A gene expression signature for insulin resistance

Physiological Genomics

Volumn 43, Issue 3, 2011, Pages 110-120

  Konstantopoulos, Nicky ^a   Foletta, Victoria C ^a   Segal, David H ^a   Shields, Katherine A ^b   Sanigorski, Andrew ^a   Windmill, Kelly ^a   Swinton, Courtney ^a   Connor, Tim ^a   Wanyonyi, Stephen ^a   Dyer, Thomas D ^c   Fahey, Richard P ^a   Watt, Rose A ^a   Curran, Joanne E ^c   Molero, Juan Carlos ^a   Krippner, Guy ^d   Collier, Greg R ^e   James, David E ^f   Blangero, John ^c   Jowett, Jeremy B ^b   Walder, Ken R ^a  

^a DEAKIN UNIVERSITY   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^d Verva Pharmaceuticals Ltd   (Australia)

^e ChemGenex Pharmaceuticals   (Australia)

^f GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Diabetes; Microarray; Personalized medicine; Screening

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; BETA LACTAM DERIVATIVE; CARBONATE DEHYDRATASE INHIBITOR; CD63 ANTIGEN; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; CYCLOPHILIN A; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOPAMINE RECEPTOR BLOCKING AGENT; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; LIPOXYGENASE INHIBITOR; LONG CHAIN FATTY ACID COENZYME A LIGASE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHODIESTERASE INHIBITOR; PROTEIN; PYRUVATE KINASE MUSCLE 2; S PHASE KINASE ASSOCIATED PROTEIN 1A; SEROTONIN ANTAGONIST; SIX TRANSMEMBRANE EPITHELIAL ANTIGEN OF THE PROSTATE; SODIUM CHANNEL BLOCKING AGENT; SULFONYLUREA DERIVATIVE; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITAMIN;

ADIPOCYTE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LYMPHOCYTE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

3T3-L1 CELLS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MICE; MIDDLE AGED; PROTEIN TRANSPORT; REPRODUCIBILITY OF RESULTS; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 79951870962     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00115.2010     Document Type: Article

References (51)

1. Adamson DJ, Frew D, Tatoud R, Wolf CR, Palmer CNA. Diclofenac antagonizes peroxisome proliferator-activated receptor- signaling. Mol Pharmacol 61: 7-12, 2002.
2. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J Jr, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Levy R, Wilson W, Grever MR, Byrd JC, Botstein D, Brown PO, Staudt LM. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403: 503-511, 2000.
3. Alpert E, Gruzman A, Lardi-Studler B, Cohen G, Reich R, Sasson S. Cyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPKα - independent manner. Diabetologia 49: 562-570, 2006.
4. Alpert E, Gruzman A, Tennenbaum T, Sasson S. Selective cyclooxy-genase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner. Biochem Pharmacol 73: 368-377, 2007.
5. Ancha H, Kurella R, McKimmey C, Lightfoot S, Harty R. Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats. Dig Dis Sci 54: 758-766, 2009.
6. Baron SH. Salicylates as hypoglycemic agents. Diabetes Care 5: 64-71, 1982.
7. Blangero J, Goring HH, Kent JW Jr, Williams JT, Peterson CP, Almasy L, Dyer TD. Quantitative trait nucleotide analysis using Bayesian model selection. Hum Biol 77: 541-559, 2005.
8. Boden WE, Moss AJ, Oakes D. Hypolipidemic effect of type Ia antiarrhythmic agents in postinfarction patients. Circulation 85: 2039-2044, 1992.
9. Carey KA, Segal D, Klein R, Sanigorski A, Walder K, Collier GR, Cameron-Smith D. Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays. Pathol Int 56: 246-255, 2006.
10. Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452: 181-186, 2008.
11. Cooper CS, Campbell C, Jhavar S. Mechanisms of disease: biomarkers and molecular targets from microarray gene expression studies in prostate cancer. Nat Clin Pract Urol 4: 677-687, 2007.
12. Cullinan A, Cantor C. Sequenom, Inc. Pharmacogenomics 9: 1211-1215, 2008.
13. Fehlbaum-Beurdeley P, Jarrige-Le Prado AC, Pallares D, Carriere J, Guihal C, Soucaille C, Rouet F, Drouin D, Sol O, Jordan H, Wu D, Lei L, Einstein R, Schweighoffer F, Bracco L. Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression. Alzheimers Dement 6: 25-38, 2010.
14. Goring HHH, Curran JE, Johnson MP, Dyer TD, Charlesworth J, Cole SA, Jowett JBM, Abraham LJ, Rainwater DL, Comuzzie AG, Mahaney MC, Almasy L, MacCluer JW, Kissebah AH, Collier GR, Moses EK, Blangero J. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet 39: 1208-1216, 2007.
15. Govers R, Coster AC, James DE. Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathway. Mol Cell Biol 24: 6456-6466, 2004.
16. Hope-Gill H, Vydelingum N, Kissebah AH, Tulloch BR, Fraser TR. Simulation and enhancement of the adipose tissue insulin response by procaine hydrochloride: evidence for a role of calcium in insulin action. Horm Metab Res 6: 457-463, 1974.
17. Jaradat MS, Wongsud B, Phornchirasilp S, Rangwala SM, Shams G, Sutton M, Romstedt KJ, Noonan DJ, Feller DR. Activation of peroxisome proliferator- activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin. Biochem Pharmacol 62: 1587-1595, 2001.
18. Kajita K, Ishizuka T, Miura A, Kanoh Y, Ishizawa M, Kimura M, Muto N, Yasuda K. Glucocorticoid-induced insulin resistance associates with activation of protein kinase C isoforms. Cell Signal 13: 169-175, 2001.
19. Kojima Y, Yoshikawa Y, Ueda E, Ueda R, Yamamoto S, Kumekawa K, Yanagihara N, Sakurai H. Insulinomimetic zinc(II) complexes with natural products: in vitro evaluation and blood glucose lowering effect in KK-Ay mice with type 2 diabetes mellitus. Chem Pharm Bull (Tokyo) 51: 1006-1008, 2003.
20. Konstantopoulos N, Marcuccio S, Kyi S, Stoichevska V, Castelli LA, Ward CW, Macaulay SL. A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport. Endocrinology 148: 374-385, 2007.
21. Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll M, Fasshauer M. Isoproterenol stimulates monocyte chemoattractant protein-1 expression and secretion in 3T3-L1 adipocytes. Regul Pept 135: 12-16, 2006.
22. Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll M, Fasshauer M. Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes. Mol Cell Endocrinol 240: 43-49, 2005.
23. Lang CH. Beta-adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor. Am J Physiol Regul Integr Comp Physiol 264:R984-R991, 1993.
24. Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272: 3406-3410, 1997.
25. Maecker H, Todd S, Levy S. The tetraspanin superfamily: molecular facilitators. FASEB J 11: 428-442, 1997.
26. Marques MMC, Junta CM, Zarate-Blades CR, Sakamoto-Hojo ET, Donadi EA, Passos GAS. Transcriptional response of peripheral lymphocytes to early fibrosarcoma: a model system for cancer detection based on hybridization signatures. Exp Biol Med 234: 802-812, 2009.
27. Miles PD, Romeo OM, Higo K, Cohen A, Rafaat K, Olefsky JM. TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 46: 1678-1683, 1997.
28. Mitchell BD, Kammerer CM, Blangero J, Mahaney MC, Rainwater DL, Dyke B, Hixson JE, Henkel RD, Sharp RM, Comuzzie AG, VandeBerg JL, Stern MP, MacCluer JW. Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans: the San Antonio Family Heart Study. Circulation 94: 2159-2170, 1996.
29. Mlinar B, Marc J, Janez A, Pfeifer M. Molecular mechanisms of insulin resistance and associated diseases. Clin Chim Acta 375: 20-35, 2007.
30. Moldes M, Lasnier F, Gauthereau X, Klein C, Pairault J, Feve B, Chambaut-Guerin AM. Tumor necrosis factor-alpha-induced adiposerelated protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion. J Biol Chem 276:33938-33946, 2001.
31. Mork NL, Robertson RP. Effects of nonsteroidal antiinflammatory drugs in conventional dosage on glucose homeostasis in patients with diabetes. West J Med 139: 46-49, 1983.
32. Nuyten DS, Hastie T, Chi JT, Chang HY, van de Vijver MJ. Combining biological gene expression signatures in predicting outcome in breast cancer: an alternative to supervised classification. Eur J Cancer 44: 2319-2329, 2008.
33. Ohgami RS, Campagna DR, McDonald A, Fleming MD. The Steap proteins are metalloreductases. Blood 108: 1388-1394, 2006.
34. Peters JM. SCF and APC: the Yin and Yang of cell cycle regulated proteolysis. Curr Opin Cell Biol 10: 759-768, 1998.
35. Peterson A, Peterson K, Tongen S, Guzman M, Corbett V, Langer O, Mazze R. Glucose intolerance as a consequence of oral terbutaline treatment for preterm labor. J Fam Pract 36: 25-31, 1993.
36. Rizza R, Mandarino L, Gerich J. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action. J Clin Endocrinol Metab 54: 131-138, 1982.
37. Rooney DP, Neely RD, Cullen C, Ennis CN, Sheridan B, Atkinson AB, Trimble ER, Bell PM. The effect of cortisol on glucose/glucose-6-phosphate cycle activity and insulin action. J Clin Endocrinol Metab 77: 1180-1183, 1993.
38. Sandra A, Marshall SJ. Arachidonic acid inhibition of insulin action and phosphoinositide turnover in fat cells. Mol Cell Endocrinol 45: 105-111, 1986.
39. Soupene E, Fyrst H, Kuypers FA. Mammalian acyl-CoA: lysophosphatidylcholine acyltransferase enzymes. Proc Natl Acad Sci USA 105: 88-93, 2008.
40. Stankiewicz M, Norman R. Diagnosis and management of polycystic ovary syndrome: a practical guide. Drugs 66: 903-912, 2006.
41. Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR. Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation. Nat Genet 36: 257-263, 2004.
42. Stegmaier K, Wong JS, Ross KN, Chow KT, Peck D, Wright RD, Lessnick SL, Kung AL, Golub TR. Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. PLoS Med 4: e122, 2007.
43. Stirban A, Negrean M, Stratmann B, Gawlowski T, Horstmann T, Gotting C, Kleesiek K, Mueller-Roesel M, Koschinsky T, Uribarri J, Vlassara H, Tschoepe D. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care 29: 2064-2071, 2006.
44. Taketa K, Yamamoto Y. Hypoglycemic effect of disopyramide in a case of diabetes mellitus under insulin treatment. Acta Med Okayama 34:289-292, 1980.
45. Tappy L. Metabolic effects of glucocorticoids: the unfinished story. Eur J Clin Invest 29: 814-815, 1999.
46. Trehanpati N, Geffers R, Sukriti Hissar S, Riese P, Toepfer T, Buer J, Kumar M, Guzman CA, Sarin SK. Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B infection. Hepatology 49: 781-790, 2009.
47. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, Parrish M, Atsma D, Witteveen A, Glas A, Delahaye L, van der Velde T, Bartelink H, Rodenhuis S, Rutgers ET, Friend SH, Bernards R. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347: 1999-2009, 2002.
48. Weiner FR, Smith PJ, Wertheimer S, Rubin CS. Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1. J Biol Chem 266: 23525-23528, 1991.
49. Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 129: 537-548, 2007.
50. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 57: 712-717, 2008.
51. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293: 1673-1677, 2001.