메뉴 건너뛰기




Volumn 35, Issue 6, 2015, Pages 2223-2232

Exendin-4 promotes beta cell proliferation via PI3k/Akt signalling pathway

Author keywords

Beta cell proliferation; Diabetes; Exendin 4; Incretin; PI3k Akt

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; EXENDIN 4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; PEPTIDE; VENOM;

EID: 84928128726     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000374027     Document Type: Article
Times cited : (31)

References (34)
  • 1
    • 0025373999 scopus 로고
    • Islets of langerhans: The puzzle of intraislet interactions and their relevance to diabetes
    • Weir GC, Bonner-Weir S: Islets of langerhans: The puzzle of intraislet interactions and their relevance to diabetes. J Clin Invest 1990;85:983-987.
    • (1990) J Clin Invest , vol.85 , pp. 983-987
    • Weir, G.C.1    Bonner-Weir, S.2
  • 2
    • 0345687862 scopus 로고    scopus 로고
    • Genes, signals, and lineages in pancreas development
    • Murtaugh LC, Melton DA: Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol 2003;19:71-89.
    • (2003) Annu Rev Cell Dev Biol , vol.19 , pp. 71-89
    • Murtaugh, L.C.1    Melton, D.A.2
  • 3
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver and pancreas
    • Zaret KS, Grompe M: Generation and regeneration of cells of the liver and pancreas. Science 2008;322:1490-1494.
    • (2008) Science , vol.322 , pp. 1490-1494
    • Zaret, K.S.1    Grompe, M.2
  • 4
    • 0036301577 scopus 로고    scopus 로고
    • Pancreatic organogenesis-developmental mechanisms and implications for therapy
    • Edlund H: Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat Rev Genet 2002;3:524-532.
    • (2002) Nat Rev Genet , vol.3 , pp. 524-532
    • Edlund, H.1
  • 5
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA: Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 6
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • Teta M, Rankin MM, Long SY, Stein GM, Kushner JA: Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 2007;12:817-826.
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 8
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia S, Bhushan A: Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 2004;114:963-968.
    • (2004) J Clin Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 10
    • 33645860514 scopus 로고    scopus 로고
    • Islet endothelial cells and pancreatic betacell proliferation: Studies in vitro and during pregnancy in adult rats
    • Johansson M, Mattsson G, Andersson A, Jansson L, Carlsson PO: Islet endothelial cells and pancreatic betacell proliferation: Studies in vitro and during pregnancy in adult rats. Endocrinology 2006;147:2315-2324.
    • (2006) Endocrinology , vol.147 , pp. 2315-2324
    • Johansson, M.1    Mattsson, G.2    Andersson, A.3    Jansson, L.4    Carlsson, P.O.5
  • 12
    • 77949324263 scopus 로고    scopus 로고
    • Expansion of beta-cell mass in response to pregnancy
    • Rieck S, Kaestner KH: Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab 2010;21:151-158.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 151-158
    • Rieck, S.1    Kaestner, K.H.2
  • 15
    • 84903598593 scopus 로고    scopus 로고
    • Increase of beta cell mass by beta cell replication, but not neogenesis, in the maternal pancreas in mice
    • Zhao X: Increase of beta cell mass by beta cell replication, but not neogenesis, in the maternal pancreas in mice. Endocr J 2014;61:623-628.
    • (2014) Endocr J , vol.61 , pp. 623-628
    • Zhao, X.1
  • 16
    • 84884583757 scopus 로고    scopus 로고
    • Incretin action in the pancreas: Potential promise, possible perils, and pathological pitfalls
    • Drucker DJ: Incretin action in the pancreas: Potential promise, possible perils, and pathological pitfalls. Diabetes 2013;62:3316-3323.
    • (2013) Diabetes , vol.62 , pp. 3316-3323
    • Drucker, D.J.1
  • 17
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ: Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 2009;5:262-269.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 18
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and meta-analysis
    • Amori RE, Lau J, Pittas AG: Efficacy and safety of incretin therapy in type 2 diabetes: Systematic review and meta-analysis. JAMA 2007;298:194-206.
    • (2007) JAMA , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 19
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA: The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006;368:1696-1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 21
    • 77954521533 scopus 로고    scopus 로고
    • Decrease in {beta}-cell proliferation precedes apoptosis during diabetes development in bio-breeding/worcester rat: Beneficial role of exendin-4
    • Perez-Arana G, Blandino-Rosano M, Prada-Oliveira A, Aguilar-Diosdado M, Segundo C: Decrease in {beta}-cell proliferation precedes apoptosis during diabetes development in bio-breeding/worcester rat: Beneficial role of exendin-4. Endocrinology 2010;151:2538-2546.
    • (2010) Endocrinology , vol.151 , pp. 2538-2546
    • Perez-Arana, G.1    Blandino-Rosano, M.2    Prada-Oliveira, A.3    Aguilar-Diosdado, M.4    Segundo, C.5
  • 22
    • 70449699592 scopus 로고    scopus 로고
    • Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents
    • Arakawa M, Ebato C, Mita T, Hirose T, Kawamori R, Fujitani Y, Watada H: Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochem Biophys Res Commun 2009;390:809-814.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 809-814
    • Arakawa, M.1    Ebato, C.2    Mita, T.3    Hirose, T.4    Kawamori, R.5    Fujitani, Y.6    Watada, H.7
  • 23
    • 70450235041 scopus 로고    scopus 로고
    • Exendin-4 promotes liver cell proliferation and enhances the pdx-1-induced liver to pancreas transdifferentiation process
    • Aviv V, Meivar-Levy I, Rachmut IH, Rubinek T, Mor E, Ferber S: Exendin-4 promotes liver cell proliferation and enhances the pdx-1-induced liver to pancreas transdifferentiation process. J Biol Chem 2009;284:33509-33520.
    • (2009) J Biol Chem , vol.284 , pp. 33509-33520
    • Aviv, V.1    Meivar-Levy, I.2    Rachmut, I.H.3    Rubinek, T.4    Mor, E.5    Ferber, S.6
  • 25
    • 84903980696 scopus 로고    scopus 로고
    • Exendin-4 stimulates islet cell replication via the igf1 receptor activation of mtorc1/s6k1
    • Xie J, El Sayed NM, Qi C, Zhao X, Moore CE, Herbert TP: Exendin-4 stimulates islet cell replication via the igf1 receptor activation of mtorc1/s6k1. J Mol Endocrinol 2014;53:105-115.
    • (2014) J Mol Endocrinol , vol.53 , pp. 105-115
    • Xie, J.1    El Sayed, N.M.2    Qi, C.3    Zhao, X.4    Moore, C.E.5    Herbert, T.P.6
  • 26
    • 79960136744 scopus 로고    scopus 로고
    • Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts
    • Tian L, Gao J, Weng G, Yi H, Tian B, O'Brien TD, Guo Z: Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts. Transpl Int 2011;24:856-864.
    • (2011) Transpl Int , vol.24 , pp. 856-864
    • Tian, L.1    Gao, J.2    Weng, G.3    Yi, H.4    Tian, B.5    O'Brien, T.D.6    Guo, Z.7
  • 27
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S: Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999;48:2270-2276.
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 28
    • 66649128739 scopus 로고    scopus 로고
    • Adaptive beta-cell proliferation is severely restricted with advanced age
    • Rankin MM, Kushner JA: Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 2009;58:1365-1372.
    • (2009) Diabetes , vol.58 , pp. 1365-1372
    • Rankin, M.M.1    Kushner, J.A.2
  • 30
    • 84875479006 scopus 로고    scopus 로고
    • Tgfbeta receptor signaling is essential for inflammation-induced but not beta-cell workload-induced beta-cell proliferation
    • Xiao X, Wiersch J, El-Gohary Y, Guo P, Prasadan K, Paredes J, Welsh C, Shiota C, Gittes GK: Tgfbeta receptor signaling is essential for inflammation-induced but not beta-cell workload-induced beta-cell proliferation. Diabetes 2013;62:1217-1226.
    • (2013) Diabetes , vol.62 , pp. 1217-1226
    • Xiao, X.1    Wiersch, J.2    El-Gohary, Y.3    Guo, P.4    Prasadan, K.5    Paredes, J.6    Welsh, C.7    Shiota, C.8    Gittes, G.K.9
  • 32
    • 33947538814 scopus 로고    scopus 로고
    • Myostatin induces cyclin d1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/akt/gsk-3 beta pathway and is antagonized by insulin-like growth factor 1
    • Yang W, Zhang Y, Li Y, Wu Z, Zhu D: Myostatin induces cyclin d1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/akt/gsk-3 beta pathway and is antagonized by insulin-like growth factor 1. J Biol Chem 2007;282:3799-3808.
    • (2007) J Biol Chem , vol.282 , pp. 3799-3808
    • Yang, W.1    Zhang, Y.2    Li, Y.3    Wu, Z.4    Zhu, D.5
  • 33
    • 4644283083 scopus 로고    scopus 로고
    • Ability of the activated pi3k/akt oncoproteins to synergize with mek1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells
    • Shelton JG, Blalock WL, White ER, Steelman LS, McCubrey JA: Ability of the activated pi3k/akt oncoproteins to synergize with mek1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells. Cell Cycle 2004;3:503-512.
    • (2004) Cell Cycle , vol.3 , pp. 503-512
    • Shelton, J.G.1    Blalock, W.L.2    White, E.R.3    Steelman, L.S.4    McCubrey, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.