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Volumn 232, Issue 2, 2017, Pages R131-R139

Gene expression signature: A powerful approach for drug discovery in diabetes

Author keywords

Complex disease; Drug discovery; Gene expression signature; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; NEW DRUG; TRANSCRIPTOME;

EID: 85012008485     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-16-0515     Document Type: Review
Times cited : (9)

References (95)
  • 3
    • 45549095488 scopus 로고    scopus 로고
    • Gene expression-based screening for inhibitors of PDGFR signaling
    • Antipova AA, Stockwell BR & Golub TR 2008 Gene expression-based screening for inhibitors of PDGFR signaling. Genome Biology 9 R47-R47. (doi:10.1186/gb-2008-9-3-r47)
    • (2008) Genome Biology , vol.9 , pp. R47-R47
    • Antipova, A.A.1    Stockwell, B.R.2    Golub, T.R.3
  • 4
    • 84858383401 scopus 로고    scopus 로고
    • Diabetes mellitus and the β cell: the last ten years
    • Ashcroft FM & Rorsman P 2012 Diabetes mellitus and the β cell: the last ten years. Cell 148 1160-1171. (doi:10.1016/j.cell.2012.02.010)
    • (2012) Cell , vol.148 , pp. 1160-1171
    • Ashcroft, F.M.1    Rorsman, P.2
  • 5
    • 84962463376 scopus 로고    scopus 로고
    • Obesity management for the treatment of type 2 diabete. Sec. 6. In Standards of Medical Care in Diabetes-2016
    • American Diabetes Association 2016 Obesity management for the treatment of type 2 diabetes. Sec. 6. In Standards of Medical Care in Diabetes-2016. Diabetes Care 39 S47-S51. (doi:10.2337/dc16-S009)
    • (2016) Diabetes Care , vol.39 , pp. S47-S51
  • 6
    • 41149141306 scopus 로고    scopus 로고
    • Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin
    • Aston-Mourney K, Proietto J, Morahan G & Andrikopoulos S 2008 Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin. Diabetologia 51 540-545. (doi:10.1007/s00125-008-0930-2)
    • (2008) Diabetologia , vol.51 , pp. 540-545
    • Aston-Mourney, K.1    Proietto, J.2    Morahan, G.3    Andrikopoulos, S.4
  • 7
    • 2942729848 scopus 로고    scopus 로고
    • Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer
    • Ayers M, Symmans WF, Stec J, Damokosh AI, Clark E, Hess K, Lecocke M, Metivier J, Booser D, Ibrahim N, et al. 2004 Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer. Journal of Clinical Oncology 22 2284-2293. (doi:10.1200/JCO.2004.05.166)
    • (2004) Journal of Clinical Oncology , vol.22 , pp. 2284-2293
    • Ayers, M.1    Symmans, W.F.2    Stec, J.3    Damokosh, A.I.4    Clark, E.5    Hess, K.6    Lecocke, M.7    Metivier, J.8    Booser, D.9    Ibrahim, N.10
  • 9
    • 84867507940 scopus 로고    scopus 로고
    • The molecular mechanisms of pancreatic beta-cell glucotoxicity: recent findings and future research directions
    • Bensellam M, Laybutt DR & Jonas JC 2012 The molecular mechanisms of pancreatic beta-cell glucotoxicity: recent findings and future research directions. Molecular and Cellular Endocrinology 364 1-27. (doi:10.1016/j.mce.2012.08.003)
    • (2012) Molecular and Cellular Endocrinology , vol.364 , pp. 1-27
    • Bensellam, M.1    Laybutt, D.R.2    Jonas, J.C.3
  • 10
    • 84890285675 scopus 로고    scopus 로고
    • Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials
    • Berhan A & Barker A 2013 Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials. BMC Endocrine Disorders 13 58. (doi:10.1186/1472-6823-13-58)
    • (2013) BMC Endocrine Disorders , vol.13 , pp. 58
    • Berhan, A.1    Barker, A.2
  • 12
    • 84904767484 scopus 로고    scopus 로고
    • Lipotoxic endoplasmic reticulum stress, beta cell failure, and type 2 diabetes mellitus
    • Biden TJ, Boslem E, Chu KY & Sue N 2014 Lipotoxic endoplasmic reticulum stress, beta cell failure, and type 2 diabetes mellitus. Trends in Endocrinology and Metabolism 25 389-398. (doi:10.1016/j. tem.2014.02.003)
    • (2014) Trends in Endocrinology and Metabolism , vol.25 , pp. 389-398
    • Biden, T.J.1    Boslem, E.2    Chu, K.Y.3    Sue, N.4
  • 13
    • 65949122087 scopus 로고    scopus 로고
    • One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial
    • Bunck MC, Diamant M, Corner A, Eliasson B, Malloy JL, Shaginian RM, Deng W, Kendall DM, Taskinen MR, Smith U, et al. 2009 One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial. Diabetes Care 32 762-768. (doi:10.2337/dc08-1797)
    • (2009) Diabetes Care , vol.32 , pp. 762-768
    • Bunck, M.C.1    Diamant, M.2    Corner, A.3    Eliasson, B.4    Malloy, J.L.5    Shaginian, R.M.6    Deng, W.7    Kendall, D.M.8    Taskinen, M.R.9    Smith, U.10
  • 14
    • 1242273636 scopus 로고    scopus 로고
    • The effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes, Diabetes
    • Buse JB, Tan MH, Prince MJ & Erickson PP 2004 The effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes. Diabetes, Obesity and Metabolism 6 133-156. (doi:10.1111/j.1462-8902.2004.00325.x)
    • (2004) Obesity and Metabolism , vol.6 , pp. 133-156
    • Buse, J.B.1    Tan, M.H.2    Prince, M.J.3    Erickson, P.P.4
  • 15
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA & Butler PC 2003 Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52 102-110. (doi:10.2337/diabetes.52.1.102)
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 18
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 inhibition-a novel strategy for diabetes treatment
    • Chao EC & Henry RR 2010 SGLT2 inhibition-a novel strategy for diabetes treatment. Nature Reviews Drug Discovery 9 551-559. (doi:10.1038/nrd3180)
    • (2010) Nature Reviews Drug Discovery , vol.9 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 19
    • 84876671873 scopus 로고    scopus 로고
    • Cancer gene expression signatures-the rise and fall?
    • Chibon F 2013 Cancer gene expression signatures-the rise and fall? European Journal of Cancer 49 2000-2009. (doi:10.1016/j. ejca.2013.02.021)
    • (2013) European Journal of Cancer , vol.49 , pp. 2000-2009
    • Chibon, F.1
  • 20
    • 0034546705 scopus 로고    scopus 로고
    • The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis
    • Chu CA, Wiernsperger N, Muscato N, Knauf M, Neal DW & Cherrington AD 2000 The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis. Metabolism 49 1619-1626. (doi:10.1053/meta.2000.18561)
    • (2000) Metabolism , vol.49 , pp. 1619-1626
    • Chu, C.A.1    Wiernsperger, N.2    Muscato, N.3    Knauf, M.4    Neal, D.W.5    Cherrington, A.D.6
  • 22
    • 84895868553 scopus 로고    scopus 로고
    • Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
    • DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, et al. 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics 46 234-244. (doi:10.1038/ng.2897)
    • (2014) Nature Genetics , vol.46 , pp. 234-244
    • Mahajan, A.1    Go, M.J.2    Zhang, W.3    Below, J.E.4    Gaulton, K.J.5
  • 23
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ & Nauck MA 2006 The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368 1696-1705. (doi:10.1016/S0140-6736(06)69705-5)
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 24
    • 84908177336 scopus 로고    scopus 로고
    • Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial
    • Dungan KM, Povedano ST, Forst T, González JGG, Atisso C, Sealls W & Fahrbach JL 2014 Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. Lancet 384 1349-1357. (doi:10.1016/S0140-6736(14)60976-4)
    • (2014) Lancet , vol.384 , pp. 1349-1357
    • Dungan, K.M.1    Povedano, S.T.2    Forst, T.3    González, J.G.G.4    Atisso, C.5    Sealls, W.6    Fahrbach, J.L.7
  • 25
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagonlike peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, Elashoff R & Butler PC 2011 Pancreatitis, pancreatic, and thyroid cancer with glucagonlike peptide-1-based therapies. Gastroenterology 141 150-156. (doi:10.1053/j.gastro.2011.02.018)
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 26
    • 84962381148 scopus 로고    scopus 로고
    • Diabetic ketoacidosis and related events in the canagliflozin type 2 diabetes clinical program
    • Erondu N, Desai M, Ways K & Meininger G 2015 Diabetic ketoacidosis and related events in the canagliflozin type 2 diabetes clinical program. Diabetes Care 38 1680-1686. (doi:10.2337/dc15-1251)
    • (2015) Diabetes Care , vol.38 , pp. 1680-1686
    • Erondu, N.1    Desai, M.2    Ways, K.3    Meininger, G.4
  • 27
    • 84908672563 scopus 로고    scopus 로고
    • Regulation of pancreatic beta cell stimulus-secretion coupling by microRNAs
    • Esguerra J, Mollet I, Salunkhe V, Wendt A & Eliasson L 2014 Regulation of pancreatic beta cell stimulus-secretion coupling by microRNAs. Genes 5 1018-1031. (doi:10.3390/genes5041018)
    • (2014) Genes , vol.5 , pp. 1018-1031
    • Esguerra, J.1    Mollet, I.2    Salunkhe, V.3    Wendt, A.4    Eliasson, L.5
  • 28
    • 1442311573 scopus 로고    scopus 로고
    • Gene expression as a drug discovery tool
    • Evans WE & Guy RK 2004 Gene expression as a drug discovery tool. Nature Genetics 36 214-215. (doi:10.1038/ng0304-214)
    • (2004) Nature Genetics , vol.36 , pp. 214-215
    • Evans, W.E.1    Guy, R.K.2
  • 30
    • 4644300651 scopus 로고    scopus 로고
    • Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes
    • Fineman MS, Shen LZ, Taylor K, Kim DD & Baron AD 2004 Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes. Diabetes/Metabolism Research and Reviews 20 411-417. (doi:10.1002/dmrr.499)
    • (2004) Diabetes/Metabolism Research and Reviews , vol.20 , pp. 411-417
    • Fineman, M.S.1    Shen, L.Z.2    Taylor, K.3    Kim, D.D.4    Baron, A.D.5
  • 33
    • 84871128672 scopus 로고    scopus 로고
    • Initial sulfonylurea use and subsequent insulin therapy in older subjects with type 2 diabetes mellitus
    • Fu AZ, Qiu Y, Davies MJ & Engel SS 2012 Initial sulfonylurea use and subsequent insulin therapy in older subjects with type 2 diabetes mellitus. Diabetes Therapy 3 12. (doi:10.1007/s13300-012-0012-9)
    • (2012) Diabetes Therapy , vol.3 , pp. 12
    • Fu, A.Z.1    Qiu, Y.2    Davies, M.J.3    Engel, S.S.4
  • 35
    • 3042695171 scopus 로고    scopus 로고
    • Thiazolidinediones: comparison of long-term effects on glycemic control and cardiovascular risk factors
    • Gegick CG & Altheimer MD 2004 Thiazolidinediones: comparison of long-term effects on glycemic control and cardiovascular risk factors. Current Medical Research and Opinion 20 919-930. (doi:10.1185/03007 9904125003908)
    • (2004) Current Medical Research and Opinion , vol.20 , pp. 919-930
    • Gegick, C.G.1    Altheimer, M.D.2
  • 36
    • 84860567470 scopus 로고    scopus 로고
    • Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model
    • Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM & Butler PC 2012 Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Diabetes 61 1250-1262. (doi:10.2337/db11-1109)
    • (2012) Diabetes , vol.61 , pp. 1250-1262
    • Gier, B.1    Matveyenko, A.V.2    Kirakossian, D.3    Dawson, D.4    Dry, S.M.5    Butler, P.C.6
  • 37
    • 36849011549 scopus 로고    scopus 로고
    • Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10, 705 Danish subjects: validation and extension of genome-wide association studies
    • Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, Albrechtsen A, Clausen JO, Rasmussen SS, Jorgensen T, Sandbaek A, et al. 2007 Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10, 705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 56 3105-3111. (doi:10.2337/db07-0856)
    • (2007) Diabetes , vol.56 , pp. 3105-3111
    • Grarup, N.1    Rose, C.S.2    Andersson, E.A.3    Andersen, G.4    Nielsen, A.L.5    Albrechtsen, A.6    Clausen, J.O.7    Rasmussen, S.S.8    Jorgensen, T.9    Sandbaek, A.10
  • 40
    • 84930458479 scopus 로고    scopus 로고
    • Sulfonylurea versus metformin monotherapy in patients with type 2 diabetes: a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis
    • Hemmingsen B, Schroll JB, Wetterslev J, Gluud C, Vaag A, Sonne DP, Lundstrøm LH & Almdal T 2014 Sulfonylurea versus metformin monotherapy in patients with type 2 diabetes: a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis. CMAJ Open 2 E162-E175. (doi:10.9778/cmajo.20130073)
    • (2014) CMAJ Open , vol.2 , pp. E162-E175
    • Hemmingsen, B.1    Schroll, J.B.2    Wetterslev, J.3    Gluud, C.4    Vaag, A.5    Sonne, D.P.6    Lundstrøm, L.H.7    Almdal, T.8
  • 46
    • 84896495719 scopus 로고    scopus 로고
    • Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
    • Kahn SE, Cooper ME & Del Prato S 2014 Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 383 1068-1083. (doi:10.1016/S0140-6736(13)62154-6)
    • (2014) Lancet , vol.383 , pp. 1068-1083
    • Kahn, S.E.1    Cooper, M.E.2    Del Prato, S.3
  • 47
    • 84870526559 scopus 로고    scopus 로고
    • Personalized oncology: recent advances and future challenges
    • Kalia M 2013 Personalized oncology: recent advances and future challenges. Metabolism 62 (Supplement 1) S11-S14. (doi:10.1016/j. metabol.2012.08.016)
    • (2013) Metabolism , vol.62 , pp. S11-S14
    • Kalia, M.1
  • 48
    • 0036068327 scopus 로고    scopus 로고
    • Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects
    • Kim YB, Ciaraldi TP, Kong A, Kim D, Chu N, Mohideen P, Mudaliar S, Henry RR & Kahn BB 2002 Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects. Diabetes 51 443-448. (doi:10.2337/diabetes.51.2.443)
    • (2002) Diabetes , vol.51 , pp. 443-448
    • Kim, Y.B.1    Ciaraldi, T.P.2    Kong, A.3    Kim, D.4    Chu, N.5    Mohideen, P.6    Mudaliar, S.7    Henry, R.R.8    Kahn, B.B.9
  • 52
    • 74849108033 scopus 로고    scopus 로고
    • Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats
    • Kwon DY, Kim YS, Ahn IS, Kim da S, Kang S, Hong SM & Park S 2009 Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats. Journal of Pharmacological Sciences 111 361-371. (doi:10.1254/jphs.09178FP)
    • (2009) Journal of Pharmacological Sciences , vol.111 , pp. 361-371
    • Kwon, D.Y.1    Kim, Y.S.2    Ahn, I.S.3    Kim da, S.4    Kang, S.5    Hong, S.M.6    Park, S.7
  • 53
    • 84946558803 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and the risk of acute pancreatitis in patients with type 2 diabetes in Taiwan: a population-based cohort study
    • Lai Y-J, Hu H-Y, Chen H-H & Chou P 2015 Dipeptidyl peptidase-4 inhibitors and the risk of acute pancreatitis in patients with type 2 diabetes in Taiwan: a population-based cohort study. Medicine 94 e1906. (doi:10.1097/MD.0000000000001906)
    • (2015) Medicine , vol.94
    • Lai, Y.-J.1    Hu, H.-Y.2    Chen, H.-H.3    Chou, P.4
  • 54
    • 19944390213 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes mellitus
    • Leahy JL 2005 Pathogenesis of type 2 diabetes mellitus. Archives of Medical Research 36 197-209. (doi:10.1016/j.arcmed.2005.01.003)
    • (2005) Archives of Medical Research , vol.36 , pp. 197-209
    • Leahy, J.L.1
  • 55
  • 56
    • 84873368730 scopus 로고    scopus 로고
    • GeneExpressionSignature: an R package for discovering functional connections using gene expression signatures
    • Li F, Cao Y, Han L, Cui X, Xie D, Wang S & Bo X 2013 GeneExpressionSignature: an R package for discovering functional connections using gene expression signatures. Omics 17 116-118. (doi:10.1089/omi.2012.0087)
    • (2013) Omics , vol.17 , pp. 116-118
    • Li, F.1    Cao, Y.2    Han, L.3    Cui, X.4    Xie, D.5    Wang, S.6    Bo, X.7
  • 57
    • 0024162998 scopus 로고
    • Metabolic effects of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis
    • Luzi L, Barrett EJ, Groop LC, Ferrannini E & DeFronzo RA 1988 Metabolic effects of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis. Diabetes 37 1470-1477. (doi:10.2337/diab.37.11.1470)
    • (1988) Diabetes , vol.37 , pp. 1470-1477
    • Luzi, L.1    Barrett, E.J.2    Groop, L.C.3    Ferrannini, E.4    DeFronzo, R.A.5
  • 59
  • 60
    • 3042798575 scopus 로고    scopus 로고
    • The phantom of lactic acidosis due to metformin in patients with diabetes
    • Misbin RI 2004 The phantom of lactic acidosis due to metformin in patients with diabetes. Diabetes Care 27 1791-1793. (doi:10.2337/diacare.27.7.1791)
    • (2004) Diabetes Care , vol.27 , pp. 1791-1793
    • Misbin, R.I.1
  • 61
    • 84875637478 scopus 로고    scopus 로고
    • More patients get good diabetes control, but only a minority meet all goals
    • Mitka M 2013 More patients get good diabetes control, but only a minority meet all goals. JAMA 309 1335-1336. (doi:10.1001/jama.2013.2414)
    • (2013) JAMA , vol.309 , pp. 1335-1336
    • Mitka, M.1
  • 63
    • 0037883037 scopus 로고    scopus 로고
    • Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
    • Miyazaki Y, He H, Mandarino LJ & DeFronzo RA 2003 Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients. Diabetes 52 1943-1950. (doi:10.2337/diabetes.52.8.1943)
    • (2003) Diabetes , vol.52 , pp. 1943-1950
    • Miyazaki, Y.1    He, H.2    Mandarino, L.J.3    DeFronzo, R.A.4
  • 64
    • 0027399655 scopus 로고
    • High risk of progression to NIDDM in South-African Indians with impaired glucose tolerance
    • Motala AA, Omar MA & Gouws E 1993 High risk of progression to NIDDM in South-African Indians with impaired glucose tolerance. Diabetes 42 556-563. (doi:10.2337/diab.42.4.556)
    • (1993) Diabetes , vol.42 , pp. 556-563
    • Motala, A.A.1    Omar, M.A.2    Gouws, E.3
  • 66
    • 85079121634 scopus 로고    scopus 로고
    • Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants
    • NCD-RisC 2016 Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet 387 1513-1530. (doi:10.1016/S0140-6736(16)00618-8)
    • (2016) Lancet , vol.387 , pp. 1513-1530
  • 68
    • 84962339296 scopus 로고    scopus 로고
    • Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition
    • Peters AL, Buschur EO, Buse JB, Cohan P, Diner JC & Hirsch IB 2015 Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care 38 1687-1693. (doi:10.2337/dc15-0843)
    • (2015) Diabetes Care , vol.38 , pp. 1687-1693
    • Peters, A.L.1    Buschur, E.O.2    Buse, J.B.3    Cohan, P.4    Diner, J.C.5    Hirsch, I.B.6
  • 69
    • 0036894342 scopus 로고    scopus 로고
    • Sulfonylurea stimulation of insulin secretion
    • Proks P, Reimann F, Green N, Gribble F & Ashcroft F 2002 Sulfonylurea stimulation of insulin secretion. Diabetes 51 (Supplement 3) S368-S376. (doi:10.2337/diabetes.51.2007.S368)
    • (2002) Diabetes , vol.51 , pp. S368-S376
    • Proks, P.1    Reimann, F.2    Green, N.3    Gribble, F.4    Ashcroft, F.5
  • 71
    • 84893252645 scopus 로고    scopus 로고
    • The promise of whole-exome sequencing in medical genetics
    • Rabbani B, Tekin M & Mahdieh N 2014 The promise of whole-exome sequencing in medical genetics. Journal of Human Genetics 59 5-15. (doi:10.1038/jhg.2013.114)
    • (2014) Journal of Human Genetics , vol.59 , pp. 5-15
    • Rabbani, B.1    Tekin, M.2    Mahdieh, N.3
  • 72
    • 85011986453 scopus 로고    scopus 로고
    • East Melbourne, Vic, Australia: RACGP
    • Royal Australian College of General Practitioners 2016 General Practice Management of Type 2 Diabetes: 2016-18. East Melbourne, Vic, Australia: RACGP. (available at: https://static.diabetesaustralia.com.au/s/fileassets/diabetes-australia/5d3298b2-abf3-487e-9d5e-0558566fc242.pdf)
    • (2016) General Practice Management of Type 2 Diabetes: 2016-18
  • 81
    • 1442335997 scopus 로고    scopus 로고
    • Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation
    • Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR & Golub TR 2004 Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nature Genetics 36 257-263. (doi:10.1038/ng1305)
    • (2004) Nature Genetics , vol.36 , pp. 257-263
    • Stegmaier, K.1    Ross, K.N.2    Colavito, S.A.3    O'Malley, S.4    Stockwell, B.R.5    Golub, T.R.6
  • 83
    • 78049466887 scopus 로고    scopus 로고
    • Evaluation of a 30-gene paclitaxel, fluorouracil, doxorubicin, and cyclophosphamide chemotherapy response predictor in a multicenter randomized trial in breast cancer
    • Tabchy A, Valero V, Vidaurre T, Lluch A, Gomez H, Martin M, Qi Y, Barajas-Figueroa LJ, Souchon E, Coutant C, et al. 2010 Evaluation of a 30-gene paclitaxel, fluorouracil, doxorubicin, and cyclophosphamide chemotherapy response predictor in a multicenter randomized trial in breast cancer. Clinical Cancer Research 16 5351-5361. (doi:10.1158/1078-0432.CCR-10-1265)
    • (2010) Clinical Cancer Research , vol.16 , pp. 5351-5361
    • Tabchy, A.1    Valero, V.2    Vidaurre, T.3    Lluch, A.4    Gomez, H.5    Martin, M.6    Qi, Y.7    Barajas-Figueroa, L.J.8    Souchon, E.9    Coutant, C.10
  • 85
    • 79960328070 scopus 로고    scopus 로고
    • Hypoglycemia in insulin-treated diabetes: a case for increased vigilance
    • Unger J & Parkin C 2011 Hypoglycemia in insulin-treated diabetes: a case for increased vigilance. Postgraduate Medicine 123 81-91. (doi:10.3810/pgm.2011.07.2307)
    • (2011) Postgraduate Medicine , vol.123 , pp. 81-91
    • Unger, J.1    Parkin, C.2
  • 88
    • 84928128726 scopus 로고    scopus 로고
    • Exendin-4 promotes beta cell proliferation via PI3k/Akt signalling pathway
    • Wang C, Chen X, Ding X, He Y, Gu C & Zhou L 2015 Exendin-4 promotes beta cell proliferation via PI3k/Akt signalling pathway. Cellular Physiology and Biochemistry 35 2223-2232. (doi:10.1159/000374027)
    • (2015) Cellular Physiology and Biochemistry , vol.35 , pp. 2223-2232
    • Wang, C.1    Chen, X.2    Ding, X.3    He, Y.4    Gu, C.5    Zhou, L.6
  • 90
    • 0028857007 scopus 로고
    • Polygenic disease: methods for mapping complex disease traits
    • Weeks DE & Lathrop GM 1995 Polygenic disease: methods for mapping complex disease traits. Trends in Genetics 11 513-519. (doi:10.1016/S0168-9525(00)89163-5)
    • (1995) Trends in Genetics , vol.11 , pp. 513-519
    • Weeks, D.E.1    Lathrop, G.M.2
  • 91
    • 9444242665 scopus 로고    scopus 로고
    • Five stages of evolving beta-cell dysfunction during progression to diabetes
    • Weir GC & Bonner-Weir S 2004 Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 53 (Supplement 3) S16-S21. (doi:10.2337/diabetes.53.suppl_3.S16)
    • (2004) Diabetes , vol.53 , pp. S16-S21
    • Weir, G.C.1    Bonner-Weir, S.2


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