TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

Journal of Experimental Medicine

Volumn 214, Issue 2, 2017, Pages 459-473

  Lang, Xueting ^a,b   Tang, Tiantian ^a   Jin, Tengchuan ^a   Ding, Chen ^c,d   Zhou, Rongbin ^a,b   Jiang, Wei ^a,b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c FUDAN UNIVERSITY   (China)

^d BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; INTERFERON; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; INTERFERON REGULATORY FACTOR 3; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR 3; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; TRIPARTITE MOTIF PROTEIN; TRIPARTITE MOTIF PROTEIN 65; UNCLASSIFIED DRUG; IFIH1 PROTEIN, MOUSE; TRIM65 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BHK CELL LINE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENCEPHALOMYOCARDITIS VIRUS; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INNATE IMMUNITY; INTERFERON PRODUCTION; MASS SPECTROMETRY; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; VIRUS IMMUNITY; ANIMAL; C57BL MOUSE; CARDIOVIRUS INFECTION; CHEMISTRY; IMMUNOLOGY; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

ANIMALS; CARDIOVIRUS INFECTIONS; ENCEPHALOMYOCARDITIS VIRUS; HUMANS; IMMUNITY, INNATE; INTERFERON-INDUCED HELICASE, IFIH1; MICE; MICE, INBRED C57BL; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; TRIPARTITE MOTIF PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 85012241943     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20160592     Document Type: Article

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