miRNAs in breast cancer tumorigenesis

Oncology Reports

Volumn 27, Issue 4, 2012, Pages 903-910

  Zhang, Zhong Ju ^a   Ma, Shi Liang ^a  

^a SHENYANG AGRICULTURAL UNIVERSITY   (China)

Author keywords

Breast cancer; miRNA

Indexed keywords

LET 7; MICRORNA; MICRORNA 106B 93 25; MICRORNA 10B; MICRORNA 126; MICRORNA 145; MICRORNA 155; MICRORNA 17 20; MICRORNA 17 5P; MICRORNA 18A 221 222; MICRORNA 18B 221 222; MICRORNA 200C; MICRORNA 205 200; MICRORNA 206; MICRORNA 20B; MICRORNA 21; MICRORNA 27A; MICRORNA 30; MICRORNA 31; MICRORNA 335; MICRORNA 34A; MICRORNA 373; MICRORNA 520C; MICRORNA 672; MICRORNA 9; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

BREAST CANCER; BREAST METASTASIS; CANCER GROWTH; CARCINOGENESIS; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL HETEROGENEITY; DISEASE ASSOCIATION; GENE TARGETING; GENETIC ASSOCIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; RNA ANALYSIS; RNA SEQUENCE;

ANIMALS; BREAST NEOPLASMS; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; SIGNAL TRANSDUCTION;

EID: 84863069464     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1611     Document Type: Review

References (94)

1. Lee R, Feinbaum R and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854, 1993. (Pubitemid 24014542)
2. Reinhart BJ, Slack FJ, Basson M, et al: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403: 901-906, 2000. (Pubitemid 30130993)
3. Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science 294: 853-858, 2001. (Pubitemid 33032103)
4. Lau NC, Lim LP, Weinstein EG and Bartel DP: An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294: 858-862, 2001. (Pubitemid 33032104)
5. Vetter G, Saumet A, Moes M, et al: miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers. Oncogene 29: 4436-4448, 2010.
6. Ambros V: MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113: 673-676, 2003.
7. Palatnik JF, Allen E, Wu X, et al: Control of leaf morphogenesis by microRNAs. Nature 425: 257-263, 2003. (Pubitemid 37158395)
8. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
9. Hatfield SD, Shcherbata HR, Fischer KA, Nakahara K, Carthew RW and Ruohola-Baker H: Stem cell division is regulated by the microRNA pathway. Nature 435: 974-978, 2005. (Pubitemid 40896325)
10. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV and Mendell JT: c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435: 839-843, 2005. (Pubitemid 40839736)
11. Ambros V: The functions of animal microRNAs. Nature 431: 350-355, 2004.
12. Tong AW and Nemunaitis J: Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy? Cancer Gene Ther 15: 341-355, 2008. (Pubitemid 351693228)
13. Croce CM and Calin GA: miRNAs, cancer, and stem cell division. Cell 122: 6-7, 2005. (Pubitemid 40977933)
14. Calin G, Dumitru C, Shimizu M, et al: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99: 15524-15529, 2002. (Pubitemid 35403967)
15. Iorio MV, Ferracin M, Liu CG, et al: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65: 7065-7070, 2005 (Pubitemid 41161233)
16. Al-Hajj M: Cancer stem cells and oncology therapeutics. Curr Opin Oncol 19: 61-64, 2007.
17. Al-Hajj M and Clarke MF: Self-renewal and solid tumor stem cells. Oncogene 23: 7274-7282, 2004. (Pubitemid 39382161)
18. Liu S, Dontu G, Mantle ID, et al: Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66: 6063-6071, 2006.
19. Dimri GP, Martinez JL, Jacobs JJL, et al: The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 62: 4736-4745, 2002.
20. Shimono Y, Zabala M, Cho RW, et al: Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 138: 592-603, 2009.
21. Yu F, Yao H, Zhu P, et al: let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131: 1109-1123, 2007. (Pubitemid 350235025)
22. Yu F, Deng H, Yao H, Liu Q, Su F and Song E: Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 29: 4194-4204, 2010.
23. Müller S, Hoege C, Pyrowolakis G and Jentsch S: SUMO, ubiquitin's mysterious cousin. Nat Rev Mol Cell Biol 2: 202-213, 2001.
24. Park SW, Hu X, Gupta P, Lin YP, Ha SG and Wei LN: SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nat Struct Mol Biol 14: 68-75, 2006. (Pubitemid 46067425)
25. Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM and Cheresh DA: Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 155: 459-470, 2001. (Pubitemid 34289336)
26. Pontier SM and Muller WJ: Integrins in mammary-stem-cell biology and breast-cancer progression - a role in cancer stem cells? J Cell Sci 122: 207-214, 2009.
27. Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer, and cancer stem cells. Nature 414: 105-111, 2001. (Pubitemid 33041634)
28. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
29. Liu CA, Wang MJ, Chi CW, Wu CW and Chen JY: Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. Oncogene 23: 8731-8742, 2004.
30. Raver-Shapira N, Marciano E, Meiri E, et al: Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26: 731-743, 2007. (Pubitemid 46856247)
31. Antonsson B and Martinou JC: The Bcl-2 protein family. Exp Cell Res 256: 50-57, 2000. (Pubitemid 30211166)
32. Cimmino A, Calin G, Fabbri M, et al: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102: 13944-13949, 2005. (Pubitemid 41377683)
33. Si ML, Zhu S, Wu H, Lu Z, Wu F and Mo YY: miR-21-mediated tumor growth. Oncogene 26: 2799-2803, 2006. (Pubitemid 46663837)
34. Chan J, Krichevsky A and Kosik K: MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65: 6029-6033, 2005. (Pubitemid 40994386)
35. Wang S, Bian C, Yang Z, et al: miR-145 inhibits breast cancer cell growth through RTKN. Int J Oncol 34: 1461-1466, 2009.
36. Kong W, He L, Coppola M, et al: MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem 285: 17869-17879, 2010.
37. Sunters A, Fernández de Mattos S, Stahl M, et al: FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem 278: 49795-49805, 2003. (Pubitemid 37548813)
38. Le MT, Teh C, Shyh-Chang N, et al: MicroRNA-125b is a novel negative regulator of p53. Genes Dev 23: 862-876, 2009.
39. Kato M, Paranjape T, Ullrich R, et al: The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells. Oncogene 28: 2419-2424, 2009.
40. Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348, 2001. (Pubitemid 32467043)
41. Fu M: Minireview: cyclin D1: normal and abnormal functions. Endocrinology 145: 5439-5447, 2004.
42. Yu Z, Wang C, Wang M, et al: A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol 182: 509-517, 2008.
43. Mertens-Talcott SU, Chintharlapalli S, Li X and Safe S: The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res 67: 11001-11011, 2007. (Pubitemid 350145930)
44. Hossain A, Kuo MT and Saunders GF: Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol 26: 8191-8201, 2006. (Pubitemid 44631015)
45. Brosh R, Shalgi R, Liran A, et al: p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol 4: 229, 2008.
46. Castro-Rivera E, Samudio I and Safe S: Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. J Biol Chem 276: 30853-30861, 2001.
47. Adams BD, Furneaux H and White BA: The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-(ER) and represses ER messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 21: 1132-1147, 2007. (Pubitemid 46984764)
48. Leivonen SK, Makela R, Ostling P, et al: Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene 28: 3926-3936, 2009.
49. Zhao JJ, Lin J, Yang H, et al: MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. J Biol Chem 283: 31079-31086, 2008.
50. Bhat-Nakshatri P, Wang G, Collins NR, et al: Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Res 37: 4850-4861, 2009.
51. Wickramasinghe NS, Manavalan TT, Dougherty SM, Riggs KA, Li Y and Klinge CM: Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Res 37: 2584-2595, 2009.
52. Gupta GP and Massague J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006. (Pubitemid 44781029)
53. Huang Q, Gumireddy K, Schrier M, et al: The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol 10: 202-210, 2008. (Pubitemid 351194050)
54. Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature 407: 249-257, 2000.
55. Vincent-Salomon A and Thiery JP: Epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res 5: 101-106, 2003. (Pubitemid 36348104)
56. Tryndyak VP, Beland FA and Pogribny IP: E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int J Cancer 126: 2575-2583, 2010.
57. Ma L, Young J, Prabhala H, et al: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12: 247-256, 2010.
58. Blagosklonny MV, Dykxhoorn DM, Wu Y, et al: miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One 4: e7181, 2009.
59. Gregory PA, Bert AG, Paterson EL, et al: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601, 2008. (Pubitemid 351627379)
60. Valastyan S, Reinhardt F, Benaich N, et al: A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell 137: 1032-1046, 2009.
61. Kong W, Yang H, He L, et al: MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 28: 6773-6784, 2008.
62. Baker AH, George SJ, Zaltsman AB, Murphy G and Newby AC: Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3. Br J Cancer 79: 1347-1355, 1999. (Pubitemid 29116789)
63. Bode W, Reinemer P, Huber R, Kleine T, Schnierer S and Tschesche H: The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J 13: 1263-1269, 1994. (Pubitemid 24090206)
64. Gabriely G, Wurdinger T, Kesari S, et al: MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol 28: 5369-5380, 2008.
65. Selaru FM, Olaru AV, Kan T, et al: MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. Hepatology 49: 1595-1601, 2009.
66. Song B, Wang C, Liu J, et al: MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. J Exp Clin Cancer Res 29: 29, 2010.
67. Zhu S, Wu H, Wu F, Nie D, Sheng S and Mo YY: MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 18: 350-359, 2008. (Pubitemid 351333899)
68. Perry SV: Vertebrate tropomyosin: distribution, properties and function. J Muscle Res Cell Motil 22: 5-49, 2001.
69. Hall A: Rho GTPases and the actin cytoskeleton. Science 279: 509-514, 1998.
70. Varga AE, Stourman NV, Zheng Q, et al: Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta. Oncogene 24: 5043-5052, 2005. (Pubitemid 41129082)
71. Lu Z, Liu M, Stribinskis V, et al: MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27: 4373-4379, 2008. (Pubitemid 352010003)
72. Asangani IA, Rasheed SAK, Nikolova DA, et al: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27: 2128-2136, 2007. (Pubitemid 351485639)
73. Yang HS, Matthews CP, Clair T, et al: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Mol Cell Biol 26: 1297-1306, 2006. (Pubitemid 43202557)
74. Benbow U and Brinckerhoff CE: The AP-1 site and MMP gene regulation: what is all the fuss about? Matrix Biol 15: 519-526, 1997. (Pubitemid 27190026)
75. Murai T, Maruyama Y, Mio K, Nishiyama H, Suga M and Sato C: Low cholesterol triggers membrane microdomain-dependent CD44 shedding and suppresses tumor cell migration. J Biol Chem 286: 1999-2007, 2011.
76. Lesley J, Hyman R and Kincade PW: CD44 and its interaction with extracellular matrix. Adv Immunol 54: 271-335, 1993. (Pubitemid 23289255)
77. Tavazoie S, Alarcón C, Oskarsson T, et al: Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451: 147-152, 2008.
78. Hakem A: RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 19: 1974-1979, 2005.
79. Clark E, Golub T, Lander E and Hynes R: Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406: 532-535, 2000. (Pubitemid 30625739)
80. Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-688, 2007. (Pubitemid 47552092)
81. Myers C, Charboneau A, Cheung I, Hanks D and Boudreau N: Sustained expression of homeobox D10 inhibits angiogenesis. A J Pathol 161: 2099-2109, 2002. (Pubitemid 35434856)
82. Lehtonen ST, Svensk A-M, Soini Y, et al: Peroxiredoxins, a novel protein family in lung cancer. Int J Cancer 111: 514-521, 2004. (Pubitemid 39045317)
83. Chang XZ, Li DQ, Hou YF, et al: Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer. Breast Cancer Res 9: R76, 2007.
84. Kümin A, Huber C, Rülicke T, Wolf E and Werner S: Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis. Am J Pathol 169: 1194-1205, 2006. (Pubitemid 351194356)
85. Chang XZ, Li DQ, Hou YF, et al: Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer. Breast Cancer Res 9: R76, 2007.
86. Suarez Y and Sessa WC: MicroRNAs as novel regulators of angiogenesis. Circ Res 104: 442-454, 2009.
87. Zhu N, Zhang D, Xie H, et al: Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. Mol Cell Biochem 351: 157-164, 2011.
88. Gerber HP, McMurtrey A, Kowalski J, et al: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway. J Biol Chem 273: 30336-30343, 1998. (Pubitemid 28545503)
89. Iva N and Karl-Heinz P: EGFL7 meets miRNA-126: an angiogenesis alliance. J Angiogenes Res 2: 9, 2010.
90. Fish JE, Santoro MM, Morton SU, et al: miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15: 272-284, 2008.
91. Boudreau N and Myers C: Breast cancer-induced angiogenesis: multiple mechanisms and the role of the microenvironment. Breast Cancer Res 5: 140-146, 2003. (Pubitemid 36519407)
92. Cascio S, D'Andrea A, Ferla R, et al: miR-20b modulates VEGF expression by targeting HIF-1α and STAT3 in MCF-7 breast cancer cells. J Cell Physiol 224: 242-249, 2010.
93. Bos R, Zhong H, Hanrahan CF, et al: Levels of hypoxia-inducible factor-1α during breast carcinogenesis. J Natl Cancer Inst 93: 309, 2001.
94. Krek A, Grun D, Poy MN, et al: Combinatorial microRNA target predictions. Nature Genet 37: 495-500, 2005. (Pubitemid 40617277)