MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells

International Journal of Molecular Medicine

Volumn 29, Issue 5, 2012, Pages 920-926

  Feng, Yin Hsun ^a,b,c   Wu, Chao Liang ^b   Shiau, Ai Li ^b   Lee, Jenq Chang ^b   Chang, Jan Gowth ^d   Lu, Pei Jung ^b   Tung, Chao Ling ^a   Feng, Li Yia ^e   Huang, Wen Tsung ^a   Tsao, Chao Jung ^a  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL KAOHSIUNG UNIVERSITY OF HOSPITALITY AND TOURISM   (Taiwan)

Author keywords

Colon cancer; Fluorouracil; Metformin; microRNA 21; Sprouty

Indexed keywords

FLUOROURACIL; METFORMIN; MICRORNA 21; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAF PROTEIN; RAS PROTEIN; SPROUTY PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN HCT116; COLON CANCER; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; GENE CONTROL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; METFORMIN; MICRORNAS; PTEN PHOSPHOHYDROLASE; UP-REGULATION;

EID: 84863234535     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.910     Document Type: Article

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