29
    • 0037468256 scopus 로고    scopus 로고
    • Common fragile sites are preferential targets for HPV16 integrations in cervical tumors
    • Thorland EC, Myers SL, Gostout BS and Smith DI: Common fragile sites are preferential targets for HPV16 integrations in cervical tumors. Oncogene 22: 1225-1237, 2003.
    • (2003) Oncogene , vol.22 , pp. 1225-1237
    • Thorland, E.C.1    Myers, S.L.2    Gostout, B.S.3    Smith, D.I.4
  • 30
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658, 2007.
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 31
    • 85043544748 scopus 로고    scopus 로고
    • MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway
    • Wu H, Ng R, Chen X, Steer CJ and Song G: MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway. Gut gutjnl-2014-308430, 2015.
    • (2014) Gut Gutjnl
    • Wu, H.1    Ng, R.2    Chen, X.3    Steer, C.J.4    Song, G.5
  • 32
    • 84875673906 scopus 로고    scopus 로고
    • Inhibition of miR-21 induces biological and behavioral alterations in diffuse large B-cell lymphoma
    • Gu L, Song G, Chen L, Nie Z, He B, Pan Y, Xu Y, Li R, Gao T, Cho WC, et al: Inhibition of miR-21 induces biological and behavioral alterations in diffuse large B-cell lymphoma. Acta Haematol 130: 87-94, 2013.
    • (2013) Acta Haematol , vol.130 , pp. 87-94
    • Gu, L.1    Song, G.2    Chen, L.3    Nie, Z.4    He, B.5    Pan, Y.6    Xu, Y.7    Li, R.8    Gao, T.9    Cho, W.C.10
  • 35
    • 84905406380 scopus 로고    scopus 로고
    • The impact of activated p-AKT expression on clinical outcomes in diffuse large B-cell lymphoma: A clinicopathological study of 262 cases
    • Hong JY, Hong ME, Choi MK, Kim YS, Chang W, Maeng CH, Park S, Lee SJ, Do IG, Jo JS, et al: The impact of activated p-AKT expression on clinical outcomes in diffuse large B-cell lymphoma: A clinicopathological study of 262 cases. Ann Oncol 25: 182-188, 2014.
    • (2014) Ann Oncol , vol.25 , pp. 182-188
    • Hong, J.Y.1    Hong, M.E.2    Choi, M.K.3    Kim, Y.S.4    Chang, W.5    Maeng, C.H.6    Park, S.7    Lee, S.J.8    Do, I.G.9    Jo, J.S.10
  • 36
    • 84934278912 scopus 로고    scopus 로고
    • MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma
    • Go H, Jang JY, Kim PJ, Kim YG, Nam SJ, Paik JH, Kim TM, Heo DS, Kim CW and Jeon YK: MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma. Oncotarget 6: 15035-15049, 2015.
    • (2015) Oncotarget , vol.6 , pp. 15035-15049
    • Go, H.1    Jang, J.Y.2    Kim, P.J.3    Kim, Y.G.4    Nam, S.J.5    Paik, J.H.6    Kim, T.M.7    Heo, D.S.8    Kim, C.W.9    Jeon, Y.K.10
  • 38
    • 43949126187 scopus 로고    scopus 로고
    • MicroRNA-155 is an Epstein-Barr virus‑induced gene that modulates Epstein-Barr virus-regulated gene expression pathways
    • Yin Q, McBride J, Fewell C, Lacey M, Wang X, Lin Z, Cameron J and Flemington EK: MicroRNA-155 is an Epstein-Barr virus‑induced gene that modulates Epstein-Barr virus-regulated gene expression pathways. J Virol 82: 5295-5306, 2008.
    • (2008) J Virol , vol.82 , pp. 5295-5306
    • Yin, Q.1    McBride, J.2    Fewell, C.3    Lacey, M.4    Wang, X.5    Lin, Z.6    Cameron, J.7    Flemington, E.K.8
  • 39
    • 84898803651 scopus 로고    scopus 로고
    • Clinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese population
    • Chen W, Wang H, Chen H, Liu S, Lu H, Kong D, Huang X, Kong Q and Lu Z: Clinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese population. Eur J Haematol 92: 407-412, 2014.
    • (2014) Eur J Haematol , vol.92 , pp. 407-412
    • Chen, W.1    Wang, H.2    Chen, H.3    Liu, S.4    Lu, H.5    Kong, D.6    Huang, X.7    Kong, Q.8    Lu, Z.9
  • 40
    • 84892184867 scopus 로고    scopus 로고
    • Plasma microRNA are disease response biomarkers in classical Hodgkin lymphoma
    • Jones K, Nourse JP, Keane C, Bhatnagar A and Gandhi MK: Plasma microRNA are disease response biomarkers in classical Hodgkin lymphoma. Clin Cancer Res 20: 253-264, 2014.
    • (2014) Clin Cancer Res , vol.20 , pp. 253-264
    • Jones, K.1    Nourse, J.P.2    Keane, C.3    Bhatnagar, A.4    Gandhi, M.K.5
  • 41
    • 0023683455 scopus 로고
    • Blast crisis of Philadelphia chromosome‑positive chronic myelocytic leukemia (CML). Treatment results of 69 patients
    • Anger B, Carbonell F, Braunger I, Heinze B, Gutensohn W, Thiel E and Heimpel H: Blast crisis of Philadelphia chromosome‑positive chronic myelocytic leukemia (CML). Treatment results of 69 patients. Blut 57: 131-137, 1988.
    • (1988) Blut , vol.57 , pp. 131-137
    • Anger, B.1    Carbonell, F.2    Braunger, I.3    Heinze, B.4    Gutensohn, W.5    Thiel, E.6    Heimpel, H.7
  • 42
    • 84921745097 scopus 로고    scopus 로고
    • Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia
    • Zhou M, Zeng J, Wang X, Wang X, Huang T, Fu Y, Sun T, Jia J and Chen C: Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia. Oncotarget 6: 1249-1261, 2015.
    • (2015) Oncotarget , vol.6 , pp. 1249-1261
    • Zhou, M.1    Zeng, J.2    Wang, X.3    Wang, X.4    Huang, T.5    Fu, Y.6    Sun, T.7    Jia, J.8    Chen, C.9
  • 45
    • 84921374186 scopus 로고    scopus 로고
    • Lo-Coco F and Testa U: MiR-21 is overexpressed in NPM1‑mutant acute myeloid leukemias
    • Riccioni R, Lulli V, Castelli G, Biffoni M, Tiberio R, Pelosi E, Lo-Coco F and Testa U: miR-21 is overexpressed in NPM1‑mutant acute myeloid leukemias. Leuk Res 39: 221-228, 2015.
    • (2015) Leuk Res , vol.39 , pp. 221-228
    • Riccioni, R.1    Lulli, V.2    Castelli, G.3    Biffoni, M.4    Tiberio, R.5    Pelosi, E.6
  • 46
    • 84940043946 scopus 로고    scopus 로고
    • Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR‑21-mediated tumor suppressor Pdcd4 repression
    • Junker F, Chabloz A, Koch U and Radtke F: Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR‑21-mediated tumor suppressor Pdcd4 repression. Blood 126: 993-1004, 2015.
    • (2015) Blood , vol.126 , pp. 993-1004
    • Junker, F.1    Chabloz, A.2    Koch, U.3    Radtke, F.4
  • 48
    • 85009941091 scopus 로고    scopus 로고
    • Downregulation of Sprouty homolog 2 by microRNA-21 inhibits proliferation, metastasis and invasion, however promotes the apoptosis of multiple myeloma cells
    • Wang JH, Zhou WW, Cheng ST, Liu BX, Liu FR and Song JQ: Downregulation of Sprouty homolog 2 by microRNA-21 inhibits proliferation, metastasis and invasion, however promotes the apoptosis of multiple myeloma cells. Mol Med Rep 12: 1810-1816, 2015.
    • (2015) Mol Med Rep , vol.12 , pp. 1810-1816
    • Wang, J.H.1    Zhou, W.W.2    Cheng, S.T.3    Liu, B.X.4    Liu, F.R.5    Song, J.Q.6
  • 49
    • 84920756023 scopus 로고    scopus 로고
    • MicroRNA-21 and the clinical outcomes of various carcinomas: A systematic review and meta-analysis
    • Wang W, Li J, Zhu W, Gao C, Jiang R, Li W, Hu Q and Zhang B: MicroRNA-21 and the clinical outcomes of various carcinomas: A systematic review and meta-analysis. BMC Cancer 14: 819, 2014.
    • (2014) BMC Cancer , vol.14 , pp. 819
    • Wang, W.1    Li, J.2    Zhu, W.3    Gao, C.4    Jiang, R.5    Li, W.6    Hu, Q.7    Zhang, B.8
  • 50
    • 55549120234 scopus 로고    scopus 로고
    • MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
    • Yan LX, Huang XF, Shao Q, Huang MY, Deng L, Wu QL, Zeng YX and Shao JY: MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 14: 2348-2360, 2008.
    • (2008) RNA , vol.14 , pp. 2348-2360
    • Yan, L.X.1    Huang, X.F.2    Shao, Q.3    Huang, M.Y.4    Deng, L.5    Wu, Q.L.6    Zeng, Y.X.7    Shao, J.Y.8
  • 51
    • 84863069464 scopus 로고    scopus 로고
    • MiRNAs in breast cancer tumorigenesis (Review)
    • Zhang ZJ and Ma SL: miRNAs in breast cancer tumorigenesis (Review). Oncol Rep 27: 903-910, 2012.
    • (2012) Oncol Rep , vol.27 , pp. 903-910
    • Zhang, Z.J.1    Ma, S.L.2
  • 53
    • 84926310220 scopus 로고    scopus 로고
    • Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker
    • Erbes T, Hirschfeld M, Rücker G, Jaeger M, Boas J, Iborra S, Mayer S, Gitsch G and Stickeler E: Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker. BMC Cancer 15: 193, 2015.
    • (2015) BMC Cancer , vol.15 , pp. 193
    • Erbes, T.1    Hirschfeld, M.2    Rücker, G.3    Jaeger, M.4    Boas, J.5    Iborra, S.6    Mayer, S.7    Gitsch, G.8    Stickeler, E.9
  • 54
    • 84957954240 scopus 로고    scopus 로고
    • Serum microRNA-21 as a potential diagnostic biomarker for breast cancer: A systematic review and meta-analysis
    • Li S, Yang X, Yang J, Zhen J and Zhang D: Serum microRNA-21 as a potential diagnostic biomarker for breast cancer: A systematic review and meta-analysis. Clin Exp Med 16: 29-35, 2014.
    • (2014) Clin Exp Med , vol.16 , pp. 29-35
    • Li, S.1    Yang, X.2    Yang, J.3    Zhen, J.4    Zhang, D.5
  • 55
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (MiR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S and Allgayer H: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27: 2128-2136, 2008.
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3    Leupold, J.H.4    Colburn, N.H.5    Post, S.6    Allgayer, H.7
  • 57
    • 84908282056 scopus 로고    scopus 로고
    • MicroRNA dysregulation as a prognostic biomarker in colorectal cancer
    • Dong Y, Yu J and Ng SS: MicroRNA dysregulation as a prognostic biomarker in colorectal cancer. Cancer Manag Res 6: 405-422, 2014.
    • (2014) Cancer Manag Res , vol.6 , pp. 405-422
    • Dong, Y.1    Yu, J.2    Ng, S.S.3
  • 59
    • 84888135550 scopus 로고    scopus 로고
    • Prognostic and predictive value of a microRNA signature in stage II colon cancer: A microRNA expression analysis
    • Zhang JX, Song W, Chen ZH, Wei JH, Liao YJ, Lei J, Hu M, Chen GZ, Liao B, Lu J, et al: Prognostic and predictive value of a microRNA signature in stage II colon cancer: A microRNA expression analysis. Lancet Oncol 14: 1295-1306, 2013.
    • (2013) Lancet Oncol , vol.14 , pp. 1295-1306
    • Zhang, J.X.1    Song, W.2    Chen, Z.H.3    Wei, J.H.4    Liao, Y.J.5    Lei, J.6    Hu, M.7    Chen, G.Z.8    Liao, B.9    Lu, J.10
  • 62
    • 80053923978 scopus 로고    scopus 로고
    • Prognostic role of microRNA-21 in various carcinomas: A systematic review and meta-analysis
    • Fu X, Han Y, Wu Y, Zhu X, Lu X, Mao F, Wang X, He X, Zhao Y and Zhao Y: Prognostic role of microRNA-21 in various carcinomas: A systematic review and meta-analysis. Eur J Clin Invest 41: 1245-1253, 2011.
    • (2011) Eur J Clin Invest , vol.41 , pp. 1245-1253
    • Fu, X.1    Han, Y.2    Wu, Y.3    Zhu, X.4    Lu, X.5    Mao, F.6    Wang, X.7    He, X.8    Zhao, Y.9    Zhao, Y.10
  • 63
    • 84928138074 scopus 로고    scopus 로고
    • Significance of serum microRNA-21 in diagnosis of hepatocellular carcinoma (HCC): Clinical analyses of patients and an HCC rat model
    • Wang X, Zhang J, Zhou L, Lu P, Zheng ZG, Sun W, Wang JL, Yang XS, Li XL, Xia N, et al: Significance of serum microRNA-21 in diagnosis of hepatocellular carcinoma (HCC): Clinical analyses of patients and an HCC rat model. Int J Clin Exp Pathol 8: 1466-1478, 2015.
    • (2015) Int J Clin Exp Pathol , vol.8 , pp. 1466-1478
    • Wang, X.1    Zhang, J.2    Zhou, L.3    Lu, P.4    Zheng, Z.G.5    Sun, W.6    Wang, J.L.7    Yang, X.S.8    Li, X.L.9    Xia, N.10
  • 67
    • 84862828919 scopus 로고    scopus 로고
    • MiR-21 as an independent biochemical recurrence predictor and potential therapeutic target for prostate cancer
    • Li T, Li RS, Li YH, Zhong S, Chen YY, Zhang CM, Hu MM and Shen ZJ: miR-21 as an independent biochemical recurrence predictor and potential therapeutic target for prostate cancer. J Urol 187: 1466-1472, 2012.
    • (2012) J Urol , vol.187 , pp. 1466-1472
    • Li, T.1    Li, R.S.2    Li, Y.H.3    Zhong, S.4    Chen, Y.Y.5    Zhang, C.M.6    Hu, M.M.7    Shen, Z.J.8
  • 71
    • 84931006188 scopus 로고    scopus 로고
    • Down‑regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer
    • Chen Z, Yuan YC, Wang Y, Liu Z, Chan HJ and Chen S: Down‑regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer. Breast Cancer Res Treat 152: 29-39, 2015.
    • (2015) Breast Cancer Res Treat , vol.152 , pp. 29-39
    • Chen, Z.1    Yuan, Y.C.2    Wang, Y.3    Liu, Z.4    Chan, H.J.5    Chen, S.6
  • 72
    • 84954539912 scopus 로고    scopus 로고
    • Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells
    • Yu X, Li R, Shi W, Jiang T, Wang Y, Li C and Qu X: Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells. Biomed Pharmacother 77: 37-44, 2016.
    • (2016) Biomed Pharmacother , vol.77 , pp. 37-44
    • Yu, X.1    Li, R.2    Shi, W.3    Jiang, T.4    Wang, Y.5    Li, C.6    Qu, X.7
  • 73
    • 70350362953 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction with protein kinase C(Epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells
    • Bourguignon LY, Spevak CC, Wong G, Xia W and Gilad E: Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem 284: 26533-26546, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 26533-26546
    • Bourguignon, L.Y.1    Spevak, C.C.2    Wong, G.3    Xia, W.4    Gilad, E.5
  • 74
    • 79956313718 scopus 로고    scopus 로고
    • Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer
    • Gong C, Yao Y, Wang Y, Liu B, Wu W, Chen J, Su F, Yao H and Song E: Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem 286: 19127-19137, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 19127-19137
    • Gong, C.1    Yao, Y.2    Wang, Y.3    Liu, B.4    Wu, W.5    Chen, J.6    Su, F.7    Yao, H.8    Song, E.9
  • 75
    • 84906054474 scopus 로고    scopus 로고
    • Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: A translational research project within the Geparquinto trial
    • Müller V, Gade S, Steinbach B, Loibl S, von Minckwitz G, Untch M, Schwedler K, Lübbe K, Schem C, Fasching PA, et al: Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: A translational research project within the Geparquinto trial. Breast Cancer Res Treat 147: 61-68, 2014.
    • (2014) Breast Cancer Res Treat , vol.147 , pp. 61-68
    • Müller, V.1    Gade, S.2    Steinbach, B.3    Loibl, S.4    Von Minckwitz, G.5    Untch, M.6    Schwedler, K.7    Lübbe, K.8    Schem, C.9    Fasching, P.A.10
  • 76
    • 84893669133 scopus 로고    scopus 로고
    • Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro
    • Deng J, Lei W, Fu JC, Zhang L, Li JH and Xiong JP: Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro. Biochem Biophys Res Commun 443: 789-795, 2014.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 789-795
    • Deng, J.1    Lei, W.2    Fu, J.C.3    Zhang, L.4    Li, J.H.5    Xiong, J.P.6
  • 77
    • 84892888388 scopus 로고    scopus 로고
    • MiR-21 overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer
    • Li B, Ren S, Li X, Wang Y, Garfield D, Zhou S, Chen X, Su C, Chen M, Kuang P, et al: miR-21 overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer. Lung Cancer 83: 146-153, 2014.
    • (2014) Lung Cancer , vol.83 , pp. 146-153
    • Li, B.1    Ren, S.2    Li, X.3    Wang, Y.4    Garfield, D.5    Zhou, S.6    Chen, X.7    Su, C.8    Chen, M.9    Kuang, P.10
  • 78
    • 84904806763 scopus 로고    scopus 로고
    • Alteration in Mir-21/PTEN expression modulates gefitinib resistance in non-small cell lung cancer
    • Shen H, Zhu F, Liu J, Xu T, Pei D, Wang R, Qian Y, Li Q, Wang L, Shi Z, et al: Alteration in Mir-21/PTEN expression modulates gefitinib resistance in non-small cell lung cancer. PLoS One 9: e103305, 2014.
    • (2014) Plos One , vol.9
    • Shen, H.1    Zhu, F.2    Liu, J.3    Xu, T.4    Pei, D.5    Wang, R.6    Qian, Y.7    Li, Q.8    Wang, L.9    Shi, Z.10
  • 79
    • 84946594918 scopus 로고    scopus 로고
    • Identification of plasma microRNA profiles for primary resistance to EGFR-TKIs in advanced non-small cell lung cancer (NSCLC) patients with EGFR activating mutation
    • Wang S, Su X, Bai H, Zhao J, Duan J, An T, Zhuo M, Wang Z, Wu M, Li Z, et al: Identification of plasma microRNA profiles for primary resistance to EGFR-TKIs in advanced non-small cell lung cancer (NSCLC) patients with EGFR activating mutation. J Hematol Oncol 8: 127, 2015.
    • (2015) J Hematol Oncol , vol.8 , pp. 127
    • Wang, S.1    Su, X.2    Bai, H.3    Zhao, J.4    Duan, J.5    An, T.6    Zhuo, M.7    Wang, Z.8    Wu, M.9    Li, Z.10
  • 80
    • 84949770766 scopus 로고    scopus 로고
    • MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer
    • Wu ZH, Tao ZH, Zhang J, Li T, Ni C, Xie J, Zhang JF and Hu XC: miRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer. Tumour Biol 37: 7245-7254, 2016.
    • (2016) Tumour Biol , vol.37 , pp. 7245-7254
    • Wu, Z.H.1    Tao, Z.H.2    Zhang, J.3    Li, T.4    Ni, C.5    Xie, J.6    Zhang, J.F.7    Hu, X.C.8
  • 81
    • 84855389885 scopus 로고    scopus 로고
    • MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells
    • Yu Y, Kanwar SS, Patel BB, Oh PS, Nautiyal J, Sarkar FH and Majumdar AP: MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells. Carcinogenesis 33: 68-76, 2012.
    • (2012) Carcinogenesis , vol.33 , pp. 68-76
    • Yu, Y.1    Kanwar, S.S.2    Patel, B.B.3    Oh, P.S.4    Nautiyal, J.5    Sarkar, F.H.6    Majumdar, A.P.7
  • 82
    • 84863234535 scopus 로고    scopus 로고
    • MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells
    • Feng YH, Wu CL, Shiau AL, Lee JC, Chang JG, Lu PJ, Tung CL, Feng LY, Huang WT and Tsao CJ: MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. Int J Mol Med 29: 920-926, 2012.
    • (2012) Int J Mol Med , vol.29 , pp. 920-926
    • Feng, Y.H.1    Wu, C.L.2    Shiau, A.L.3    Lee, J.C.4    Chang, J.G.5    Lu, P.J.6    Tung, C.L.7    Feng, L.Y.8    Huang, W.T.9    Tsao, C.J.10
  • 83
    • 84870469858 scopus 로고    scopus 로고
    • MicroRNA-21 (MiR-21) expression promotes growth, metastasis, and chemo-or radioresistance in non-small cell lung cancer cells by targeting PTEN
    • Liu ZL, Wang H, Liu J and Wang ZX: MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo-or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol Cell Biochem 372: 35-45, 2013.
    • (2013) Mol Cell Biochem , vol.372 , pp. 35-45
    • Liu, Z.L.1    Wang, H.2    Liu, J.3    Wang, Z.X.4
  • 84
    • 84981764236 scopus 로고    scopus 로고
    • MicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4
    • Wei X, Wang W, Wang L, Zhang Y, Zhang X, Chen M, Wang F, Yu J, Ma Y and Sun G: MicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4. Cancer Med 5: 693-702, 2016.
    • (2016) Cancer Med , vol.5 , pp. 693-702
    • Wei, X.1    Wang, W.2    Wang, L.3    Zhang, Y.4    Zhang, X.5    Chen, M.6    Wang, F.7    Yu, J.8    Ma, Y.9    Sun, G.10
  • 85
    • 84876768229 scopus 로고    scopus 로고
    • Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole‑3‑carbinol
    • Paik WH, Kim HR, Park JK, Song BJ, Lee SH and Hwang JH: Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole‑3‑carbinol. Anticancer Res 33: 1473-1481, 2013.
    • (2013) Anticancer Res , vol.33 , pp. 1473-1481
    • Paik, W.H.1    Kim, H.R.2    Park, J.K.3    Song, B.J.4    Lee, S.H.5    Hwang, J.H.6
  • 88
    • 84945143807 scopus 로고    scopus 로고
    • Xu S and Sun X: MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway
    • He C, Dong X, Zhai B, Jiang X, Dong D, Li B, Jiang H, Xu S and Sun X: miR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway. Oncotarget 6: 28867-28881, 2015.
    • (2015) Oncotarget , vol.6 , pp. 28867-28881
    • He, C.1    Dong, X.2    Zhai, B.3    Jiang, X.4    Dong, D.5    Li, B.6    Jiang, H.7
  • 89
    • 84901455567 scopus 로고    scopus 로고
    • Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway
    • Echevarría-Vargas IM, Valiyeva F and Vivas-Mejía PE: Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway. PLoS One 9: e97094, 2014.
    • (2014) Plos One , vol.9
    • Echevarría-Vargas, I.M.1    Valiyeva, F.2    Vivas-Mejía, P.E.3
  • 90
    • 84880397014 scopus 로고    scopus 로고
    • MiR-21 modulates paclitaxel sensitivity and hypoxia-inducible factor-1α expression in human ovarian cancer cells
    • Xie Z, Cao L and Zhang J: miR-21 modulates paclitaxel sensitivity and hypoxia-inducible factor-1α expression in human ovarian cancer cells. Oncol Lett 6: 795-800, 2013.
    • (2013) Oncol Lett , vol.6 , pp. 795-800
    • Xie, Z.1    Cao, L.2    Zhang, J.3
  • 91
    • 84938799830 scopus 로고    scopus 로고
    • Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma
    • Lan F, Pan Q, Yu H and Yue X: Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma. J Neurochem 134: 811-818, 2015.
    • (2015) J Neurochem , vol.134 , pp. 811-818
    • Lan, F.1    Pan, Q.2    Yu, H.3    Yue, X.4
  • 92
    • 77956178738 scopus 로고    scopus 로고
    • MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity
    • Shi L, Chen J, Yang J, Pan T, Zhang S and Wang Z: miR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res 1352: 255-264, 2010.
    • (2010) Brain Res , vol.1352 , pp. 255-264
    • Shi, L.1    Chen, J.2    Yang, J.3    Pan, T.4    Zhang, S.5    Wang, Z.6
  • 93
    • 84922601431 scopus 로고    scopus 로고
    • WP1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting STAT3/miR-21 axis
    • Zhou X, Ren Y, Liu A, Jin R, Jiang Q, Huang Y, Kong L, Wang X and Zhang L: WP1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting STAT3/miR-21 axis. Sci Rep 4: 7461, 2014.
    • (2014) Sci Rep , vol.4 , pp. 7461
    • Zhou, X.1    Ren, Y.2    Liu, A.3    Jin, R.4    Jiang, Q.5    Huang, Y.6    Kong, L.7    Wang, X.8    Zhang, L.9
  • 94
    • 84855781227 scopus 로고    scopus 로고
    • Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells
    • Bourguignon LY, Earle C, Wong G, Spevak CC and Krueger K: Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene 31: 149-160, 2012.
    • (2012) Oncogene , vol.31 , pp. 149-160
    • Bourguignon, L.Y.1    Earle, C.2    Wong, G.3    Spevak, C.C.4    Krueger, K.5
  • 95
    • 84885995312 scopus 로고    scopus 로고
    • Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin‑induced Apoptosis by suppressing PDCD4 and Fas-L
    • Yang GD, Huang TJ, Peng LX, Yang CF, Liu RY, Huang HB, Chu QQ, Yang HJ, Huang JL, Zhu ZY, et al: Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin‑induced Apoptosis by suppressing PDCD4 and Fas-L. PLoS One 8: e78355, 2013.
    • (2013) Plos One , vol.8
    • Yang, G.D.1    Huang, T.J.2    Peng, L.X.3    Yang, C.F.4    Liu, R.Y.5    Huang, H.B.6    Chu, Q.Q.7    Yang, H.J.8    Huang, J.L.9    Zhu, Z.Y.10
  • 96
    • 84876312892 scopus 로고    scopus 로고
    • MiR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN
    • Yang SM, Huang C, Li XF, Yu MZ, He Y and Li J: miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology 306: 162-168, 2013.
    • (2013) Toxicology , vol.306 , pp. 162-168
    • Yang, S.M.1    Huang, C.2    Li, X.F.3    Yu, M.Z.4    He, Y.5    Li, J.6
  • 97
    • 79954523687 scopus 로고    scopus 로고
    • MicroRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells
    • Tao J, Lu Q, Wu D, Li P, Xu B, Qing W, Wang M, Zhang Z and Zhang W: microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells. Oncol Rep 25: 1721-1729, 2011.
    • (2011) Oncol Rep , vol.25 , pp. 1721-1729
    • Tao, J.1    Lu, Q.2    Wu, D.3    Li, P.4    Xu, B.5    Qing, W.6    Wang, M.7    Zhang, Z.8    Zhang, W.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.