MicroRNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD4

Cancer Medicine

Volumn 5, Issue 4, 2016, Pages 693-702

  Wei, Xueju ^a,b   Wang, Weibin ^c   Wang, Lanlan ^a,b   Zhang, Yuanyuan ^a,b   Zhang, Xian ^a   Chen, Mingtai ^b   Wang, Fang ^b   Yu, Jia ^b   Ma, Yanni ^b   Sun, Guotao ^a  

^a HENAN UNIVERSITY   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

5 Fluorouracil; MiR 21; Pancreatic cancer; PDCD4; PTEN

Indexed keywords

FLUOROURACIL; LENTIVIRUS VECTOR; MICRORNA 21; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN PDCD4; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; MICRORNA; MIRN21 MICRORNA, HUMAN; PDCD4 PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; RNA BINDING PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; HUMAN; HUMAN CELL; LENTIVIRINAE; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; TUMOR SUPPRESSOR GENE; VIRAL GENE DELIVERY SYSTEM; CELL MOTION; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; PANCREATIC NEOPLASMS; TUMOR CELL LINE;

APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; PANCREATIC NEOPLASMS; PTEN PHOSPHOHYDROLASE; RNA-BINDING PROTEINS;

EID: 84981764236     PISSN: None     EISSN: 20457634     Source Type: Journal    
DOI: 10.1002/cam4.626     Document Type: Article

References (28)

1. Jemal, A., R. Siegel, E. Ward, Y. Hao, J. Xu, and M. J. Thun . 2009. Cancer statistics, 2009. CA Cancer J. Clin. 59:225-249.
2. Siegel, R., D. Naishadham, and A. Jemal . 2013. Cancer statistics. CA Cancer J. Clin. 63:11-30.
3. Maisey, N., I. Chau, D. Cunningham, A. Norman, M. Seymour, T. Hickish, et al. 2002. Multicenter randomized phase III trial comparing protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin in inoperable pancreatic cancer. J. Clin. Oncol. 20:3130-3136.
4. Tomari, Y., and P. D. Zamore . 2005. MicroRNA biogenesis: Drosha can't cut it without a partner. Curr. Biol. 15:R61-R64.
5. Wu, W. K., C. W. Lee, C. H. Cho, D. Fan, K. Wu, J. Yu, et al. 2010. MicroRNA dysregulation in gastric cancer: a new player enters the game. Oncogene 29:5761-5771.
6. Garzon, R., G. A. Calin, and C. M. Croce . 2009. MicroRNAs in cancer. Annu. Rev. Med. 60:167-179.
7. Sorrentino, A., C. G. Liu, A. Addario, C. Peschle, G. Scambia, and C. Ferlini . 2008. Role of microRNAs in drug-resistant ovarian cancer cells. Gynecol. Oncol. 111:478-486.
8. Aslam, M. I., M. Patel, B. Singh, J. S. Jameson, and J. H. Pringle . 2012. MicroRNA manipulation in colorectal cancer cells: from laboratory to clinical application. J. Transl. Med. 10:128.
9. Hong, L., Y. Han, Y. Zhang, H. Zhang, Q. Zhao, K. Wu, et al. 2013. MicroRNA-21: a therapeutic target forreversing drug resistance in cancer. Expert Opin. Ther. Targets 17:1073-1080.
10. Mei, M., Y. Ren, X. Zhou, X. B. Yuan, L. Han, G. X. Wang, et al. 2010. Downregulation of miR-21 enhances chemotherapeutic effect of taxol in breast carcinoma cells. Technol. Cancer Res. Treat. 9:77-86.
11. Gong, C., Y. Yao, Y. Wang, B. Liu, W. Wu, J. Chen, et al. 2011. Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J. Biol. Chem. 286:19127-19137.
12. Wang, Z. X., B. B. Lu, H. Wang, Z. X. Cheng, and Y. M. Yin . 2011. MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN. Arch. Med. Res. 42:281-290.
13. Yang, S. M., C. Huang, X. F. Li, M. Z. Yu, Y. He, and J. Li . 2013. miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology 306:162-168.
14. Hwang, J. H., J. Voortman, E. Giovannetti, S. M. Steinberg, L. G. Leon, Y. T. Kim, et al. 2010. Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer. PLoS ONE 5:e10630.
15. Donahue, T. R., A. H. Nguyen, J. Moughan, L. Li, S. Tatishchev, P. Toste, et al. 2014. Stromal MicroRNA-21 levels predict response to 5-fluorouracil in patients with pancreatic cancer. J. Surg. Oncol. 110:952-959.
16. Giovannetti, E., N. Funel, G. J. Peters, M. Del Chiaro, L. A. Erozenci, E. Vasile, et al. 2010. MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer Res. 70:4528-4538.
17. Chen, C., D. A. Ridzon, A. J. Broomer, Z. Zhou, D. H. Lee, J. T. Nguyen, et al. 2005. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 33:e179.
18. Ali, S., A. Ahmad, S. Banerjee, S. Padhye, K. Dominiak, J. M. Schaffert, et al. 2010. Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF. Cancer Res. 70:3606-3617.
19. Bourguignon, L. Y., C. C. Spevak, G. Wong, W. Xia, and E. Gilad . 2009. Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J. Biol. Chem. 284:26533-26546.
20. Li, Y., W. Li, Y. Yang, Y. Lu, C. He, G. Hu, et al. 2009. MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res. 1286:13-18.
21. Park, J. K., E. J. Lee, C. Esau, and T. D. Schmittgen . 2009. Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. Pancreas 38:e190-e199.
22. Young, M. R., A. N. Santhanam, N. Yoshikawa, and N. H. Colburn . 2010. Have tumor suppressor PDCD4 and its counteragent oncogenic miR-21 gone rogue? Mol. Interv. 10:76-79.
23. Allgayer, H. 2010. Pdcd4, a colon cancer prognostic that is regulated by a microRNA. Crit. Rev. Oncol. Hematol. 73:185-191.
24. Liwak, U., N. Thakor, L. E. Jordan, R. Roy, S. M. Lewis, O. E. Pardo, et al. 2012. Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2. Mol. Cell. Biol. 32:1818-1829.
25. Dennis, M. D., L. S. Jefferson, and S. R. Kimball . 2012. Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J. Biol. Chem. 287:42890-42899.
26. Singh, P., R. Marikkannu, N. Bitomsky, and K. H. Klempnauer . 2009. Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response. Oncogene 28:3758-3764.
27. Meng, F., R. Henson, H. Wehbe-Janek, K. Ghoshal, S. T. Jacob, and T. Patel . 2007. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133:647-658.
28. Bunney, T. D., and M. Katan . 2010. Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat. Rev. Cancer 10:342-352.